Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Cheng-Wei Chan, Chu-Leng Yu, Jiunn-Cherng Lin, Yu-Cheng Hsieh, Che-Chen Lin, Chen-Ying Hung, Cheng-Hung Li, Ying-Chieh Liao, Chu-Pin Lo, Jin-Long Huang, Ching-Heng Lin, Tsu-Juey Wu

ABSTRACT

OBJECTIVE: Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM patients from a nationwide cohort. METHODS: T2DM patients using different add-on oral ADAs after an initial metformin therapy of > 90 days were identified from the Taiwan National Health Insurance Database. Five classes of ADAs, including sulphonylureas (SU), glinides, thiazolidinediones (TZD), alpha-glucosidase inhibitors (AGI), and dipeptidyl peptidase-4 inhibitors (DPP-4I) were selected for analysis. The reference group was the SU added to metformin. Patients were excluded if aged < 20 years, had a history of stroke or acute coronary syndrome (ACS), or were receiving insulin treatment. The primary outcomes included any major adverse cardiovascular event (MACE) including ACS, ischemic/hemorrhagic stroke, and death. A Cox regression model was used to estimate the hazard ratio (HR) for MACE. RESULTS: A total of 26,742 patients receiving their add-on drug to metformin of either SU (n = 24,277), glinides (n = 962), TZD (n = 581), AGI (n = 808), or DPP-4I (n = 114) were analyzed. After a mean follow-up duration of 6.6 ± 3.4 years, a total of 4775 MACEs occurred. Compared with the SU+metformin group (reference), the TZD+metformin (adjusted HR: 0.66; 95% CI 0.50-0.88, p = 0.004) and AGI+metformin (adjusted HR: 0.74; 95% CI 0.59-0.94, p = 0.01) groups showed a significantly lower risk of MACE. CONCLUSION: Both TZD and AGI, when used as an add-on drug to metformin were associated with lower MACE risk when compared with SU added to metformin in this retrospective cohort study. Trial registration CE13152B-3. Registered 7 Mar, 2013, retrospectively registered. More... »

PAGES

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-018-0663-6

DOI

http://dx.doi.org/10.1186/s12933-018-0663-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100622469

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29368615


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Cheng-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Chu-Leng", 
        "id": "sg:person.01346366353.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346366353.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Providence University", 
          "id": "https://www.grid.ac/institutes/grid.412550.7", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan", 
            "Department of Internal Medicine, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan", 
            "Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Jiunn-Cherng", 
        "id": "sg:person.01344612700.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344612700.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Providence University", 
          "id": "https://www.grid.ac/institutes/grid.412550.7", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan", 
            "Department of Internal Medicine, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan", 
            "Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsieh", 
        "givenName": "Yu-Cheng", 
        "id": "sg:person.01052761375.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052761375.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taichung Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410764.0", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Che-Chen", 
        "id": "sg:person.01010676064.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010676064.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hungkuang University", 
          "id": "https://www.grid.ac/institutes/grid.411432.1", 
          "name": [
            "Department of Internal Medicine, Hsinchu Branch, Taipei Veterans General Hospital, Hsinchu, Taiwan", 
            "Department of Nutrition, Hung-Kuang University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Chen-Ying", 
        "id": "sg:person.01303245070.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303245070.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Cheng-Hung", 
        "id": "sg:person.01001035065.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001035065.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Ying-Chieh", 
        "id": "sg:person.01003610574.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003610574.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Providence University", 
          "id": "https://www.grid.ac/institutes/grid.412550.7", 
          "name": [
            "Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lo", 
        "givenName": "Chu-Pin", 
        "id": "sg:person.0634676004.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634676004.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jin-Long", 
        "id": "sg:person.01202737413.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737413.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taichung Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410764.0", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Ching-Heng", 
        "id": "sg:person.01216002731.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002731.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Tsu-Juey", 
        "id": "sg:person.01060745663.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060745663.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.281.21.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000047333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-016-0350-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000374984", 
          "https://doi.org/10.1186/s12933-016-0350-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0802987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000508710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0215-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001690612", 
          "https://doi.org/10.1186/s12933-015-0215-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0215-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001690612", 
          "https://doi.org/10.1186/s12933-015-0215-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.9400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003355322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003390540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003390540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003390540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1307684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003605360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.236687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004864327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.236687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004864327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000125864.01546.f2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006580193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000125864.01546.f2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006580193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000103683.99399.7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007027759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2008121270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2008121270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa072761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010634292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000353679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012499189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1501352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014732526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1506930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014737752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2016-013927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015423655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.27.3.699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015616431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)07037-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015697368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmicm066227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016174528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.298.10.1180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016607544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0124287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016741907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1305889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018262898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019925590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc14-2441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021071301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021491768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep11442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026972419", 
          "https://doi.org/10.1038/srep11442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9149(74)90089-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027274680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1504720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027808643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67528-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029983783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc08-1411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031275794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diabres.2015.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031294600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3803/enm.2016.31.2.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0806470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034293538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dme.12800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035076934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.12692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037750932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1820229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1820229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200207000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040855375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200207000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040855375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-0181fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041692899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc13-0356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041849805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.290.4.486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042599369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjdrc-2014-000059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048544559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.12704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051492701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.21.9.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0499-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083403180", 
          "https://doi.org/10.1186/s12933-017-0499-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0499-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083403180", 
          "https://doi.org/10.1186/s12933-017-0499-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc17-er07b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085439778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dme.13384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085448528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0571-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090371630", 
          "https://doi.org/10.1186/s12933-017-0571-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0571-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090371630", 
          "https://doi.org/10.1186/s12933-017-0571-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(17)30309-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091687219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(17)30317-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091687220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0617-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092246149", 
          "https://doi.org/10.1186/s12933-017-0617-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-017-0623-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092450156", 
          "https://doi.org/10.1186/s12933-017-0623-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "OBJECTIVE: Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM patients from a nationwide cohort.\nMETHODS: T2DM patients using different add-on oral ADAs after an initial metformin therapy of >\u00a090\u00a0days were identified from the Taiwan National Health Insurance Database. Five classes of ADAs, including sulphonylureas (SU), glinides, thiazolidinediones (TZD), alpha-glucosidase inhibitors (AGI), and dipeptidyl peptidase-4 inhibitors (DPP-4I) were selected for analysis. The reference group was the SU added to metformin. Patients were excluded if aged\u00a0<\u00a020\u00a0years, had a history of stroke or acute coronary syndrome (ACS), or were receiving insulin treatment. The primary outcomes included any major adverse cardiovascular event (MACE) including ACS, ischemic/hemorrhagic stroke, and death. A Cox regression model was used to estimate the hazard ratio (HR) for MACE.\nRESULTS: A total of 26,742 patients receiving their add-on drug to metformin of either SU (n\u00a0=\u00a024,277), glinides (n\u00a0=\u00a0962), TZD (n\u00a0=\u00a0581), AGI (n\u00a0=\u00a0808), or DPP-4I (n\u00a0=\u00a0114) were analyzed. After a mean follow-up duration of 6.6\u00a0\u00b1\u00a03.4\u00a0years, a total of 4775 MACEs occurred. Compared with the SU+metformin group (reference), the TZD+metformin (adjusted HR: 0.66; 95% CI 0.50-0.88, p\u00a0=\u00a00.004) and AGI+metformin (adjusted HR: 0.74; 95% CI 0.59-0.94, p\u00a0=\u00a00.01) groups showed a significantly lower risk of MACE.\nCONCLUSION: Both TZD and AGI, when used as an add-on drug to metformin were associated with lower MACE risk when compared with SU added to metformin in this retrospective cohort study. Trial registration CE13152B-3. Registered 7 Mar, 2013, retrospectively registered.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12933-018-0663-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031021", 
        "issn": [
          "1475-2840"
        ], 
        "name": "Cardiovascular Diabetology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes patients: a nationwide cohort observational study", 
    "pagination": "20", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d424adcced71a9e3a5acb2c2c34d55723ddba06b315b5eb9369fa797fc5faf1e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29368615"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147637"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12933-018-0663-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100622469"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12933-018-0663-6", 
      "https://app.dimensions.ai/details/publication/pub.1100622469"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12933-018-0663-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12933-018-0663-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12933-018-0663-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12933-018-0663-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12933-018-0663-6'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      80 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12933-018-0663-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Na7bc83c9888f4e0c8f8e01dcd2f44cf0
4 schema:citation sg:pub.10.1038/srep11442
5 sg:pub.10.1186/s12933-015-0215-2
6 sg:pub.10.1186/s12933-016-0350-4
7 sg:pub.10.1186/s12933-017-0499-5
8 sg:pub.10.1186/s12933-017-0571-1
9 sg:pub.10.1186/s12933-017-0617-4
10 sg:pub.10.1186/s12933-017-0623-6
11 https://doi.org/10.1001/jama.2016.9400
12 https://doi.org/10.1001/jama.281.21.2005
13 https://doi.org/10.1001/jama.290.4.486
14 https://doi.org/10.1001/jama.298.10.1180
15 https://doi.org/10.1016/0002-9149(74)90089-7
16 https://doi.org/10.1016/j.diabres.2015.06.005
17 https://doi.org/10.1016/s0140-6736(05)67528-9
18 https://doi.org/10.1016/s0140-6736(98)07037-8
19 https://doi.org/10.1016/s2213-8587(17)30309-1
20 https://doi.org/10.1016/s2213-8587(17)30317-0
21 https://doi.org/10.1056/nejmicm066227
22 https://doi.org/10.1056/nejmoa072761
23 https://doi.org/10.1056/nejmoa0802987
24 https://doi.org/10.1056/nejmoa0806470
25 https://doi.org/10.1056/nejmoa1305889
26 https://doi.org/10.1056/nejmoa1307684
27 https://doi.org/10.1056/nejmoa1501352
28 https://doi.org/10.1056/nejmoa1504720
29 https://doi.org/10.1056/nejmoa1506930
30 https://doi.org/10.1056/nejmra041001
31 https://doi.org/10.1093/eurheartj/ehr154
32 https://doi.org/10.1096/fj.03-0181fje
33 https://doi.org/10.1097/00004872-200207000-00028
34 https://doi.org/10.1097/md.0000000000003721
35 https://doi.org/10.1111/dme.12800
36 https://doi.org/10.1111/dme.13384
37 https://doi.org/10.1111/dom.12692
38 https://doi.org/10.1111/dom.12704
39 https://doi.org/10.1136/bmjdrc-2014-000059
40 https://doi.org/10.1136/bmjopen-2016-013927
41 https://doi.org/10.1159/000353679
42 https://doi.org/10.1161/01.cir.0000103683.99399.7e
43 https://doi.org/10.1161/01.str.0000125864.01546.f2
44 https://doi.org/10.1161/circresaha.110.236687
45 https://doi.org/10.1371/journal.pone.0124287
46 https://doi.org/10.1677/joe.0.1820229
47 https://doi.org/10.1681/asn.2008121270
48 https://doi.org/10.2337/dc08-1411
49 https://doi.org/10.2337/dc13-0356
50 https://doi.org/10.2337/dc14-2441
51 https://doi.org/10.2337/dc17-er07b
52 https://doi.org/10.2337/diacare.21.9.1529
53 https://doi.org/10.2337/diacare.27.3.699
54 https://doi.org/10.3803/enm.2016.31.2.239
55 schema:datePublished 2018-12
56 schema:datePublishedReg 2018-12-01
57 schema:description OBJECTIVE: Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM patients from a nationwide cohort. METHODS: T2DM patients using different add-on oral ADAs after an initial metformin therapy of > 90 days were identified from the Taiwan National Health Insurance Database. Five classes of ADAs, including sulphonylureas (SU), glinides, thiazolidinediones (TZD), alpha-glucosidase inhibitors (AGI), and dipeptidyl peptidase-4 inhibitors (DPP-4I) were selected for analysis. The reference group was the SU added to metformin. Patients were excluded if aged < 20 years, had a history of stroke or acute coronary syndrome (ACS), or were receiving insulin treatment. The primary outcomes included any major adverse cardiovascular event (MACE) including ACS, ischemic/hemorrhagic stroke, and death. A Cox regression model was used to estimate the hazard ratio (HR) for MACE. RESULTS: A total of 26,742 patients receiving their add-on drug to metformin of either SU (n = 24,277), glinides (n = 962), TZD (n = 581), AGI (n = 808), or DPP-4I (n = 114) were analyzed. After a mean follow-up duration of 6.6 ± 3.4 years, a total of 4775 MACEs occurred. Compared with the SU+metformin group (reference), the TZD+metformin (adjusted HR: 0.66; 95% CI 0.50-0.88, p = 0.004) and AGI+metformin (adjusted HR: 0.74; 95% CI 0.59-0.94, p = 0.01) groups showed a significantly lower risk of MACE. CONCLUSION: Both TZD and AGI, when used as an add-on drug to metformin were associated with lower MACE risk when compared with SU added to metformin in this retrospective cohort study. Trial registration CE13152B-3. Registered 7 Mar, 2013, retrospectively registered.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N50efd4bf9c334b10acffb1b8f2af7634
62 Nce26c3d9825a41b78664e0bcbd7782b9
63 sg:journal.1031021
64 schema:name Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes patients: a nationwide cohort observational study
65 schema:pagination 20
66 schema:productId N37433f313bb94fb0b80ecb2f69964dab
67 N411fe76fcd474d05ae8f2a4f183dd236
68 N4874ceff14e5475a99af0f5443e8731c
69 N5ebf713edd8d4e30b306f2c19ba6b925
70 N9ed778f44301417b97e164c47d44561d
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100622469
72 https://doi.org/10.1186/s12933-018-0663-6
73 schema:sdDatePublished 2019-04-10T13:32
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N2056536f36ec4208b3449f72769d1adc
76 schema:url http://link.springer.com/10.1186/s12933-018-0663-6
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N2056536f36ec4208b3449f72769d1adc schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N23af98b1773a47c58c8a691ac0432d1b rdf:first sg:person.01344612700.24
83 rdf:rest Nc16ef2552ab34e48bed357c1c2e5c32b
84 N36891acd311640798c63b9eb40cd4b97 rdf:first sg:person.01303245070.17
85 rdf:rest Nb31c5a8b3b6345a089ba7299613f6908
86 N37433f313bb94fb0b80ecb2f69964dab schema:name dimensions_id
87 schema:value pub.1100622469
88 rdf:type schema:PropertyValue
89 N411fe76fcd474d05ae8f2a4f183dd236 schema:name pubmed_id
90 schema:value 29368615
91 rdf:type schema:PropertyValue
92 N4874ceff14e5475a99af0f5443e8731c schema:name nlm_unique_id
93 schema:value 101147637
94 rdf:type schema:PropertyValue
95 N500fc6a239514ef6a261dce61e61121d rdf:first sg:person.01216002731.11
96 rdf:rest Nc249ce84751148668dc953c9c59dd364
97 N50efd4bf9c334b10acffb1b8f2af7634 schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N5ebf713edd8d4e30b306f2c19ba6b925 schema:name readcube_id
100 schema:value d424adcced71a9e3a5acb2c2c34d55723ddba06b315b5eb9369fa797fc5faf1e
101 rdf:type schema:PropertyValue
102 N9ed778f44301417b97e164c47d44561d schema:name doi
103 schema:value 10.1186/s12933-018-0663-6
104 rdf:type schema:PropertyValue
105 Na7bc83c9888f4e0c8f8e01dcd2f44cf0 rdf:first Nfda058d8c42040dda0b2e88bbf132846
106 rdf:rest Nf62643a09c89465890535f4f644e42fd
107 Nb31c5a8b3b6345a089ba7299613f6908 rdf:first sg:person.01001035065.87
108 rdf:rest Nfd85eef7997446a483327f384385a546
109 Nc16ef2552ab34e48bed357c1c2e5c32b rdf:first sg:person.01052761375.03
110 rdf:rest Ncc230569a2fb4743b0d3120035c8273c
111 Nc249ce84751148668dc953c9c59dd364 rdf:first sg:person.01060745663.64
112 rdf:rest rdf:nil
113 Ncc230569a2fb4743b0d3120035c8273c rdf:first sg:person.01010676064.36
114 rdf:rest N36891acd311640798c63b9eb40cd4b97
115 Nce26c3d9825a41b78664e0bcbd7782b9 schema:volumeNumber 17
116 rdf:type schema:PublicationVolume
117 Ndd73dcdd621e4f008ae9dd1679c7819c rdf:first sg:person.0634676004.01
118 rdf:rest Ne253bbe0dbb04d85bcecfb277380cd5c
119 Ne253bbe0dbb04d85bcecfb277380cd5c rdf:first sg:person.01202737413.28
120 rdf:rest N500fc6a239514ef6a261dce61e61121d
121 Nf62643a09c89465890535f4f644e42fd rdf:first sg:person.01346366353.41
122 rdf:rest N23af98b1773a47c58c8a691ac0432d1b
123 Nfd85eef7997446a483327f384385a546 rdf:first sg:person.01003610574.11
124 rdf:rest Ndd73dcdd621e4f008ae9dd1679c7819c
125 Nfda058d8c42040dda0b2e88bbf132846 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
126 schema:familyName Chan
127 schema:givenName Cheng-Wei
128 rdf:type schema:Person
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
133 schema:name Clinical Sciences
134 rdf:type schema:DefinedTerm
135 sg:journal.1031021 schema:issn 1475-2840
136 schema:name Cardiovascular Diabetology
137 rdf:type schema:Periodical
138 sg:person.01001035065.87 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
139 schema:familyName Li
140 schema:givenName Cheng-Hung
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001035065.87
142 rdf:type schema:Person
143 sg:person.01003610574.11 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
144 schema:familyName Liao
145 schema:givenName Ying-Chieh
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003610574.11
147 rdf:type schema:Person
148 sg:person.01010676064.36 schema:affiliation https://www.grid.ac/institutes/grid.410764.0
149 schema:familyName Lin
150 schema:givenName Che-Chen
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010676064.36
152 rdf:type schema:Person
153 sg:person.01052761375.03 schema:affiliation https://www.grid.ac/institutes/grid.412550.7
154 schema:familyName Hsieh
155 schema:givenName Yu-Cheng
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052761375.03
157 rdf:type schema:Person
158 sg:person.01060745663.64 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
159 schema:familyName Wu
160 schema:givenName Tsu-Juey
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060745663.64
162 rdf:type schema:Person
163 sg:person.01202737413.28 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
164 schema:familyName Huang
165 schema:givenName Jin-Long
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737413.28
167 rdf:type schema:Person
168 sg:person.01216002731.11 schema:affiliation https://www.grid.ac/institutes/grid.410764.0
169 schema:familyName Lin
170 schema:givenName Ching-Heng
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002731.11
172 rdf:type schema:Person
173 sg:person.01303245070.17 schema:affiliation https://www.grid.ac/institutes/grid.411432.1
174 schema:familyName Hung
175 schema:givenName Chen-Ying
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303245070.17
177 rdf:type schema:Person
178 sg:person.01344612700.24 schema:affiliation https://www.grid.ac/institutes/grid.412550.7
179 schema:familyName Lin
180 schema:givenName Jiunn-Cherng
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344612700.24
182 rdf:type schema:Person
183 sg:person.01346366353.41 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
184 schema:familyName Yu
185 schema:givenName Chu-Leng
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346366353.41
187 rdf:type schema:Person
188 sg:person.0634676004.01 schema:affiliation https://www.grid.ac/institutes/grid.412550.7
189 schema:familyName Lo
190 schema:givenName Chu-Pin
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634676004.01
192 rdf:type schema:Person
193 sg:pub.10.1038/srep11442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026972419
194 https://doi.org/10.1038/srep11442
195 rdf:type schema:CreativeWork
196 sg:pub.10.1186/s12933-015-0215-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001690612
197 https://doi.org/10.1186/s12933-015-0215-2
198 rdf:type schema:CreativeWork
199 sg:pub.10.1186/s12933-016-0350-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000374984
200 https://doi.org/10.1186/s12933-016-0350-4
201 rdf:type schema:CreativeWork
202 sg:pub.10.1186/s12933-017-0499-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083403180
203 https://doi.org/10.1186/s12933-017-0499-5
204 rdf:type schema:CreativeWork
205 sg:pub.10.1186/s12933-017-0571-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090371630
206 https://doi.org/10.1186/s12933-017-0571-1
207 rdf:type schema:CreativeWork
208 sg:pub.10.1186/s12933-017-0617-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092246149
209 https://doi.org/10.1186/s12933-017-0617-4
210 rdf:type schema:CreativeWork
211 sg:pub.10.1186/s12933-017-0623-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092450156
212 https://doi.org/10.1186/s12933-017-0623-6
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1001/jama.2016.9400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003355322
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1001/jama.281.21.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000047333
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/jama.290.4.486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042599369
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1001/jama.298.10.1180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016607544
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0002-9149(74)90089-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027274680
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.diabres.2015.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031294600
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0140-6736(05)67528-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029983783
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0140-6736(98)07037-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015697368
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s2213-8587(17)30309-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091687219
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s2213-8587(17)30317-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091687220
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejmicm066227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016174528
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1056/nejmoa072761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010634292
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1056/nejmoa0802987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000508710
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1056/nejmoa0806470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034293538
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1056/nejmoa1305889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018262898
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejmoa1307684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003605360
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa1501352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014732526
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa1504720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027808643
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1056/nejmoa1506930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014737752
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejmra041001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019925590
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/eurheartj/ehr154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021491768
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1096/fj.03-0181fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1041692899
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/00004872-200207000-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040855375
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/md.0000000000003721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003390540
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/dme.12800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035076934
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/dme.13384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085448528
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/dom.12692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037750932
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/dom.12704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051492701
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/bmjdrc-2014-000059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048544559
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1136/bmjopen-2016-013927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015423655
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1159/000353679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012499189
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1161/01.cir.0000103683.99399.7e schema:sameAs https://app.dimensions.ai/details/publication/pub.1007027759
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1161/01.str.0000125864.01546.f2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006580193
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1161/circresaha.110.236687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004864327
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1371/journal.pone.0124287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016741907
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1677/joe.0.1820229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039333410
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1681/asn.2008121270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009770370
287 rdf:type schema:CreativeWork
288 https://doi.org/10.2337/dc08-1411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031275794
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2337/dc13-0356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041849805
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2337/dc14-2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021071301
293 rdf:type schema:CreativeWork
294 https://doi.org/10.2337/dc17-er07b schema:sameAs https://app.dimensions.ai/details/publication/pub.1085439778
295 rdf:type schema:CreativeWork
296 https://doi.org/10.2337/diacare.21.9.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748434
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2337/diacare.27.3.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015616431
299 rdf:type schema:CreativeWork
300 https://doi.org/10.3803/enm.2016.31.2.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032119412
301 rdf:type schema:CreativeWork
302 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
303 schema:name Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
304 Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.410764.0 schema:alternateName Taichung Veterans General Hospital
307 schema:name Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.411432.1 schema:alternateName Hungkuang University
310 schema:name Department of Internal Medicine, Hsinchu Branch, Taipei Veterans General Hospital, Hsinchu, Taiwan
311 Department of Nutrition, Hung-Kuang University, Taichung, Taiwan
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.412550.7 schema:alternateName Providence University
314 schema:name Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
315 Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan
316 Department of Internal Medicine, Chiayi Branch, Taichung Veterans General Hospital, Chiayi, Taiwan
317 Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...