Which early life events or current environmental and lifestyle factors influence lung function in adolescents? – results from the GINIplus ... View Full Text


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Article Info

DATE

2017-07-12

AUTHORS

Agnes Luzak, Elaine Fuertes, Claudia Flexeder, Marie Standl, Andrea von Berg, Dietrich Berdel, Sibylle Koletzko, Joachim Heinrich, Dennis Nowak, Holger Schulz

ABSTRACT

BackgroundVarious factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current environmental/lifestyle factors and allergic diseases on lung function in 15-year-olds.MethodsBest subset selection was performed for linear regression models to investigate associations between 21 diverse early life events and current factors with spirometric parameters (forced vital capacity, forced expiratory volume in 1 s and maximal mid-expiratory flow (FEF25–75)) in 1326 participants of the German GINIplus and LISAplus birth cohorts. To reduce model complexity, one model for each spirometric parameter was replicated 1000 times in random subpopulations (N = 884). Only those factors that were included in >70% of the replication models were retained in the final analysis.ResultsA higher peak weight velocity and early lung infections were the early life events prevalently associated with airflow limitation and FEF25–75. Current environmental/lifestyle factors at age 15 years and allergic diseases that were associated with lung function were: indoor second-hand smoke exposure, vitamin D concentration, body mass index (BMI) and asthma status. Sex and height captured the majority of the explained variance (>75%), followed by BMI (≤23.7%). The variance explained by early life events was comparatively low (median: 4.8%; range: 0.2–22.4%), but these events were consistently negatively associated with airway function.ConclusionsAlthough the explained variance was mainly captured by well-known factors included in lung function prediction equations, our findings indicate early life and current factors that should be considered in studies on lung health among adolescents. More... »

PAGES

138

References to SciGraph publications

  • 2012-06-07. Die zwei deutschen Geburtskohorten GINIplus und LISAplus in BUNDESGESUNDHEITSBLATT - GESUNDHEITSFORSCHUNG - GESUNDHEITSSCHUTZ
  • 2010-09-30. Parental education and lung function of children in the PATY study in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2014-12-24. Early origins of chronic obstructive lung diseases across the life course in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • Journal

    TITLE

    Respiratory Research

    ISSUE

    1

    VOLUME

    18

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12931-017-0619-5

    DOI

    http://dx.doi.org/10.1186/s12931-017-0619-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090600697

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28701166


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    38 schema:description BackgroundVarious factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current environmental/lifestyle factors and allergic diseases on lung function in 15-year-olds.MethodsBest subset selection was performed for linear regression models to investigate associations between 21 diverse early life events and current factors with spirometric parameters (forced vital capacity, forced expiratory volume in 1 s and maximal mid-expiratory flow (FEF25–75)) in 1326 participants of the German GINIplus and LISAplus birth cohorts. To reduce model complexity, one model for each spirometric parameter was replicated 1000 times in random subpopulations (N = 884). Only those factors that were included in >70% of the replication models were retained in the final analysis.ResultsA higher peak weight velocity and early lung infections were the early life events prevalently associated with airflow limitation and FEF25–75. Current environmental/lifestyle factors at age 15 years and allergic diseases that were associated with lung function were: indoor second-hand smoke exposure, vitamin D concentration, body mass index (BMI) and asthma status. Sex and height captured the majority of the explained variance (>75%), followed by BMI (≤23.7%). The variance explained by early life events was comparatively low (median: 4.8%; range: 0.2–22.4%), but these events were consistently negatively associated with airway function.ConclusionsAlthough the explained variance was mainly captured by well-known factors included in lung function prediction equations, our findings indicate early life and current factors that should be considered in studies on lung health among adolescents.
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    45 D concentrations
    46 FEF25-75
    47 GINIplus
    48 German GINIplus
    49 Higher peak weight velocity
    50 LISAplus birth cohorts
    51 LISAplus studies
    52 adolescents
    53 age 15
    54 airflow limitation
    55 airway function
    56 allergic diseases
    57 analysis
    58 association
    59 asthma status
    60 birth cohort
    61 body mass index
    62 cohort
    63 complexity
    64 concentration
    65 current factors
    66 different stages
    67 disease
    68 early life
    69 early life events
    70 early lung infection
    71 environmental/lifestyle factors
    72 equations
    73 events
    74 exposure
    75 factors
    76 final analysis
    77 findings
    78 function
    79 health
    80 height
    81 importance
    82 index
    83 infection
    84 investigation
    85 life
    86 life events
    87 lifestyle factors
    88 limitations
    89 linear regression models
    90 lung function
    91 lung function prediction equations
    92 lung health
    93 lung infection
    94 majority
    95 mass index
    96 model
    97 model complexity
    98 parameters
    99 participants
    100 peak weight velocity
    101 prediction equations
    102 random subpopulation
    103 regression models
    104 relative importance
    105 replication model
    106 results
    107 second-hand smoke exposure
    108 selection
    109 sex
    110 smoke exposure
    111 spirometric parameters
    112 stage
    113 status
    114 study
    115 subpopulations
    116 subset selection
    117 time
    118 variance
    119 velocity
    120 vitamin D concentrations
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    122 years
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