Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell, Deborah J. Cook, Michael G. Surette, for the PROSPECT Investigators, Canadian Critical Care Trials Group, Canadian Critical Care Translational Biology Group

ABSTRACT

BACKGROUND: Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile the microbial composition of critically ill mechanically ventilated patients, and to determine whether microbial diversity is associated with illness severity and mortality. METHODS: We conducted a prospective, observational study of mechanically ventilated critically ill patients with a high incidence of pneumonia in 2 intensive care units (ICUs) in Hamilton, Canada, nested within a randomized trial for the prevention of healthcare-associated infections. The microbial profiles of specimens from 3 anatomical sites (respiratory, and upper and lower gastrointestinal tracts) were characterized using 16S ribosomal RNA gene sequencing. RESULTS: We collected 65 specimens from 34 ICU patients enrolled in the trial (29 endotracheal aspirates, 26 gastric aspirates and 10 stool specimens). Specimens were collected at a median time of 3 days (lower respiratory tract and gastric aspirates; interquartile range [IQR] 2-4) and 6 days (stool; IQR 4.25-6.75) following ICU admission. We observed a loss of biogeographical distinction between the lower respiratory tract and gastrointestinal tract microbiota during critical illness. Moreover, microbial diversity in the respiratory tract was inversely correlated with APACHE II score (r = - 0.46, p = 0.013) and was associated with hospital mortality (Median Shannon index: Discharged alive; 1.964 vs. Deceased; 1.348, p = 0.045). CONCLUSIONS: The composition of the host-associated microbial communities is severely perturbed during critical illness. Reduced microbial diversity reflects high illness severity and is associated with mortality. Microbial diversity may be a biomarker of prognostic value in mechanically ventilated patients. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01782755 . Registered February 4 2013. More... »

PAGES

245

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12931-018-0950-5

    DOI

    http://dx.doi.org/10.1186/s12931-018-0950-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110465193

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30526610


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    413 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada
    414 Department of Medicine, McMaster University, Health Sciences Bldg, 3N8F, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada
    415 Department of Pathology and Molecular Medicine, Hamilton, ON, Canada
    416 Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    417 Hamilton Health Sciences, Hamilton, ON, Canada
    418 Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada
    419 St. Joseph’s Healthcare, Hamilton, ON, Canada
    420 rdf:type schema:Organization
    421 https://www.grid.ac/institutes/grid.413615.4 schema:alternateName Hamilton Health Sciences
    422 schema:name Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada
    423 Hamilton Health Sciences, Hamilton, ON, Canada
    424 rdf:type schema:Organization
    425 https://www.grid.ac/institutes/grid.415400.4 schema:alternateName Public Health Ontario
    426 schema:name Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    427 Department of Medicine, University of Toronto, Toronto, ON, Canada
    428 Public Health Ontario, Toronto, ON, Canada
    429 rdf:type schema:Organization
     




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