Obesity attenuates gender differences in cardiovascular mortality View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Xin Song, Adam G Tabák, Björn Zethelius, John S Yudkin, Stefan Söderberg, Tiina Laatikainen, Coen DA Stehouwer, Rachel Dankner, Pekka Jousilahti, Altan Onat, Peter M Nilsson, Ilhan Satman, Olga Vaccaro, Jaakko Tuomilehto, Qing Qiao, for the DECODE Study Group

ABSTRACT

BACKGROUND: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. METHODS: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. RESULTS: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and ≥35.0 kg/m(2)). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. CONCLUSIONS: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation. More... »

PAGES

144

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12933-014-0144-5

DOI

http://dx.doi.org/10.1186/s12933-014-0144-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020535562

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25928355


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