Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río, N. A. Risebrough

ABSTRACT

BACKGROUND: A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1 s (FEV1) versus once-daily tiotropium/olodaterol (TIO/OLO) 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated the cost effectiveness of UMEC/VI versus TIO/OLO from a Spanish National Healthcare System perspective, using data from this study and Spanish literature. METHODS: This analysis was conducted from the perspective of the Spanish National Healthcare System with a 3-year horizon as base case. A disease progression model using a linked risk equation approach was used to estimate disease progression and associated healthcare costs, and quality-adjusted life years (QALYs). The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study was used to develop the statistical risk equations for clinical endpoints, and costs were calculated using a health state approach (by dyspnea severity). Utilities for QALY calculation were estimated using patient baseline characteristics within a regression fit to Spanish observational data. Treatment effect, expressed as change from baseline in FEV1 was obtained from the head-to-head study and used in the model (UMEC/VI minus TIO/OLO difference: + 52 mL [95% confidence interval: 28, 77]). Baseline patient characteristics were sourced from Spanish literature or the head-to-head study if unavailable. A scenario analysis using only the intent-to-treat (ITT) population from the head-to-head study, and sensitivity analyses (including probabilistic sensitivity analyses), were conducted. Direct healthcare costs (2017 Euro) were obtained from Spanish sources and costs and benefits were discounted at 3% per annum. RESULTS: UMEC/VI was associated with small improvements in QALYs (+ 0.029) over a 3-year time horizon, compared with TIO/OLO, alongside cost savings of €393/patient. The ITT scenario analysis and sensitivity analyses had similar results. All probabilistic simulations resulted in UMEC/VI being less costly and more effective than TIO/OLO. CONCLUSION: UMEC/VI dominated TIO/OLO (more effective and less expensive). These results may aid payers and decision-makers in Spain when making judgements on which long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA) treatments can be considered cost effective in Spain. More... »

PAGES

224

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-018-0916-7

DOI

http://dx.doi.org/10.1186/s12931-018-0916-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110046879

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30458866


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0104", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Statistics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/01", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Mathematical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoxazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzyl Alcohols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorobenzenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cost-Benefit Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "National Health Programs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinuclidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tiotropium Bromide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Value Evidence and Outcomes, GSK, 980 Great West Road, TW8 9GS, Brentford, Middlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Driessen", 
        "givenName": "M. T.", 
        "id": "sg:person.01355010313.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355010313.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ICON Health Economics, ICON plc, Abingdon, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whalen", 
        "givenName": "J.", 
        "id": "sg:person.012365335416.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012365335416.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ICON Health Economics, ICON plc, Abingdon, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seewoodharry Buguth", 
        "givenName": "B.", 
        "id": "sg:person.016215347516.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215347516.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.419327.a", 
          "name": [
            "Departamento de Evaluaci\u00f3n de Medicamentos, GSK, Tres Cantos, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vallejo-Aparicio", 
        "givenName": "L. A.", 
        "id": "sg:person.01034450761.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034450761.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Global Respiratory Franchise, GSK, Brentford, Middlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naya", 
        "givenName": "I. P.", 
        "id": "sg:person.010453460731.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010453460731.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "Value Evidence and Outcomes, GSK, 980 Great West Road, TW8 9GS, Brentford, Middlesex, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asukai", 
        "givenName": "Y.", 
        "id": "sg:person.0667422360.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667422360.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital de Alta Resoluci\u00f3n de Loja, Granada, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alc\u00e1zar-Navarrete", 
        "givenName": "B.", 
        "id": "sg:person.01276123024.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276123024.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Vall d'Hebron", 
          "id": "https://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Pneumology Department, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miravitlles", 
        "givenName": "M.", 
        "id": "sg:person.0717175004.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717175004.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario La Paz", 
          "id": "https://www.grid.ac/institutes/grid.81821.32", 
          "name": [
            "Hospital Universitario La Paz-IdiPAZ, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-R\u00edo", 
        "givenName": "F.", 
        "id": "sg:person.0647036707.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647036707.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ICON Health Economics, ICON, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Risebrough", 
        "givenName": "N. A.", 
        "id": "sg:person.01317033320.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317033320.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1579-2129(11)60005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000319374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2013.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001828920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1579-2129(06)60198-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002071910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.04.00014304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002783277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12890-015-0092-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003319957", 
          "https://doi.org/10.1186/s12890-015-0092-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12890-015-0092-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003319957", 
          "https://doi.org/10.1186/s12890-015-0092-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2016.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003847006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200703-456so", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003862874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ceor.s116546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005467765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chest.2016.02.646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005507752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)61298-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009754337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x15610781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010146834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x15610781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010146834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2014.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011888243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbres.2010.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013908107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2015.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015492289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.115725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015885352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.115725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015885352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.111.004580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016840988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11589270-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016970437", 
          "https://doi.org/10.2165/11589270-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12913-016-1482-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017525147", 
          "https://doi.org/10.1186/s12913-016-1482-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12913-016-1482-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017525147", 
          "https://doi.org/10.1186/s12913-016-1482-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2010.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017740638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s102962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018309917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2016.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018318934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x16662009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019326703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x16662009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019326703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbr.2012.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021093523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10198-010-0244-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021425920", 
          "https://doi.org/10.1007/s10198-010-0244-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.125.1.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021989040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd009285.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024626911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbres.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026046567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0089866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029826109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s102494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030549045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-11-122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035511693", 
          "https://doi.org/10.1186/1465-9921-11-122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(14)70065-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037998562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npjpcrm.2016.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040854561", 
          "https://doi.org/10.1038/npjpcrm.2016.79"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2014.08.1852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041386772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12955-014-0120-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043272853", 
          "https://doi.org/10.1186/s12955-014-0120-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12955-014-0120-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043272853", 
          "https://doi.org/10.1186/s12955-014-0120-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x16653118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047284001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x16653118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047284001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.123.3.784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047972268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.123.3.784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047972268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s94006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048170698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s103335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049076154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0805800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049406405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-14-49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051849337", 
          "https://doi.org/10.1186/1465-9921-14-49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465814559209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1753465814559209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064075695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s124482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074191215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd012066.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083738889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s119032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084386308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s124420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084386315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s131016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084815232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbres.2017.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085129170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arbr.2017.03.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085442018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s137872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091138880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s41030-017-0048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091308147", 
          "https://doi.org/10.1007/s41030-017-0048-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s41030-017-0048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091308147", 
          "https://doi.org/10.1007/s41030-017-0048-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2017.08.1495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092327942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-017-0626-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092478443", 
          "https://doi.org/10.1007/s12325-017-0626-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12931-017-0683-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092982027", 
          "https://doi.org/10.1186/s12931-017-0683-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/1393003.congress-2017.pa2792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099874223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/1393003.congress-2017.pa2792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099874223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/1393003.congress-2017.pa2792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099874223"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1\u00a0s (FEV1) versus once-daily tiotropium/olodaterol (TIO/OLO) 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated the cost effectiveness of UMEC/VI versus TIO/OLO from a Spanish National Healthcare System perspective, using data from this study and Spanish literature.\nMETHODS: This analysis was conducted from the perspective of the Spanish National Healthcare System with a 3-year horizon as base case. A disease progression model using a linked risk equation approach was used to estimate disease progression and associated healthcare costs, and quality-adjusted life years (QALYs). The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study was used to develop the statistical risk equations for clinical endpoints, and costs were calculated using a health state approach (by dyspnea severity). Utilities for QALY calculation were estimated using patient baseline characteristics within a regression fit to Spanish observational data. Treatment effect, expressed as change from baseline in FEV1 was obtained from the head-to-head study and used in the model (UMEC/VI minus TIO/OLO difference: +\u200952\u00a0mL [95% confidence interval: 28, 77]). Baseline patient characteristics were sourced from Spanish literature or the head-to-head study if unavailable. A scenario analysis using only the intent-to-treat (ITT) population from the head-to-head study, and sensitivity analyses (including probabilistic sensitivity analyses), were conducted. Direct healthcare costs (2017 Euro) were obtained from Spanish sources and costs and benefits were discounted at 3% per annum.\nRESULTS: UMEC/VI was associated with small improvements in QALYs (+\u20090.029) over a 3-year time horizon, compared with TIO/OLO, alongside cost savings of \u20ac393/patient. The ITT scenario analysis and sensitivity analyses had similar results. All probabilistic simulations resulted in UMEC/VI being less costly and more effective than TIO/OLO.\nCONCLUSION: UMEC/VI dominated TIO/OLO (more effective and less expensive). These results may aid payers and decision-makers in Spain when making judgements on which long-acting muscarinic antagonist/long-acting \u03b22-agonist (LAMA/LABA) treatments can be considered cost effective in Spain.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12931-018-0916-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028525", 
        "issn": [
          "1465-9921", 
          "1465-993X"
        ], 
        "name": "Respiratory Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a Spanish National Healthcare System perspective", 
    "pagination": "224", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8da908d47a2575801957217f87f8c6681e5b5e4fda5fc3bbc08a1d62fc060f4d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30458866"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101090633"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12931-018-0916-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110046879"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12931-018-0916-7", 
      "https://app.dimensions.ai/details/publication/pub.1110046879"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89789_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12931-018-0916-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0916-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0916-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0916-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0916-7'


 

This table displays all metadata directly associated to this object as RDF triples.

395 TRIPLES      21 PREDICATES      101 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12931-018-0916-7 schema:about N10fe11398f854b5b89b2d9c85287b2c3
2 N1dce4fbf94144e579b8d2329c93460ef
3 N4881bd75977a46439d77111472dac47e
4 N55360393b3cd4ec7a9bdb03ef7536920
5 N58ac633747e7429d8774a6b3d3ca287f
6 N5bf1c3e4121e44f89305f50b82220830
7 N5de646c8faf945d3ad46e67d9d6f340f
8 N79ea38a3239d4afe96abe11eff915f54
9 N7b7c5ce7d0a64a1ba5a0a9558904156c
10 N9a608e1d7c6d4599a5c92c715f8bea8f
11 N9f20531f638b4a8499a312f1930817cc
12 Nbe465e05087d4e2888ffc776eeac0704
13 Nc417bfbcbc4842f19d4c5630ef6f25fe
14 Ncd810caa7467446e95b2e94ec32c59a7
15 Nd020d32ea50941d8955ce7e9276db5d4
16 Nd0ffd2597e7e4aa0811ff1d7a72a15ad
17 Ne55de03266be4490a78af8bc9d7b663a
18 Nf0f5a9f2e3714aef999c7ae01c9aff36
19 anzsrc-for:01
20 anzsrc-for:0104
21 schema:author Ne38ce90f413642a8b6494b0e7eaa4829
22 schema:citation sg:pub.10.1007/s10198-010-0244-4
23 sg:pub.10.1007/s12325-017-0626-4
24 sg:pub.10.1007/s41030-017-0048-0
25 sg:pub.10.1038/npjpcrm.2016.79
26 sg:pub.10.1186/1465-9921-11-122
27 sg:pub.10.1186/1465-9921-14-49
28 sg:pub.10.1186/s12890-015-0092-1
29 sg:pub.10.1186/s12913-016-1482-7
30 sg:pub.10.1186/s12931-017-0683-x
31 sg:pub.10.1186/s12955-014-0120-5
32 sg:pub.10.2165/11589270-000000000-00000
33 https://doi.org/10.1002/14651858.cd009285.pub2
34 https://doi.org/10.1002/14651858.cd012066.pub2
35 https://doi.org/10.1016/j.arbr.2012.05.003
36 https://doi.org/10.1016/j.arbr.2017.03.017
37 https://doi.org/10.1016/j.arbres.2010.06.008
38 https://doi.org/10.1016/j.arbres.2012.04.001
39 https://doi.org/10.1016/j.arbres.2017.03.018
40 https://doi.org/10.1016/j.chest.2016.02.646
41 https://doi.org/10.1016/j.jval.2010.09.011
42 https://doi.org/10.1016/j.jval.2014.08.1852
43 https://doi.org/10.1016/j.jval.2016.10.016
44 https://doi.org/10.1016/j.jval.2017.08.1495
45 https://doi.org/10.1016/j.rmed.2013.06.001
46 https://doi.org/10.1016/j.rmed.2014.10.002
47 https://doi.org/10.1016/j.rmed.2015.04.018
48 https://doi.org/10.1016/j.rmed.2016.01.001
49 https://doi.org/10.1016/s0140-6736(09)61298-8
50 https://doi.org/10.1016/s1579-2129(06)60198-5
51 https://doi.org/10.1016/s1579-2129(11)60005-0
52 https://doi.org/10.1016/s2213-2600(14)70065-7
53 https://doi.org/10.1056/nejmoa0805800
54 https://doi.org/10.1124/pr.111.004580
55 https://doi.org/10.1136/thx.2009.115725
56 https://doi.org/10.1164/rccm.200703-456so
57 https://doi.org/10.1177/0272989x15610781
58 https://doi.org/10.1177/0272989x16653118
59 https://doi.org/10.1177/0272989x16662009
60 https://doi.org/10.1177/1753465814559209
61 https://doi.org/10.1183/09031936.04.00014304
62 https://doi.org/10.1183/1393003.congress-2017.pa2792
63 https://doi.org/10.1371/journal.pone.0089866
64 https://doi.org/10.1378/chest.123.3.784
65 https://doi.org/10.1378/chest.125.1.249
66 https://doi.org/10.2147/ceor.s116546
67 https://doi.org/10.2147/copd.s102494
68 https://doi.org/10.2147/copd.s102962
69 https://doi.org/10.2147/copd.s103335
70 https://doi.org/10.2147/copd.s119032
71 https://doi.org/10.2147/copd.s124420
72 https://doi.org/10.2147/copd.s124482
73 https://doi.org/10.2147/copd.s131016
74 https://doi.org/10.2147/copd.s137872
75 https://doi.org/10.2147/copd.s94006
76 schema:datePublished 2018-12
77 schema:datePublishedReg 2018-12-01
78 schema:description BACKGROUND: A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1 s (FEV1) versus once-daily tiotropium/olodaterol (TIO/OLO) 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated the cost effectiveness of UMEC/VI versus TIO/OLO from a Spanish National Healthcare System perspective, using data from this study and Spanish literature. METHODS: This analysis was conducted from the perspective of the Spanish National Healthcare System with a 3-year horizon as base case. A disease progression model using a linked risk equation approach was used to estimate disease progression and associated healthcare costs, and quality-adjusted life years (QALYs). The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study was used to develop the statistical risk equations for clinical endpoints, and costs were calculated using a health state approach (by dyspnea severity). Utilities for QALY calculation were estimated using patient baseline characteristics within a regression fit to Spanish observational data. Treatment effect, expressed as change from baseline in FEV1 was obtained from the head-to-head study and used in the model (UMEC/VI minus TIO/OLO difference: + 52 mL [95% confidence interval: 28, 77]). Baseline patient characteristics were sourced from Spanish literature or the head-to-head study if unavailable. A scenario analysis using only the intent-to-treat (ITT) population from the head-to-head study, and sensitivity analyses (including probabilistic sensitivity analyses), were conducted. Direct healthcare costs (2017 Euro) were obtained from Spanish sources and costs and benefits were discounted at 3% per annum. RESULTS: UMEC/VI was associated with small improvements in QALYs (+ 0.029) over a 3-year time horizon, compared with TIO/OLO, alongside cost savings of €393/patient. The ITT scenario analysis and sensitivity analyses had similar results. All probabilistic simulations resulted in UMEC/VI being less costly and more effective than TIO/OLO. CONCLUSION: UMEC/VI dominated TIO/OLO (more effective and less expensive). These results may aid payers and decision-makers in Spain when making judgements on which long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA) treatments can be considered cost effective in Spain.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree true
82 schema:isPartOf N96cddb47662d4e6aa2a79f151ac61b4e
83 Nfe54a312b5dc4a68b8530c7f464b831b
84 sg:journal.1028525
85 schema:name Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a Spanish National Healthcare System perspective
86 schema:pagination 224
87 schema:productId N4b157cbe232e4837b30e3cae467f4ef1
88 N8f4a95e851824aeabd644a1968a4eff8
89 N935580b1b21343019f293f9100820614
90 Nbd7e3616f7cc472cb114b4ec5ef75f89
91 Ndada742fe0bd49b8b56b22038a0e2d77
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110046879
93 https://doi.org/10.1186/s12931-018-0916-7
94 schema:sdDatePublished 2019-04-11T09:51
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N08c5584ff2254059902e211ca3190349
97 schema:url https://link.springer.com/10.1186%2Fs12931-018-0916-7
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N08c5584ff2254059902e211ca3190349 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N0bb5bb8d11cc44628cabe2cc07825905 rdf:first sg:person.0667422360.61
104 rdf:rest Nd4a37ed433d6417ca3254631422a837f
105 N10fe11398f854b5b89b2d9c85287b2c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Prospective Studies
107 rdf:type schema:DefinedTerm
108 N1bfe5537799e44e3a24718830588970b rdf:first sg:person.010453460731.31
109 rdf:rest N0bb5bb8d11cc44628cabe2cc07825905
110 N1dce4fbf94144e579b8d2329c93460ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Cross-Over Studies
112 rdf:type schema:DefinedTerm
113 N4881bd75977a46439d77111472dac47e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Single-Blind Method
115 rdf:type schema:DefinedTerm
116 N4b157cbe232e4837b30e3cae467f4ef1 schema:name pubmed_id
117 schema:value 30458866
118 rdf:type schema:PropertyValue
119 N55360393b3cd4ec7a9bdb03ef7536920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name National Health Programs
121 rdf:type schema:DefinedTerm
122 N58ac633747e7429d8774a6b3d3ca287f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Spain
124 rdf:type schema:DefinedTerm
125 N5bf1c3e4121e44f89305f50b82220830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Pulmonary Disease, Chronic Obstructive
127 rdf:type schema:DefinedTerm
128 N5de646c8faf945d3ad46e67d9d6f340f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 N60fd2b82738e4294be55752496900ce6 rdf:first sg:person.0647036707.63
132 rdf:rest N72acba5724ae4b83bb7c5f0ca666a3df
133 N719948d99cba41998a2bd2864660bc0c schema:name Hospital de Alta Resolución de Loja, Granada, Spain
134 rdf:type schema:Organization
135 N72acba5724ae4b83bb7c5f0ca666a3df rdf:first sg:person.01317033320.99
136 rdf:rest rdf:nil
137 N79ea38a3239d4afe96abe11eff915f54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Middle Aged
139 rdf:type schema:DefinedTerm
140 N7b7c5ce7d0a64a1ba5a0a9558904156c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aged
142 rdf:type schema:DefinedTerm
143 N86d9e38851a340509461d6f810769dd8 rdf:first sg:person.016215347516.38
144 rdf:rest Nebacea2c0be4484da3cab4f25d2b183a
145 N8f4a95e851824aeabd644a1968a4eff8 schema:name dimensions_id
146 schema:value pub.1110046879
147 rdf:type schema:PropertyValue
148 N935580b1b21343019f293f9100820614 schema:name doi
149 schema:value 10.1186/s12931-018-0916-7
150 rdf:type schema:PropertyValue
151 N96cddb47662d4e6aa2a79f151ac61b4e schema:volumeNumber 19
152 rdf:type schema:PublicationVolume
153 N9a608e1d7c6d4599a5c92c715f8bea8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Chlorobenzenes
155 rdf:type schema:DefinedTerm
156 N9f20531f638b4a8499a312f1930817cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Tiotropium Bromide
158 rdf:type schema:DefinedTerm
159 Nb0a94bd8a9a545cc8120d43d8b22aa68 schema:name ICON Health Economics, ICON plc, Abingdon, UK
160 rdf:type schema:Organization
161 Nbd7e3616f7cc472cb114b4ec5ef75f89 schema:name nlm_unique_id
162 schema:value 101090633
163 rdf:type schema:PropertyValue
164 Nbe465e05087d4e2888ffc776eeac0704 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Benzyl Alcohols
166 rdf:type schema:DefinedTerm
167 Nc14e9d7a8e9d4c039e5cfb34a5208317 rdf:first sg:person.0717175004.13
168 rdf:rest N60fd2b82738e4294be55752496900ce6
169 Nc417bfbcbc4842f19d4c5630ef6f25fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Quinuclidines
171 rdf:type schema:DefinedTerm
172 Ncd810caa7467446e95b2e94ec32c59a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Cost-Benefit Analysis
174 rdf:type schema:DefinedTerm
175 Nd020d32ea50941d8955ce7e9276db5d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Male
177 rdf:type schema:DefinedTerm
178 Nd0ffd2597e7e4aa0811ff1d7a72a15ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 Nd4a37ed433d6417ca3254631422a837f rdf:first sg:person.01276123024.24
182 rdf:rest Nc14e9d7a8e9d4c039e5cfb34a5208317
183 Ndada742fe0bd49b8b56b22038a0e2d77 schema:name readcube_id
184 schema:value 8da908d47a2575801957217f87f8c6681e5b5e4fda5fc3bbc08a1d62fc060f4d
185 rdf:type schema:PropertyValue
186 Ne38ce90f413642a8b6494b0e7eaa4829 rdf:first sg:person.01355010313.69
187 rdf:rest Nf30469e8f16c4814a0b0222238efd54c
188 Ne55de03266be4490a78af8bc9d7b663a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Drug Combinations
190 rdf:type schema:DefinedTerm
191 Nebacea2c0be4484da3cab4f25d2b183a rdf:first sg:person.01034450761.23
192 rdf:rest N1bfe5537799e44e3a24718830588970b
193 Nf0f5a9f2e3714aef999c7ae01c9aff36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Benzoxazines
195 rdf:type schema:DefinedTerm
196 Nf14ddd6d608c4450a41a62301939b975 schema:name ICON Health Economics, ICON plc, Abingdon, UK
197 rdf:type schema:Organization
198 Nf30469e8f16c4814a0b0222238efd54c rdf:first sg:person.012365335416.59
199 rdf:rest N86d9e38851a340509461d6f810769dd8
200 Nfd7a336d9e384e57bd39295496005208 schema:name ICON Health Economics, ICON, Toronto, ON, Canada
201 rdf:type schema:Organization
202 Nfe54a312b5dc4a68b8530c7f464b831b schema:issueNumber 1
203 rdf:type schema:PublicationIssue
204 anzsrc-for:01 schema:inDefinedTermSet anzsrc-for:
205 schema:name Mathematical Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:0104 schema:inDefinedTermSet anzsrc-for:
208 schema:name Statistics
209 rdf:type schema:DefinedTerm
210 sg:journal.1028525 schema:issn 1465-9921
211 1465-993X
212 schema:name Respiratory Research
213 rdf:type schema:Periodical
214 sg:person.01034450761.23 schema:affiliation https://www.grid.ac/institutes/grid.419327.a
215 schema:familyName Vallejo-Aparicio
216 schema:givenName L. A.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034450761.23
218 rdf:type schema:Person
219 sg:person.010453460731.31 schema:affiliation https://www.grid.ac/institutes/grid.418236.a
220 schema:familyName Naya
221 schema:givenName I. P.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010453460731.31
223 rdf:type schema:Person
224 sg:person.012365335416.59 schema:affiliation Nb0a94bd8a9a545cc8120d43d8b22aa68
225 schema:familyName Whalen
226 schema:givenName J.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012365335416.59
228 rdf:type schema:Person
229 sg:person.01276123024.24 schema:affiliation N719948d99cba41998a2bd2864660bc0c
230 schema:familyName Alcázar-Navarrete
231 schema:givenName B.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276123024.24
233 rdf:type schema:Person
234 sg:person.01317033320.99 schema:affiliation Nfd7a336d9e384e57bd39295496005208
235 schema:familyName Risebrough
236 schema:givenName N. A.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317033320.99
238 rdf:type schema:Person
239 sg:person.01355010313.69 schema:affiliation https://www.grid.ac/institutes/grid.418236.a
240 schema:familyName Driessen
241 schema:givenName M. T.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355010313.69
243 rdf:type schema:Person
244 sg:person.016215347516.38 schema:affiliation Nf14ddd6d608c4450a41a62301939b975
245 schema:familyName Seewoodharry Buguth
246 schema:givenName B.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016215347516.38
248 rdf:type schema:Person
249 sg:person.0647036707.63 schema:affiliation https://www.grid.ac/institutes/grid.81821.32
250 schema:familyName García-Río
251 schema:givenName F.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647036707.63
253 rdf:type schema:Person
254 sg:person.0667422360.61 schema:affiliation https://www.grid.ac/institutes/grid.418236.a
255 schema:familyName Asukai
256 schema:givenName Y.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667422360.61
258 rdf:type schema:Person
259 sg:person.0717175004.13 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
260 schema:familyName Miravitlles
261 schema:givenName M.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717175004.13
263 rdf:type schema:Person
264 sg:pub.10.1007/s10198-010-0244-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021425920
265 https://doi.org/10.1007/s10198-010-0244-4
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s12325-017-0626-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092478443
268 https://doi.org/10.1007/s12325-017-0626-4
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s41030-017-0048-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091308147
271 https://doi.org/10.1007/s41030-017-0048-0
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/npjpcrm.2016.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040854561
274 https://doi.org/10.1038/npjpcrm.2016.79
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/1465-9921-11-122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035511693
277 https://doi.org/10.1186/1465-9921-11-122
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/1465-9921-14-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051849337
280 https://doi.org/10.1186/1465-9921-14-49
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/s12890-015-0092-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003319957
283 https://doi.org/10.1186/s12890-015-0092-1
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/s12913-016-1482-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017525147
286 https://doi.org/10.1186/s12913-016-1482-7
287 rdf:type schema:CreativeWork
288 sg:pub.10.1186/s12931-017-0683-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092982027
289 https://doi.org/10.1186/s12931-017-0683-x
290 rdf:type schema:CreativeWork
291 sg:pub.10.1186/s12955-014-0120-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043272853
292 https://doi.org/10.1186/s12955-014-0120-5
293 rdf:type schema:CreativeWork
294 sg:pub.10.2165/11589270-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016970437
295 https://doi.org/10.2165/11589270-000000000-00000
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/14651858.cd009285.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024626911
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/14651858.cd012066.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083738889
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.arbr.2012.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021093523
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.arbr.2017.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085442018
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.arbres.2010.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013908107
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.arbres.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026046567
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.arbres.2017.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085129170
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.chest.2016.02.646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005507752
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.jval.2010.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017740638
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.jval.2014.08.1852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041386772
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.jval.2016.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018318934
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.jval.2017.08.1495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092327942
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.rmed.2013.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001828920
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.rmed.2014.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011888243
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.rmed.2015.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015492289
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.rmed.2016.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003847006
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0140-6736(09)61298-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009754337
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s1579-2129(06)60198-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002071910
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s1579-2129(11)60005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000319374
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s2213-2600(14)70065-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037998562
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1056/nejmoa0805800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049406405
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1124/pr.111.004580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016840988
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1136/thx.2009.115725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015885352
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1164/rccm.200703-456so schema:sameAs https://app.dimensions.ai/details/publication/pub.1003862874
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1177/0272989x15610781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010146834
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1177/0272989x16653118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047284001
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1177/0272989x16662009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019326703
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1177/1753465814559209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064075695
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1183/09031936.04.00014304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002783277
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1183/1393003.congress-2017.pa2792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099874223
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pone.0089866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029826109
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1378/chest.123.3.784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047972268
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1378/chest.125.1.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021989040
362 rdf:type schema:CreativeWork
363 https://doi.org/10.2147/ceor.s116546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005467765
364 rdf:type schema:CreativeWork
365 https://doi.org/10.2147/copd.s102494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030549045
366 rdf:type schema:CreativeWork
367 https://doi.org/10.2147/copd.s102962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018309917
368 rdf:type schema:CreativeWork
369 https://doi.org/10.2147/copd.s103335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049076154
370 rdf:type schema:CreativeWork
371 https://doi.org/10.2147/copd.s119032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084386308
372 rdf:type schema:CreativeWork
373 https://doi.org/10.2147/copd.s124420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084386315
374 rdf:type schema:CreativeWork
375 https://doi.org/10.2147/copd.s124482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074191215
376 rdf:type schema:CreativeWork
377 https://doi.org/10.2147/copd.s131016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084815232
378 rdf:type schema:CreativeWork
379 https://doi.org/10.2147/copd.s137872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091138880
380 rdf:type schema:CreativeWork
381 https://doi.org/10.2147/copd.s94006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048170698
382 rdf:type schema:CreativeWork
383 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
384 schema:name Pneumology Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.418236.a schema:alternateName GlaxoSmithKline (United Kingdom)
387 schema:name Global Respiratory Franchise, GSK, Brentford, Middlesex, UK
388 Value Evidence and Outcomes, GSK, 980 Great West Road, TW8 9GS, Brentford, Middlesex, UK
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.419327.a schema:alternateName GlaxoSmithKline (Spain)
391 schema:name Departamento de Evaluación de Medicamentos, GSK, Tres Cantos, Madrid, Spain
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.81821.32 schema:alternateName Hospital Universitario La Paz
394 schema:name Hospital Universitario La Paz-IdiPAZ, Madrid, Spain
395 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...