Impact of stress on oocyte quality and reproductive outcome View Full Text


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Article Info

DATE

2016-03-29

AUTHORS

Shilpa Prasad, Meenakshi Tiwari, Ashutosh N. Pandey, Tulsidas G. Shrivastav, Shail K. Chaube

ABSTRACT

Stress is an important factor that affects physical and mental status of a healthy person disturbing homeostasis of the body. Changes in the lifestyle are one of the major causes that lead to psychological stress. Psychological stress could impact the biology of female reproduction by targeting at the level of ovary, follicle and oocyte. The increased level of stress hormone such as cortisol reduces estradiol production possibly by affecting the granulosa cell functions within the follicle, which results deterioration in oocyte quality. Adaptation of lifestyle behaviours may generate reactive oxygen species (ROS) in the ovary, which further affects female reproduction. Balance between level of ROS and antioxidants within the ovary are important for maintenance of female reproductive health. Physiological level of ROS modulates oocyte functions, while its accumulation leads to oxidative stress (OS). OS triggers apoptosis in majority of germ cells within the ovary and even in ovulated oocytes. Although both mitochondria- as well as death-receptor pathways are involved in oocyte apoptosis, OS-induced mitochondria-mediated pathway plays a major role in the elimination of majority of germ cells from ovary. OS in the follicular fluid deteriorates oocyte quality and reduces reproductive outcome. On the other hand, antioxidants reduce ROS levels and protect against OS-mediated germ cell apoptosis and thereby depletion of germ cells from the ovary. Indeed, OS is one of the major factors that has a direct negative impact on oocyte quality and limits female reproductive outcome in several mammalian species including human. More... »

PAGES

36

References to SciGraph publications

  • 2013-07-16. Lifestyle factors and reproductive health: taking control of your fertility in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2013-05-01. Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2012-02-07. High cytosolic free calcium level signals apoptosis through mitochondria-caspase mediated pathway in rat eggs cultured in vitro in APOPTOSIS
  • 2015-05-10. Apoptosis in mammalian oocytes: a review in APOPTOSIS
  • 2005-07-14. Role of oxidative stress in female reproduction in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2001-01. Oxidative stress and the ovary. in REPRODUCTIVE SCIENCES
  • 2011-07-12. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 2005-03. Reactive oxygen species in ovarian physiology in REPRODUCTIVE MEDICINE AND BIOLOGY
  • 2005-08. Hydrogen peroxide modulates meiotic cell cycle and induces morphological features characteristic of apoptosis in rat oocytes cultured in vitro in APOPTOSIS
  • 2005-09-02. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2012-06-29. The effects of oxidative stress on female reproduction: a review in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2004-12-03. Role of reactive oxygen species in gynecologic diseases in REPRODUCTIVE MEDICINE AND BIOLOGY
  • 2009-05-04. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2014-08-26. Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals in SPRINGERPLUS
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    http://scigraph.springernature.com/pub.10.1186/s12929-016-0253-4

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    http://dx.doi.org/10.1186/s12929-016-0253-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048639392

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27026099


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