Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-10

AUTHORS

Noriho Sakamoto, Tomoyuki Kakugawa, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Tatsuhiko Harada, Hiroshi Ishimoto, Kazuhiro Yatera, Yutaka Kuwatsuka, Toshihide Hara, Kunihiro Ichinose, Yasushi Obase, Yuji Ishimatsu, Shigeru Kohno, Hiroshi Mukae

ABSTRACT

BackgroundInterstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (SSc). Although the pathogenesis of SSc-ILD is not well understood, neutrophils may play a pivotal role in this process. Neutrophils store azurophil granules that contain defensins, antimicrobial peptides that function in regulating the inflammatory response, and IL-8, a potent chemoattractant for neutrophils. The present study evaluated the levels of defensins and IL-8 in patients with SSc-ILD to determine their roles in disease pathogenesis.MethodsDefensins (also known as human neutrophil peptides, HNPs) and IL-8 levels were measured in the serum and bronchoalveolar lavage fluid (BALF) of 33 patients with SSc-ILD and in 20 healthy controls by using ELISA.ResultsBALF analysis revealed a significant increase in HNPs in SSc-ILD patients (median; 240.0 pg/mL) than that of healthy controls (79.7 pg/mL). Additionally, IL-8 levels were higher in SSc-ILD patient serum and BALF as compared to healthy controls (16.4 pg/mL vs. 5.8 pg/mL and 15.4 pg/mL vs. 14.5 pg/mL, respectively). However, plasma HNPs levels were relatively unchanged. HNP and IL-8 levels in patient BALF displayed a significant positive correlation significantly correlated (r = 0.774, p <0.01), and which also correlated with clinical disease parameters—such as ILD biomarkers, pulmonary function tests, ratio of neutrophils and eosinophils in BALF, tricuspid regurgitation peak gradient (TRPG), and the extent of high-resolution computed tomography (HRCT) findings in the lung. Levels of plasma HNPs and serum IL-8 did not show a significant correlation with any clinical parameter. SSc-ILD progression was evaluated by pulmonary function tests, but no association was observed between VC change ratios and HNPs or IL-8 levels.ConclusionsBALF levels of HNPs and IL-8 were higher in SSc-ILD than in healthy controls, and are associated with various clinical disease parameters. Further studies are needed to clarify the role of defensins and IL-8 in SSc-ILD pathogenesis. More... »

PAGES

148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12931-015-0308-1

DOI

http://dx.doi.org/10.1186/s12931-015-0308-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034106681

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26654954


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoalveolar Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Diseases, Interstitial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Scleroderma, Systemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Defensins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Noriho", 
        "id": "sg:person.01057344215.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057344215.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakugawa", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.01310021215.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310021215.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Atsuko", 
        "id": "sg:person.01111773607.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111773607.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Shota", 
        "id": "sg:person.01100163421.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100163421.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yura", 
        "givenName": "Hirokazu", 
        "id": "sg:person.0706670514.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706670514.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "Tatsuhiko", 
        "id": "sg:person.01224047057.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224047057.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishimoto", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01342450607.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yatera", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01032646234.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwatsuka", 
        "givenName": "Yutaka", 
        "id": "sg:person.01270016444.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270016444.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Toshihide", 
        "id": "sg:person.0632662733.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632662733.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichinose", 
        "givenName": "Kunihiro", 
        "id": "sg:person.01141315711.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141315711.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obase", 
        "givenName": "Yasushi", 
        "id": "sg:person.01045143143.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045143143.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiopulmonary Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Cardiopulmonary Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishimatsu", 
        "givenName": "Yuji", 
        "id": "sg:person.01173572615.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173572615.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Shigeru", 
        "id": "sg:person.01311530576.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311530576.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
            "Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11926-014-0411-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050953488", 
          "https://doi.org/10.1007/s11926-014-0411-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-12-93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031253550", 
          "https://doi.org/10.1186/1465-9921-12-93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020029478", 
          "https://doi.org/10.1186/ar2766"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12-10", 
    "datePublishedReg": "2015-12-10", 
    "description": "BackgroundInterstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (SSc). Although the pathogenesis of SSc-ILD is not well understood, neutrophils may play a pivotal role in this process. Neutrophils store azurophil granules that contain defensins, antimicrobial peptides that function in regulating the inflammatory response, and IL-8, a potent chemoattractant for neutrophils. The present study evaluated the levels of defensins and IL-8 in patients with SSc-ILD to determine their roles in disease pathogenesis.MethodsDefensins (also known as human neutrophil peptides, HNPs) and IL-8 levels were measured in the serum and bronchoalveolar lavage fluid (BALF) of 33 patients with SSc-ILD and in 20 healthy controls by using ELISA.ResultsBALF analysis revealed a significant increase in HNPs in SSc-ILD patients (median; 240.0\u00a0pg/mL) than that of healthy controls (79.7\u00a0pg/mL). Additionally, IL-8 levels were higher in SSc-ILD patient serum and BALF as compared to healthy controls (16.4\u00a0pg/mL vs. 5.8\u00a0pg/mL and 15.4\u00a0pg/mL vs. 14.5\u00a0pg/mL, respectively). However, plasma HNPs levels were relatively unchanged. HNP and IL-8 levels in patient BALF displayed a significant positive correlation significantly correlated (r\u2009=\u20090.774, p <0.01), and which also correlated with clinical disease parameters\u2014such as ILD biomarkers, pulmonary function tests, ratio of neutrophils and eosinophils in BALF, tricuspid regurgitation peak gradient (TRPG), and the extent of high-resolution computed tomography (HRCT) findings in the lung. Levels of plasma HNPs and serum IL-8 did not show a significant correlation with any clinical parameter. SSc-ILD progression was evaluated by pulmonary function tests, but no association was observed between VC change ratios and HNPs or IL-8 levels.ConclusionsBALF levels of HNPs and IL-8 were higher in SSc-ILD than in healthy controls, and are associated with various clinical disease parameters. Further studies are needed to clarify the role of defensins and IL-8 in SSc-ILD pathogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12931-015-0308-1", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5883692", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6081539", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1028525", 
        "issn": [
          "1465-9921", 
          "1465-993X"
        ], 
        "name": "Respiratory Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "keywords": [
      "bronchoalveolar lavage fluid", 
      "IL-8 levels", 
      "tricuspid regurgitation peak gradient", 
      "pulmonary function tests", 
      "SSc-ILD", 
      "IL-8", 
      "healthy controls", 
      "systemic sclerosis", 
      "function tests", 
      "patient's bronchoalveolar lavage fluid", 
      "BackgroundInterstitial lung disease", 
      "SSc-ILD patients", 
      "SSc-ILD progression", 
      "clinical disease parameters", 
      "serum IL-8", 
      "ratio of neutrophils", 
      "\u03b1-defensin levels", 
      "cause of mortality", 
      "role of defensins", 
      "HNP levels", 
      "levels of defensins", 
      "tomography findings", 
      "interstitial pneumonia", 
      "lavage fluid", 
      "clinical parameters", 
      "lung disease", 
      "peak gradient", 
      "inflammatory response", 
      "patient sera", 
      "clinical disease", 
      "patients", 
      "potent chemoattractant", 
      "disease pathogenesis", 
      "disease parameters", 
      "neutrophils", 
      "significant positive correlation", 
      "pathogenesis", 
      "sclerosis", 
      "Further studies", 
      "significant correlation", 
      "significant increase", 
      "azurophil granules", 
      "disease", 
      "serum", 
      "present study", 
      "pivotal role", 
      "positive correlation", 
      "association", 
      "HNP", 
      "defensins", 
      "antimicrobial peptides", 
      "levels", 
      "pneumonia", 
      "eosinophils", 
      "lung", 
      "control", 
      "mortality", 
      "ELISA", 
      "progression", 
      "biomarkers", 
      "role", 
      "chemoattractant", 
      "cause", 
      "study", 
      "correlation", 
      "test", 
      "findings", 
      "peptides", 
      "response", 
      "change ratio", 
      "HNPs", 
      "granules", 
      "ratio", 
      "increase", 
      "fluid", 
      "extent", 
      "analysis", 
      "parameters", 
      "process", 
      "gradient"
    ], 
    "name": "Association of elevated \u03b1-defensin levels with interstitial pneumonia in patients with systemic sclerosis", 
    "pagination": "148", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034106681"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12931-015-0308-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26654954"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12931-015-0308-1", 
      "https://app.dimensions.ai/details/publication/pub.1034106681"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_684.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12931-015-0308-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12931-015-0308-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12931-015-0308-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12931-015-0308-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12931-015-0308-1'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      125 URIs      114 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12931-015-0308-1 schema:about N0e70e92f2b584b9c9b2b56354ffbb333
2 N1c8c5f5ee5aa491596f6de601b8c101d
3 N1e2932cd335341fab69da27448e42707
4 N2e7a34b9c49347efa32a5ffd351d8883
5 N39b86a6479ae4b14a47a02bf36a379c4
6 N43e0f42d688045b58ded0ab7578d1af7
7 N5ca5bbac313c4a0ab7d0bc9605a330af
8 N65e48a9bc280497b8fdfe99fed6d480a
9 N6a6dd0d010aa4c0291ae52c16fafb836
10 N6c5f9b4786934abd83f8026fc67c602d
11 N7fbfcb85fdf045029af3e4098cfe0104
12 N8b7028d926aa4dd6b1ff5a664ebc0b26
13 N9765e926c85843b0a7f3fdf1d0b66e2e
14 N9a65d838180c4a1da7ebbddf846c33c6
15 Na8acbdc38ac74f8db93150a1bb5eec76
16 Nd09c272611c04749be3282a73a2b2245
17 Ne7d555371f344a4ea2ee42456bf012c4
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N4f80d1e4d78348f7948c712887041e0e
21 schema:citation sg:pub.10.1007/s11926-014-0411-1
22 sg:pub.10.1186/1465-9921-12-93
23 sg:pub.10.1186/ar2766
24 schema:datePublished 2015-12-10
25 schema:datePublishedReg 2015-12-10
26 schema:description BackgroundInterstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (SSc). Although the pathogenesis of SSc-ILD is not well understood, neutrophils may play a pivotal role in this process. Neutrophils store azurophil granules that contain defensins, antimicrobial peptides that function in regulating the inflammatory response, and IL-8, a potent chemoattractant for neutrophils. The present study evaluated the levels of defensins and IL-8 in patients with SSc-ILD to determine their roles in disease pathogenesis.MethodsDefensins (also known as human neutrophil peptides, HNPs) and IL-8 levels were measured in the serum and bronchoalveolar lavage fluid (BALF) of 33 patients with SSc-ILD and in 20 healthy controls by using ELISA.ResultsBALF analysis revealed a significant increase in HNPs in SSc-ILD patients (median; 240.0 pg/mL) than that of healthy controls (79.7 pg/mL). Additionally, IL-8 levels were higher in SSc-ILD patient serum and BALF as compared to healthy controls (16.4 pg/mL vs. 5.8 pg/mL and 15.4 pg/mL vs. 14.5 pg/mL, respectively). However, plasma HNPs levels were relatively unchanged. HNP and IL-8 levels in patient BALF displayed a significant positive correlation significantly correlated (r = 0.774, p <0.01), and which also correlated with clinical disease parameters—such as ILD biomarkers, pulmonary function tests, ratio of neutrophils and eosinophils in BALF, tricuspid regurgitation peak gradient (TRPG), and the extent of high-resolution computed tomography (HRCT) findings in the lung. Levels of plasma HNPs and serum IL-8 did not show a significant correlation with any clinical parameter. SSc-ILD progression was evaluated by pulmonary function tests, but no association was observed between VC change ratios and HNPs or IL-8 levels.ConclusionsBALF levels of HNPs and IL-8 were higher in SSc-ILD than in healthy controls, and are associated with various clinical disease parameters. Further studies are needed to clarify the role of defensins and IL-8 in SSc-ILD pathogenesis.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N3153c027990e446db9fc36f1cd2181d2
30 Nf1efa9f20be14b498b7c4a672cf38e6f
31 sg:journal.1028525
32 schema:keywords BackgroundInterstitial lung disease
33 ELISA
34 Further studies
35 HNP
36 HNP levels
37 HNPs
38 IL-8
39 IL-8 levels
40 SSc-ILD
41 SSc-ILD patients
42 SSc-ILD progression
43 analysis
44 antimicrobial peptides
45 association
46 azurophil granules
47 biomarkers
48 bronchoalveolar lavage fluid
49 cause
50 cause of mortality
51 change ratio
52 chemoattractant
53 clinical disease
54 clinical disease parameters
55 clinical parameters
56 control
57 correlation
58 defensins
59 disease
60 disease parameters
61 disease pathogenesis
62 eosinophils
63 extent
64 findings
65 fluid
66 function tests
67 gradient
68 granules
69 healthy controls
70 increase
71 inflammatory response
72 interstitial pneumonia
73 lavage fluid
74 levels
75 levels of defensins
76 lung
77 lung disease
78 mortality
79 neutrophils
80 parameters
81 pathogenesis
82 patient sera
83 patient's bronchoalveolar lavage fluid
84 patients
85 peak gradient
86 peptides
87 pivotal role
88 pneumonia
89 positive correlation
90 potent chemoattractant
91 present study
92 process
93 progression
94 pulmonary function tests
95 ratio
96 ratio of neutrophils
97 response
98 role
99 role of defensins
100 sclerosis
101 serum
102 serum IL-8
103 significant correlation
104 significant increase
105 significant positive correlation
106 study
107 systemic sclerosis
108 test
109 tomography findings
110 tricuspid regurgitation peak gradient
111 α-defensin levels
112 schema:name Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis
113 schema:pagination 148
114 schema:productId N782c6830ed964c0494ef6ba763872df8
115 N8411b81648b9475999baef624ee9f2cf
116 Nef6bd09a2c0049c6a0021a8c8671dd9c
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034106681
118 https://doi.org/10.1186/s12931-015-0308-1
119 schema:sdDatePublished 2022-09-02T15:59
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N72ae8b4dce474521a7fdb66d37b4741b
122 schema:url https://doi.org/10.1186/s12931-015-0308-1
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N0e70e92f2b584b9c9b2b56354ffbb333 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Interleukin-8
128 rdf:type schema:DefinedTerm
129 N1c27ed1321d946a8a7297adc209adcd1 rdf:first sg:person.01270016444.02
130 rdf:rest N31412d3c583142bda0bedba8143672b4
131 N1c8c5f5ee5aa491596f6de601b8c101d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Retrospective Studies
133 rdf:type schema:DefinedTerm
134 N1e2932cd335341fab69da27448e42707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Up-Regulation
136 rdf:type schema:DefinedTerm
137 N21846e94641144679b69967984fa365e rdf:first sg:person.0706670514.50
138 rdf:rest N9ce0b1d3c8bf4d60a7c6b307143cbb2c
139 N2e7a34b9c49347efa32a5ffd351d8883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N2f182a30f17740ea92bf22bc36c6e293 rdf:first sg:person.01032646234.50
143 rdf:rest N1c27ed1321d946a8a7297adc209adcd1
144 N300d4c7aa86140569f2935082b421f8c rdf:first sg:person.01173572615.54
145 rdf:rest N981a1ccae1a741f8b4dd0fadb3c1a3fa
146 N31412d3c583142bda0bedba8143672b4 rdf:first sg:person.0632662733.36
147 rdf:rest N7fb3c2ca48d144bea33e45cd0dd006e5
148 N3153c027990e446db9fc36f1cd2181d2 schema:issueNumber 1
149 rdf:type schema:PublicationIssue
150 N39b86a6479ae4b14a47a02bf36a379c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Lung Diseases, Interstitial
152 rdf:type schema:DefinedTerm
153 N43e0f42d688045b58ded0ab7578d1af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Bronchoalveolar Lavage Fluid
155 rdf:type schema:DefinedTerm
156 N4f80d1e4d78348f7948c712887041e0e rdf:first sg:person.01057344215.61
157 rdf:rest N82fcd8671074480f859beb15b474cdfb
158 N5ca5bbac313c4a0ab7d0bc9605a330af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Prognosis
160 rdf:type schema:DefinedTerm
161 N65e48a9bc280497b8fdfe99fed6d480a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Scleroderma, Systemic
163 rdf:type schema:DefinedTerm
164 N68850fc59c1d4a43b3c60a6f95fdc839 rdf:first sg:person.01111773607.17
165 rdf:rest Nf16763c6cb6d4577913f2a915401c807
166 N6a6dd0d010aa4c0291ae52c16fafb836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name alpha-Defensins
168 rdf:type schema:DefinedTerm
169 N6c5f9b4786934abd83f8026fc67c602d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Middle Aged
171 rdf:type schema:DefinedTerm
172 N72ae8b4dce474521a7fdb66d37b4741b schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 N782c6830ed964c0494ef6ba763872df8 schema:name pubmed_id
175 schema:value 26654954
176 rdf:type schema:PropertyValue
177 N7fb3c2ca48d144bea33e45cd0dd006e5 rdf:first sg:person.01141315711.07
178 rdf:rest Nf8f9aa22f79c4382953a4a87180a7f02
179 N7fbfcb85fdf045029af3e4098cfe0104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 N82fcd8671074480f859beb15b474cdfb rdf:first sg:person.01310021215.73
183 rdf:rest N68850fc59c1d4a43b3c60a6f95fdc839
184 N8411b81648b9475999baef624ee9f2cf schema:name dimensions_id
185 schema:value pub.1034106681
186 rdf:type schema:PropertyValue
187 N8b7028d926aa4dd6b1ff5a664ebc0b26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Severity of Illness Index
189 rdf:type schema:DefinedTerm
190 N9765e926c85843b0a7f3fdf1d0b66e2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Aged
192 rdf:type schema:DefinedTerm
193 N981a1ccae1a741f8b4dd0fadb3c1a3fa rdf:first sg:person.01311530576.67
194 rdf:rest Ndfbfbd93a9864348b1c0e9001c4a97ba
195 N9a65d838180c4a1da7ebbddf846c33c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Biomarkers
197 rdf:type schema:DefinedTerm
198 N9ce0b1d3c8bf4d60a7c6b307143cbb2c rdf:first sg:person.01224047057.36
199 rdf:rest Nb62ac48987d04c868b4b029d9d5bb7cf
200 Na8acbdc38ac74f8db93150a1bb5eec76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Enzyme-Linked Immunosorbent Assay
202 rdf:type schema:DefinedTerm
203 Nb62ac48987d04c868b4b029d9d5bb7cf rdf:first sg:person.01342450607.40
204 rdf:rest N2f182a30f17740ea92bf22bc36c6e293
205 Nd09c272611c04749be3282a73a2b2245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Female
207 rdf:type schema:DefinedTerm
208 Ndfbfbd93a9864348b1c0e9001c4a97ba rdf:first sg:person.01143125277.28
209 rdf:rest rdf:nil
210 Ne7d555371f344a4ea2ee42456bf012c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Predictive Value of Tests
212 rdf:type schema:DefinedTerm
213 Nef6bd09a2c0049c6a0021a8c8671dd9c schema:name doi
214 schema:value 10.1186/s12931-015-0308-1
215 rdf:type schema:PropertyValue
216 Nf16763c6cb6d4577913f2a915401c807 rdf:first sg:person.01100163421.32
217 rdf:rest N21846e94641144679b69967984fa365e
218 Nf1efa9f20be14b498b7c4a672cf38e6f schema:volumeNumber 16
219 rdf:type schema:PublicationVolume
220 Nf8f9aa22f79c4382953a4a87180a7f02 rdf:first sg:person.01045143143.47
221 rdf:rest N300d4c7aa86140569f2935082b421f8c
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
226 schema:name Clinical Sciences
227 rdf:type schema:DefinedTerm
228 sg:grant.5883692 http://pending.schema.org/fundedItem sg:pub.10.1186/s12931-015-0308-1
229 rdf:type schema:MonetaryGrant
230 sg:grant.6081539 http://pending.schema.org/fundedItem sg:pub.10.1186/s12931-015-0308-1
231 rdf:type schema:MonetaryGrant
232 sg:journal.1028525 schema:issn 1465-9921
233 1465-993X
234 schema:name Respiratory Research
235 schema:publisher Springer Nature
236 rdf:type schema:Periodical
237 sg:person.01032646234.50 schema:affiliation grid-institutes:grid.271052.3
238 schema:familyName Yatera
239 schema:givenName Kazuhiro
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032646234.50
241 rdf:type schema:Person
242 sg:person.01045143143.47 schema:affiliation grid-institutes:grid.174567.6
243 schema:familyName Obase
244 schema:givenName Yasushi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045143143.47
246 rdf:type schema:Person
247 sg:person.01057344215.61 schema:affiliation grid-institutes:grid.174567.6
248 schema:familyName Sakamoto
249 schema:givenName Noriho
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057344215.61
251 rdf:type schema:Person
252 sg:person.01100163421.32 schema:affiliation grid-institutes:grid.174567.6
253 schema:familyName Nakashima
254 schema:givenName Shota
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100163421.32
256 rdf:type schema:Person
257 sg:person.01111773607.17 schema:affiliation grid-institutes:grid.174567.6
258 schema:familyName Hara
259 schema:givenName Atsuko
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111773607.17
261 rdf:type schema:Person
262 sg:person.01141315711.07 schema:affiliation grid-institutes:grid.174567.6
263 schema:familyName Ichinose
264 schema:givenName Kunihiro
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141315711.07
266 rdf:type schema:Person
267 sg:person.01143125277.28 schema:affiliation grid-institutes:grid.271052.3
268 schema:familyName Mukae
269 schema:givenName Hiroshi
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28
271 rdf:type schema:Person
272 sg:person.01173572615.54 schema:affiliation grid-institutes:grid.174567.6
273 schema:familyName Ishimatsu
274 schema:givenName Yuji
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173572615.54
276 rdf:type schema:Person
277 sg:person.01224047057.36 schema:affiliation grid-institutes:grid.174567.6
278 schema:familyName Harada
279 schema:givenName Tatsuhiko
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224047057.36
281 rdf:type schema:Person
282 sg:person.01270016444.02 schema:affiliation grid-institutes:grid.174567.6
283 schema:familyName Kuwatsuka
284 schema:givenName Yutaka
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270016444.02
286 rdf:type schema:Person
287 sg:person.01310021215.73 schema:affiliation grid-institutes:grid.174567.6
288 schema:familyName Kakugawa
289 schema:givenName Tomoyuki
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310021215.73
291 rdf:type schema:Person
292 sg:person.01311530576.67 schema:affiliation grid-institutes:grid.174567.6
293 schema:familyName Kohno
294 schema:givenName Shigeru
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311530576.67
296 rdf:type schema:Person
297 sg:person.01342450607.40 schema:affiliation grid-institutes:grid.271052.3
298 schema:familyName Ishimoto
299 schema:givenName Hiroshi
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342450607.40
301 rdf:type schema:Person
302 sg:person.0632662733.36 schema:affiliation grid-institutes:grid.174567.6
303 schema:familyName Hara
304 schema:givenName Toshihide
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632662733.36
306 rdf:type schema:Person
307 sg:person.0706670514.50 schema:affiliation grid-institutes:grid.174567.6
308 schema:familyName Yura
309 schema:givenName Hirokazu
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706670514.50
311 rdf:type schema:Person
312 sg:pub.10.1007/s11926-014-0411-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050953488
313 https://doi.org/10.1007/s11926-014-0411-1
314 rdf:type schema:CreativeWork
315 sg:pub.10.1186/1465-9921-12-93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031253550
316 https://doi.org/10.1186/1465-9921-12-93
317 rdf:type schema:CreativeWork
318 sg:pub.10.1186/ar2766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020029478
319 https://doi.org/10.1186/ar2766
320 rdf:type schema:CreativeWork
321 grid-institutes:grid.174567.6 schema:alternateName Department of Cardiopulmonary Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
322 Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan
323 Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
324 Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
325 schema:name Department of Cardiopulmonary Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
326 Department of Dermatology, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan
327 Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
328 Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
329 rdf:type schema:Organization
330 grid-institutes:grid.271052.3 schema:alternateName Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
331 schema:name Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
332 Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...