Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-11

AUTHORS

Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine, Valérie Freiche

ABSTRACT

BACKGROUND: Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is now the most frequent digestive neoplasia in cats and comprises 60 to 75% of gastrointestinal lymphoma cases. Given that LGAL shares common clinical, paraclinical and ultrasonographic features with inflammatory bowel diseases, establishing a diagnosis is challenging. A review was designed to summarise current knowledge of the pathogenesis, diagnosis, prognosis and treatment of feline LGAL. Electronic searches of PubMed and Science Direct were carried out without date or language restrictions. RESULTS: A total of 176 peer-reviewed documents were identified and most of which were published in the last twenty years. 130 studies were found from the veterinary literature and 46 from the human medicine literature. Heterogeneity of study designs and outcome measures made meta-analysis inappropriate. The pathophysiology of feline LGAL still needs to be elucidated, not least the putative roles of infectious agents, environmental factors as well as genetic events. The most common therapeutic strategy is combination treatment with prednisolone and chlorambucil, and prolonged remission can often be achieved. Developments in immunohistochemical analysis and clonality testing have improved the confidence of clinicians in obtaining a correct diagnosis between LGAL and IBD. The condition shares similarities with some diseases in humans, especially human indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. CONCLUSIONS: The pathophysiology of feline LGAL still needs to be elucidated and prospective studies as well as standardisation of therapeutic strategies are needed. A combination of conventional histopathology and immunohistochemistry remains the current gold-standard test, but clinicians should be cautious about reclassifying cats previously diagnosed with IBD to lymphoma on the basis of clonality testing. Importantly, feline LGAL could be considered to be a potential animal model for indolent digestive T-cell lymphoproliferative disorder, a rare condition in human medicine. More... »

PAGES

306

Journal

TITLE

BMC Veterinary Research

ISSUE

1

VOLUME

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12917-018-1635-5

DOI

http://dx.doi.org/10.1186/s12917-018-1635-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107534388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30305106


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    "description": "BACKGROUND: Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is now the most frequent digestive neoplasia in cats and comprises 60 to 75% of gastrointestinal lymphoma cases. Given that LGAL shares common clinical, paraclinical and ultrasonographic features with inflammatory bowel diseases, establishing a diagnosis is challenging. A review was designed to summarise current knowledge of the pathogenesis, diagnosis, prognosis and treatment of feline LGAL. Electronic searches of PubMed and Science Direct were carried out without date or language restrictions.\nRESULTS: A total of 176 peer-reviewed documents were identified and most of which were published in the last twenty years. 130 studies were found from the veterinary literature and 46 from the human medicine literature. Heterogeneity of study designs and outcome measures made meta-analysis inappropriate. The pathophysiology of feline LGAL still needs to be elucidated, not least the putative roles of infectious agents, environmental factors as well as genetic events. The most common therapeutic strategy is combination treatment with prednisolone and chlorambucil, and prolonged remission can often be achieved. Developments in immunohistochemical analysis and clonality testing have improved the confidence of clinicians in obtaining a correct diagnosis between LGAL and IBD. The condition shares similarities with some diseases in humans, especially human indolent T-cell lymphoproliferative disorder of the gastrointestinal tract.\nCONCLUSIONS: The pathophysiology of feline LGAL still needs to be elucidated and prospective studies as well as standardisation of therapeutic strategies are needed. A combination of conventional histopathology and immunohistochemistry remains the current gold-standard test, but clinicians should be cautious about reclassifying cats previously diagnosed with IBD to lymphoma on the basis of clonality testing. Importantly, feline LGAL could be considered to be a potential animal model for indolent digestive T-cell lymphoproliferative disorder, a rare condition in human medicine.", 
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361 INSERM UMR 1163, CNRS ERL 8254, Institut Imagine, Paris, France
362 INSERM UMR 1163, Institut Imagine, Paris, France
363 schema:name Gastroenterology Department, Hôpital Européen Georges Pompidou, Assistance Publique – Hôpitaux de Paris (APHP), Université Paris Descartes, Sorbonne Paris Cité, Paris, France
364 Hematology Department, Hôpital Universitaire Necker – Enfants Malades, Assistance Publique – Hôpitaux de Paris (APHP), Paris, France
365 INSERM 1163, Institut Imagine, Site Hôpital Universitaire Necker – Enfants Malades, Paris, France
366 INSERM UMR 1163, CNRS ERL 8254, Institut Imagine, Paris, France
367 INSERM UMR 1163, Institut Imagine, Paris, France
368 Pathology Department, Hôpital Universitaire Necker – Enfants Malades, Assistance Publique – Hôpitaux de Paris (APHP), Université Paris Descartes, Sorbonne Paris Cité, Paris, France
369 Université Paris Descartes, Sorbonne Paris Cité, Paris, France
370 rdf:type schema:Organization
371 grid-institutes:grid.7429.8 schema:alternateName UMR 1163, Laboratory of Intestinal Immunity, INSERM, Paris, France
372 schema:name UMR 1163, Laboratory of Intestinal Immunity, INSERM, Paris, France
373 Université Paris Descartes, Sorbonne Paris Cité, Paris, France
374 rdf:type schema:Organization
 




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