Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-17

AUTHORS

Florian M. Karl, Rolf Holle, Robert Bals, Timm Greulich, Rudolf A. Jörres, Annika Karch, Armin Koch, Stefan Karrasch, Reiner Leidl, Holger Schulz, Claus Vogelmeier, Margarethe E. Wacker, for the COSYCONET Study Group

ABSTRACT

BackgroundAlpha-1-Antitrypsin Deficiency (AATD) is an economically unexplored genetic disease.MethodsDirect and indirect costs (based on self-reported information on healthcare utilization) and health-related quality of life (HRQL, as assessed by SGRQ, CAT, and EQ-5D-3 L) were compared between 131 AATD patients (106 with, 25 without augmentation therapy (AT)) and 2,049 COPD patients without AATD participating in the COSYCONET COPD cohort. The medication costs of AT were excluded from all analyses to reveal differences associated with morbidity profiles. The association of AATD (with/without AT) with costs or HRQL was examined using generalized linear regression modelling (GLM) adjusting for age, sex, GOLD grade, BMI, smoking status, education and comorbidities.ResultsAdjusted mean direct annual costs were €6,099 in AATD patients without AT, €7,117 in AATD patients with AT (excluding costs for AT), and €7,460 in COPD patients without AATD. AATD with AT was significantly associated with higher outpatient (+273%) but lower inpatient (−35%) and medication costs (−10%, disregarding AT) compared with COPD patients without AATD. There were no significant differences between groups regarding indirect costs and HRQL.ConclusionApart from AT costs, AATD patients tended to have lower, though not significant, overall costs and similar HRQL compared to COPD patients without AATD. AT was not associated with lower costs or higher HRQL.Trial registrationNCT01245933 More... »

PAGES

60

Journal

TITLE

Respiratory Research

ISSUE

1

VOLUME

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-017-0543-8

DOI

http://dx.doi.org/10.1186/s12931-017-0543-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084862406

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28416015


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29 schema:description BackgroundAlpha-1-Antitrypsin Deficiency (AATD) is an economically unexplored genetic disease.MethodsDirect and indirect costs (based on self-reported information on healthcare utilization) and health-related quality of life (HRQL, as assessed by SGRQ, CAT, and EQ-5D-3 L) were compared between 131 AATD patients (106 with, 25 without augmentation therapy (AT)) and 2,049 COPD patients without AATD participating in the COSYCONET COPD cohort. The medication costs of AT were excluded from all analyses to reveal differences associated with morbidity profiles. The association of AATD (with/without AT) with costs or HRQL was examined using generalized linear regression modelling (GLM) adjusting for age, sex, GOLD grade, BMI, smoking status, education and comorbidities.ResultsAdjusted mean direct annual costs were €6,099 in AATD patients without AT, €7,117 in AATD patients with AT (excluding costs for AT), and €7,460 in COPD patients without AATD. AATD with AT was significantly associated with higher outpatient (+273%) but lower inpatient (−35%) and medication costs (−10%, disregarding AT) compared with COPD patients without AATD. There were no significant differences between groups regarding indirect costs and HRQL.ConclusionApart from AT costs, AATD patients tended to have lower, though not significant, overall costs and similar HRQL compared to COPD patients without AATD. AT was not associated with lower costs or higher HRQL.Trial registrationNCT01245933
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35 schema:keywords AATD
36 AATD patients
37 AT
38 BMI
39 COPD cohort
40 COPD patients
41 COSYCONET COPD cohort
42 ConclusionApart
43 HRQL
44 MethodsDirect
45 age
46 analysis
47 annual cost
48 association
49 cohort
50 comorbidities
51 cost
52 deficiency
53 differences
54 direct annual cost
55 disease
56 education
57 genetic diseases
58 gold grades
59 grade
60 group
61 health-related quality
62 higher HRQL
63 higher outpatient
64 indirect costs
65 inpatients
66 life
67 linear regression modelling
68 low cost
69 lower inpatient
70 medication costs
71 modelling
72 morbidity profile
73 outpatients
74 overall cost
75 patients
76 profile
77 quality
78 regression modelling
79 sex
80 significant differences
81 similar HRQL
82 smoking status
83 status
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