The paradox role of caspase cascade in ionizing radiation therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Najmeh Rahmanian, Seyed Jalal Hosseinimehr, Ali Khalaj

ABSTRACT

Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence. More... »

PAGES

88

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12929-016-0306-8

DOI

http://dx.doi.org/10.1186/s12929-016-0306-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039585766

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27923354


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