Impact of post-procedural glycemic variability on cardiovascular morbidity and mortality after transcatheter aortic valve implantation: a post hoc cohort analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Guillaume Besch, Sebastien Pili-Floury, Caroline Morel, Martine Gilard, Guillaume Flicoteaux, Lucie Salomon du Mont, Andrea Perrotti, Nicolas Meneveau, Sidney Chocron, Francois Schiele, Herve Le Breton, Emmanuel Samain, Romain Chopard

ABSTRACT

BACKGROUND: Glycemic variability is associated with worse outcomes after cardiac surgery, but the prognosis value of early glycemic variability after transcatheter aortic valve implantation is not known. This study was therefore designed to analyze the prognosis significance of post-procedural glycemic variability within 30 days after transcatheter aortic valve implantation. METHODS: A post hoc analysis of patients from our center included in the FRANCE and FRANCE-2 registries was conducted. Post-procedural glycemic variability was assessed by calculating the mean daily δ blood glucose during the first 2 days after transcatheter aortic valve implantation. Major complications within 30 days were death, stroke, myocardial infarction, acute heart failure, and life-threatening cardiac arrhythmias. RESULTS: We analyzed 160 patients (age (median [interquartile] = 84 [80-88] years; diabetes mellitus (n) = 41 (26%) patients; logistic Euroscore = 20 [12-32]). The median value of mean daily δ blood glucose was 4.3 mmol l-1. The rate of major complications within 30 days after procedure among patients with the lowest quartile of glycemic variability was 12%, increasing from 12 to 26%, and 39% in the second, third, and fourth quartiles, respectively. In multivariate analysis, glycemic variability was independently associated with an increased risk of major complications within 30 days after the procedure (odds ratio [95% CI] = 1.83 [1.19-2.83]; p = 0.006). CONCLUSIONS: This study showed that post-procedural glycemic variability was associated with an increased risk of major complications within 30 days after transcatheter aortic valve implantation. Trial registration Clinical trial registration number https://www.clinicaltrials.gov/ ; identifier: NCT02726958; date: April 4th, 2016. More... »

PAGES

27

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-019-0831-3

DOI

http://dx.doi.org/10.1186/s12933-019-0831-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112682869

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30857532


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254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.411158.8 schema:alternateName Centre Hospitalier Universitaire de Besançon
256 schema:name Department of Anesthesiology and Intensive Care, University Hospital of Besancon, 3 Boulevard Alexander Fleming, 25000, Besancon, France
257 Department of Cardiology, University Hospital of Besancon, 25000, Besancon, France
258 Department of Cardiothoracic Surgery, University Hospital of Besancon, 25000, Besancon, France
259 Department of Vascular Surgery, University Hospital of Besancon, 25000, Besancon, France
260 EA3920, University of Franche-Comte, 25000, Besancon, France
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.411766.3 schema:alternateName Centre Hospitalier Régional Universitaire de Brest
263 schema:name Department of Cardiology, University Hospital of Brest, 29609, Brest, France
264 rdf:type schema:Organization
265 https://www.grid.ac/institutes/grid.7459.f schema:alternateName University of Franche-Comté
266 schema:name Department of Anesthesiology and Intensive Care, University Hospital of Besancon, 3 Boulevard Alexander Fleming, 25000, Besancon, France
267 EA3920, University of Franche-Comte, 25000, Besancon, France
268 rdf:type schema:Organization
 




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