Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Kathrin Kahnert, Peter Alter, Tobias Welte, Rudolf M. Huber, Jürgen Behr, Frank Biertz, Henrik Watz, Robert Bals, Claus F. Vogelmeier, Rudolf A. Jörres

ABSTRACT

BACKGROUND: Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid within the network of multiple relationships between function, exacerbation and comorbidities. METHODS: We used baseline data from the German COPD cohort COSYCONET which were evaluated by standard multiple regression analyses as well as path analysis to quantify the network of relations between parameters, particularly uric acid. RESULTS: Data from 1966 patients were analyzed. Uric acid was significantly associated with reduced FEV1, reduced 6-MWD, higher burden of exacerbations (GOLD criteria) and cardiovascular comorbidities, in addition to risk factors such as BMI and packyears. These associations remained significant after taking into account their multiple interdependences. Compared to uric acid levels the diagnosis of hyperuricemia and its medication played a minor role. CONCLUSION: Within the limits of a cross-sectional approach, our results strongly suggest that uric acid is a biomarker of high impact in COPD and plays a genuine role for relevant outcomes such as physical capacity and exacerbations. These findings suggest that more attention should be paid to uric acid in the evaluation of COPD disease status. More... »

PAGES

110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-018-0815-y

DOI

http://dx.doi.org/10.1186/s12931-018-0815-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104385446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29866121


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exercise", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Forced Expiratory Flow Rates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Volume Measurements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Disease, Chronic Obstructive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center,Member of the German Center for Lung Research (DZL), Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kahnert", 
        "givenName": "Kathrin", 
        "id": "sg:person.013235012411.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235012411.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Germany, Member of the German Center for Lung Research (DZL), Baldingerstrasse, 35043, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alter", 
        "givenName": "Peter", 
        "id": "sg:person.01065373312.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065373312.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Pneumology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welte", 
        "givenName": "Tobias", 
        "id": "sg:person.01200122325.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center,Member of the German Center for Lung Research (DZL), Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huber", 
        "givenName": "Rudolf M.", 
        "id": "sg:person.01230464277.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230464277.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center,Member of the German Center for Lung Research (DZL), Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Behr", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.0776277206.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776277206.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Institute for Biostatistics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Biertz", 
        "givenName": "Frank", 
        "id": "sg:person.0722513343.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722513343.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Woehrendamm 80, 22927, Grosshansdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watz", 
        "givenName": "Henrik", 
        "id": "sg:person.01242232714.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242232714.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum des Saarlandes", 
          "id": "https://www.grid.ac/institutes/grid.411937.9", 
          "name": [
            "Department of Internal Medicine V \u2013 Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Kirrberger Stra\u00dfe 1, 66424, Homburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bals", 
        "givenName": "Robert", 
        "id": "sg:person.01124232770.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124232770.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Germany, Member of the German Center for Lung Research (DZL), Baldingerstrasse, 35043, Marburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogelmeier", 
        "givenName": "Claus F.", 
        "id": "sg:person.01124635224.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124635224.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f6rres", 
        "givenName": "Rudolf A.", 
        "id": "sg:person.016104551234.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016104551234.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/abbi.1993.1204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006123967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011437552", 
          "https://doi.org/10.1186/ar2952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012550957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016085724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/rmed.2003.1440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016085724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0163408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019219275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.128.4.2640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019493052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.03.00034603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021472062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201201-0034oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028216478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s87202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032141683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2016.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032729782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep19520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034868679", 
          "https://doi.org/10.1038/srep19520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201508-1653oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040095813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2005.040527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041782665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2005.040527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041782665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0954-6111(03)00129-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045175967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0954-6111(03)00129-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045175967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2014-205271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050717711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2014-205271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050717711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00080312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050761388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.014536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.014536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00209212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12932/ap0337.32.1.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064757578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/ijms.8.470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073619442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201701-0218pp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079404015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chest.2017.04.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085180612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0177501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085419537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12882-017-0736-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092465864", 
          "https://doi.org/10.1186/s12882-017-0736-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2017-210273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093076173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2017-210273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093076173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2018.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101112984"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid within the network of multiple relationships between function, exacerbation and comorbidities.\nMETHODS: We used baseline data from the German COPD cohort COSYCONET which were evaluated by standard multiple regression analyses as well as path analysis to quantify the network of relations between parameters, particularly uric acid.\nRESULTS: Data from 1966 patients were analyzed. Uric acid was significantly associated with reduced FEV1, reduced 6-MWD, higher burden of exacerbations (GOLD criteria) and cardiovascular comorbidities, in addition to risk factors such as BMI and packyears. These associations remained significant after taking into account their multiple interdependences. Compared to uric acid levels the diagnosis of hyperuricemia and its medication played a minor role.\nCONCLUSION: Within the limits of a cross-sectional approach, our results strongly suggest that uric acid is a biomarker of high impact in COPD and plays a genuine role for relevant outcomes such as physical capacity and exacerbations. These findings suggest that more attention should be paid to uric acid in the evaluation of COPD disease status.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12931-018-0815-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028525", 
        "issn": [
          "1465-9921", 
          "1465-993X"
        ], 
        "name": "Respiratory Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach", 
    "pagination": "110", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dc0898add732df1fd0adc3cb8b60093830b82794a63f5a23f7d9f7fbe76c052b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29866121"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101090633"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12931-018-0815-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104385446"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12931-018-0815-y", 
      "https://app.dimensions.ai/details/publication/pub.1104385446"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12931-018-0815-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0815-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0815-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0815-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12931-018-0815-y'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      69 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12931-018-0815-y schema:about N00a4b77e85124567964d44651f394e25
2 N07d46c423fba474d977d8a146c24171d
3 N2fc990529c2e4b538f1461824611fb3c
4 N5de28709f93b4c0b977b3f2a01f110d1
5 N5ef5d7bf7d56432b925086c51b228c43
6 N6b7fa3c929c748e1ba4ba34fc84097e2
7 N7729d67e944446e2a3226907613b8e88
8 N8522a425fb864122ab81a31a68dfea57
9 N94721756534f405491e6957b21d2eed1
10 N952cd3ed3e2b43e78b36f22e480fb855
11 Nb885e4ac99954a1f9c5c454a43b4b9ca
12 Nbd7f9ee398564740b7e8db57756968ba
13 Nd182ba48951149378ff6e989c83f7a11
14 Ndbf3c6e0af984c4e9017f2b495c75846
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author Nc92d43f1b55d4f9092e72199d6019009
18 schema:citation sg:pub.10.1038/srep19520
19 sg:pub.10.1186/ar2952
20 sg:pub.10.1186/s12882-017-0736-x
21 https://doi.org/10.1006/abbi.1993.1204
22 https://doi.org/10.1016/j.chest.2017.04.174
23 https://doi.org/10.1016/j.rmed.2016.03.008
24 https://doi.org/10.1016/j.rmed.2018.02.011
25 https://doi.org/10.1016/s0954-6111(03)00129-x
26 https://doi.org/10.1053/rmed.2003.1440
27 https://doi.org/10.1093/eurheartj/ehi879
28 https://doi.org/10.1136/thoraxjnl-2014-205271
29 https://doi.org/10.1136/thoraxjnl-2017-210273
30 https://doi.org/10.1136/thx.2005.040527
31 https://doi.org/10.1161/circulationaha.114.014536
32 https://doi.org/10.1164/rccm.201201-0034oc
33 https://doi.org/10.1164/rccm.201508-1653oc
34 https://doi.org/10.1164/rccm.201701-0218pp
35 https://doi.org/10.1183/09031936.00080312
36 https://doi.org/10.1183/09031936.00209212
37 https://doi.org/10.1183/09031936.03.00034603
38 https://doi.org/10.12932/ap0337.32.1.2014
39 https://doi.org/10.1371/journal.pone.0163408
40 https://doi.org/10.1371/journal.pone.0177501
41 https://doi.org/10.1378/chest.128.4.2640
42 https://doi.org/10.2147/copd.s87202
43 https://doi.org/10.7150/ijms.8.470
44 schema:datePublished 2018-12
45 schema:datePublishedReg 2018-12-01
46 schema:description BACKGROUND: Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid within the network of multiple relationships between function, exacerbation and comorbidities. METHODS: We used baseline data from the German COPD cohort COSYCONET which were evaluated by standard multiple regression analyses as well as path analysis to quantify the network of relations between parameters, particularly uric acid. RESULTS: Data from 1966 patients were analyzed. Uric acid was significantly associated with reduced FEV1, reduced 6-MWD, higher burden of exacerbations (GOLD criteria) and cardiovascular comorbidities, in addition to risk factors such as BMI and packyears. These associations remained significant after taking into account their multiple interdependences. Compared to uric acid levels the diagnosis of hyperuricemia and its medication played a minor role. CONCLUSION: Within the limits of a cross-sectional approach, our results strongly suggest that uric acid is a biomarker of high impact in COPD and plays a genuine role for relevant outcomes such as physical capacity and exacerbations. These findings suggest that more attention should be paid to uric acid in the evaluation of COPD disease status.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N30213d93bb31478682348e7f88001f9f
51 N732f5ad39dc5474c8dfe893da02835ee
52 sg:journal.1028525
53 schema:name Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach
54 schema:pagination 110
55 schema:productId N103b7afa1c7f4d2988f635b7329cd366
56 N3c6abf5967084c899dcdf52f2a1e791b
57 N7d9f00583fe245b4b83f4af5e358f233
58 Nbf54f840b0144264988215c888a28b5b
59 Nf92e42dc20ec499d999aea5a4c080ecc
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104385446
61 https://doi.org/10.1186/s12931-018-0815-y
62 schema:sdDatePublished 2019-04-10T20:11
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Nbfabb8d7359743beaad8605d836d3320
65 schema:url https://link.springer.com/10.1186%2Fs12931-018-0815-y
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N00a4b77e85124567964d44651f394e25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Aged
71 rdf:type schema:DefinedTerm
72 N07d46c423fba474d977d8a146c24171d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Biomarkers
74 rdf:type schema:DefinedTerm
75 N103b7afa1c7f4d2988f635b7329cd366 schema:name readcube_id
76 schema:value dc0898add732df1fd0adc3cb8b60093830b82794a63f5a23f7d9f7fbe76c052b
77 rdf:type schema:PropertyValue
78 N1bcf070935964734b1d9fa9a99554c46 rdf:first sg:person.01065373312.37
79 rdf:rest Nf7bbb952e52243fe8efa90cf9355e420
80 N29199a3465a0454cb283690ce35f1cb0 schema:name Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Germany, Member of the German Center for Lung Research (DZL), Baldingerstrasse, 35043, Marburg, Germany
81 rdf:type schema:Organization
82 N2fc990529c2e4b538f1461824611fb3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Lung
84 rdf:type schema:DefinedTerm
85 N30213d93bb31478682348e7f88001f9f schema:issueNumber 1
86 rdf:type schema:PublicationIssue
87 N3c6abf5967084c899dcdf52f2a1e791b schema:name doi
88 schema:value 10.1186/s12931-018-0815-y
89 rdf:type schema:PropertyValue
90 N3ea32fb7532244dbbae6b587dccad39a schema:name Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, Member of the German Center for Lung Research, Woehrendamm 80, 22927, Grosshansdorf, Germany
91 rdf:type schema:Organization
92 N4ce0139f71434095ac640ec85b18c862 rdf:first sg:person.0722513343.39
93 rdf:rest Ne79c60171fa840fba0df12f8d4f652be
94 N5640b1976276497c8274b0fc0bb1891b schema:name Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Germany, Member of the German Center for Lung Research (DZL), Baldingerstrasse, 35043, Marburg, Germany
95 rdf:type schema:Organization
96 N57aa59f5e9e94a05a099c26fa909c5d9 rdf:first sg:person.01124635224.62
97 rdf:rest Nebcbc794d2824402bb627a18f3dec9d7
98 N5de28709f93b4c0b977b3f2a01f110d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Exercise
100 rdf:type schema:DefinedTerm
101 N5ef5d7bf7d56432b925086c51b228c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Lung Volume Measurements
103 rdf:type schema:DefinedTerm
104 N642cf87b4b1b43cfa2cae85bdf02b5ac rdf:first sg:person.01230464277.15
105 rdf:rest Nf344f3cc89ba4a5c9b7955eecdab7f02
106 N6b7fa3c929c748e1ba4ba34fc84097e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cross-Sectional Studies
108 rdf:type schema:DefinedTerm
109 N732f5ad39dc5474c8dfe893da02835ee schema:volumeNumber 19
110 rdf:type schema:PublicationVolume
111 N7729d67e944446e2a3226907613b8e88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Pulmonary Disease, Chronic Obstructive
113 rdf:type schema:DefinedTerm
114 N7d9f00583fe245b4b83f4af5e358f233 schema:name nlm_unique_id
115 schema:value 101090633
116 rdf:type schema:PropertyValue
117 N8522a425fb864122ab81a31a68dfea57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Uric Acid
119 rdf:type schema:DefinedTerm
120 N94721756534f405491e6957b21d2eed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N952cd3ed3e2b43e78b36f22e480fb855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 Nb885e4ac99954a1f9c5c454a43b4b9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 Nbd7f9ee398564740b7e8db57756968ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Comorbidity
131 rdf:type schema:DefinedTerm
132 Nbf54f840b0144264988215c888a28b5b schema:name pubmed_id
133 schema:value 29866121
134 rdf:type schema:PropertyValue
135 Nbfabb8d7359743beaad8605d836d3320 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 Nc92d43f1b55d4f9092e72199d6019009 rdf:first sg:person.013235012411.97
138 rdf:rest N1bcf070935964734b1d9fa9a99554c46
139 Nd182ba48951149378ff6e989c83f7a11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 Ndbf3c6e0af984c4e9017f2b495c75846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Forced Expiratory Flow Rates
144 rdf:type schema:DefinedTerm
145 Ne45709c20c56471685d2783cbfb47d84 rdf:first sg:person.01124232770.20
146 rdf:rest N57aa59f5e9e94a05a099c26fa909c5d9
147 Ne79c60171fa840fba0df12f8d4f652be rdf:first sg:person.01242232714.08
148 rdf:rest Ne45709c20c56471685d2783cbfb47d84
149 Nebcbc794d2824402bb627a18f3dec9d7 rdf:first sg:person.016104551234.34
150 rdf:rest rdf:nil
151 Nf344f3cc89ba4a5c9b7955eecdab7f02 rdf:first sg:person.0776277206.39
152 rdf:rest N4ce0139f71434095ac640ec85b18c862
153 Nf7bbb952e52243fe8efa90cf9355e420 rdf:first sg:person.01200122325.47
154 rdf:rest N642cf87b4b1b43cfa2cae85bdf02b5ac
155 Nf92e42dc20ec499d999aea5a4c080ecc schema:name dimensions_id
156 schema:value pub.1104385446
157 rdf:type schema:PropertyValue
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
162 schema:name Cardiorespiratory Medicine and Haematology
163 rdf:type schema:DefinedTerm
164 sg:journal.1028525 schema:issn 1465-9921
165 1465-993X
166 schema:name Respiratory Research
167 rdf:type schema:Periodical
168 sg:person.01065373312.37 schema:affiliation N5640b1976276497c8274b0fc0bb1891b
169 schema:familyName Alter
170 schema:givenName Peter
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065373312.37
172 rdf:type schema:Person
173 sg:person.01124232770.20 schema:affiliation https://www.grid.ac/institutes/grid.411937.9
174 schema:familyName Bals
175 schema:givenName Robert
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124232770.20
177 rdf:type schema:Person
178 sg:person.01124635224.62 schema:affiliation N29199a3465a0454cb283690ce35f1cb0
179 schema:familyName Vogelmeier
180 schema:givenName Claus F.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124635224.62
182 rdf:type schema:Person
183 sg:person.01200122325.47 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
184 schema:familyName Welte
185 schema:givenName Tobias
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47
187 rdf:type schema:Person
188 sg:person.01230464277.15 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
189 schema:familyName Huber
190 schema:givenName Rudolf M.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230464277.15
192 rdf:type schema:Person
193 sg:person.01242232714.08 schema:affiliation N3ea32fb7532244dbbae6b587dccad39a
194 schema:familyName Watz
195 schema:givenName Henrik
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242232714.08
197 rdf:type schema:Person
198 sg:person.013235012411.97 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
199 schema:familyName Kahnert
200 schema:givenName Kathrin
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235012411.97
202 rdf:type schema:Person
203 sg:person.016104551234.34 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
204 schema:familyName Jörres
205 schema:givenName Rudolf A.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016104551234.34
207 rdf:type schema:Person
208 sg:person.0722513343.39 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
209 schema:familyName Biertz
210 schema:givenName Frank
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722513343.39
212 rdf:type schema:Person
213 sg:person.0776277206.39 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
214 schema:familyName Behr
215 schema:givenName Jürgen
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776277206.39
217 rdf:type schema:Person
218 sg:pub.10.1038/srep19520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034868679
219 https://doi.org/10.1038/srep19520
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/ar2952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011437552
222 https://doi.org/10.1186/ar2952
223 rdf:type schema:CreativeWork
224 sg:pub.10.1186/s12882-017-0736-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092465864
225 https://doi.org/10.1186/s12882-017-0736-x
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1006/abbi.1993.1204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006123967
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.chest.2017.04.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085180612
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.rmed.2016.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032729782
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.rmed.2018.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101112984
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0954-6111(03)00129-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045175967
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1053/rmed.2003.1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016085724
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/eurheartj/ehi879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012550957
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1136/thoraxjnl-2014-205271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050717711
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1136/thoraxjnl-2017-210273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093076173
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1136/thx.2005.040527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041782665
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1161/circulationaha.114.014536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052982640
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1164/rccm.201201-0034oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1028216478
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1164/rccm.201508-1653oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1040095813
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1164/rccm.201701-0218pp schema:sameAs https://app.dimensions.ai/details/publication/pub.1079404015
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1183/09031936.00080312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050761388
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1183/09031936.00209212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123979
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1183/09031936.03.00034603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021472062
260 rdf:type schema:CreativeWork
261 https://doi.org/10.12932/ap0337.32.1.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064757578
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1371/journal.pone.0163408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019219275
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0177501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085419537
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1378/chest.128.4.2640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019493052
268 rdf:type schema:CreativeWork
269 https://doi.org/10.2147/copd.s87202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032141683
270 rdf:type schema:CreativeWork
271 https://doi.org/10.7150/ijms.8.470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073619442
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
274 schema:name Department of Pneumology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
275 Institute for Biostatistics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.411937.9 schema:alternateName Universitätsklinikum des Saarlandes
278 schema:name Department of Internal Medicine V – Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Kirrberger Straße 1, 66424, Homburg, Germany
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
281 schema:name Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center,Member of the German Center for Lung Research (DZL), Munich, Germany
282 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-Universität München, Ziemssenstr. 1, 80336, Munich, Germany
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...