Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Priscila Silva Franco, Paula Suellen Guimarães Gois, Thádia Evelyn de Araújo, Rafaela José da Silva, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Francesca Ietta, Lara Affonso dos Santos, Maria Célia dos Santos, José Roberto Mineo, Eloisa Amália Vieira Ferro

ABSTRACT

BACKGROUND: Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlândia city, Brazil, two virulent strains were isolated: TgChBrUD1 and TgChBrUD2. Congenital toxoplasmosis is more prevalent in South America compared to Europe, and more often associated with severe symptoms, usually as a result of infection with atypical strains. METHODS: Considering that T. gondii has shown high genetic diversity in Brazil, the effectiveness of traditional treatment may not be the same, as more virulent strains of atypical genotypes may predominate. Thus, the aim of this study were to evaluate the Brazilian strain infection rate in human villous explants and the azithromycin efficacy with regard to the control of these strains compared to traditional therapy. Villi were infected with RH, ME49, TgChBrUD1 or TgChBrUD2 strains and treated with azithromycin, spiramycin or a combination of pyrimethamine plus sulfadiazine. The villous viability was analyzed by LDH assay and morphological analysis. Parasite proliferation, as well as production of cytokines was analyzed by qPCR and ELISA, respectively. Statistical analysis was performed using the GraphPad Prism 5.0. RESULTS: The treatments were not toxic and TgChBrUD1 infected villi showed a higher parasite burden compared with others strains. Treatments significantly reduced the intracellular proliferation of T. gondii, regardless of the strain. TgChBrUD1-infected villi produced a larger amount of MIF, IL-6 and TGF-β1 compared with other infected villi. Azithromycin treatment increased MIF production by RH- or TgChBrUD2-infected villi, but in ME49- or TgChBrUD1-infected villi, the MIF production was not altered by treatment. On the other hand, azithromycin treatment induced lower IL-6 production by ME49- or TgChBrUD1-infected villi. CONCLUSIONS: Azithromycin treatment was effective against T. gondii Brazilian strains compared with conventional treatment. Also, the TgChBrUD1 strain replicated more in villi and modulated important cytokines involved in parasite control, showing that different strains use different strategies to evade the host immune response and ensure their survival. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12929-019-0503-3

DOI

http://dx.doi.org/10.1186/s12929-019-0503-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111576827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30665403


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franco", 
        "givenName": "Priscila Silva", 
        "id": "sg:person.01273720346.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273720346.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gois", 
        "givenName": "Paula Suellen Guimar\u00e3es", 
        "id": "sg:person.014327061425.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014327061425.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Ara\u00fajo", 
        "givenName": "Th\u00e1dia Evelyn", 
        "id": "sg:person.016103545747.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016103545747.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Silva", 
        "givenName": "Rafaela Jos\u00e9", 
        "id": "sg:person.015576473535.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576473535.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Freitas Barbosa", 
        "givenName": "Bellisa", 
        "id": "sg:person.01357214300.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357214300.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Federal do Tri\u00e2ngulo Mineiro", 
          "id": "https://www.grid.ac/institutes/grid.411281.f", 
          "name": [
            "Laborat\u00f3rio de Biologia Celular, Instituto de Ci\u00eancias Biom\u00e9dicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Oliveira Gomes", 
        "givenName": "Angelica", 
        "id": "sg:person.01174652500.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174652500.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Siena", 
          "id": "https://www.grid.ac/institutes/grid.9024.f", 
          "name": [
            "Department of Life Sciences, University of Siena, Siena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ietta", 
        "givenName": "Francesca", 
        "id": "sg:person.01043664134.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043664134.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dos Santos", 
        "givenName": "Lara Affonso", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dos Santos", 
        "givenName": "Maria C\u00e9lia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunoparasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mineo", 
        "givenName": "Jos\u00e9 Roberto", 
        "id": "sg:person.01053607347.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053607347.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Uberl\u00e2ndia", 
          "id": "https://www.grid.ac/institutes/grid.411284.a", 
          "name": [
            "Laborat\u00f3rio de Imunofisiologia da Reprodu\u00e7\u00e3o, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Av. Par\u00e1, 1720, Building: 2B, CEP, 38405-320, Uberl\u00e2ndia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferro", 
        "givenName": "Eloisa Am\u00e1lia Vieira", 
        "id": "sg:person.013644103264.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013644103264.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1086/590149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002383787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.38.1.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004204477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2011.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005593408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1447-0756.2010.01459.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005643066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2008.070432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006324216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1891/0730-0832.34.5.274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010441997", 
          "https://doi.org/10.1891/0730-0832.34.5.274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2011.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010874653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1504.081306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011983484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012481337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/viru.22833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013210290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00778.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013463847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2009.00778.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013463847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00078-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013792105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2009.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014736723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-014-3920-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015661738", 
          "https://doi.org/10.1007/s00436-014-3920-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1203190109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016341737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2004.07.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016567025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1301128110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017771039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3024.1998.00152.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018805700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-3024.1998.00152.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018805700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018833267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018833267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.03.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019178358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exppara.2011.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019972733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020554250", 
          "https://doi.org/10.1038/nri1200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020554250", 
          "https://doi.org/10.1038/nri1200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2007.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020846756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2015.00181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021027327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021838052", 
          "https://doi.org/10.1038/37132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021838052", 
          "https://doi.org/10.1038/37132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pedhc.2010.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023799779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0000277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023926871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0074-02762009000200026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024821096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-013-2017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024849983", 
          "https://doi.org/10.1007/s10096-013-2017-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-013-2017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024849983", 
          "https://doi.org/10.1007/s10096-013-2017-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gas010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025297294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.puhe.2007.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025507061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2006.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025944507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-12-132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026952223", 
          "https://doi.org/10.1186/1479-5876-12-132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027674374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16412-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030211666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00947-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032586689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2011.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032975030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2009.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033716695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182013001844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034283411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034501590", 
          "https://doi.org/10.1038/nature05395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034501590", 
          "https://doi.org/10.1038/nature05395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20100717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034934026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182011001478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035735171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01113-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036277452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2004.07.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037750314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60072-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039042300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040839963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.05013-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040854929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/322800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041479744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-016-2656-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042469963", 
          "https://doi.org/10.1007/s10096-016-2656-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1466252315000183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043186653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043314229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijantimicag.2007.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044484880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044847687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2005.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044847687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182012000765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046717105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182009991065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046744920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-0528.2003.02325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052470346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02502-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053393901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268815003295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053972559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1051/parasite/2008153366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057051405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/dna.2011.1333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059252648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/172.6.1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059705560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/jmm.0.04860-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060391787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.138.9.5403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064281905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.167.8.4574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074891260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083312139", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exppara.2017.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091144562"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberl\u00e2ndia city, Brazil, two virulent strains were isolated: TgChBrUD1 and TgChBrUD2. Congenital toxoplasmosis is more prevalent in South America compared to Europe, and more often associated with severe symptoms, usually as a result of infection with atypical strains.\nMETHODS: Considering that T. gondii has shown high genetic diversity in Brazil, the effectiveness of traditional treatment may not be the same, as more virulent strains of atypical genotypes may predominate. Thus, the aim of this study were to evaluate the Brazilian strain infection rate in human villous explants and the azithromycin efficacy with regard to the control of these strains compared to traditional therapy. Villi were infected with RH, ME49, TgChBrUD1 or TgChBrUD2 strains and treated with azithromycin, spiramycin or a combination of pyrimethamine plus sulfadiazine. The villous viability was analyzed by LDH assay and morphological analysis. Parasite proliferation, as well as production of cytokines was analyzed by qPCR and ELISA, respectively. Statistical analysis was performed using the GraphPad Prism 5.0.\nRESULTS: The treatments were not toxic and TgChBrUD1 infected villi showed a higher parasite burden compared with others strains. Treatments significantly reduced the intracellular proliferation of T. gondii, regardless of the strain. TgChBrUD1-infected villi produced a larger amount of MIF, IL-6 and TGF-\u03b21 compared with other infected villi. Azithromycin treatment increased MIF production by RH- or TgChBrUD2-infected villi, but in ME49- or TgChBrUD1-infected villi, the MIF production was not altered by treatment. On the other hand, azithromycin treatment induced lower IL-6 production by ME49- or TgChBrUD1-infected villi.\nCONCLUSIONS: Azithromycin treatment was effective against T. gondii Brazilian strains compared with conventional treatment. Also, the TgChBrUD1 strain replicated more in villi and modulated important cytokines involved in parasite control, showing that different strains use different strategies to evade the host immune response and ensure their survival.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12929-019-0503-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105665", 
        "issn": [
          "1021-7770", 
          "1423-0127"
        ], 
        "name": "Journal of Biomedical Science", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants", 
    "pagination": "10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c39a1cbb1365d46700344fea22801f66b0b8b39c53df2a7598a03bbe5992b188"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30665403"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421567"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12929-019-0503-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111576827"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12929-019-0503-3", 
      "https://app.dimensions.ai/details/publication/pub.1111576827"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000325_0000000325/records_100778_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12929-019-0503-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12929-019-0503-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12929-019-0503-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12929-019-0503-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12929-019-0503-3'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      95 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12929-019-0503-3 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N240e1bf1af09408780dd3479c9a12b8e
4 schema:citation sg:pub.10.1007/s00436-014-3920-y
5 sg:pub.10.1007/s10096-013-2017-3
6 sg:pub.10.1007/s10096-016-2656-2
7 sg:pub.10.1038/37132
8 sg:pub.10.1038/nature05395
9 sg:pub.10.1038/nri1200
10 sg:pub.10.1186/1479-5876-12-132
11 sg:pub.10.1891/0730-0832.34.5.274
12 https://app.dimensions.ai/details/publication/pub.1083312139
13 https://doi.org/10.1016/j.actatropica.2011.10.018
14 https://doi.org/10.1016/j.ajpath.2011.02.005
15 https://doi.org/10.1016/j.ajpath.2012.03.029
16 https://doi.org/10.1016/j.amjmed.2004.07.021
17 https://doi.org/10.1016/j.amjmed.2004.07.023
18 https://doi.org/10.1016/j.exppara.2011.08.016
19 https://doi.org/10.1016/j.exppara.2017.08.004
20 https://doi.org/10.1016/j.ijantimicag.2007.04.015
21 https://doi.org/10.1016/j.ijpara.2006.03.003
22 https://doi.org/10.1016/j.ijpara.2007.09.004
23 https://doi.org/10.1016/j.pedhc.2010.04.008
24 https://doi.org/10.1016/j.placenta.2009.07.002
25 https://doi.org/10.1016/j.placenta.2009.08.002
26 https://doi.org/10.1016/j.placenta.2011.08.012
27 https://doi.org/10.1016/j.placenta.2013.09.005
28 https://doi.org/10.1016/j.placenta.2013.12.013
29 https://doi.org/10.1016/j.pt.2005.08.001
30 https://doi.org/10.1016/j.pt.2005.11.001
31 https://doi.org/10.1016/j.puhe.2007.08.009
32 https://doi.org/10.1016/s0140-6736(04)16412-x
33 https://doi.org/10.1016/s0140-6736(07)60072-5
34 https://doi.org/10.1017/s0031182009991065
35 https://doi.org/10.1017/s0031182011001478
36 https://doi.org/10.1017/s0031182012000765
37 https://doi.org/10.1017/s0031182013001844
38 https://doi.org/10.1017/s0950268815003295
39 https://doi.org/10.1017/s1466252315000183
40 https://doi.org/10.1046/j.1365-3024.1998.00152.x
41 https://doi.org/10.1046/j.1471-0528.2003.02325.x
42 https://doi.org/10.1051/parasite/2008153366
43 https://doi.org/10.1073/pnas.1203190109
44 https://doi.org/10.1073/pnas.1301128110
45 https://doi.org/10.1084/jem.20100717
46 https://doi.org/10.1086/322800
47 https://doi.org/10.1086/590149
48 https://doi.org/10.1089/dna.2011.1333
49 https://doi.org/10.1093/infdis/172.6.1561
50 https://doi.org/10.1093/molehr/gas010
51 https://doi.org/10.1099/jmm.0.04860-0
52 https://doi.org/10.1111/j.1447-0756.2010.01459.x
53 https://doi.org/10.1111/j.1600-0897.2009.00778.x
54 https://doi.org/10.1128/aac.38.1.31
55 https://doi.org/10.1128/cmr.00078-09
56 https://doi.org/10.1128/cmr.05013-11
57 https://doi.org/10.1128/iai.00947-10
58 https://doi.org/10.1128/jcm.01113-09
59 https://doi.org/10.1128/jcm.02502-12
60 https://doi.org/10.1210/endo.138.9.5403
61 https://doi.org/10.1371/journal.pgen.1000404
62 https://doi.org/10.1371/journal.pmed.1000351
63 https://doi.org/10.1371/journal.pntd.0000277
64 https://doi.org/10.1590/s0074-02762009000200026
65 https://doi.org/10.2353/ajpath.2008.070432
66 https://doi.org/10.3201/eid1504.081306
67 https://doi.org/10.3389/fmicb.2015.00181
68 https://doi.org/10.4049/jimmunol.167.8.4574
69 https://doi.org/10.4161/viru.22833
70 schema:datePublished 2019-12
71 schema:datePublishedReg 2019-12-01
72 schema:description BACKGROUND: Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlândia city, Brazil, two virulent strains were isolated: TgChBrUD1 and TgChBrUD2. Congenital toxoplasmosis is more prevalent in South America compared to Europe, and more often associated with severe symptoms, usually as a result of infection with atypical strains. METHODS: Considering that T. gondii has shown high genetic diversity in Brazil, the effectiveness of traditional treatment may not be the same, as more virulent strains of atypical genotypes may predominate. Thus, the aim of this study were to evaluate the Brazilian strain infection rate in human villous explants and the azithromycin efficacy with regard to the control of these strains compared to traditional therapy. Villi were infected with RH, ME49, TgChBrUD1 or TgChBrUD2 strains and treated with azithromycin, spiramycin or a combination of pyrimethamine plus sulfadiazine. The villous viability was analyzed by LDH assay and morphological analysis. Parasite proliferation, as well as production of cytokines was analyzed by qPCR and ELISA, respectively. Statistical analysis was performed using the GraphPad Prism 5.0. RESULTS: The treatments were not toxic and TgChBrUD1 infected villi showed a higher parasite burden compared with others strains. Treatments significantly reduced the intracellular proliferation of T. gondii, regardless of the strain. TgChBrUD1-infected villi produced a larger amount of MIF, IL-6 and TGF-β1 compared with other infected villi. Azithromycin treatment increased MIF production by RH- or TgChBrUD2-infected villi, but in ME49- or TgChBrUD1-infected villi, the MIF production was not altered by treatment. On the other hand, azithromycin treatment induced lower IL-6 production by ME49- or TgChBrUD1-infected villi. CONCLUSIONS: Azithromycin treatment was effective against T. gondii Brazilian strains compared with conventional treatment. Also, the TgChBrUD1 strain replicated more in villi and modulated important cytokines involved in parasite control, showing that different strains use different strategies to evade the host immune response and ensure their survival.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N8eb41cf1f29349ff8c0e31247862847e
77 N9a6330dff0d34349be691eb0eebf2111
78 sg:journal.1105665
79 schema:name Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants
80 schema:pagination 10
81 schema:productId N010a1b227ada4338af40d21ac5c1d764
82 N1a38dd3061bd4cba84745bf97e2b3fa8
83 N378f5b03f63a47568454d3d5ea2206eb
84 N4926714abbcf40fcb5365edb3fd67031
85 N82aa85abc74241619575605dcc86ca80
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111576827
87 https://doi.org/10.1186/s12929-019-0503-3
88 schema:sdDatePublished 2019-04-11T08:55
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N2de4d9133a4b4a1f86d312626089d005
91 schema:url https://link.springer.com/10.1186%2Fs12929-019-0503-3
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N010a1b227ada4338af40d21ac5c1d764 schema:name pubmed_id
96 schema:value 30665403
97 rdf:type schema:PropertyValue
98 N01862cfbbb25448fafd4c9f74196b462 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
99 schema:familyName dos Santos
100 schema:givenName Maria Célia
101 rdf:type schema:Person
102 N1a38dd3061bd4cba84745bf97e2b3fa8 schema:name nlm_unique_id
103 schema:value 9421567
104 rdf:type schema:PropertyValue
105 N240e1bf1af09408780dd3479c9a12b8e rdf:first sg:person.01273720346.66
106 rdf:rest Nca2e6d4a7bb546cf865886f3f166a468
107 N2bc434c44d0146d0baf851ac6a4e3cdf rdf:first sg:person.016103545747.36
108 rdf:rest Na62f2ac3d7c843d29b7a328829bb4570
109 N2de4d9133a4b4a1f86d312626089d005 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N3091689ac67a4012a6e51384e45fe2fb rdf:first sg:person.013644103264.35
112 rdf:rest rdf:nil
113 N378f5b03f63a47568454d3d5ea2206eb schema:name doi
114 schema:value 10.1186/s12929-019-0503-3
115 rdf:type schema:PropertyValue
116 N4926714abbcf40fcb5365edb3fd67031 schema:name readcube_id
117 schema:value c39a1cbb1365d46700344fea22801f66b0b8b39c53df2a7598a03bbe5992b188
118 rdf:type schema:PropertyValue
119 N52f12e0fc2684948ba1fb50b030b920a rdf:first sg:person.01357214300.33
120 rdf:rest N9424ad77e8a5486e8b062bc3cbdc8d64
121 N82aa85abc74241619575605dcc86ca80 schema:name dimensions_id
122 schema:value pub.1111576827
123 rdf:type schema:PropertyValue
124 N8953602ef87642e8835073425fde421c rdf:first sg:person.01043664134.53
125 rdf:rest Na8902a90d7cd4980a7c67190aecaee65
126 N8eb41cf1f29349ff8c0e31247862847e schema:volumeNumber 26
127 rdf:type schema:PublicationVolume
128 N9424ad77e8a5486e8b062bc3cbdc8d64 rdf:first sg:person.01174652500.10
129 rdf:rest N8953602ef87642e8835073425fde421c
130 N9a6330dff0d34349be691eb0eebf2111 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 Na62f2ac3d7c843d29b7a328829bb4570 rdf:first sg:person.015576473535.80
133 rdf:rest N52f12e0fc2684948ba1fb50b030b920a
134 Na8902a90d7cd4980a7c67190aecaee65 rdf:first Nedbdfef5b8c34a7aa276bdb6df0b0e1c
135 rdf:rest Nc7590d51dc6c4a26995a5ac30238159d
136 Nb45eeb50b0be479dadc47925ec6ae675 rdf:first sg:person.01053607347.75
137 rdf:rest N3091689ac67a4012a6e51384e45fe2fb
138 Nc7590d51dc6c4a26995a5ac30238159d rdf:first N01862cfbbb25448fafd4c9f74196b462
139 rdf:rest Nb45eeb50b0be479dadc47925ec6ae675
140 Nca2e6d4a7bb546cf865886f3f166a468 rdf:first sg:person.014327061425.18
141 rdf:rest N2bc434c44d0146d0baf851ac6a4e3cdf
142 Nedbdfef5b8c34a7aa276bdb6df0b0e1c schema:affiliation https://www.grid.ac/institutes/grid.411284.a
143 schema:familyName dos Santos
144 schema:givenName Lara Affonso
145 rdf:type schema:Person
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical Microbiology
151 rdf:type schema:DefinedTerm
152 sg:journal.1105665 schema:issn 1021-7770
153 1423-0127
154 schema:name Journal of Biomedical Science
155 rdf:type schema:Periodical
156 sg:person.01043664134.53 schema:affiliation https://www.grid.ac/institutes/grid.9024.f
157 schema:familyName Ietta
158 schema:givenName Francesca
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043664134.53
160 rdf:type schema:Person
161 sg:person.01053607347.75 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
162 schema:familyName Mineo
163 schema:givenName José Roberto
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053607347.75
165 rdf:type schema:Person
166 sg:person.01174652500.10 schema:affiliation https://www.grid.ac/institutes/grid.411281.f
167 schema:familyName de Oliveira Gomes
168 schema:givenName Angelica
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174652500.10
170 rdf:type schema:Person
171 sg:person.01273720346.66 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
172 schema:familyName Franco
173 schema:givenName Priscila Silva
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273720346.66
175 rdf:type schema:Person
176 sg:person.01357214300.33 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
177 schema:familyName de Freitas Barbosa
178 schema:givenName Bellisa
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357214300.33
180 rdf:type schema:Person
181 sg:person.013644103264.35 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
182 schema:familyName Ferro
183 schema:givenName Eloisa Amália Vieira
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013644103264.35
185 rdf:type schema:Person
186 sg:person.014327061425.18 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
187 schema:familyName Gois
188 schema:givenName Paula Suellen Guimarães
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014327061425.18
190 rdf:type schema:Person
191 sg:person.015576473535.80 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
192 schema:familyName da Silva
193 schema:givenName Rafaela José
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576473535.80
195 rdf:type schema:Person
196 sg:person.016103545747.36 schema:affiliation https://www.grid.ac/institutes/grid.411284.a
197 schema:familyName de Araújo
198 schema:givenName Thádia Evelyn
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016103545747.36
200 rdf:type schema:Person
201 sg:pub.10.1007/s00436-014-3920-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015661738
202 https://doi.org/10.1007/s00436-014-3920-y
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10096-013-2017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024849983
205 https://doi.org/10.1007/s10096-013-2017-3
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s10096-016-2656-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042469963
208 https://doi.org/10.1007/s10096-016-2656-2
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/37132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021838052
211 https://doi.org/10.1038/37132
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/nature05395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034501590
214 https://doi.org/10.1038/nature05395
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nri1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020554250
217 https://doi.org/10.1038/nri1200
218 rdf:type schema:CreativeWork
219 sg:pub.10.1186/1479-5876-12-132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026952223
220 https://doi.org/10.1186/1479-5876-12-132
221 rdf:type schema:CreativeWork
222 sg:pub.10.1891/0730-0832.34.5.274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010441997
223 https://doi.org/10.1891/0730-0832.34.5.274
224 rdf:type schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1083312139 schema:CreativeWork
226 https://doi.org/10.1016/j.actatropica.2011.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032975030
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.ajpath.2011.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005593408
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.ajpath.2012.03.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019178358
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.amjmed.2004.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037750314
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.amjmed.2004.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016567025
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.exppara.2011.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019972733
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.exppara.2017.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091144562
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.ijantimicag.2007.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044484880
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ijpara.2006.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025944507
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ijpara.2007.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020846756
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.pedhc.2010.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023799779
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.placenta.2009.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014736723
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.placenta.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033716695
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.placenta.2011.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010874653
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.placenta.2013.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012481337
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.placenta.2013.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040839963
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.pt.2005.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044847687
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.pt.2005.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018833267
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.puhe.2007.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025507061
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0140-6736(04)16412-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030211666
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0140-6736(07)60072-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039042300
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1017/s0031182009991065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046744920
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1017/s0031182011001478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035735171
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1017/s0031182012000765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046717105
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1017/s0031182013001844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034283411
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1017/s0950268815003295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053972559
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1017/s1466252315000183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043186653
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1046/j.1365-3024.1998.00152.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018805700
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1046/j.1471-0528.2003.02325.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052470346
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1051/parasite/2008153366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057051405
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.1203190109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016341737
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.1301128110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017771039
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1084/jem.20100717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034934026
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1086/322800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041479744
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1086/590149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002383787
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1089/dna.2011.1333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059252648
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/infdis/172.6.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059705560
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/molehr/gas010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025297294
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1099/jmm.0.04860-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060391787
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1447-0756.2010.01459.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005643066
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1600-0897.2009.00778.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013463847
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1128/aac.38.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004204477
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/cmr.00078-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013792105
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/cmr.05013-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040854929
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/iai.00947-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032586689
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1128/jcm.01113-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036277452
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/jcm.02502-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053393901
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1210/endo.138.9.5403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064281905
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pgen.1000404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027674374
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pmed.1000351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043314229
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1371/journal.pntd.0000277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023926871
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1590/s0074-02762009000200026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024821096
329 rdf:type schema:CreativeWork
330 https://doi.org/10.2353/ajpath.2008.070432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006324216
331 rdf:type schema:CreativeWork
332 https://doi.org/10.3201/eid1504.081306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011983484
333 rdf:type schema:CreativeWork
334 https://doi.org/10.3389/fmicb.2015.00181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021027327
335 rdf:type schema:CreativeWork
336 https://doi.org/10.4049/jimmunol.167.8.4574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074891260
337 rdf:type schema:CreativeWork
338 https://doi.org/10.4161/viru.22833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013210290
339 rdf:type schema:CreativeWork
340 https://www.grid.ac/institutes/grid.411281.f schema:alternateName Universidade Federal do Triângulo Mineiro
341 schema:name Laboratório de Biologia Celular, Instituto de Ciências Biomédicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.411284.a schema:alternateName Federal University of Uberlândia
344 schema:name Laboratório de Imunofisiologia da Reprodução, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará, 1720, Building: 2B, CEP, 38405-320, Uberlândia, Brazil
345 Laboratório de Imunoparasitologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, Brazil
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.9024.f schema:alternateName University of Siena
348 schema:name Department of Life Sciences, University of Siena, Siena, Italy
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...