Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-16

AUTHORS

Csaba Mátyás, Attila Kovács, Balázs Tamás Németh, Attila Oláh, Szilveszter Braun, Márton Tokodi, Bálint András Barta, Kálmán Benke, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely, Tamás Radovits

ABSTRACT

BACKGROUND: Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices of left ventricular (LV) pressure-volume (PV) analysis to detect cardiac dysfunction in rat models of type-1 (T1DM) and type-2 (T2DM) diabetes mellitus. METHODS: Rat models of T1DM (induced by 60 mg/kg streptozotocin, n = 8) and T2DM (32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively) were compared. Echocardiography and LV PV analysis were performed. LV short-axis recordings were used for STE analysis. Global circumferential strain, peak strain rate values in systole (SrS), isovolumic relaxation (SrIVR) and early diastole (SrE) were measured. LV contractility, active relaxation and stiffness were measured by PV analysis. RESULTS: In T1DM, contractility and active relaxation were deteriorated to a greater extent compared to T2DM. In contrast, diastolic stiffness was impaired in T2DM. Correspondingly, STE described more severe systolic dysfunction in T1DM. Among diastolic STE parameters, SrIVR was more decreased in T1DM, however, SrE was more reduced in T2DM. In T1DM, SrS correlated with contractility, SrIVR with active relaxation, while in T2DM SrE was related to cardiac stiffness, cardiomyocyte diameter and fibrosis. CONCLUSIONS: Strain and strain rate parameters can be valuable and feasible measures to describe the dynamic changes in contractility, active relaxation and LV stiffness in animal models of T1DM and T2DM. STE corresponds to PV analysis and also correlates with markers of histological myocardial remodeling. More... »

PAGES

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-017-0645-0

DOI

http://dx.doi.org/10.1186/s12933-017-0645-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100421756

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29338775


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32 schema:description BACKGROUND: Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices of left ventricular (LV) pressure-volume (PV) analysis to detect cardiac dysfunction in rat models of type-1 (T1DM) and type-2 (T2DM) diabetes mellitus. METHODS: Rat models of T1DM (induced by 60 mg/kg streptozotocin, n = 8) and T2DM (32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively) were compared. Echocardiography and LV PV analysis were performed. LV short-axis recordings were used for STE analysis. Global circumferential strain, peak strain rate values in systole (SrS), isovolumic relaxation (SrIVR) and early diastole (SrE) were measured. LV contractility, active relaxation and stiffness were measured by PV analysis. RESULTS: In T1DM, contractility and active relaxation were deteriorated to a greater extent compared to T2DM. In contrast, diastolic stiffness was impaired in T2DM. Correspondingly, STE described more severe systolic dysfunction in T1DM. Among diastolic STE parameters, SrIVR was more decreased in T1DM, however, SrE was more reduced in T2DM. In T1DM, SrS correlated with contractility, SrIVR with active relaxation, while in T2DM SrE was related to cardiac stiffness, cardiomyocyte diameter and fibrosis. CONCLUSIONS: Strain and strain rate parameters can be valuable and feasible measures to describe the dynamic changes in contractility, active relaxation and LV stiffness in animal models of T1DM and T2DM. STE corresponds to PV analysis and also correlates with markers of histological myocardial remodeling.
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40 LV contractility
41 LV short-axis recordings
42 LV stiffness
43 PV analysis
44 SRE
45 SRIVR
46 STE
47 STE analysis
48 STE parameters
49 Sr
50 T1DM
51 T2DM
52 T2DM SrE
53 active relaxation
54 analysis
55 animal models
56 animals
57 cardiac dysfunction
58 cardiac stiffness
59 cardiomyocyte diameter
60 changes
61 characteristic cardiac dysfunction
62 circumferential strain
63 comparison
64 contractility
65 contrast
66 control animals
67 conventional non-invasive methods
68 detection
69 diabetic rat model
70 diameter
71 diastole
72 diastolic STE parameters
73 diastolic function
74 diastolic stiffness
75 dynamic changes
76 dysfunction
77 early diastole
78 echocardiography
79 extent
80 feasible measures
81 fibrosis
82 function
83 global circumferential strain
84 greater extent
85 hemodynamics
86 histological myocardial remodeling
87 index
88 invasive hemodynamics
89 isovolumic relaxation
90 markers
91 measurement of systolic
92 measurements
93 measures
94 mellitus
95 method
96 model
97 myocardial remodeling
98 non-invasive method
99 parameters
100 peak strain rate values
101 pressure-volume analysis
102 rat model
103 rate parameters
104 rate values
105 recordings
106 relaxation
107 remodeling
108 severe systolic dysfunction
109 short-axis recordings
110 speckle-tracking echocardiography
111 stiffness
112 strain rate values
113 strains
114 systole
115 systolic
116 systolic dysfunction
117 type 1
118 type 2
119 type 2 diabetic rat model
120 values
121 ventricular pressure-volume analysis
122 schema:name Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
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