Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Bart de Brouwer, Marjolein Drent, Jody M. W. van den Ouweland, Petal A. Wijnen, Coline H. M. van Moorsel, Otto Bekers, Jan C. Grutters, Eric S. White, Rob Janssen

ABSTRACT

Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in both lung diseases. Emphysema is caused by an elastase/anti-elastase imbalance leading to accelerated elastin degradation. Elastinolysis is however, also accelerated in the IPF patients' lungs. The amino acids desmosine and isodesmosine (DES) are unique to elastin. During the degradation process, elastases liberate DES from elastin fibers. Blood DES levels consequently reflect the rate of systemic elastinolysis and are increased in COPD. This is the first report describing elevated DES levels in IPF patients. We also demonstrated that the age-related increment of DES concentrations is enhanced in IPF. Our current study suggests that elastinolysis is a shared pathogenic step in both COPD and IPF. Further investigation is required to establish the relevance of accelerated elastin degradation in IPF and to determine whether decelerating this process leads to slower progression of lung fibrosis and better survival for patients with IPF. More... »

PAGES

45

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-018-0747-6

DOI

http://dx.doi.org/10.1186/s12931-018-0747-6

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https://app.dimensions.ai/details/publication/pub.1101632860

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29558926


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