Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-11

AUTHORS

Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, Yasuko K. Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata, Koichi Node, for the PROLOGUE Study Investigators

ABSTRACT

BackgroundDiabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study.MethodsPatients in the PROLOGUE study were assigned randomly to either add-on sitagliptin treatment or conventional antidiabetic treatment. Of the 463 patients in the overall study, 115 patients (55 in the sitagliptin group and 60 in the conventional group) who had complete echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e′) at baseline and after 12 and 24 months were included in this study. The primary endpoint of this post hoc sub-analysis was a comparison of the changes in the ratio of E to e′ (E/e′) between the two groups from baseline to 24 months.ResultsThe baseline-adjusted change in E/e′ during 24 months was significantly lower in the sitagliptin group than in the conventional group (−0.18 ± 0.55 vs. 1.91 ± 0.53, p = 0.008), irrespective of a higher E/e′ value at baseline in the sitagliptin group. In analysis of covariance, sitagliptin treatment was significantly associated with change in E/e′ over 24 months (β = −9.959, p = 0.001), independent of other clinical variables at baseline such as blood pressure, HbA1c, and medications for diabetes. Changes in other clinical variables including blood pressure and glycemic parameters, and echocardiographic parameters, such as cardiac structure and systolic function, were comparable between the two groups. There was also no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive C-reactive protein between the two groups during the study period.ConclusionsAdding sitagliptin to conventional antidiabetic regimens in patients with T2DM for 24 months attenuated the annual exacerbation in the echocardiographic parameter of diastolic dysfunction (E/e′) independent of other clinical variables such as blood pressure and glycemic control.Trial registration UMIN000004490 (University Hospital Medical Information Network Clinical Trials). https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005356; registered November 1, 2010 More... »

PAGES

63

References to SciGraph publications

  • 2009-08-05. Intensive glucose control and macrovascular outcomes in type 2 diabetes in DIABETOLOGIA
  • 2016-09-13. Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study in CARDIOVASCULAR DIABETOLOGY
  • 2016-11-03. Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study in CARDIOVASCULAR DIABETOLOGY
  • 2015-01-13. Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes in CARDIOVASCULAR DIABETOLOGY
  • 2015-02-07. Targeting metabolic disturbance in the diabetic heart in CARDIOVASCULAR DIABETOLOGY
  • 2016-11-09. Liraglutide improves cardiac function in patients with type 2 diabetes and chronic heart failure in ENDOCRINE
  • 2015-06-19. Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial in CARDIOVASCULAR DIABETOLOGY
  • 2014-09-24. Left ventricular diastolic function in patients with type 2 diabetes treated with a dipeptidyl peptidase-4 inhibitor- a pilot study in DIABETOLOGY & METABOLIC SYNDROME
  • 2012-01-31. The effect of glucagon-like peptide 1 on cardiovascular risk in NATURE REVIEWS CARDIOLOGY
  • 2014-09-26. The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: systematic review and meta-analysis of published observational studies in BMC CARDIOVASCULAR DISORDERS
  • 2014-01-30. Molecular mechanisms of diabetic cardiomyopathy in DIABETOLOGIA
  • Journal

    TITLE

    Cardiovascular Diabetology

    ISSUE

    1

    VOLUME

    16

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12933-017-0546-2

    DOI

    http://dx.doi.org/10.1186/s12933-017-0546-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085387341

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28490337


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetes Mellitus, Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diabetic Cardiomyopathies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diastole", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dipeptidyl Peptidase 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dipeptidyl-Peptidase IV Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Therapy, Combination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Echocardiography, Doppler", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitral Valve", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Predictive Value of Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recovery of Function", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sitagliptin Phosphate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stroke Volume", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Dysfunction, Left", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Function, Left", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412772.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamada", 
            "givenName": "Hirotsugu", 
            "id": "sg:person.01273746600.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273746600.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Atsushi", 
            "id": "sg:person.012413241515.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012413241515.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412772.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kusunose", 
            "givenName": "Kenya", 
            "id": "sg:person.01165555702.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165555702.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412772.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amano", 
            "givenName": "Rie", 
            "id": "sg:person.01167647441.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167647441.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.267335.6", 
              "name": [
                "Department of Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuhisa", 
            "givenName": "Munehide", 
            "id": "sg:person.01301727525.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301727525.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daida", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01210161412.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210161412.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260026.0", 
              "name": [
                "Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Masaaki", 
            "id": "sg:person.011006743562.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011006743562.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.177174.3", 
              "name": [
                "Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsutsui", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01237620371.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237620371.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413410.3", 
              "name": [
                "Cardiovascular Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nanasato", 
            "givenName": "Mamoru", 
            "id": "sg:person.01060634467.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060634467.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414932.9", 
              "name": [
                "Division of Cardiology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamiya", 
            "givenName": "Haruo", 
            "id": "sg:person.016476655561.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016476655561.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bando", 
            "givenName": "Yasuko K.", 
            "id": "sg:person.01212064011.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212064011.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Diabetes, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "Department of Diabetes, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Odawara", 
            "givenName": "Masato", 
            "id": "sg:person.01075741657.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075741657.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Research Center, Saga University, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Clinical Research Center, Saga University, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Hisako", 
            "id": "sg:person.01117403727.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117403727.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murohara", 
            "givenName": "Toyoaki", 
            "id": "sg:person.01166405657.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166405657.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412772.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sata", 
            "givenName": "Masataka", 
            "id": "sg:person.01263307474.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263307474.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412339.e", 
              "name": [
                "Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Node", 
            "givenName": "Koichi", 
            "id": "sg:person.01100453460.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100453460.13"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "for the PROLOGUE Study Investigators", 
            "id": "sg:person.013345016107.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013345016107.77"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12020-016-1166-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035172305", 
              "https://doi.org/10.1007/s12020-016-1166-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-016-0438-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026329343", 
              "https://doi.org/10.1186/s12933-016-0438-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2261-14-129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014303102", 
              "https://doi.org/10.1186/1471-2261-14-129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-014-0168-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049471524", 
              "https://doi.org/10.1186/s12933-014-0168-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-015-0242-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024056200", 
              "https://doi.org/10.1186/s12933-015-0242-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-016-0472-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026625639", 
              "https://doi.org/10.1186/s12933-016-0472-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-014-3171-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040609974", 
              "https://doi.org/10.1007/s00125-014-3171-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1470-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043090546", 
              "https://doi.org/10.1007/s00125-009-1470-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-015-0173-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007239220", 
              "https://doi.org/10.1186/s12933-015-0173-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1758-5996-6-103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003619412", 
              "https://doi.org/10.1186/1758-5996-6-103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrcardio.2011.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024392708", 
              "https://doi.org/10.1038/nrcardio.2011.211"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05-11", 
        "datePublishedReg": "2017-05-11", 
        "description": "BackgroundDiabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study.MethodsPatients in the PROLOGUE study were assigned randomly to either add-on sitagliptin treatment or conventional antidiabetic treatment. Of the 463 patients in the overall study, 115 patients (55 in the sitagliptin group and 60 in the conventional group) who had complete echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e\u2032) at baseline and after 12 and 24\u00a0months were included in this study. The primary endpoint of this post hoc sub-analysis was a comparison of the changes in the ratio of E to e\u2032 (E/e\u2032) between the two groups from baseline to 24\u00a0months.ResultsThe baseline-adjusted change in E/e\u2032 during 24\u00a0months was significantly lower in the sitagliptin group than in the conventional group (\u22120.18\u00a0\u00b1\u00a00.55 vs. 1.91\u00a0\u00b1\u00a00.53, p\u00a0=\u00a00.008), irrespective of a higher E/e\u2032 value at baseline in the sitagliptin group. In analysis of covariance, sitagliptin treatment was significantly associated with change in E/e\u2032 over 24\u00a0months (\u03b2\u00a0=\u00a0\u22129.959, p\u00a0=\u00a00.001), independent of other clinical variables at baseline such as blood pressure, HbA1c, and medications for diabetes. Changes in other clinical variables including blood pressure and glycemic parameters, and echocardiographic parameters, such as cardiac structure and systolic function, were comparable between the two groups. There was also no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive C-reactive protein between the two groups during the study period.ConclusionsAdding sitagliptin to conventional antidiabetic regimens in patients with T2DM for 24\u00a0months attenuated the annual exacerbation in the echocardiographic parameter of diastolic dysfunction (E/e\u2032) independent of other clinical variables such as blood pressure and glycemic control.Trial registration UMIN000004490 (University Hospital Medical Information Network Clinical Trials). https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005356; registered November 1, 2010", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12933-017-0546-2", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9341100", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1031021", 
            "issn": [
              "1475-2840"
            ], 
            "name": "Cardiovascular Diabetology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "keywords": [
          "effect of sitagliptin", 
          "echocardiographic parameters", 
          "blood pressure", 
          "clinical variables", 
          "PROLOGUE study", 
          "diastolic dysfunction", 
          "sitagliptin group", 
          "sitagliptin treatment", 
          "diastolic function", 
          "cardiac function", 
          "peak early diastolic transmitral flow velocity", 
          "N-terminal pro-brain natriuretic peptide", 
          "early diastolic mitral annular velocity", 
          "high-sensitive C-reactive protein", 
          "early diastolic transmitral flow velocity", 
          "diastolic mitral annular velocity", 
          "left ventricular diastolic function", 
          "diastolic transmitral flow velocity", 
          "dipeptidyl peptidase-4 inhibitors", 
          "complete echocardiographic data", 
          "baseline-adjusted change", 
          "mitral annular velocity", 
          "brain natriuretic peptide", 
          "ventricular diastolic function", 
          "peptidase-4 inhibitors", 
          "transmitral flow velocity", 
          "C-reactive protein", 
          "type 2 diabetes", 
          "antidiabetic regimens", 
          "annual exacerbations", 
          "cardiovascular events", 
          "primary endpoint", 
          "glycemic parameters", 
          "systolic function", 
          "heart failure", 
          "antidiabetic treatment", 
          "glycemic control", 
          "serum levels", 
          "natriuretic peptide", 
          "TRIAL REGISTRATION", 
          "subgroup analysis", 
          "echocardiographic data", 
          "annular velocity", 
          "conventional group", 
          "antidiabetic agents", 
          "analysis of covariance", 
          "patients", 
          "clinical concern", 
          "cardiac structure", 
          "type 2", 
          "study period", 
          "sitagliptin", 
          "months", 
          "baseline", 
          "life expectancy", 
          "significant differences", 
          "diabetes", 
          "dysfunction", 
          "treatment", 
          "group", 
          "MethodsPatients", 
          "BackgroundDiabetes", 
          "HbA1c", 
          "T2DM", 
          "medications", 
          "regimens", 
          "exacerbation", 
          "recptno", 
          "study", 
          "endpoint", 
          "risk", 
          "CGI", 
          "inhibitors", 
          "changes", 
          "pressure", 
          "expectancy", 
          "overall study", 
          "flow velocity", 
          "shortening", 
          "function", 
          "effect", 
          "major matter", 
          "failure", 
          "agents", 
          "peptides", 
          "variables", 
          "period", 
          "differences", 
          "levels", 
          "control", 
          "protein", 
          "ratio", 
          "events", 
          "analysis", 
          "concern", 
          "registration", 
          "data", 
          "impact", 
          "comparison", 
          "parameters", 
          "covariance", 
          "values", 
          "JP", 
          "influence", 
          "velocity", 
          "matter", 
          "structure"
        ], 
        "name": "Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study", 
        "pagination": "63", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085387341"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12933-017-0546-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28490337"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12933-017-0546-2", 
          "https://app.dimensions.ai/details/publication/pub.1085387341"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_753.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12933-017-0546-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12933-017-0546-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12933-017-0546-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12933-017-0546-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12933-017-0546-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    448 TRIPLES      21 PREDICATES      167 URIs      148 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12933-017-0546-2 schema:about N031584eb757341cd89d77274097f02da
    2 N033195c44f4b4047b4b05bf8e68b6f3e
    3 N059d1acbfd6e4732ade9c0c13e3e8421
    4 N0a7ac2cef553426b9bcdd23b7070521b
    5 N0ccdbd41f857449cb0d34553be34012b
    6 N150dae4728dc4f418dff6e8bc183b0ea
    7 N274b5152b9694a76900097df2cb90055
    8 N345ca2bd5e82449b8192cb567e4067fc
    9 N3ad73f9e97c64867bcd560ae7e5da5b4
    10 N593d0752c3b44407aa5ddf0ffd8a431c
    11 N656c8ae337694aafa1d86b431cc88ae4
    12 N6747a4ea98444a74a7bd5772b307244a
    13 N8e736ce72dee40149554fbc1b04bf118
    14 N98085073359143e090bdd77fe1e1bd05
    15 N9accc580a55e4e4b8ccf838972098ea2
    16 Na88b200e0f304910930407e91e511000
    17 Nae3d83efa29b48e8b53ed1655e8ec6d7
    18 Nb806f0ae2a6c4df3843ff4baddd5a856
    19 Nd3715febee3246f18be0c0d64fe5d597
    20 Nd71646ee527446bea68c99a993054155
    21 Ne8cac2a5bd3746b5bf285800c27718cc
    22 Nea399cd9ed8246d58cdb2f3d33df5a39
    23 Nf04f27a35c4b4d98adc92a19c8573231
    24 Nfc34619805c24f44bcc857333a02567f
    25 anzsrc-for:11
    26 anzsrc-for:1102
    27 schema:author N29336a0734d8464b8910d746510d618c
    28 schema:citation sg:pub.10.1007/s00125-009-1470-0
    29 sg:pub.10.1007/s00125-014-3171-6
    30 sg:pub.10.1007/s12020-016-1166-4
    31 sg:pub.10.1038/nrcardio.2011.211
    32 sg:pub.10.1186/1471-2261-14-129
    33 sg:pub.10.1186/1758-5996-6-103
    34 sg:pub.10.1186/s12933-014-0168-x
    35 sg:pub.10.1186/s12933-015-0173-8
    36 sg:pub.10.1186/s12933-015-0242-z
    37 sg:pub.10.1186/s12933-016-0438-x
    38 sg:pub.10.1186/s12933-016-0472-8
    39 schema:datePublished 2017-05-11
    40 schema:datePublishedReg 2017-05-11
    41 schema:description BackgroundDiabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study.MethodsPatients in the PROLOGUE study were assigned randomly to either add-on sitagliptin treatment or conventional antidiabetic treatment. Of the 463 patients in the overall study, 115 patients (55 in the sitagliptin group and 60 in the conventional group) who had complete echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e′) at baseline and after 12 and 24 months were included in this study. The primary endpoint of this post hoc sub-analysis was a comparison of the changes in the ratio of E to e′ (E/e′) between the two groups from baseline to 24 months.ResultsThe baseline-adjusted change in E/e′ during 24 months was significantly lower in the sitagliptin group than in the conventional group (−0.18 ± 0.55 vs. 1.91 ± 0.53, p = 0.008), irrespective of a higher E/e′ value at baseline in the sitagliptin group. In analysis of covariance, sitagliptin treatment was significantly associated with change in E/e′ over 24 months (β = −9.959, p = 0.001), independent of other clinical variables at baseline such as blood pressure, HbA1c, and medications for diabetes. Changes in other clinical variables including blood pressure and glycemic parameters, and echocardiographic parameters, such as cardiac structure and systolic function, were comparable between the two groups. There was also no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive C-reactive protein between the two groups during the study period.ConclusionsAdding sitagliptin to conventional antidiabetic regimens in patients with T2DM for 24 months attenuated the annual exacerbation in the echocardiographic parameter of diastolic dysfunction (E/e′) independent of other clinical variables such as blood pressure and glycemic control.Trial registration UMIN000004490 (University Hospital Medical Information Network Clinical Trials). https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000005356; registered November 1, 2010
    42 schema:genre article
    43 schema:isAccessibleForFree true
    44 schema:isPartOf N4017b3155f964450b0a3bd2b91be750d
    45 N60ac48527db44ef3bbbb99f771bccf80
    46 sg:journal.1031021
    47 schema:keywords BackgroundDiabetes
    48 C-reactive protein
    49 CGI
    50 HbA1c
    51 JP
    52 MethodsPatients
    53 N-terminal pro-brain natriuretic peptide
    54 PROLOGUE study
    55 T2DM
    56 TRIAL REGISTRATION
    57 agents
    58 analysis
    59 analysis of covariance
    60 annual exacerbations
    61 annular velocity
    62 antidiabetic agents
    63 antidiabetic regimens
    64 antidiabetic treatment
    65 baseline
    66 baseline-adjusted change
    67 blood pressure
    68 brain natriuretic peptide
    69 cardiac function
    70 cardiac structure
    71 cardiovascular events
    72 changes
    73 clinical concern
    74 clinical variables
    75 comparison
    76 complete echocardiographic data
    77 concern
    78 control
    79 conventional group
    80 covariance
    81 data
    82 diabetes
    83 diastolic dysfunction
    84 diastolic function
    85 diastolic mitral annular velocity
    86 diastolic transmitral flow velocity
    87 differences
    88 dipeptidyl peptidase-4 inhibitors
    89 dysfunction
    90 early diastolic mitral annular velocity
    91 early diastolic transmitral flow velocity
    92 echocardiographic data
    93 echocardiographic parameters
    94 effect
    95 effect of sitagliptin
    96 endpoint
    97 events
    98 exacerbation
    99 expectancy
    100 failure
    101 flow velocity
    102 function
    103 glycemic control
    104 glycemic parameters
    105 group
    106 heart failure
    107 high-sensitive C-reactive protein
    108 impact
    109 influence
    110 inhibitors
    111 left ventricular diastolic function
    112 levels
    113 life expectancy
    114 major matter
    115 matter
    116 medications
    117 mitral annular velocity
    118 months
    119 natriuretic peptide
    120 overall study
    121 parameters
    122 patients
    123 peak early diastolic transmitral flow velocity
    124 peptidase-4 inhibitors
    125 peptides
    126 period
    127 pressure
    128 primary endpoint
    129 protein
    130 ratio
    131 recptno
    132 regimens
    133 registration
    134 risk
    135 serum levels
    136 shortening
    137 significant differences
    138 sitagliptin
    139 sitagliptin group
    140 sitagliptin treatment
    141 structure
    142 study
    143 study period
    144 subgroup analysis
    145 systolic function
    146 transmitral flow velocity
    147 treatment
    148 type 2
    149 type 2 diabetes
    150 values
    151 variables
    152 velocity
    153 ventricular diastolic function
    154 schema:name Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study
    155 schema:pagination 63
    156 schema:productId N2e0b0ff146644649a7f0e410e6446d81
    157 N99c322f96c15471b918589f61518106d
    158 Neffaf902ffef4b98989a22d0e13bf0ad
    159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085387341
    160 https://doi.org/10.1186/s12933-017-0546-2
    161 schema:sdDatePublished 2022-10-01T06:44
    162 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    163 schema:sdPublisher N66f0b6bef7b0485692fcf7c4cc88432c
    164 schema:url https://doi.org/10.1186/s12933-017-0546-2
    165 sgo:license sg:explorer/license/
    166 sgo:sdDataset articles
    167 rdf:type schema:ScholarlyArticle
    168 N031584eb757341cd89d77274097f02da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Mitral Valve
    170 rdf:type schema:DefinedTerm
    171 N033195c44f4b4047b4b05bf8e68b6f3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Dipeptidyl-Peptidase IV Inhibitors
    173 rdf:type schema:DefinedTerm
    174 N059d1acbfd6e4732ade9c0c13e3e8421 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Aged
    176 rdf:type schema:DefinedTerm
    177 N0a7ac2cef553426b9bcdd23b7070521b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Humans
    179 rdf:type schema:DefinedTerm
    180 N0ccdbd41f857449cb0d34553be34012b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Diastole
    182 rdf:type schema:DefinedTerm
    183 N150dae4728dc4f418dff6e8bc183b0ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Adult
    185 rdf:type schema:DefinedTerm
    186 N1718e57fbf794c86b68f6e195459dd2d rdf:first sg:person.016476655561.56
    187 rdf:rest N2da9ec61562146ddbd0516cdf0beba28
    188 N274b5152b9694a76900097df2cb90055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Female
    190 rdf:type schema:DefinedTerm
    191 N29336a0734d8464b8910d746510d618c rdf:first sg:person.01273746600.06
    192 rdf:rest N8ec305a2587b4c50be29428b912bbc07
    193 N2da9ec61562146ddbd0516cdf0beba28 rdf:first sg:person.01212064011.34
    194 rdf:rest Nebae3071752e445db4663782a1fa96f4
    195 N2e0b0ff146644649a7f0e410e6446d81 schema:name pubmed_id
    196 schema:value 28490337
    197 rdf:type schema:PropertyValue
    198 N2ef5c0ae96bd4a5781fb4b6cc6714415 rdf:first sg:person.01237620371.23
    199 rdf:rest N41dfbe3032ce43d9bf00db6d5d8ee1b0
    200 N345ca2bd5e82449b8192cb567e4067fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Sitagliptin Phosphate
    202 rdf:type schema:DefinedTerm
    203 N3ad73f9e97c64867bcd560ae7e5da5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Middle Aged
    205 rdf:type schema:DefinedTerm
    206 N3b60053abe2b4eb9b7e6d1d953cb52de rdf:first sg:person.01301727525.28
    207 rdf:rest N92f60dfbb1ab4dd2827a6f7d54fd5130
    208 N4017b3155f964450b0a3bd2b91be750d schema:volumeNumber 16
    209 rdf:type schema:PublicationVolume
    210 N402056c9ce88469eaab2114ca3830ded rdf:first sg:person.01165555702.56
    211 rdf:rest N8491631874884715870c8a51cf752532
    212 N41dfbe3032ce43d9bf00db6d5d8ee1b0 rdf:first sg:person.01060634467.02
    213 rdf:rest N1718e57fbf794c86b68f6e195459dd2d
    214 N4c5be6cb5aa84aaf8e85f162e297cdb9 rdf:first sg:person.01117403727.01
    215 rdf:rest Ne785e4bfe6624b4994a443efc5a26bbb
    216 N54ad92d901664ba1b3245e364e18cc60 rdf:first sg:person.013345016107.77
    217 rdf:rest rdf:nil
    218 N593d0752c3b44407aa5ddf0ffd8a431c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Diabetic Cardiomyopathies
    220 rdf:type schema:DefinedTerm
    221 N60ac48527db44ef3bbbb99f771bccf80 schema:issueNumber 1
    222 rdf:type schema:PublicationIssue
    223 N656c8ae337694aafa1d86b431cc88ae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Stroke Volume
    225 rdf:type schema:DefinedTerm
    226 N66f0b6bef7b0485692fcf7c4cc88432c schema:name Springer Nature - SN SciGraph project
    227 rdf:type schema:Organization
    228 N6747a4ea98444a74a7bd5772b307244a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Time Factors
    230 rdf:type schema:DefinedTerm
    231 N684698b1c42842aa8adc1241567bb534 rdf:first sg:person.01100453460.13
    232 rdf:rest N54ad92d901664ba1b3245e364e18cc60
    233 N8491631874884715870c8a51cf752532 rdf:first sg:person.01167647441.03
    234 rdf:rest N3b60053abe2b4eb9b7e6d1d953cb52de
    235 N8e736ce72dee40149554fbc1b04bf118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Ventricular Dysfunction, Left
    237 rdf:type schema:DefinedTerm
    238 N8ec305a2587b4c50be29428b912bbc07 rdf:first sg:person.012413241515.35
    239 rdf:rest N402056c9ce88469eaab2114ca3830ded
    240 N92f60dfbb1ab4dd2827a6f7d54fd5130 rdf:first sg:person.01210161412.38
    241 rdf:rest Nf176673f8392482e91793992cb340f73
    242 N98085073359143e090bdd77fe1e1bd05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Diabetes Mellitus, Type 2
    244 rdf:type schema:DefinedTerm
    245 N99c322f96c15471b918589f61518106d schema:name doi
    246 schema:value 10.1186/s12933-017-0546-2
    247 rdf:type schema:PropertyValue
    248 N9accc580a55e4e4b8ccf838972098ea2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Male
    250 rdf:type schema:DefinedTerm
    251 Na88b200e0f304910930407e91e511000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Drug Therapy, Combination
    253 rdf:type schema:DefinedTerm
    254 Na94c879c5def4a89bb0b93ed8960d5d6 rdf:first sg:person.01263307474.04
    255 rdf:rest N684698b1c42842aa8adc1241567bb534
    256 Nae3d83efa29b48e8b53ed1655e8ec6d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Recovery of Function
    258 rdf:type schema:DefinedTerm
    259 Nb806f0ae2a6c4df3843ff4baddd5a856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Predictive Value of Tests
    261 rdf:type schema:DefinedTerm
    262 Nd3715febee3246f18be0c0d64fe5d597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Ventricular Function, Left
    264 rdf:type schema:DefinedTerm
    265 Nd71646ee527446bea68c99a993054155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    266 schema:name Echocardiography, Doppler
    267 rdf:type schema:DefinedTerm
    268 Ne785e4bfe6624b4994a443efc5a26bbb rdf:first sg:person.01166405657.56
    269 rdf:rest Na94c879c5def4a89bb0b93ed8960d5d6
    270 Ne8cac2a5bd3746b5bf285800c27718cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    271 schema:name Japan
    272 rdf:type schema:DefinedTerm
    273 Nea399cd9ed8246d58cdb2f3d33df5a39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Prospective Studies
    275 rdf:type schema:DefinedTerm
    276 Nebae3071752e445db4663782a1fa96f4 rdf:first sg:person.01075741657.94
    277 rdf:rest N4c5be6cb5aa84aaf8e85f162e297cdb9
    278 Neffaf902ffef4b98989a22d0e13bf0ad schema:name dimensions_id
    279 schema:value pub.1085387341
    280 rdf:type schema:PropertyValue
    281 Nf04f27a35c4b4d98adc92a19c8573231 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    282 schema:name Treatment Outcome
    283 rdf:type schema:DefinedTerm
    284 Nf176673f8392482e91793992cb340f73 rdf:first sg:person.011006743562.77
    285 rdf:rest N2ef5c0ae96bd4a5781fb4b6cc6714415
    286 Nfc34619805c24f44bcc857333a02567f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    287 schema:name Dipeptidyl Peptidase 4
    288 rdf:type schema:DefinedTerm
    289 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    290 schema:name Medical and Health Sciences
    291 rdf:type schema:DefinedTerm
    292 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    293 schema:name Cardiorespiratory Medicine and Haematology
    294 rdf:type schema:DefinedTerm
    295 sg:grant.9341100 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-017-0546-2
    296 rdf:type schema:MonetaryGrant
    297 sg:journal.1031021 schema:issn 1475-2840
    298 schema:name Cardiovascular Diabetology
    299 schema:publisher Springer Nature
    300 rdf:type schema:Periodical
    301 sg:person.01060634467.02 schema:affiliation grid-institutes:grid.413410.3
    302 schema:familyName Nanasato
    303 schema:givenName Mamoru
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060634467.02
    305 rdf:type schema:Person
    306 sg:person.01075741657.94 schema:affiliation grid-institutes:grid.410793.8
    307 schema:familyName Odawara
    308 schema:givenName Masato
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075741657.94
    310 rdf:type schema:Person
    311 sg:person.01100453460.13 schema:affiliation grid-institutes:grid.412339.e
    312 schema:familyName Node
    313 schema:givenName Koichi
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100453460.13
    315 rdf:type schema:Person
    316 sg:person.011006743562.77 schema:affiliation grid-institutes:grid.260026.0
    317 schema:familyName Ito
    318 schema:givenName Masaaki
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011006743562.77
    320 rdf:type schema:Person
    321 sg:person.01117403727.01 schema:affiliation grid-institutes:grid.412339.e
    322 schema:familyName Yoshida
    323 schema:givenName Hisako
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117403727.01
    325 rdf:type schema:Person
    326 sg:person.01165555702.56 schema:affiliation grid-institutes:grid.412772.5
    327 schema:familyName Kusunose
    328 schema:givenName Kenya
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165555702.56
    330 rdf:type schema:Person
    331 sg:person.01166405657.56 schema:affiliation grid-institutes:grid.27476.30
    332 schema:familyName Murohara
    333 schema:givenName Toyoaki
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166405657.56
    335 rdf:type schema:Person
    336 sg:person.01167647441.03 schema:affiliation grid-institutes:grid.412772.5
    337 schema:familyName Amano
    338 schema:givenName Rie
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167647441.03
    340 rdf:type schema:Person
    341 sg:person.01210161412.38 schema:affiliation grid-institutes:grid.258269.2
    342 schema:familyName Daida
    343 schema:givenName Hiroyuki
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210161412.38
    345 rdf:type schema:Person
    346 sg:person.01212064011.34 schema:affiliation grid-institutes:grid.27476.30
    347 schema:familyName Bando
    348 schema:givenName Yasuko K.
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212064011.34
    350 rdf:type schema:Person
    351 sg:person.01237620371.23 schema:affiliation grid-institutes:grid.177174.3
    352 schema:familyName Tsutsui
    353 schema:givenName Hiroyuki
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237620371.23
    355 rdf:type schema:Person
    356 sg:person.012413241515.35 schema:affiliation grid-institutes:grid.412339.e
    357 schema:familyName Tanaka
    358 schema:givenName Atsushi
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012413241515.35
    360 rdf:type schema:Person
    361 sg:person.01263307474.04 schema:affiliation grid-institutes:grid.412772.5
    362 schema:familyName Sata
    363 schema:givenName Masataka
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263307474.04
    365 rdf:type schema:Person
    366 sg:person.01273746600.06 schema:affiliation grid-institutes:grid.412772.5
    367 schema:familyName Yamada
    368 schema:givenName Hirotsugu
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273746600.06
    370 rdf:type schema:Person
    371 sg:person.01301727525.28 schema:affiliation grid-institutes:grid.267335.6
    372 schema:familyName Matsuhisa
    373 schema:givenName Munehide
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301727525.28
    375 rdf:type schema:Person
    376 sg:person.013345016107.77 schema:familyName for the PROLOGUE Study Investigators
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013345016107.77
    378 rdf:type schema:Person
    379 sg:person.016476655561.56 schema:affiliation grid-institutes:grid.414932.9
    380 schema:familyName Kamiya
    381 schema:givenName Haruo
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016476655561.56
    383 rdf:type schema:Person
    384 sg:pub.10.1007/s00125-009-1470-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043090546
    385 https://doi.org/10.1007/s00125-009-1470-0
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1007/s00125-014-3171-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040609974
    388 https://doi.org/10.1007/s00125-014-3171-6
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1007/s12020-016-1166-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035172305
    391 https://doi.org/10.1007/s12020-016-1166-4
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/nrcardio.2011.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024392708
    394 https://doi.org/10.1038/nrcardio.2011.211
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1186/1471-2261-14-129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014303102
    397 https://doi.org/10.1186/1471-2261-14-129
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1186/1758-5996-6-103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003619412
    400 https://doi.org/10.1186/1758-5996-6-103
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1186/s12933-014-0168-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049471524
    403 https://doi.org/10.1186/s12933-014-0168-x
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1186/s12933-015-0173-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007239220
    406 https://doi.org/10.1186/s12933-015-0173-8
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1186/s12933-015-0242-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024056200
    409 https://doi.org/10.1186/s12933-015-0242-z
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1186/s12933-016-0438-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026329343
    412 https://doi.org/10.1186/s12933-016-0438-x
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1186/s12933-016-0472-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026625639
    415 https://doi.org/10.1186/s12933-016-0472-8
    416 rdf:type schema:CreativeWork
    417 grid-institutes:grid.177174.3 schema:alternateName Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    418 schema:name Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    419 rdf:type schema:Organization
    420 grid-institutes:grid.258269.2 schema:alternateName Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    421 schema:name Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
    422 rdf:type schema:Organization
    423 grid-institutes:grid.260026.0 schema:alternateName Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    424 schema:name Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    425 rdf:type schema:Organization
    426 grid-institutes:grid.267335.6 schema:alternateName Department of Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan
    427 schema:name Department of Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan
    428 rdf:type schema:Organization
    429 grid-institutes:grid.27476.30 schema:alternateName Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    430 schema:name Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    431 rdf:type schema:Organization
    432 grid-institutes:grid.410793.8 schema:alternateName Department of Diabetes, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo, Japan
    433 schema:name Department of Diabetes, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo, Japan
    434 rdf:type schema:Organization
    435 grid-institutes:grid.412339.e schema:alternateName Clinical Research Center, Saga University, Saga, Japan
    436 Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan
    437 schema:name Clinical Research Center, Saga University, Saga, Japan
    438 Department of Cardiovascular Medicine, Saga University, 5-5-1 Nabeshima, Saga, Japan
    439 rdf:type schema:Organization
    440 grid-institutes:grid.412772.5 schema:alternateName Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan
    441 schema:name Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan
    442 rdf:type schema:Organization
    443 grid-institutes:grid.413410.3 schema:alternateName Cardiovascular Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan
    444 schema:name Cardiovascular Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan
    445 rdf:type schema:Organization
    446 grid-institutes:grid.414932.9 schema:alternateName Division of Cardiology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan
    447 schema:name Division of Cardiology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan
    448 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...