Multiscale X-ray phase contrast imaging of human cartilage for investigating osteoarthritis formation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-07

AUTHORS

Annie Horng, Johannes Stroebel, Tobias Geith, Stefan Milz, Alexandra Pacureanu, Yang Yang, Peter Cloetens, Goran Lovric, Alberto Mittone, Alberto Bravin, Paola Coan

ABSTRACT

BackgroundThe evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging (X-PCI) offers increased sensitivity with respect to standard radiography and CT allowing an enhanced visibility of adjoining, low density structures with an almost histological image resolution. This study examined the feasibility of X-PCI for high-resolution (sub-) micrometer analysis of different stages in tissue degeneration of human cartilage samples and compare it to histology and transmission electron microscopy.MethodsTen 10%-formalin preserved healthy and moderately degenerated osteochondral samples, post-mortem extracted from human knee joints, were examined using four different X-PCI tomographic set-ups using synchrotron radiation the European Synchrotron Radiation Facility (France) and the Swiss Light Source (Switzerland). Volumetric datasets were acquired with voxel sizes between 0.7 × 0.7 × 0.7 and 0.1 × 0.1 × 0.1 µm3. Data were reconstructed by a filtered back-projection algorithm, post-processed by ImageJ, the WEKA machine learning pixel classification tool and VGStudio max. For correlation, osteochondral samples were processed for histology and transmission electron microscopy.ResultsX-PCI provides a three-dimensional visualization of healthy and moderately degenerated cartilage samples down to a (sub-)cellular level with good correlation to histologic and transmission electron microscopy images. X-PCI is able to resolve the three layers and the architectural organization of cartilage including changes in chondrocyte cell morphology, chondrocyte subgroup distribution and (re-)organization as well as its subtle matrix structures.ConclusionsX-PCI captures comprehensive cartilage tissue transformation in its environment and might serve as a tissue-preserving, staining-free and volumetric virtual histology tool for examining and chronicling cartilage behavior in basic research/laboratory experiments of cartilage disease evolution. More... »

PAGES

42

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12929-021-00739-1

DOI

http://dx.doi.org/10.1186/s12929-021-00739-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138669459

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34098949


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cartilage, Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Phase-Contrast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoarthritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "RZM \u2013 Radiologisches Zentrum Munich-Pasing, Pippinger Str. 25, 81245, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Clinical Radiology, Faculty of Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany", 
            "RZM \u2013 Radiologisches Zentrum Munich-Pasing, Pippinger Str. 25, 81245, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horng", 
        "givenName": "Annie", 
        "id": "sg:person.01011216473.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011216473.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stroebel", 
        "givenName": "Johannes", 
        "id": "sg:person.016054057075.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016054057075.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Interventional Radiology, Klinikum Rechts der Isar of the Technical University of Munich, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Department of Interventional Radiology, Klinikum Rechts der Isar of the Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geith", 
        "givenName": "Tobias", 
        "id": "sg:person.0764413000.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764413000.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Medicine, Anatomische Anstalt, Neuroanatomy, Ludwig Maximilians University, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Faculty of Medicine, Anatomische Anstalt, Neuroanatomy, Ludwig Maximilians University, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milz", 
        "givenName": "Stefan", 
        "id": "sg:person.01360747147.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360747147.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Synchrotron Radiation Facility, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.5398.7", 
          "name": [
            "European Synchrotron Radiation Facility, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pacureanu", 
        "givenName": "Alexandra", 
        "id": "sg:person.0742764221.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742764221.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Synchrotron Light Source II, Brookhaven National Laboratory, 11973, Upton, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.202665.5", 
          "name": [
            "European Synchrotron Radiation Facility, Grenoble, France", 
            "National Synchrotron Light Source II, Brookhaven National Laboratory, 11973, Upton, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Yang", 
        "id": "sg:person.07663701425.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07663701425.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Synchrotron Radiation Facility, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.5398.7", 
          "name": [
            "European Synchrotron Radiation Facility, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cloetens", 
        "givenName": "Peter", 
        "id": "sg:person.01204051271.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204051271.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Scherrer Institute (Swiss Light Source), Villigen, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.5991.4", 
          "name": [
            "Paul Scherrer Institute (Swiss Light Source), Villigen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lovric", 
        "givenName": "Goran", 
        "id": "sg:person.01315017310.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315017310.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CELLS: ALBA Synchrotron, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.423639.9", 
          "name": [
            "CELLS: ALBA Synchrotron, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mittone", 
        "givenName": "Alberto", 
        "id": "sg:person.01153066656.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153066656.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Synchrotron Radiation Facility, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.5398.7", 
          "name": [
            "European Synchrotron Radiation Facility, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bravin", 
        "givenName": "Alberto", 
        "id": "sg:person.01011435605.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011435605.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Clinical Radiology, Faculty of Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany", 
            "Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coan", 
        "givenName": "Paola", 
        "id": "sg:person.0654276456.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654276456.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00330-004-2355-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041602450", 
          "https://doi.org/10.1007/s00330-004-2355-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12859-017-1934-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093055870", 
          "https://doi.org/10.1186/s12859-017-1934-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-001-1301-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075176595", 
          "https://doi.org/10.1007/s00330-001-1301-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-06-07", 
    "datePublishedReg": "2021-06-07", 
    "description": "BackgroundThe evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging (X-PCI) offers increased sensitivity with respect to standard radiography and CT allowing an enhanced visibility of adjoining, low density structures with an almost histological image resolution. This study examined the feasibility of X-PCI for high-resolution (sub-) micrometer analysis of different stages in tissue degeneration of human cartilage samples and compare it to histology and transmission electron microscopy.MethodsTen 10%-formalin preserved healthy and moderately degenerated osteochondral samples, post-mortem extracted from human knee joints, were examined using four different X-PCI tomographic set-ups using synchrotron radiation the European Synchrotron Radiation Facility (France) and the Swiss Light Source (Switzerland). Volumetric datasets were acquired with voxel sizes between 0.7\u2009\u00d7\u20090.7\u2009\u00d7\u20090.7 and 0.1\u2009\u00d7\u20090.1\u2009\u00d7\u20090.1 \u00b5m3. Data were reconstructed by a filtered back-projection algorithm, post-processed by ImageJ, the WEKA machine learning pixel classification tool and VGStudio max. For correlation, osteochondral samples were processed for histology and transmission electron microscopy.ResultsX-PCI provides a three-dimensional visualization of healthy and moderately degenerated cartilage samples down to a (sub-)cellular level with good correlation to histologic and transmission electron microscopy images. X-PCI is able to resolve the three layers and the architectural organization of cartilage including changes in chondrocyte cell morphology, chondrocyte subgroup distribution and (re-)organization as well as its subtle matrix structures.ConclusionsX-PCI captures comprehensive cartilage tissue transformation in its environment and might serve as a tissue-preserving, staining-free and volumetric virtual histology tool for examining and chronicling cartilage behavior in basic research/laboratory experiments of cartilage disease evolution.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12929-021-00739-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105665", 
        "issn": [
          "1021-7770", 
          "1423-0127"
        ], 
        "name": "Journal of Biomedical Science", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "keywords": [
      "X-ray phase-contrast imaging", 
      "phase-contrast imaging", 
      "transmission electron microscopy", 
      "European Synchrotron Radiation Facility", 
      "Swiss Light Source", 
      "Synchrotron Radiation Facility", 
      "filtered back-projection algorithm", 
      "transmission electron microscopy images", 
      "synchrotron radiation", 
      "Radiation Facility", 
      "back-projection algorithm", 
      "contrast imaging", 
      "light source", 
      "electron microscopy", 
      "low-density structures", 
      "density structure", 
      "electron microscopy images", 
      "microscopy images", 
      "VGStudio MAX", 
      "image resolution", 
      "microscopy", 
      "radiation", 
      "voxel size", 
      "three-dimensional visualization", 
      "imaging", 
      "enhanced visibility", 
      "structure", 
      "evolution", 
      "resolution", 
      "laboratory experiments", 
      "layer", 
      "standard radiography", 
      "tissue transformation", 
      "Re", 
      "samples", 
      "source", 
      "experiments", 
      "morphology", 
      "distribution", 
      "radiography", 
      "images", 
      "formation", 
      "technique", 
      "correlation", 
      "facilities", 
      "visibility", 
      "sensitivity", 
      "good correlation", 
      "size", 
      "respect", 
      "behavior", 
      "cartilage behavior", 
      "feasibility", 
      "matrix structure", 
      "visualization", 
      "volumetric datasets", 
      "cartilage samples", 
      "tool", 
      "osteochondral samples", 
      "data", 
      "thinness", 
      "transformation", 
      "max", 
      "environment", 
      "changes", 
      "analysis", 
      "subgroup distribution", 
      "human cartilage samples", 
      "CT", 
      "study", 
      "levels", 
      "WEKA machine", 
      "different stages", 
      "stage", 
      "algorithm", 
      "PCI", 
      "machine", 
      "cell morphology", 
      "human knee joint", 
      "lack", 
      "tissue degeneration", 
      "classification tool", 
      "architectural organization", 
      "human cartilage", 
      "dataset", 
      "cartilage", 
      "formalin", 
      "joints", 
      "disease evolution", 
      "cartilage degeneration", 
      "knee joint", 
      "histology", 
      "degeneration", 
      "organization", 
      "histologic", 
      "MethodsTen"
    ], 
    "name": "Multiscale X-ray phase contrast imaging of human cartilage for investigating osteoarthritis formation", 
    "pagination": "42", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1138669459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12929-021-00739-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34098949"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12929-021-00739-1", 
      "https://app.dimensions.ai/details/publication/pub.1138669459"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_876.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12929-021-00739-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12929-021-00739-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12929-021-00739-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12929-021-00739-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12929-021-00739-1'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      22 PREDICATES      134 URIs      123 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12929-021-00739-1 schema:about N0e43e765908d401d86fa2b9c6b20cae6
2 N10dab408c8df4bacb4d5379b937ae193
3 N2abefc71ec1c4f63a87a0a1aeacc71db
4 N2d2ec0852fbc4483a81ff15966de549e
5 N3dfd485c6ec448b39246fe736a80cce0
6 N7121543cb1c74540ada169799bb8a511
7 Nbd1cd8feab874bb6a589f5829ffea1b5
8 Nd7d006c9b9d141a296fac4f7243e3176
9 Nf1625b0df4804db7a190d1799560bbf2
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author N2f60a4969e954959876f67d7aaf3837b
13 schema:citation sg:pub.10.1007/s00330-001-1301-2
14 sg:pub.10.1007/s00330-004-2355-8
15 sg:pub.10.1186/s12859-017-1934-z
16 schema:datePublished 2021-06-07
17 schema:datePublishedReg 2021-06-07
18 schema:description BackgroundThe evolution of cartilage degeneration is still not fully understood, partly due to its thinness, low radio-opacity and therefore lack of adequately resolving imaging techniques. X-ray phase-contrast imaging (X-PCI) offers increased sensitivity with respect to standard radiography and CT allowing an enhanced visibility of adjoining, low density structures with an almost histological image resolution. This study examined the feasibility of X-PCI for high-resolution (sub-) micrometer analysis of different stages in tissue degeneration of human cartilage samples and compare it to histology and transmission electron microscopy.MethodsTen 10%-formalin preserved healthy and moderately degenerated osteochondral samples, post-mortem extracted from human knee joints, were examined using four different X-PCI tomographic set-ups using synchrotron radiation the European Synchrotron Radiation Facility (France) and the Swiss Light Source (Switzerland). Volumetric datasets were acquired with voxel sizes between 0.7 × 0.7 × 0.7 and 0.1 × 0.1 × 0.1 µm3. Data were reconstructed by a filtered back-projection algorithm, post-processed by ImageJ, the WEKA machine learning pixel classification tool and VGStudio max. For correlation, osteochondral samples were processed for histology and transmission electron microscopy.ResultsX-PCI provides a three-dimensional visualization of healthy and moderately degenerated cartilage samples down to a (sub-)cellular level with good correlation to histologic and transmission electron microscopy images. X-PCI is able to resolve the three layers and the architectural organization of cartilage including changes in chondrocyte cell morphology, chondrocyte subgroup distribution and (re-)organization as well as its subtle matrix structures.ConclusionsX-PCI captures comprehensive cartilage tissue transformation in its environment and might serve as a tissue-preserving, staining-free and volumetric virtual histology tool for examining and chronicling cartilage behavior in basic research/laboratory experiments of cartilage disease evolution.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree true
22 schema:isPartOf N851a3a5d6a444a4c9af0fa654002228f
23 Nf207e06275d545148082bd4490975cd2
24 sg:journal.1105665
25 schema:keywords CT
26 European Synchrotron Radiation Facility
27 MethodsTen
28 PCI
29 Radiation Facility
30 Re
31 Swiss Light Source
32 Synchrotron Radiation Facility
33 VGStudio MAX
34 WEKA machine
35 X-ray phase-contrast imaging
36 algorithm
37 analysis
38 architectural organization
39 back-projection algorithm
40 behavior
41 cartilage
42 cartilage behavior
43 cartilage degeneration
44 cartilage samples
45 cell morphology
46 changes
47 classification tool
48 contrast imaging
49 correlation
50 data
51 dataset
52 degeneration
53 density structure
54 different stages
55 disease evolution
56 distribution
57 electron microscopy
58 electron microscopy images
59 enhanced visibility
60 environment
61 evolution
62 experiments
63 facilities
64 feasibility
65 filtered back-projection algorithm
66 formalin
67 formation
68 good correlation
69 histologic
70 histology
71 human cartilage
72 human cartilage samples
73 human knee joint
74 image resolution
75 images
76 imaging
77 joints
78 knee joint
79 laboratory experiments
80 lack
81 layer
82 levels
83 light source
84 low-density structures
85 machine
86 matrix structure
87 max
88 microscopy
89 microscopy images
90 morphology
91 organization
92 osteochondral samples
93 phase-contrast imaging
94 radiation
95 radiography
96 resolution
97 respect
98 samples
99 sensitivity
100 size
101 source
102 stage
103 standard radiography
104 structure
105 study
106 subgroup distribution
107 synchrotron radiation
108 technique
109 thinness
110 three-dimensional visualization
111 tissue degeneration
112 tissue transformation
113 tool
114 transformation
115 transmission electron microscopy
116 transmission electron microscopy images
117 visibility
118 visualization
119 volumetric datasets
120 voxel size
121 schema:name Multiscale X-ray phase contrast imaging of human cartilage for investigating osteoarthritis formation
122 schema:pagination 42
123 schema:productId N1755b9a65f7541fbba8c575072da98a8
124 Na3d9fa8c6d1044f2a5f9a51cbe9ffe97
125 Ne47a258e74d345e59d135037640b8656
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1138669459
127 https://doi.org/10.1186/s12929-021-00739-1
128 schema:sdDatePublished 2022-05-20T07:38
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher Ne13f7eaeed434ca08607a06dad7ae4ea
131 schema:url https://doi.org/10.1186/s12929-021-00739-1
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N06edb6de038349c6a5b6b7531b02b69f rdf:first sg:person.01011435605.85
136 rdf:rest Nd7271077b0a14a5b9edabc353551d4a2
137 N0c6d2b460b9244289349e66c07171234 rdf:first sg:person.0764413000.90
138 rdf:rest Ne44af146e0084bf59e50c6fd8d13eb36
139 N0e43e765908d401d86fa2b9c6b20cae6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 N10dab408c8df4bacb4d5379b937ae193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Microscopy, Phase-Contrast
144 rdf:type schema:DefinedTerm
145 N1755b9a65f7541fbba8c575072da98a8 schema:name pubmed_id
146 schema:value 34098949
147 rdf:type schema:PropertyValue
148 N2abefc71ec1c4f63a87a0a1aeacc71db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Male
150 rdf:type schema:DefinedTerm
151 N2d2ec0852fbc4483a81ff15966de549e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cartilage, Articular
153 rdf:type schema:DefinedTerm
154 N2f60a4969e954959876f67d7aaf3837b rdf:first sg:person.01011216473.01
155 rdf:rest N49e7467c1aac4206bfa66d48258c9e27
156 N3dfd485c6ec448b39246fe736a80cce0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Tomography, X-Ray Computed
158 rdf:type schema:DefinedTerm
159 N49e7467c1aac4206bfa66d48258c9e27 rdf:first sg:person.016054057075.60
160 rdf:rest N0c6d2b460b9244289349e66c07171234
161 N5d38a240f54041e6b8475dd615ea6938 rdf:first sg:person.0742764221.74
162 rdf:rest N80ed8dbfb2a747ce97063a937ef2854b
163 N7121543cb1c74540ada169799bb8a511 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Humans
165 rdf:type schema:DefinedTerm
166 N80ed8dbfb2a747ce97063a937ef2854b rdf:first sg:person.07663701425.14
167 rdf:rest Nfa82fb90374e44e5bb04caebaee1d4f1
168 N851a3a5d6a444a4c9af0fa654002228f schema:volumeNumber 28
169 rdf:type schema:PublicationVolume
170 N9bc79d31d5664fd1834436da9bf211f8 rdf:first sg:person.01315017310.35
171 rdf:rest Nabc8f7d4d9074124993c6fef62804865
172 Na3d9fa8c6d1044f2a5f9a51cbe9ffe97 schema:name dimensions_id
173 schema:value pub.1138669459
174 rdf:type schema:PropertyValue
175 Nabc8f7d4d9074124993c6fef62804865 rdf:first sg:person.01153066656.73
176 rdf:rest N06edb6de038349c6a5b6b7531b02b69f
177 Nbd1cd8feab874bb6a589f5829ffea1b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Aged
179 rdf:type schema:DefinedTerm
180 Nd7271077b0a14a5b9edabc353551d4a2 rdf:first sg:person.0654276456.54
181 rdf:rest rdf:nil
182 Nd7d006c9b9d141a296fac4f7243e3176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Aged, 80 and over
184 rdf:type schema:DefinedTerm
185 Ne13f7eaeed434ca08607a06dad7ae4ea schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Ne44af146e0084bf59e50c6fd8d13eb36 rdf:first sg:person.01360747147.42
188 rdf:rest N5d38a240f54041e6b8475dd615ea6938
189 Ne47a258e74d345e59d135037640b8656 schema:name doi
190 schema:value 10.1186/s12929-021-00739-1
191 rdf:type schema:PropertyValue
192 Nf1625b0df4804db7a190d1799560bbf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Osteoarthritis
194 rdf:type schema:DefinedTerm
195 Nf207e06275d545148082bd4490975cd2 schema:issueNumber 1
196 rdf:type schema:PublicationIssue
197 Nfa82fb90374e44e5bb04caebaee1d4f1 rdf:first sg:person.01204051271.65
198 rdf:rest N9bc79d31d5664fd1834436da9bf211f8
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
203 schema:name Clinical Sciences
204 rdf:type schema:DefinedTerm
205 sg:journal.1105665 schema:issn 1021-7770
206 1423-0127
207 schema:name Journal of Biomedical Science
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01011216473.01 schema:affiliation grid-institutes:None
211 schema:familyName Horng
212 schema:givenName Annie
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011216473.01
214 rdf:type schema:Person
215 sg:person.01011435605.85 schema:affiliation grid-institutes:grid.5398.7
216 schema:familyName Bravin
217 schema:givenName Alberto
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011435605.85
219 rdf:type schema:Person
220 sg:person.01153066656.73 schema:affiliation grid-institutes:grid.423639.9
221 schema:familyName Mittone
222 schema:givenName Alberto
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153066656.73
224 rdf:type schema:Person
225 sg:person.01204051271.65 schema:affiliation grid-institutes:grid.5398.7
226 schema:familyName Cloetens
227 schema:givenName Peter
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204051271.65
229 rdf:type schema:Person
230 sg:person.01315017310.35 schema:affiliation grid-institutes:grid.5991.4
231 schema:familyName Lovric
232 schema:givenName Goran
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315017310.35
234 rdf:type schema:Person
235 sg:person.01360747147.42 schema:affiliation grid-institutes:grid.5252.0
236 schema:familyName Milz
237 schema:givenName Stefan
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360747147.42
239 rdf:type schema:Person
240 sg:person.016054057075.60 schema:affiliation grid-institutes:grid.5252.0
241 schema:familyName Stroebel
242 schema:givenName Johannes
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016054057075.60
244 rdf:type schema:Person
245 sg:person.0654276456.54 schema:affiliation grid-institutes:grid.5252.0
246 schema:familyName Coan
247 schema:givenName Paola
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654276456.54
249 rdf:type schema:Person
250 sg:person.0742764221.74 schema:affiliation grid-institutes:grid.5398.7
251 schema:familyName Pacureanu
252 schema:givenName Alexandra
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742764221.74
254 rdf:type schema:Person
255 sg:person.0764413000.90 schema:affiliation grid-institutes:grid.6936.a
256 schema:familyName Geith
257 schema:givenName Tobias
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764413000.90
259 rdf:type schema:Person
260 sg:person.07663701425.14 schema:affiliation grid-institutes:grid.202665.5
261 schema:familyName Yang
262 schema:givenName Yang
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07663701425.14
264 rdf:type schema:Person
265 sg:pub.10.1007/s00330-001-1301-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075176595
266 https://doi.org/10.1007/s00330-001-1301-2
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00330-004-2355-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041602450
269 https://doi.org/10.1007/s00330-004-2355-8
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/s12859-017-1934-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093055870
272 https://doi.org/10.1186/s12859-017-1934-z
273 rdf:type schema:CreativeWork
274 grid-institutes:None schema:alternateName RZM – Radiologisches Zentrum Munich-Pasing, Pippinger Str. 25, 81245, Munich, Germany
275 schema:name Department of Clinical Radiology, Faculty of Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany
276 RZM – Radiologisches Zentrum Munich-Pasing, Pippinger Str. 25, 81245, Munich, Germany
277 rdf:type schema:Organization
278 grid-institutes:grid.202665.5 schema:alternateName National Synchrotron Light Source II, Brookhaven National Laboratory, 11973, Upton, NY, USA
279 schema:name European Synchrotron Radiation Facility, Grenoble, France
280 National Synchrotron Light Source II, Brookhaven National Laboratory, 11973, Upton, NY, USA
281 rdf:type schema:Organization
282 grid-institutes:grid.423639.9 schema:alternateName CELLS: ALBA Synchrotron, Barcelona, Spain
283 schema:name CELLS: ALBA Synchrotron, Barcelona, Spain
284 rdf:type schema:Organization
285 grid-institutes:grid.5252.0 schema:alternateName Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany
286 Faculty of Medicine, Anatomische Anstalt, Neuroanatomy, Ludwig Maximilians University, Munich, Germany
287 schema:name Department of Clinical Radiology, Faculty of Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany
288 Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-University Munich, Am Coulombwall 1, 85748, Garching, Germany
289 Faculty of Medicine, Anatomische Anstalt, Neuroanatomy, Ludwig Maximilians University, Munich, Germany
290 rdf:type schema:Organization
291 grid-institutes:grid.5398.7 schema:alternateName European Synchrotron Radiation Facility, Grenoble, France
292 schema:name European Synchrotron Radiation Facility, Grenoble, France
293 rdf:type schema:Organization
294 grid-institutes:grid.5991.4 schema:alternateName Paul Scherrer Institute (Swiss Light Source), Villigen, Switzerland
295 schema:name Paul Scherrer Institute (Swiss Light Source), Villigen, Switzerland
296 rdf:type schema:Organization
297 grid-institutes:grid.6936.a schema:alternateName Department of Interventional Radiology, Klinikum Rechts der Isar of the Technical University of Munich, Munich, Germany
298 schema:name Department of Interventional Radiology, Klinikum Rechts der Isar of the Technical University of Munich, Munich, Germany
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...