In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus View Full Text


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Article Info

DATE

2019-12

AUTHORS

Suelen Mendonça Soares, Robert Domingues, Emanuelle Baldo Gaspar, Patrício Azevedo dos Santos, Kirley Marques Canuto, Alessandro Pelegrine Minho, Maria Isabel Botelho Vieira

ABSTRACT

BACKGROUND: Haemonchosis affects sheep husbandry and its treatment is often compromised due to the development of anthelminthic resistance. Plant-derived bioactive compounds have been studied as alternative to control Haemonchus contortus. The objective of this study was to evaluate the effect of Senecio brasiliensis extracts on H. contortus egg hatching and infective larvae migration. RESULTS: The aqueous extract from dried and fresh plant and alkaloid-enriched fraction of the previously dried leaves of S. brasiliensis inhibited H. contortus egg hatching. The main plant compound in alkaloid fraction was integerrimine, a pyrrolizidine alkaloid (PA). However, the aqueous extract from dried plant displayed higher efficacy when compared to their alkaloid enriched or non-polar fractions, meaning that, although PAs contributed to the ovicidal effect, other compounds in the plant can also contribute to their effect. Furthermore, the aqueous extract from dried plant also had higher efficacy than aqueous extract from fresh plant in larvae migration inhibition. Finally, extract from dried plant presented low in vitro cytotoxic effect. CONCLUSION: Taken together our results suggest a good anthelmintic effect of S. brasiliensis, especially when aqueous extract is prepared from dried plant. Further in vivo studies should be performed focused on forms of administration of this extract in rearing sheep. More... »

PAGES

99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12917-019-1843-7

DOI

http://dx.doi.org/10.1186/s12917-019-1843-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112984745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30909906


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12917-019-1843-7'


 

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