Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

C. M. Rosa, R. Gimenes, D. H. S. Campos, G. N. Guirado, C. Gimenes, A. A. H. Fernandes, A. C. Cicogna, R. M. Queiroz, I. Falcão-Pires, D. Miranda-Silva, P. Rodrigues, F. R. Laurindo, D. C. Fernandes, C. R. Correa, M. P. Okoshi, K. Okoshi

ABSTRACT

PURPOSE: Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains scarce. The actions of antioxidant apocynin include inhibiting reactive oxygen species (ROS) generation by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and ROS scavenging. We evaluated the effects of apocynin on cardiac remodeling in spontaneously hypertensive rats (SHR) with diabetes mellitus (DM). METHODS: Male SHR were divided into four groups: control (SHR, n = 16); SHR treated with apocynin (SHR-APO; 16 mg/kg/day, added to drinking water; n = 16); diabetic SHR (SHR-DM, n = 13); and SHR-DM treated with apocynin (SHR-DM-APO, n = 14), for eight weeks. DM was induced by streptozotocin (40 mg/kg, single dose). Statistical analyzes: ANOVA and Tukey or Mann-Whitney. RESULTS: Echocardiogram in diabetic groups showed higher left ventricular and left atrium diameters indexed for body weight, and higher isovolumetric relaxation time than normoglycemic rats; systolic function did not differ between groups. Isolated papillary muscle showed impaired contractile and relaxation function in diabetic groups. Developed tension was lower in SHR-APO than SHR. Myocardial hydroxyproline concentration was higher in SHR-DM than SHR, interstitial collagen fraction was higher in SHR-DM-APO than SHR-APO, and type III collagen protein expression was lower in SHR-DM and SHR-DM-APO than their controls. Type I collagen and lysyl oxidase expression did not differ between groups. Apocynin did not change collagen tissue. Myocardial lipid hydroperoxide concentration was higher in SHR-DM than SHR and SHR-DM-APO. Glutathione peroxidase activity was lower and catalase higher in SHR-DM than SHR. Apocynin attenuated antioxidant enzyme activity changes in SHR-DM-APO. Advanced glycation end-products and NADPH oxidase activity did not differ between groups. CONCLUSION: Apocynin reduces oxidative stress independently of NADPH oxidase activity and does not change ventricular or myocardial function in spontaneously hypertensive rats with diabetes mellitus. The apocynin-induced myocardial functional impairment in SHR shows that apocynin actions need to be clarified during sustained chronic pressure overload. More... »

PAGES

126

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-016-0442-1

DOI

http://dx.doi.org/10.1186/s12933-016-0442-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027515049

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27585437


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetophenones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetic Cardiomyopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Peroxidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertrophy, Left Ventricular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Peroxidation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Peroxides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred SHR", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptozocin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Function, Left", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Remodeling", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosa", 
        "givenName": "C. M.", 
        "id": "sg:person.01021715315.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021715315.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gimenes", 
        "givenName": "R.", 
        "id": "sg:person.01165015424.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165015424.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campos", 
        "givenName": "D. H. S.", 
        "id": "sg:person.016265477762.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016265477762.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guirado", 
        "givenName": "G. N.", 
        "id": "sg:person.0643462751.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643462751.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Sagrado Cora\u00e7\u00e3o", 
          "id": "https://www.grid.ac/institutes/grid.412296.a", 
          "name": [
            "Sagrado Cora\u00e7\u00e3o University-USC, Bauru, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gimenes", 
        "givenName": "C.", 
        "id": "sg:person.01130176152.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130176152.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Chemistry and Biochemistry, Institute of Biosciences, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandes", 
        "givenName": "A. A. H.", 
        "id": "sg:person.013443265762.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443265762.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cicogna", 
        "givenName": "A. C.", 
        "id": "sg:person.01142707732.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142707732.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Queiroz", 
        "givenName": "R. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Porto", 
          "id": "https://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falc\u00e3o-Pires", 
        "givenName": "I.", 
        "id": "sg:person.01212020537.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212020537.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Porto", 
          "id": "https://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miranda-Silva", 
        "givenName": "D.", 
        "id": "sg:person.0726342575.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726342575.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Porto", 
          "id": "https://www.grid.ac/institutes/grid.5808.5", 
          "name": [
            "Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodrigues", 
        "givenName": "P.", 
        "id": "sg:person.01264245630.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264245630.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Department of Cardiopneumology, Medical School, Sao Paulo University-USP, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laurindo", 
        "givenName": "F. R.", 
        "id": "sg:person.01311703276.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311703276.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Department of Cardiopneumology, Medical School, Sao Paulo University-USP, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandes", 
        "givenName": "D. C.", 
        "id": "sg:person.011323552657.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011323552657.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Pathology, Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Correa", 
        "givenName": "C. R.", 
        "id": "sg:person.016240425640.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016240425640.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okoshi", 
        "givenName": "M. P.", 
        "id": "sg:person.01136143715.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136143715.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okoshi", 
        "givenName": "K.", 
        "id": "sg:person.01314756716.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314756716.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.carpath.2009.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000637575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/457848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001473982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00287.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004063505", 
          "https://doi.org/10.1111/j.1523-1755.2005.00287.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00064.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004125977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y01-060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004535381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000354526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005525512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00188.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005638532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0325-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005757775", 
          "https://doi.org/10.1186/s12974-015-0325-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0325-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005757775", 
          "https://doi.org/10.1186/s12974-015-0325-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2010.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006064242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jdi.12250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006374958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2016.04.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006691671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0173-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007239220", 
          "https://doi.org/10.1186/s12933-015-0173-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0173-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007239220", 
          "https://doi.org/10.1186/s12933-015-0173-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0100-879x1997000900013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007419852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdiacomp.2010.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007725460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00331.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008262135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000082814.62655.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008957334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000082814.62655.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008957334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1536/jhj.45.647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009144289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2001.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009519004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3317/jraas.2001.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009519004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.2001.1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010237549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-1536-5-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010526898", 
          "https://doi.org/10.1186/1755-1536-5-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2011.01369.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010640780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc16-s005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011036334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01919538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013207932", 
          "https://doi.org/10.1007/bf01919538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-011-0184-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013614483", 
          "https://doi.org/10.1007/s00395-011-0184-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2005.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013772893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms161025234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013984724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40200-014-0084-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014058205", 
          "https://doi.org/10.1186/s40200-014-0084-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40200-014-0084-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014058205", 
          "https://doi.org/10.1186/s40200-014-0084-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00174.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014245482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20100529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014293233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20100529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014293233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1056-8719(94)90092-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015548648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1056-8719(94)90092-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015548648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0271-5317(01)00275-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015584770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-1800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015693095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2006.12.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015849252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-005-7652-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015951647", 
          "https://doi.org/10.1007/s11373-005-7652-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-005-7652-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015951647", 
          "https://doi.org/10.1007/s11373-005-7652-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00471-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016254144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(03)00471-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016254144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2012.03.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016801033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-13-55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017729747", 
          "https://doi.org/10.1186/1475-2840-13-55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471141755.ph0547s70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017738050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(01)01516-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017812833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2015.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018349312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2016.04.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018572761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2007.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019233818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/653789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019346854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phrs.2007.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020012978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10741-012-9313-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020403360", 
          "https://doi.org/10.1007/s10741-012-9313-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10741-012-9313-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020403360", 
          "https://doi.org/10.1007/s10741-012-9313-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000374053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022150159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.100214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023144844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.100214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023144844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/8695716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023201706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2015.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023809461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.103200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023819468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.103200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023819468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.107.103200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023819468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nutres.2006.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024300783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(03)00508-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024957746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(03)00508-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024957746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-12-169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025178556", 
          "https://doi.org/10.1186/1475-2840-12-169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcts.2006.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025891829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc07-0272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028370534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(08)01213-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029111854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00335.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032547095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0308-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032835564", 
          "https://doi.org/10.1186/s12933-015-0308-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.6.660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032911793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvn185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033728510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/5698931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034610157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2008.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034752304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-12-152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036271498", 
          "https://doi.org/10.1186/1475-2840-12-152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037084752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037084752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/7409196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037292709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.redox.2013.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037717214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.5084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037814415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-13-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039215046", 
          "https://doi.org/10.1186/1475-2840-13-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0100-879x2004000400019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040225526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00114.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040780983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/294284a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041326000", 
          "https://doi.org/10.1038/294284a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2012.164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041765451", 
          "https://doi.org/10.1038/aps.2012.164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y10-063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042232130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12013-007-0039-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042739209", 
          "https://doi.org/10.1007/s12013-007-0039-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-12-28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044947301", 
          "https://doi.org/10.1186/1475-2840-12-28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arcmed.2015.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045626730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000369683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045951403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12933-015-0255-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046452258", 
          "https://doi.org/10.1186/s12933-015-0255-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2010.04.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046626195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1253/circj.cj-13-1187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048470802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03639045.2015.1052080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048663081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc08-s247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048977453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/726940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049461396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y97-163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051539115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.111.076075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051906371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.111.076075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051906371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/515042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051993131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2013.5814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052572854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2007-1544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064249097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078309146", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4239/wjd.v6.i4.662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079089259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/jaha.114.001598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079108477"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "PURPOSE: Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains scarce. The actions of antioxidant apocynin include inhibiting reactive oxygen species (ROS) generation by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and ROS scavenging. We evaluated the effects of apocynin on cardiac remodeling in spontaneously hypertensive rats (SHR) with diabetes mellitus (DM).\nMETHODS: Male SHR were divided into four groups: control (SHR, n\u00a0=\u00a016); SHR treated with apocynin (SHR-APO; 16\u00a0mg/kg/day, added to drinking water; n\u00a0=\u00a016); diabetic SHR (SHR-DM, n\u00a0=\u00a013); and SHR-DM treated with apocynin (SHR-DM-APO, n\u00a0=\u00a014), for eight weeks. DM was induced by streptozotocin (40\u00a0mg/kg, single dose). Statistical analyzes: ANOVA and Tukey or Mann-Whitney.\nRESULTS: Echocardiogram in diabetic groups showed higher left ventricular and left atrium diameters indexed for body weight, and higher isovolumetric relaxation time than normoglycemic rats; systolic function did not differ between groups. Isolated papillary muscle showed impaired contractile and relaxation function in diabetic groups. Developed tension was lower in SHR-APO than SHR. Myocardial hydroxyproline concentration was higher in SHR-DM than SHR, interstitial collagen fraction was higher in SHR-DM-APO than SHR-APO, and type III collagen protein expression was lower in SHR-DM and SHR-DM-APO than their controls. Type I collagen and lysyl oxidase expression did not differ between groups. Apocynin did not change collagen tissue. Myocardial lipid hydroperoxide concentration was higher in SHR-DM than SHR and SHR-DM-APO. Glutathione peroxidase activity was lower and catalase higher in SHR-DM than SHR. Apocynin attenuated antioxidant enzyme activity changes in SHR-DM-APO. Advanced glycation end-products and NADPH oxidase activity did not differ between groups.\nCONCLUSION: Apocynin reduces oxidative stress independently of NADPH oxidase activity and does not change ventricular or myocardial function in spontaneously hypertensive rats with diabetes mellitus. The apocynin-induced myocardial functional impairment in SHR shows that apocynin actions need to be clarified during sustained chronic pressure overload.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12933-016-0442-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5489650", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031021", 
        "issn": [
          "1475-2840"
        ], 
        "name": "Cardiovascular Diabetology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus", 
    "pagination": "126", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "83130b78ee0563b3702e87c36af147b6c9958094be58e382261a34d376d60432"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27585437"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147637"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12933-016-0442-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027515049"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12933-016-0442-1", 
      "https://app.dimensions.ai/details/publication/pub.1027515049"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70046_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12933-016-0442-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12933-016-0442-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12933-016-0442-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12933-016-0442-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12933-016-0442-1'


 

This table displays all metadata directly associated to this object as RDF triples.

556 TRIPLES      21 PREDICATES      140 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12933-016-0442-1 schema:about N070d7d2ea2bc47788cf32c53fb79d138
2 N1d430829d2274fe582e4b524d27844f1
3 N2c67b145b22a40b0b3a2b735d313f367
4 N38d23f6af7164669b3b0dc5fdf4216b0
5 N559deabcae5f444787d4ab81c7440518
6 N676e24228e9b4c898ab0bfdc7574c316
7 N94a6bb9814ac41409913bbb86fd712be
8 N963d06954b2c4e7cbb655001abe615a2
9 N9991c01ad76949309de1b9df3a0344bc
10 Na47dc8eb66de448791b420a775652865
11 Nb217997782b84da7821f195f2d5dde8d
12 Nc6676669799843039dfd6cdd8cfa6996
13 Nd0f4525835bd445c93ed06c7f0e3ac74
14 Nd9df4b229d044782b12367ab9bc8300a
15 Ndefbe150b1f34b95bedf7a9fea4a25f2
16 Ne15d1f1b0b254ab6910ab15910441013
17 Neca0df1b1acb45f6a52b7cfc127979e1
18 Nf64b959151564c14bc5333d885d92384
19 Nf73c65a676c44742a6afc9b9d6c7b76b
20 Nf7a235a91e9548c1a8232d3c8fe957b5
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author Ndfdded753dc84d86a1acff26ae93ccc0
24 schema:citation sg:pub.10.1007/bf01919538
25 sg:pub.10.1007/s00395-011-0184-x
26 sg:pub.10.1007/s10741-012-9313-3
27 sg:pub.10.1007/s11373-005-7652-y
28 sg:pub.10.1007/s12013-007-0039-0
29 sg:pub.10.1038/294284a0
30 sg:pub.10.1038/aps.2012.164
31 sg:pub.10.1111/j.1523-1755.2005.00287.x
32 sg:pub.10.1186/1475-2840-12-152
33 sg:pub.10.1186/1475-2840-12-169
34 sg:pub.10.1186/1475-2840-12-28
35 sg:pub.10.1186/1475-2840-13-11
36 sg:pub.10.1186/1475-2840-13-55
37 sg:pub.10.1186/1755-1536-5-15
38 sg:pub.10.1186/s12933-015-0173-8
39 sg:pub.10.1186/s12933-015-0255-7
40 sg:pub.10.1186/s12933-015-0308-y
41 sg:pub.10.1186/s12974-015-0325-5
42 sg:pub.10.1186/s40200-014-0084-3
43 https://app.dimensions.ai/details/publication/pub.1078309146
44 https://doi.org/10.1002/0471141755.ph0547s70
45 https://doi.org/10.1006/jmcc.2001.1431
46 https://doi.org/10.1016/1056-8719(94)90092-2
47 https://doi.org/10.1016/j.arcmed.2015.08.005
48 https://doi.org/10.1016/j.carpath.2009.07.003
49 https://doi.org/10.1016/j.ejcts.2006.07.006
50 https://doi.org/10.1016/j.ejphar.2006.12.034
51 https://doi.org/10.1016/j.ejphar.2010.04.030
52 https://doi.org/10.1016/j.freeradbiomed.2010.03.010
53 https://doi.org/10.1016/j.ijcard.2012.03.063
54 https://doi.org/10.1016/j.ijcard.2016.04.101
55 https://doi.org/10.1016/j.ijcard.2016.04.178
56 https://doi.org/10.1016/j.jacc.2008.05.019
57 https://doi.org/10.1016/j.jdiacomp.2010.02.001
58 https://doi.org/10.1016/j.nutres.2006.09.012
59 https://doi.org/10.1016/j.phrs.2007.07.003
60 https://doi.org/10.1016/j.phymed.2015.06.011
61 https://doi.org/10.1016/j.redox.2013.12.002
62 https://doi.org/10.1016/j.taap.2005.07.011
63 https://doi.org/10.1016/j.taap.2007.12.013
64 https://doi.org/10.1016/j.yjmcc.2015.12.011
65 https://doi.org/10.1016/s0014-2999(01)01516-3
66 https://doi.org/10.1016/s0024-3205(03)00508-3
67 https://doi.org/10.1016/s0076-6879(08)01213-5
68 https://doi.org/10.1016/s0271-5317(01)00275-5
69 https://doi.org/10.1016/s0735-1097(03)00471-6
70 https://doi.org/10.1042/cs20100529
71 https://doi.org/10.1089/ars.2013.5814
72 https://doi.org/10.1093/cvr/cvn185
73 https://doi.org/10.1111/j.1463-1326.2011.01369.x
74 https://doi.org/10.1111/jdi.12250
75 https://doi.org/10.1139/y01-060
76 https://doi.org/10.1139/y10-063
77 https://doi.org/10.1139/y97-163
78 https://doi.org/10.1152/ajpcell.00188.2006
79 https://doi.org/10.1152/ajpcell.00331.2011
80 https://doi.org/10.1152/ajpheart.00114.2008
81 https://doi.org/10.1152/ajpheart.00174.2006
82 https://doi.org/10.1152/ajpheart.00335.2010
83 https://doi.org/10.1152/ajplung.00064.2011
84 https://doi.org/10.1155/2012/726940
85 https://doi.org/10.1155/2013/653789
86 https://doi.org/10.1155/2015/457848
87 https://doi.org/10.1155/2015/515042
88 https://doi.org/10.1155/2016/5698931
89 https://doi.org/10.1155/2016/7409196
90 https://doi.org/10.1155/2016/8695716
91 https://doi.org/10.1159/000354526
92 https://doi.org/10.1159/000369683
93 https://doi.org/10.1159/000374053
94 https://doi.org/10.1161/01.cir.101.6.660
95 https://doi.org/10.1161/01.hyp.0000082814.62655.85
96 https://doi.org/10.1161/cir.0000000000000350
97 https://doi.org/10.1161/circulationaha.111.076075
98 https://doi.org/10.1161/hypertensionaha.107.100214
99 https://doi.org/10.1161/hypertensionaha.107.103200
100 https://doi.org/10.1161/jaha.114.001598
101 https://doi.org/10.1210/en.2007-1544
102 https://doi.org/10.1253/circj.cj-13-1187
103 https://doi.org/10.1536/jhj.45.647
104 https://doi.org/10.1590/s0100-879x1997000900013
105 https://doi.org/10.1590/s0100-879x2004000400019
106 https://doi.org/10.18632/oncotarget.5084
107 https://doi.org/10.2337/db09-1800
108 https://doi.org/10.2337/dc07-0272
109 https://doi.org/10.2337/dc08-s247
110 https://doi.org/10.2337/dc16-s005
111 https://doi.org/10.3109/03639045.2015.1052080
112 https://doi.org/10.3317/jraas.2001.005
113 https://doi.org/10.3390/ijms161025234
114 https://doi.org/10.4239/wjd.v6.i4.662
115 schema:datePublished 2016-12
116 schema:datePublishedReg 2016-12-01
117 schema:description PURPOSE: Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains scarce. The actions of antioxidant apocynin include inhibiting reactive oxygen species (ROS) generation by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and ROS scavenging. We evaluated the effects of apocynin on cardiac remodeling in spontaneously hypertensive rats (SHR) with diabetes mellitus (DM). METHODS: Male SHR were divided into four groups: control (SHR, n = 16); SHR treated with apocynin (SHR-APO; 16 mg/kg/day, added to drinking water; n = 16); diabetic SHR (SHR-DM, n = 13); and SHR-DM treated with apocynin (SHR-DM-APO, n = 14), for eight weeks. DM was induced by streptozotocin (40 mg/kg, single dose). Statistical analyzes: ANOVA and Tukey or Mann-Whitney. RESULTS: Echocardiogram in diabetic groups showed higher left ventricular and left atrium diameters indexed for body weight, and higher isovolumetric relaxation time than normoglycemic rats; systolic function did not differ between groups. Isolated papillary muscle showed impaired contractile and relaxation function in diabetic groups. Developed tension was lower in SHR-APO than SHR. Myocardial hydroxyproline concentration was higher in SHR-DM than SHR, interstitial collagen fraction was higher in SHR-DM-APO than SHR-APO, and type III collagen protein expression was lower in SHR-DM and SHR-DM-APO than their controls. Type I collagen and lysyl oxidase expression did not differ between groups. Apocynin did not change collagen tissue. Myocardial lipid hydroperoxide concentration was higher in SHR-DM than SHR and SHR-DM-APO. Glutathione peroxidase activity was lower and catalase higher in SHR-DM than SHR. Apocynin attenuated antioxidant enzyme activity changes in SHR-DM-APO. Advanced glycation end-products and NADPH oxidase activity did not differ between groups. CONCLUSION: Apocynin reduces oxidative stress independently of NADPH oxidase activity and does not change ventricular or myocardial function in spontaneously hypertensive rats with diabetes mellitus. The apocynin-induced myocardial functional impairment in SHR shows that apocynin actions need to be clarified during sustained chronic pressure overload.
118 schema:genre research_article
119 schema:inLanguage en
120 schema:isAccessibleForFree true
121 schema:isPartOf N0c5c6d18915e45d6a2ad971abc1db97d
122 N7452e71fab39439a8ee0e9fc3cdd5b5d
123 sg:journal.1031021
124 schema:name Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus
125 schema:pagination 126
126 schema:productId N301a2c2dad294d029fe9ca71e9e908c3
127 N495601a397134c76a57ebf73c6461b0f
128 N7e5554342165412da529321d17f3f7e6
129 N8149c342a51c45f780b30051d32f6796
130 Nd2bd90b5d1a541928b2d5ed9975fdbb5
131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027515049
132 https://doi.org/10.1186/s12933-016-0442-1
133 schema:sdDatePublished 2019-04-11T12:39
134 schema:sdLicense https://scigraph.springernature.com/explorer/license/
135 schema:sdPublisher N23ce361af6d84dd99742a047aac73a2d
136 schema:url https://link.springer.com/10.1186%2Fs12933-016-0442-1
137 sgo:license sg:explorer/license/
138 sgo:sdDataset articles
139 rdf:type schema:ScholarlyArticle
140 N070d7d2ea2bc47788cf32c53fb79d138 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Lipid Peroxides
142 rdf:type schema:DefinedTerm
143 N0c5c6d18915e45d6a2ad971abc1db97d schema:volumeNumber 15
144 rdf:type schema:PublicationVolume
145 N1d430829d2274fe582e4b524d27844f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Diabetic Cardiomyopathies
147 rdf:type schema:DefinedTerm
148 N23ce361af6d84dd99742a047aac73a2d schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N2c67b145b22a40b0b3a2b735d313f367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Diabetes Mellitus, Experimental
152 rdf:type schema:DefinedTerm
153 N301a2c2dad294d029fe9ca71e9e908c3 schema:name readcube_id
154 schema:value 83130b78ee0563b3702e87c36af147b6c9958094be58e382261a34d376d60432
155 rdf:type schema:PropertyValue
156 N314d20e27ac04de089b986eba9337969 rdf:first sg:person.01212020537.99
157 rdf:rest Ncae69d7513ca4f489512503ab8aae7c8
158 N32564aef2b5f495b93624de1ef3f053b rdf:first sg:person.01264245630.02
159 rdf:rest N3332f064ff8b4f18a2d42da513213b87
160 N3332f064ff8b4f18a2d42da513213b87 rdf:first sg:person.01311703276.19
161 rdf:rest N9d1fd97368b3477ea645c59586e19358
162 N38d23f6af7164669b3b0dc5fdf4216b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 N3eb11db9e24f43f6962cdc3548e10e3b rdf:first sg:person.0643462751.23
166 rdf:rest Nb976931cb16748f7aae5b33fdf5ea3f9
167 N45a44546bfad45b6826d5c05180b03e4 rdf:first Nf32e7561d6534153a97771a93a4df70f
168 rdf:rest N314d20e27ac04de089b986eba9337969
169 N495601a397134c76a57ebf73c6461b0f schema:name dimensions_id
170 schema:value pub.1027515049
171 rdf:type schema:PropertyValue
172 N559deabcae5f444787d4ab81c7440518 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Ventricular Remodeling
174 rdf:type schema:DefinedTerm
175 N676e24228e9b4c898ab0bfdc7574c316 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Streptozocin
177 rdf:type schema:DefinedTerm
178 N7452e71fab39439a8ee0e9fc3cdd5b5d schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 N7522029f19e542099e0466654e4b86e3 rdf:first sg:person.013443265762.31
181 rdf:rest N8638a533c5f44f718a0df70a67015ca2
182 N7e5554342165412da529321d17f3f7e6 schema:name doi
183 schema:value 10.1186/s12933-016-0442-1
184 rdf:type schema:PropertyValue
185 N7f1e896879f04399a296cef4a2bd43da rdf:first sg:person.01314756716.09
186 rdf:rest rdf:nil
187 N8149c342a51c45f780b30051d32f6796 schema:name nlm_unique_id
188 schema:value 101147637
189 rdf:type schema:PropertyValue
190 N8638a533c5f44f718a0df70a67015ca2 rdf:first sg:person.01142707732.77
191 rdf:rest N45a44546bfad45b6826d5c05180b03e4
192 N94a6bb9814ac41409913bbb86fd712be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Hypertrophy, Left Ventricular
194 rdf:type schema:DefinedTerm
195 N963d06954b2c4e7cbb655001abe615a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Rats, Inbred SHR
197 rdf:type schema:DefinedTerm
198 N9991c01ad76949309de1b9df3a0344bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Catalase
200 rdf:type schema:DefinedTerm
201 N9d1fd97368b3477ea645c59586e19358 rdf:first sg:person.011323552657.00
202 rdf:rest Na85dde38a2a948589db914e9ae698129
203 Na47dc8eb66de448791b420a775652865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Glutathione Peroxidase
205 rdf:type schema:DefinedTerm
206 Na85dde38a2a948589db914e9ae698129 rdf:first sg:person.016240425640.43
207 rdf:rest Nffd34b47718d4976890119cb28456975
208 Nb217997782b84da7821f195f2d5dde8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Collagen Type III
210 rdf:type schema:DefinedTerm
211 Nb976931cb16748f7aae5b33fdf5ea3f9 rdf:first sg:person.01130176152.98
212 rdf:rest N7522029f19e542099e0466654e4b86e3
213 Nc6676669799843039dfd6cdd8cfa6996 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Ventricular Function, Left
215 rdf:type schema:DefinedTerm
216 Ncae69d7513ca4f489512503ab8aae7c8 rdf:first sg:person.0726342575.24
217 rdf:rest N32564aef2b5f495b93624de1ef3f053b
218 Nd03b9bb362784657afdc2c8ae1e40e16 rdf:first sg:person.016265477762.30
219 rdf:rest N3eb11db9e24f43f6962cdc3548e10e3b
220 Nd0f4525835bd445c93ed06c7f0e3ac74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Animals
222 rdf:type schema:DefinedTerm
223 Nd2bd90b5d1a541928b2d5ed9975fdbb5 schema:name pubmed_id
224 schema:value 27585437
225 rdf:type schema:PropertyValue
226 Nd9df4b229d044782b12367ab9bc8300a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Acetophenones
228 rdf:type schema:DefinedTerm
229 Ndefbe150b1f34b95bedf7a9fea4a25f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Myocardium
231 rdf:type schema:DefinedTerm
232 Ndfdded753dc84d86a1acff26ae93ccc0 rdf:first sg:person.01021715315.58
233 rdf:rest Ne8eeee111be54a51bb63c168129fd293
234 Ne15d1f1b0b254ab6910ab15910441013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Oxidative Stress
236 rdf:type schema:DefinedTerm
237 Ne8eeee111be54a51bb63c168129fd293 rdf:first sg:person.01165015424.67
238 rdf:rest Nd03b9bb362784657afdc2c8ae1e40e16
239 Neca0df1b1acb45f6a52b7cfc127979e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Myocardial Contraction
241 rdf:type schema:DefinedTerm
242 Nf32e7561d6534153a97771a93a4df70f schema:affiliation https://www.grid.ac/institutes/grid.410543.7
243 schema:familyName Queiroz
244 schema:givenName R. M.
245 rdf:type schema:Person
246 Nf64b959151564c14bc5333d885d92384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Lipid Peroxidation
248 rdf:type schema:DefinedTerm
249 Nf73c65a676c44742a6afc9b9d6c7b76b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Antioxidants
251 rdf:type schema:DefinedTerm
252 Nf7a235a91e9548c1a8232d3c8fe957b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
253 schema:name Hypertension
254 rdf:type schema:DefinedTerm
255 Nffd34b47718d4976890119cb28456975 rdf:first sg:person.01136143715.55
256 rdf:rest N7f1e896879f04399a296cef4a2bd43da
257 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
258 schema:name Medical and Health Sciences
259 rdf:type schema:DefinedTerm
260 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
261 schema:name Clinical Sciences
262 rdf:type schema:DefinedTerm
263 sg:grant.5489650 http://pending.schema.org/fundedItem sg:pub.10.1186/s12933-016-0442-1
264 rdf:type schema:MonetaryGrant
265 sg:journal.1031021 schema:issn 1475-2840
266 schema:name Cardiovascular Diabetology
267 rdf:type schema:Periodical
268 sg:person.01021715315.58 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
269 schema:familyName Rosa
270 schema:givenName C. M.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021715315.58
272 rdf:type schema:Person
273 sg:person.01130176152.98 schema:affiliation https://www.grid.ac/institutes/grid.412296.a
274 schema:familyName Gimenes
275 schema:givenName C.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130176152.98
277 rdf:type schema:Person
278 sg:person.011323552657.00 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
279 schema:familyName Fernandes
280 schema:givenName D. C.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011323552657.00
282 rdf:type schema:Person
283 sg:person.01136143715.55 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
284 schema:familyName Okoshi
285 schema:givenName M. P.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136143715.55
287 rdf:type schema:Person
288 sg:person.01142707732.77 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
289 schema:familyName Cicogna
290 schema:givenName A. C.
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142707732.77
292 rdf:type schema:Person
293 sg:person.01165015424.67 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
294 schema:familyName Gimenes
295 schema:givenName R.
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165015424.67
297 rdf:type schema:Person
298 sg:person.01212020537.99 schema:affiliation https://www.grid.ac/institutes/grid.5808.5
299 schema:familyName Falcão-Pires
300 schema:givenName I.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212020537.99
302 rdf:type schema:Person
303 sg:person.01264245630.02 schema:affiliation https://www.grid.ac/institutes/grid.5808.5
304 schema:familyName Rodrigues
305 schema:givenName P.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264245630.02
307 rdf:type schema:Person
308 sg:person.01311703276.19 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
309 schema:familyName Laurindo
310 schema:givenName F. R.
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311703276.19
312 rdf:type schema:Person
313 sg:person.01314756716.09 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
314 schema:familyName Okoshi
315 schema:givenName K.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314756716.09
317 rdf:type schema:Person
318 sg:person.013443265762.31 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
319 schema:familyName Fernandes
320 schema:givenName A. A. H.
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443265762.31
322 rdf:type schema:Person
323 sg:person.016240425640.43 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
324 schema:familyName Correa
325 schema:givenName C. R.
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016240425640.43
327 rdf:type schema:Person
328 sg:person.016265477762.30 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
329 schema:familyName Campos
330 schema:givenName D. H. S.
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016265477762.30
332 rdf:type schema:Person
333 sg:person.0643462751.23 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
334 schema:familyName Guirado
335 schema:givenName G. N.
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643462751.23
337 rdf:type schema:Person
338 sg:person.0726342575.24 schema:affiliation https://www.grid.ac/institutes/grid.5808.5
339 schema:familyName Miranda-Silva
340 schema:givenName D.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726342575.24
342 rdf:type schema:Person
343 sg:pub.10.1007/bf01919538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013207932
344 https://doi.org/10.1007/bf01919538
345 rdf:type schema:CreativeWork
346 sg:pub.10.1007/s00395-011-0184-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013614483
347 https://doi.org/10.1007/s00395-011-0184-x
348 rdf:type schema:CreativeWork
349 sg:pub.10.1007/s10741-012-9313-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020403360
350 https://doi.org/10.1007/s10741-012-9313-3
351 rdf:type schema:CreativeWork
352 sg:pub.10.1007/s11373-005-7652-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015951647
353 https://doi.org/10.1007/s11373-005-7652-y
354 rdf:type schema:CreativeWork
355 sg:pub.10.1007/s12013-007-0039-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042739209
356 https://doi.org/10.1007/s12013-007-0039-0
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/294284a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041326000
359 https://doi.org/10.1038/294284a0
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/aps.2012.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041765451
362 https://doi.org/10.1038/aps.2012.164
363 rdf:type schema:CreativeWork
364 sg:pub.10.1111/j.1523-1755.2005.00287.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004063505
365 https://doi.org/10.1111/j.1523-1755.2005.00287.x
366 rdf:type schema:CreativeWork
367 sg:pub.10.1186/1475-2840-12-152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036271498
368 https://doi.org/10.1186/1475-2840-12-152
369 rdf:type schema:CreativeWork
370 sg:pub.10.1186/1475-2840-12-169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025178556
371 https://doi.org/10.1186/1475-2840-12-169
372 rdf:type schema:CreativeWork
373 sg:pub.10.1186/1475-2840-12-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044947301
374 https://doi.org/10.1186/1475-2840-12-28
375 rdf:type schema:CreativeWork
376 sg:pub.10.1186/1475-2840-13-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039215046
377 https://doi.org/10.1186/1475-2840-13-11
378 rdf:type schema:CreativeWork
379 sg:pub.10.1186/1475-2840-13-55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017729747
380 https://doi.org/10.1186/1475-2840-13-55
381 rdf:type schema:CreativeWork
382 sg:pub.10.1186/1755-1536-5-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010526898
383 https://doi.org/10.1186/1755-1536-5-15
384 rdf:type schema:CreativeWork
385 sg:pub.10.1186/s12933-015-0173-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007239220
386 https://doi.org/10.1186/s12933-015-0173-8
387 rdf:type schema:CreativeWork
388 sg:pub.10.1186/s12933-015-0255-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046452258
389 https://doi.org/10.1186/s12933-015-0255-7
390 rdf:type schema:CreativeWork
391 sg:pub.10.1186/s12933-015-0308-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1032835564
392 https://doi.org/10.1186/s12933-015-0308-y
393 rdf:type schema:CreativeWork
394 sg:pub.10.1186/s12974-015-0325-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005757775
395 https://doi.org/10.1186/s12974-015-0325-5
396 rdf:type schema:CreativeWork
397 sg:pub.10.1186/s40200-014-0084-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014058205
398 https://doi.org/10.1186/s40200-014-0084-3
399 rdf:type schema:CreativeWork
400 https://app.dimensions.ai/details/publication/pub.1078309146 schema:CreativeWork
401 https://doi.org/10.1002/0471141755.ph0547s70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017738050
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1006/jmcc.2001.1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010237549
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/1056-8719(94)90092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015548648
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/j.arcmed.2015.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045626730
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/j.carpath.2009.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000637575
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1016/j.ejcts.2006.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025891829
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/j.ejphar.2006.12.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015849252
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1016/j.ejphar.2010.04.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046626195
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1016/j.freeradbiomed.2010.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006064242
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/j.ijcard.2012.03.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016801033
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1016/j.ijcard.2016.04.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006691671
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1016/j.ijcard.2016.04.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018572761
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1016/j.jacc.2008.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034752304
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1016/j.jdiacomp.2010.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007725460
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1016/j.nutres.2006.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024300783
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1016/j.phrs.2007.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020012978
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1016/j.phymed.2015.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023809461
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1016/j.redox.2013.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037717214
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1016/j.taap.2005.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013772893
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1016/j.taap.2007.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019233818
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1016/j.yjmcc.2015.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018349312
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1016/s0014-2999(01)01516-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017812833
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1016/s0024-3205(03)00508-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024957746
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1016/s0076-6879(08)01213-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029111854
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1016/s0271-5317(01)00275-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015584770
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1016/s0735-1097(03)00471-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016254144
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1042/cs20100529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014293233
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1089/ars.2013.5814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052572854
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1093/cvr/cvn185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033728510
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1111/j.1463-1326.2011.01369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010640780
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1111/jdi.12250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006374958
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1139/y01-060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004535381
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1139/y10-063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042232130
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1139/y97-163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051539115
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1152/ajpcell.00188.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005638532
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1152/ajpcell.00331.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008262135
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1152/ajpheart.00114.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040780983
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1152/ajpheart.00174.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014245482
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1152/ajpheart.00335.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032547095
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1152/ajplung.00064.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004125977
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1155/2012/726940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049461396
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1155/2013/653789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019346854
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1155/2015/457848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001473982
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1155/2015/515042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051993131
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1155/2016/5698931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034610157
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1155/2016/7409196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037292709
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1155/2016/8695716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023201706
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1159/000354526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005525512
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1159/000369683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045951403
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1159/000374053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022150159
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1161/01.cir.101.6.660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032911793
502 rdf:type schema:CreativeWork
503 https://doi.org/10.1161/01.hyp.0000082814.62655.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008957334
504 rdf:type schema:CreativeWork
505 https://doi.org/10.1161/cir.0000000000000350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037084752
506 rdf:type schema:CreativeWork
507 https://doi.org/10.1161/circulationaha.111.076075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051906371
508 rdf:type schema:CreativeWork
509 https://doi.org/10.1161/hypertensionaha.107.100214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023144844
510 rdf:type schema:CreativeWork
511 https://doi.org/10.1161/hypertensionaha.107.103200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023819468
512 rdf:type schema:CreativeWork
513 https://doi.org/10.1161/jaha.114.001598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079108477
514 rdf:type schema:CreativeWork
515 https://doi.org/10.1210/en.2007-1544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249097
516 rdf:type schema:CreativeWork
517 https://doi.org/10.1253/circj.cj-13-1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048470802
518 rdf:type schema:CreativeWork
519 https://doi.org/10.1536/jhj.45.647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009144289
520 rdf:type schema:CreativeWork
521 https://doi.org/10.1590/s0100-879x1997000900013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007419852
522 rdf:type schema:CreativeWork
523 https://doi.org/10.1590/s0100-879x2004000400019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040225526
524 rdf:type schema:CreativeWork
525 https://doi.org/10.18632/oncotarget.5084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037814415
526 rdf:type schema:CreativeWork
527 https://doi.org/10.2337/db09-1800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015693095
528 rdf:type schema:CreativeWork
529 https://doi.org/10.2337/dc07-0272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028370534
530 rdf:type schema:CreativeWork
531 https://doi.org/10.2337/dc08-s247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048977453
532 rdf:type schema:CreativeWork
533 https://doi.org/10.2337/dc16-s005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011036334
534 rdf:type schema:CreativeWork
535 https://doi.org/10.3109/03639045.2015.1052080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048663081
536 rdf:type schema:CreativeWork
537 https://doi.org/10.3317/jraas.2001.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009519004
538 rdf:type schema:CreativeWork
539 https://doi.org/10.3390/ijms161025234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013984724
540 rdf:type schema:CreativeWork
541 https://doi.org/10.4239/wjd.v6.i4.662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079089259
542 rdf:type schema:CreativeWork
543 https://www.grid.ac/institutes/grid.11899.38 schema:alternateName University of Sao Paulo
544 schema:name Department of Cardiopneumology, Medical School, Sao Paulo University-USP, Sao Paulo, Brazil
545 rdf:type schema:Organization
546 https://www.grid.ac/institutes/grid.410543.7 schema:alternateName Sao Paulo State University
547 schema:name Department of Chemistry and Biochemistry, Institute of Biosciences, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil
548 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil
549 Department of Pathology, Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo, Brazil
550 rdf:type schema:Organization
551 https://www.grid.ac/institutes/grid.412296.a schema:alternateName Universidade Sagrado Coração
552 schema:name Sagrado Coração University-USC, Bauru, Sao Paulo, Brazil
553 rdf:type schema:Organization
554 https://www.grid.ac/institutes/grid.5808.5 schema:alternateName University of Porto
555 schema:name Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal
556 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...