Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase ... View Full Text


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Article Info

DATE

2016-06-18

AUTHORS

Jun-ichi Oyama, Atsushi Tanaka, Yasunori Sato, Hirofumi Tomiyama, Masataka Sata, Tomoko Ishizu, Isao Taguchi, Takanori Kuroyanagi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Mitsuru Ohishi, Kazuo Eguchi, Yukihito Higashi, Hirotsugu Yamada, Koji Maemura, Junya Ako, Yasuko K. Bando, Shinichiro Ueda, Teruo Inoue, Toyoaki Murohara, Koichi Node, On behalf of the PRIZE Study Investigators

ABSTRACT

BackgroundXanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia.MethodsThe study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. A total of 500 patients with asymptomatic hyperuricemia (uric acid >7.0 mg/dL) and carotid intima-media thickness ≥1.1 mm will be randomized centrally to receive either febuxostat (10–60 mg/day) or non-pharmacological treatment. Randomization is carried out using the dynamic allocation method stratified according to age (<65, ≥65 year), gender, presence or absence of diabetes mellitus, serum uric acid (<8.0, ≥8.0 mg/dL), and carotid intima-media thickness (<1.3, ≥1.3 mm). In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. Carotid intima-media thickness will be evaluated using ultrasonography performed by skilled technicians at a central laboratory. Follow-up will be continued for 24 months. The primary endpoint is percentage change in mean intima-media thickness of the common carotid artery 24 months after baseline, measured by carotid ultrasound imaging.ConclusionsPRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia.Trial Registration Unique trial Number, UMIN000012911 (https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000015081&language=E) More... »

PAGES

87

Journal

TITLE

Cardiovascular Diabetology

ISSUE

1

VOLUME

15

Author Affiliations

  • Department of Cardiovascular Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, 849-8501, Saga, Japan
  • Department of Clinical Research, Chiba University Graduate School of Medicine, Chiba, Japan
  • Department of Cardiology, Tokyo Medical University, Tokyo, Japan
  • Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
  • Department of Clinical Laboratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Department of Cardiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan
  • Department of Cardiovascular Medicine, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, Japan
  • Internal Medicine (III), Department of Cardiology, Osaka Medical College, Takatsuki, Japan
  • Department of Cardiovascular Medicine and Hypertension, Kagoshima University, Kagoshima, Japan
  • Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan
  • Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • Department of Cardiovascular Medicine, Kitasato University, Sagamihara, Japan
  • Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Nishihara, Japan
  • Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12933-016-0409-2

    DOI

    http://dx.doi.org/10.1186/s12933-016-0409-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023751257

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27317093


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