Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Manish Suthar, Saniya Gupta, Suhail Bukhari, Venkatesh Ponemone

ABSTRACT

BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by α-granules of platelets that augment the rate of natural healing process with decrease in time. The purpose of this case series was to evaluate the safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers on the lower extremity. METHODS: Autologous PRP was prepared from whole blood utilizing a rapid, intraoperative point-of-care system that works on the principle of density gradient centrifugation. Twenty Four (24) patients with non-healing ulcers of different etiologies, who met the inclusion criteria, were treated with single dose of subcutaneous PRP injections along with topical application of PRP gel under compassionate use. RESULTS: The mean age of the treated patients was 62.5 ± 13.53 years and they were followed-up for a period of 24 weeks. All the patients showed signs of wound healing with reduction in wound size, and the mean time duration to ulcer healing was 8.2 weeks. Also, an average five fold increase in the platelet concentrate was observed in the final PRP product obtained using the rapid point-of-care device, and the average platelet dose administered to the patients was 70.10 × 108. CONCLUSION: This case series has demonstrated the potential safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers. TRIAL REGISTRATION: NCT03026855 , Registered 4 January 2017 'Retrospectively'. More... »

PAGES

16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12929-017-0324-1

DOI

http://dx.doi.org/10.1186/s12929-017-0324-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084251120

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28241824


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Component Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Transfusion, Autologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet-Rich Plasma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ulcer", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fortis Memorial Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.464839.4", 
          "name": [
            "TotipotentRX Center for Cellular Medicine (Cesca Therapeutics Inc., USA), Fortis Memorial Research Institute, Gurgaon-122002, Delhi, (NCR), India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suthar", 
        "givenName": "Manish", 
        "id": "sg:person.011366222577.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011366222577.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fortis Memorial Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.464839.4", 
          "name": [
            "TotipotentRX Center for Cellular Medicine (Cesca Therapeutics Inc., USA), Fortis Memorial Research Institute, Gurgaon-122002, Delhi, (NCR), India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Saniya", 
        "id": "sg:person.07773261577.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07773261577.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fortis Escorts Heart Institute", 
          "id": "https://www.grid.ac/institutes/grid.417966.b", 
          "name": [
            "Fortis Escorts Heart Institute and Research Center, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bukhari", 
        "givenName": "Suhail", 
        "id": "sg:person.010041374777.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010041374777.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fortis Memorial Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.464839.4", 
          "name": [
            "TotipotentRX Center for Cellular Medicine (Cesca Therapeutics Inc., USA), Fortis Memorial Research Institute, Gurgaon-122002, Delhi, (NCR), India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ponemone", 
        "givenName": "Venkatesh", 
        "id": "sg:person.01244115411.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244115411.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jcjd.2013.08.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001531580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0741-5214(95)70245-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003202737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0741-5214(95)70245-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003202737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/413604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007968415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08977190600821327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008495503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12875-014-0211-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009289386", 
          "https://doi.org/10.1186/s12875-014-0211-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12875-014-0211-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009289386", 
          "https://doi.org/10.1186/s12875-014-0211-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2008.01862.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009849041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/hcl140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014677223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bot.0b013e31817e793f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015562095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bot.0b013e31817e793f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015562095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0973-6247.53882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016444057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/837620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016933049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2347-9264.139703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021457677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.b.30886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021816294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0974-2077.150786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024601866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0974-2077.150786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024601866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/ojrm.2012.13005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030712229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/rme.13.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034653126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2015.0635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036341123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0970-9290.38931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038596460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198609000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039782621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198609000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039782621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.moh.0000177831.70657.e8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044097694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.moh.0000177831.70657.e8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044097694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.moh.0000177831.70657.e8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044097694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006899.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049601259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5309.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051448595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008505-200110000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060287637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008505-200110000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060287637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008505-200110000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060287637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/jowc.2008.17.2.28179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064825587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075244643", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077260790", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078138858", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078177995", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078467557", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by \u03b1-granules of platelets that augment the rate of natural healing process with decrease in time. The purpose of this case series was to evaluate the safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers on the lower extremity.\nMETHODS: Autologous PRP was prepared from whole blood utilizing a rapid, intraoperative point-of-care system that works on the principle of density gradient centrifugation. Twenty Four (24) patients with non-healing ulcers of different etiologies, who met the inclusion criteria, were treated with single dose of subcutaneous PRP injections along with topical application of PRP gel under compassionate use.\nRESULTS: The mean age of the treated patients was 62.5\u2009\u00b1\u200913.53\u00a0years and they were followed-up for a period of 24\u00a0weeks. All the patients showed signs of wound healing with reduction in wound size, and the mean time duration to ulcer healing was 8.2\u00a0weeks. Also, an average five fold increase in the platelet concentrate was observed in the final PRP product obtained using the rapid point-of-care device, and the average platelet dose administered to the patients was 70.10\u2009\u00d7\u2009108.\nCONCLUSION: This case series has demonstrated the potential safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers.\nTRIAL REGISTRATION: NCT03026855 , Registered 4 January 2017 'Retrospectively'.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12929-017-0324-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105665", 
        "issn": [
          "1021-7770", 
          "1423-0127"
        ], 
        "name": "Journal of Biomedical Science", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series", 
    "pagination": "16", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d739bb43457952619606e213c7475949e30fcaec6501976ff7f7cbf978ec8e7e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28241824"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421567"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12929-017-0324-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084251120"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12929-017-0324-1", 
      "https://app.dimensions.ai/details/publication/pub.1084251120"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54338_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12929-017-0324-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12929-017-0324-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12929-017-0324-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12929-017-0324-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12929-017-0324-1'


 

This table displays all metadata directly associated to this object as RDF triples.

235 TRIPLES      21 PREDICATES      73 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12929-017-0324-1 schema:about N0279c455f7374ca8bb6f634bae5ef985
2 N13cc3c3814d449f7b1cb83e64354a1c6
3 N29cab31ed52044b2a02e53148defdf3a
4 N2ed7ec5bb4b04e5b9b2fcd8c9477e167
5 N402c59aff6ae4e2d98491b1e93fed673
6 N4baa41b4467c461282642d51bafe6a6e
7 N6d34ef3e18154258a1f0e92adf0c06b2
8 N7344e704674246afaa72fc1822c30dd2
9 N748b66f8d6f64448aee6612c617a092b
10 N884ace2f05a7475db3beeeac88c5b84e
11 N96db03021e8643c09ccf807efe89d8ee
12 Nb95b86e344d3436fab787ef319295c4e
13 Nef6be9aba5a94d4c8cfaa2c236e130ad
14 Nf46330465f8a42b3bc2ead6d66fc03d7
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N245f49ddaeb94af7af25849826eb8a19
18 schema:citation sg:pub.10.1186/s12875-014-0211-8
19 https://app.dimensions.ai/details/publication/pub.1075244643
20 https://app.dimensions.ai/details/publication/pub.1077260790
21 https://app.dimensions.ai/details/publication/pub.1078138858
22 https://app.dimensions.ai/details/publication/pub.1078177995
23 https://app.dimensions.ai/details/publication/pub.1078467557
24 https://doi.org/10.1002/14651858.cd006899.pub2
25 https://doi.org/10.1002/jbm.b.30886
26 https://doi.org/10.1016/j.jcjd.2013.08.271
27 https://doi.org/10.1016/s0741-5214(95)70245-8
28 https://doi.org/10.1080/08977190600821327
29 https://doi.org/10.1089/wound.2015.0635
30 https://doi.org/10.1093/qjmed/hcl140
31 https://doi.org/10.1097/00000658-198609000-00011
32 https://doi.org/10.1097/00008505-200110000-00002
33 https://doi.org/10.1097/01.moh.0000177831.70657.e8
34 https://doi.org/10.1097/bot.0b013e31817e793f
35 https://doi.org/10.1111/j.1537-2995.2008.01862.x
36 https://doi.org/10.1126/science.276.5309.75
37 https://doi.org/10.1155/2013/413604
38 https://doi.org/10.1155/2013/837620
39 https://doi.org/10.1172/jci32169
40 https://doi.org/10.12968/jowc.2008.17.2.28179
41 https://doi.org/10.2217/rme.13.59
42 https://doi.org/10.2741/2947
43 https://doi.org/10.4103/0970-9290.38931
44 https://doi.org/10.4103/0973-6247.53882
45 https://doi.org/10.4103/0974-2077.150786
46 https://doi.org/10.4103/2347-9264.139703
47 https://doi.org/10.4236/ojrm.2012.13005
48 schema:datePublished 2017-12
49 schema:datePublishedReg 2017-12-01
50 schema:description BACKGROUND: Non-healing ulcers are a major health problem worldwide and have great impact at personal, professional and social levels, with high cost in terms of human and material resources. Recalcitrant non-healing ulcers are inevitable and detrimental to the lower limb and are a major cause of non-traumatic lower limb amputations. Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. PRP is a conglomeration of thrombocytes, cytokines and various growth factors which are secreted by α-granules of platelets that augment the rate of natural healing process with decrease in time. The purpose of this case series was to evaluate the safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers on the lower extremity. METHODS: Autologous PRP was prepared from whole blood utilizing a rapid, intraoperative point-of-care system that works on the principle of density gradient centrifugation. Twenty Four (24) patients with non-healing ulcers of different etiologies, who met the inclusion criteria, were treated with single dose of subcutaneous PRP injections along with topical application of PRP gel under compassionate use. RESULTS: The mean age of the treated patients was 62.5 ± 13.53 years and they were followed-up for a period of 24 weeks. All the patients showed signs of wound healing with reduction in wound size, and the mean time duration to ulcer healing was 8.2 weeks. Also, an average five fold increase in the platelet concentrate was observed in the final PRP product obtained using the rapid point-of-care device, and the average platelet dose administered to the patients was 70.10 × 108. CONCLUSION: This case series has demonstrated the potential safety and efficacy of autologous platelet rich plasma for the treatment of chronic non-healing ulcers. TRIAL REGISTRATION: NCT03026855 , Registered 4 January 2017 'Retrospectively'.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N3061acd9a3dc4275a8a88eac902cffc6
55 N3374a95fd9f5499aa3a92571c7e26426
56 sg:journal.1105665
57 schema:name Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series
58 schema:pagination 16
59 schema:productId N24d58739152243448e916eed708ae814
60 N4fc001dda34f44218ced27d7c402a26a
61 N7825711ad5434a709e7cd85fe56f53f6
62 N9c647ff487fe4f539dd59c1ceed672db
63 Nc72f65d0607e4945a95d0922acd47682
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251120
65 https://doi.org/10.1186/s12929-017-0324-1
66 schema:sdDatePublished 2019-04-11T10:21
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nd3892fa4ade24ffd9a1d65a724b8acb2
69 schema:url https://link.springer.com/10.1186%2Fs12929-017-0324-1
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N0279c455f7374ca8bb6f634bae5ef985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Blood Component Transfusion
75 rdf:type schema:DefinedTerm
76 N13cc3c3814d449f7b1cb83e64354a1c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Ulcer
78 rdf:type schema:DefinedTerm
79 N245f49ddaeb94af7af25849826eb8a19 rdf:first sg:person.011366222577.02
80 rdf:rest N724f0597c03b4bd78b20d8522cc74030
81 N24d58739152243448e916eed708ae814 schema:name nlm_unique_id
82 schema:value 9421567
83 rdf:type schema:PropertyValue
84 N29cab31ed52044b2a02e53148defdf3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Adult
86 rdf:type schema:DefinedTerm
87 N2ed7ec5bb4b04e5b9b2fcd8c9477e167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Humans
89 rdf:type schema:DefinedTerm
90 N3061acd9a3dc4275a8a88eac902cffc6 schema:volumeNumber 24
91 rdf:type schema:PublicationVolume
92 N3374a95fd9f5499aa3a92571c7e26426 schema:issueNumber 1
93 rdf:type schema:PublicationIssue
94 N402c59aff6ae4e2d98491b1e93fed673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Platelet-Rich Plasma
96 rdf:type schema:DefinedTerm
97 N4baa41b4467c461282642d51bafe6a6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Blood Transfusion, Autologous
99 rdf:type schema:DefinedTerm
100 N4fc001dda34f44218ced27d7c402a26a schema:name readcube_id
101 schema:value d739bb43457952619606e213c7475949e30fcaec6501976ff7f7cbf978ec8e7e
102 rdf:type schema:PropertyValue
103 N6d34ef3e18154258a1f0e92adf0c06b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Follow-Up Studies
105 rdf:type schema:DefinedTerm
106 N724f0597c03b4bd78b20d8522cc74030 rdf:first sg:person.07773261577.11
107 rdf:rest Nceb3dfd9ede2434cb12895c77ece2e10
108 N7344e704674246afaa72fc1822c30dd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Aged
110 rdf:type schema:DefinedTerm
111 N748b66f8d6f64448aee6612c617a092b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Adolescent
113 rdf:type schema:DefinedTerm
114 N7825711ad5434a709e7cd85fe56f53f6 schema:name pubmed_id
115 schema:value 28241824
116 rdf:type schema:PropertyValue
117 N884ace2f05a7475db3beeeac88c5b84e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged, 80 and over
119 rdf:type schema:DefinedTerm
120 N96db03021e8643c09ccf807efe89d8ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Middle Aged
122 rdf:type schema:DefinedTerm
123 N9c647ff487fe4f539dd59c1ceed672db schema:name doi
124 schema:value 10.1186/s12929-017-0324-1
125 rdf:type schema:PropertyValue
126 Nb3b131e6b70747e59264fc5b3f152aa5 rdf:first sg:person.01244115411.29
127 rdf:rest rdf:nil
128 Nb95b86e344d3436fab787ef319295c4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 Nc72f65d0607e4945a95d0922acd47682 schema:name dimensions_id
132 schema:value pub.1084251120
133 rdf:type schema:PropertyValue
134 Nceb3dfd9ede2434cb12895c77ece2e10 rdf:first sg:person.010041374777.58
135 rdf:rest Nb3b131e6b70747e59264fc5b3f152aa5
136 Nd3892fa4ade24ffd9a1d65a724b8acb2 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nef6be9aba5a94d4c8cfaa2c236e130ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Chronic Disease
140 rdf:type schema:DefinedTerm
141 Nf46330465f8a42b3bc2ead6d66fc03d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
148 schema:name Clinical Sciences
149 rdf:type schema:DefinedTerm
150 sg:journal.1105665 schema:issn 1021-7770
151 1423-0127
152 schema:name Journal of Biomedical Science
153 rdf:type schema:Periodical
154 sg:person.010041374777.58 schema:affiliation https://www.grid.ac/institutes/grid.417966.b
155 schema:familyName Bukhari
156 schema:givenName Suhail
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010041374777.58
158 rdf:type schema:Person
159 sg:person.011366222577.02 schema:affiliation https://www.grid.ac/institutes/grid.464839.4
160 schema:familyName Suthar
161 schema:givenName Manish
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011366222577.02
163 rdf:type schema:Person
164 sg:person.01244115411.29 schema:affiliation https://www.grid.ac/institutes/grid.464839.4
165 schema:familyName Ponemone
166 schema:givenName Venkatesh
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244115411.29
168 rdf:type schema:Person
169 sg:person.07773261577.11 schema:affiliation https://www.grid.ac/institutes/grid.464839.4
170 schema:familyName Gupta
171 schema:givenName Saniya
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07773261577.11
173 rdf:type schema:Person
174 sg:pub.10.1186/s12875-014-0211-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009289386
175 https://doi.org/10.1186/s12875-014-0211-8
176 rdf:type schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1075244643 schema:CreativeWork
178 https://app.dimensions.ai/details/publication/pub.1077260790 schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1078138858 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1078177995 schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1078467557 schema:CreativeWork
182 https://doi.org/10.1002/14651858.cd006899.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049601259
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/jbm.b.30886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021816294
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jcjd.2013.08.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001531580
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0741-5214(95)70245-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003202737
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1080/08977190600821327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008495503
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1089/wound.2015.0635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036341123
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1093/qjmed/hcl140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014677223
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/00000658-198609000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039782621
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/00008505-200110000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060287637
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/01.moh.0000177831.70657.e8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044097694
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/bot.0b013e31817e793f schema:sameAs https://app.dimensions.ai/details/publication/pub.1015562095
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1111/j.1537-2995.2008.01862.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009849041
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1126/science.276.5309.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051448595
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1155/2013/413604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007968415
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1155/2013/837620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016933049
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1172/jci32169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028037015
213 rdf:type schema:CreativeWork
214 https://doi.org/10.12968/jowc.2008.17.2.28179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064825587
215 rdf:type schema:CreativeWork
216 https://doi.org/10.2217/rme.13.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034653126
217 rdf:type schema:CreativeWork
218 https://doi.org/10.2741/2947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915095
219 rdf:type schema:CreativeWork
220 https://doi.org/10.4103/0970-9290.38931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038596460
221 rdf:type schema:CreativeWork
222 https://doi.org/10.4103/0973-6247.53882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016444057
223 rdf:type schema:CreativeWork
224 https://doi.org/10.4103/0974-2077.150786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024601866
225 rdf:type schema:CreativeWork
226 https://doi.org/10.4103/2347-9264.139703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021457677
227 rdf:type schema:CreativeWork
228 https://doi.org/10.4236/ojrm.2012.13005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030712229
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.417966.b schema:alternateName Fortis Escorts Heart Institute
231 schema:name Fortis Escorts Heart Institute and Research Center, New Delhi, India
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.464839.4 schema:alternateName Fortis Memorial Research Institute
234 schema:name TotipotentRX Center for Cellular Medicine (Cesca Therapeutics Inc., USA), Fortis Memorial Research Institute, Gurgaon-122002, Delhi, (NCR), India
235 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...