Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg, Mika Scheinin

ABSTRACT

BACKGROUND: α2-adrenoceptors are important regulators of vascular tone and blood pressure. Regulation of cell proliferation is a less well investigated consequence of α2-adrenoceptor activation. We have previously shown that α2B-adrenoceptor activation stimulates proliferation of vascular smooth muscle cells (VSMCs). This may be important for blood vessel development and plasticity and for the pathology and therapeutics of cardiovascular disorders. The underlying cellular mechanisms have remained mostly unknown. This study explored pathways of regulation of gene expression and intracellular signaling related to α2B-adrenoceptor-evoked VSMC proliferation. RESULTS: The cellular mechanisms and signaling pathways of α2B-adrenoceptor-evoked proliferation of VSMCs are complex and include redundancy. Functional enrichment analysis and pathway analysis identified differentially expressed genes associated with α2B-adrenoceptor-regulated VSMC proliferation. They included the upregulated genes Egr1, F3, Ptgs2 and Serpine1 and the downregulated genes Cx3cl1, Cav1, Rhoa, Nppb and Prrx1. The most highly upregulated gene, Lypd8, represents a novel finding in the VSMC context. Inhibitor library screening and kinase activity profiling were applied to identify kinases in the involved signaling pathways. Putative upstream kinases identified by two different screens included PKC, Raf-1, Src, the MAP kinases p38 and JNK and the receptor tyrosine kinases EGFR and HGF/HGFR. As a novel finding, the Src family kinase Lyn was also identified as a putative upstream kinase. CONCLUSIONS: α2B-adrenoceptors may mediate their pro-proliferative effects in VSMCs by promoting the activity of bFGF and PDGF and the growth factor receptors EGFR, HGFR and VEGFR-1/2. The Src family kinase Lyn was also identified as a putative upstream kinase. Lyn is known to be expressed in VSMCs and has been identified as an important regulator of GPCR trafficking and GPCR effects on cell proliferation. Identified Ser/Thr kinases included several PKC isoforms and the β-adrenoceptor kinases 1 and 2. Cross-talk between the signaling mechanisms involved in α2B-adrenoceptor-evoked VSMC proliferation thus appears to involve PKC activation, subsequent changes in gene expression, transactivation of EGFR, and modulation of kinase activities and growth factor-mediated signaling. While many of the identified individual signals were relatively small in terms of effect size, many of them were validated by combining pathway analysis and our integrated screening approach. More... »

PAGES

65

References to SciGraph publications

  • 2004-10. Not so strange bedfellows: G-protein-coupled receptors and Src family kinases in ONCOGENE
  • 2009-04. Cloning and characterization of a human LYPD7, a new member of the Ly-6 superfamily in MOLECULAR BIOLOGY REPORTS
  • 2005-03. Regulation of intracellular Ca2+ and calcineurin by NO/PKG in proliferation of vascular smooth muscle cells in ACTA PHARMACOLOGICA SINICA
  • 2010-10. The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferation in ACTA PHARMACOLOGICA SINICA
  • 2006-04. 1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway in KIDNEY INTERNATIONAL
  • 2003-12. Met, metastasis, motility and more in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1992-02. Cytokine Regulation of Proliferation and ICAM-1 Expression of Human Dermal Microvascular Endothelial Cells In Vitro in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-12. Functions of the Lyn tyrosine kinase in health and disease in CELL COMMUNICATION AND SIGNALING
  • 2003-12. VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor 2 in an in vitro Angiogenesis Model in LABORATORY INVESTIGATION
  • 2011. Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells in EXPERIMENTAL & MOLECULAR MEDICINE
  • 2006-12. Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR in BIOLOGICAL PROCEDURES ONLINE
  • 2014-03. The cyclic AMP response element-binding protein (CREB) mediates smooth muscle cell proliferation in response to angiotensin II in JOURNAL OF CELL COMMUNICATION AND SIGNALING
  • 2008. Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle in TROPOMYOSIN
  • 2016-03-30. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia in NATURE
  • 2008-02. Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival in ONCOGENE
  • 2013. Multisystemic Functions of Alkaline Phosphatases in PHOSPHATASE MODULATORS
  • 2012-08. Gene expression in sheep carotid arteries: major changes with maturational development in PEDIATRIC RESEARCH
  • 2016. Peptide Microarrays for Medical Applications in Autoimmunity, Infection, and Cancer in PEPTIDE MICROARRAYS
  • 2011-01. G protein-coupled receptors: novel targets for drug discovery in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2002-03. MAPK signal pathways in the regulation of cell proliferation in mammalian cells in CELL RESEARCH
  • 1995. Regulation of HGF and HGFR gene expression in EPITHELIAL-MESENCHYMAL INTERACTIONS IN CANCER
  • 2009-05. Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferation in ACTA PHARMACOLOGICA SINICA
  • 2008-12-11. A role for VEGF as a negative regulator of pericyte function and vessel maturation in NATURE
  • 2014-10. Geminin Interference Facilitates Vascular Smooth Muscle Cell Proliferation by Upregulation of CDK-1 in CARDIOVASCULAR DRUGS AND THERAPY
  • 2006-07. Human breast cell lines exhibit functional α2-adrenoceptors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1998-05. Erythropoietin receptor-operated Ca2+ channels: Activation by phospholipase C-γ1 in KIDNEY INTERNATIONAL
  • 2011-12. Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells in VASCULAR CELL
  • 1999-12. Analysis of human transcriptomes in NATURE GENETICS
  • 2013-12. Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells in CARDIOVASCULAR DIABETOLOGY
  • 1997-07. α2-Adrenoceptors in opossum kidney cells couple to stimulation of mitogen-activated protein kinase independently of adenylyl cyclase inhibition in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1997. Protein kinase CK2 (“casein kinase-2”) and its implication in cell division and proliferation in PROGRESS IN CELL CYCLE RESEARCH
  • 2007-12. Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets in BMC GENOMICS
  • 2011-06. Nitric Oxide Inhibits Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia by Increasing the Ubiquitination and Degradation of UbcH10 in CELL BIOCHEMISTRY AND BIOPHYSICS
  • 2014-12. Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression in BMC SYSTEMS BIOLOGY
  • 2006. The α2-Adrenergic Receptors in THE ADRENERGIC RECEPTORS
  • 2013. Peptide Microarrays for Profiling of Serine/Threonine Kinase Activity of Recombinant Kinases and Lysates of Cells and Tissue Samples in GENE REGULATION
  • 2014-07. Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation in JOURNAL OF NATURAL MEDICINES
  • 2012-07. Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2 in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2004-12. CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2016-10. Role of CX3CL1 in Diseases in ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12918-017-0439-8

    DOI

    http://dx.doi.org/10.1186/s12918-017-0439-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090289133

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28659168


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    336 schema:description BACKGROUND: α2-adrenoceptors are important regulators of vascular tone and blood pressure. Regulation of cell proliferation is a less well investigated consequence of α2-adrenoceptor activation. We have previously shown that α2B-adrenoceptor activation stimulates proliferation of vascular smooth muscle cells (VSMCs). This may be important for blood vessel development and plasticity and for the pathology and therapeutics of cardiovascular disorders. The underlying cellular mechanisms have remained mostly unknown. This study explored pathways of regulation of gene expression and intracellular signaling related to α2B-adrenoceptor-evoked VSMC proliferation. RESULTS: The cellular mechanisms and signaling pathways of α2B-adrenoceptor-evoked proliferation of VSMCs are complex and include redundancy. Functional enrichment analysis and pathway analysis identified differentially expressed genes associated with α2B-adrenoceptor-regulated VSMC proliferation. They included the upregulated genes Egr1, F3, Ptgs2 and Serpine1 and the downregulated genes Cx3cl1, Cav1, Rhoa, Nppb and Prrx1. The most highly upregulated gene, Lypd8, represents a novel finding in the VSMC context. Inhibitor library screening and kinase activity profiling were applied to identify kinases in the involved signaling pathways. Putative upstream kinases identified by two different screens included PKC, Raf-1, Src, the MAP kinases p38 and JNK and the receptor tyrosine kinases EGFR and HGF/HGFR. As a novel finding, the Src family kinase Lyn was also identified as a putative upstream kinase. CONCLUSIONS: α2B-adrenoceptors may mediate their pro-proliferative effects in VSMCs by promoting the activity of bFGF and PDGF and the growth factor receptors EGFR, HGFR and VEGFR-1/2. The Src family kinase Lyn was also identified as a putative upstream kinase. Lyn is known to be expressed in VSMCs and has been identified as an important regulator of GPCR trafficking and GPCR effects on cell proliferation. Identified Ser/Thr kinases included several PKC isoforms and the β-adrenoceptor kinases 1 and 2. Cross-talk between the signaling mechanisms involved in α2B-adrenoceptor-evoked VSMC proliferation thus appears to involve PKC activation, subsequent changes in gene expression, transactivation of EGFR, and modulation of kinase activities and growth factor-mediated signaling. While many of the identified individual signals were relatively small in terms of effect size, many of them were validated by combining pathway analysis and our integrated screening approach.
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