Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-27

AUTHORS

Youhei Takahashi, Atsushi Saito, Hirofumi Chiba, Koji Kuronuma, Kimiyuki Ikeda, Tomofumi Kobayashi, Shigeru Ariki, Motoko Takahashi, Yasushi Sasaki, Hiroki Takahashi

ABSTRACT

BackgroundIdiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers reported the possible role of microbiome composition in IPF. The roles of microbiomes in respiratory functions and as clinical biomarkers for IPF remain unknown. In this study, we aim to identify the relationship between the microbial environment in the lung and clinical findings.MethodsThirty-four subjects diagnosed with IPF were included in this analysis. The 16S rDNA was purified from bronchoalveolar lavage fluid obtained at the time of diagnosis and analyzed using next-generation sequencing techniques to characterize the bacterial communities. Furthermore, microbiomes from mice with bleomycin-induced lung fibrosis were analyzed.ResultsThe most prevalent lung phyla were Firmicutes, Proteobacteria and Bacteroidetes. Decreased microbial diversity was found in patients with low forced vital capacity (FVC) and early mortality. Additionally, the diversity and relative abundance of Firmicutes, Streptococcaceae, and Veillonellaceae were significantly associated with FVC, 6-min walk distance, and serum surfactant protein D. Bleomycin-induced lung fibrosis resulted in decrease of diversity and alteration of microbiota in PCoA analysis. These results support the observations in human specimens.ConclusionsThis study identified relationships between specific taxa in BALF and clinical findings, which were also supported by experiments in a mouse model. Our data suggest the possibility that loss of microbial diversity is associated with disease activities of IPF. More... »

PAGES

34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-018-0736-9

DOI

http://dx.doi.org/10.1186/s12931-018-0736-9

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https://app.dimensions.ai/details/publication/pub.1101248957

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29486761


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34 BackgroundIdiopathic pulmonary fibrosis
35 Bacteroidetes
36 ConclusionsThis study
37 FVC
38 Firmicutes
39 IPF
40 Proteobacteria
41 Streptococcaceae
42 Veillonellaceae
43 abundance
44 activity
45 alteration of microbiota
46 alterations
47 analysis
48 bacterial communities
49 biomarkers
50 bleomycin
51 bleomycin-induced lung fibrosis
52 bronchoalveolar lavage fluid
53 capacity
54 clinical biomarkers
55 clinical findings
56 community
57 composition
58 data
59 decrease
60 decrease of diversity
61 diagnosis
62 disease activity
63 distance
64 diversity
65 early mortality
66 environment
67 experiments
68 fibrosis
69 findings
70 fluid
71 form
72 function
73 human specimens
74 idiopathic interstitial pneumonia
75 idiopathic pulmonary fibrosis
76 interstitial pneumonia
77 lavage fluid
78 loss
79 lung
80 lung fibrosis
81 lung microbiome
82 mice
83 microbial diversity
84 microbial environment
85 microbiome
86 microbiome composition
87 microbiota
88 model
89 mortality
90 mouse model
91 next-generation sequencing techniques
92 observations
93 paper
94 patients
95 phyla
96 pneumonia
97 possibility
98 possible role
99 progression
100 pulmonary fibrosis
101 rDNA
102 recent paper
103 relationship
104 relative abundance
105 respiratory function
106 results
107 role
108 role of microbiome
109 sequencing techniques
110 severe form
111 specific taxa
112 specimens
113 study
114 subjects
115 taxa
116 technique
117 time
118 time of diagnosis
119 vital capacity
120 walk distance
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