Molecular characterization of the apoptosis-related SH3RF1 and SH3RF2 genes and their association with exercise performance in Arabian horses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

K. Ropka-Molik, M. Stefaniuk-Szmukier, K. Piórkowska, T. Szmatoła, M. Bugno-Poniewierska

ABSTRACT

BACKGROUND: Apoptosis plays an important role in the regulation of healthy tissue growth and development as well as in controlling the maintenance of homeostasis in exercising muscles. During an intensive physical effort, the regulation of cell death by apoptosis results in the replacement of unaccustomed muscle cells by new cells that are better suited to exercise. The aim of this study was to determine the expression of two genes (SH3FR1 and SH3RF2) that control apoptosis in muscle tissues during training periods characterized by different intensities. The gene expression levels were estimated using real-time PCR method in skeletal muscle biopsies collected from 15 Arabian horses (untrained, after an intense gallop phase, and at the end of the racing season). An association study was performed on 250 Arabian horses to assess the effect of the SH3RF2:c.796 T > C (p.Ser266Pro) variant on race performance traits in flat gallop-racing. RESULTS: A gene expression analysis confirmed a significant decrease (p < 0.01) in the anti-apoptotic SH3RF2 (POSHER) gene during training periods that differed in intensity. The highest SH3RF2 expression level was detected in the muscles of untrained horses, whereas the lowest expression was identified at the end of the racing season in horses that were fully adapted to the exercise. A non-significant decrease in SH3RF1 gene expression following the training periods was observed. Moreover, a serine substitution by proline at amino acid position 266 (CC genotype) was negatively associated with the probability of winning races, the number of races in which a horse occurred and the financial value of the prizes. Horses with the TT genotype achieved the highest financial benefits, both for total winnings and for winnings per race in which the horses participated. CONCLUSIONS: The present study showed the supposed regulation mechanism of exercise-induced apoptosis in horses at the molecular level. The identified SH3RF2: c.796 T > C missense variant was associated with selected racing performance traits, which is important information during the evaluation of horses' exercise predisposition. The association results and frequencies of the CT and TT genotypes suggest the possibility of using SH3RF2 variant in selection to improve the racing performance of Arabian horses. More... »

PAGES

237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12917-018-1567-0

DOI

http://dx.doi.org/10.1186/s12917-018-1567-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106149678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30107803


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Horses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physical Conditioning, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physical Fitness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Running", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Research Institute of Animal Production", 
          "id": "https://www.grid.ac/institutes/grid.419741.e", 
          "name": [
            "Department of Animal Molecular Biology, National Research Institute of Animal Production, Krak\u00f3w, Poland", 
            "Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ropka-Molik", 
        "givenName": "K.", 
        "id": "sg:person.01037576213.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037576213.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Horse Breeding, Institute of Animal Science, the University of Agriculture in Cracow, Krak\u00f3w, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stefaniuk-Szmukier", 
        "givenName": "M.", 
        "id": "sg:person.011637056533.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011637056533.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Institute of Animal Production", 
          "id": "https://www.grid.ac/institutes/grid.419741.e", 
          "name": [
            "Department of Animal Molecular Biology, National Research Institute of Animal Production, Krak\u00f3w, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pi\u00f3rkowska", 
        "givenName": "K.", 
        "id": "sg:person.01106456037.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106456037.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Institute of Animal Production", 
          "id": "https://www.grid.ac/institutes/grid.419741.e", 
          "name": [
            "Department of Animal Molecular Biology, National Research Institute of Animal Production, Krak\u00f3w, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szmato\u0142a", 
        "givenName": "T.", 
        "id": "sg:person.01046572754.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046572754.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Agriculture in Krakow", 
          "id": "https://www.grid.ac/institutes/grid.410701.3", 
          "name": [
            "Institute of Veterinary Sciences University of Agriculture in Krakow, Krak\u00f3w, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bugno-Poniewierska", 
        "givenName": "M.", 
        "id": "sg:person.01320676240.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320676240.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf03340125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001422678", 
          "https://doi.org/10.1007/bf03340125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.20441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005735904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1232392100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008847002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1249/00005768-199312000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010936918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015021383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2013.5773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015168951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2012.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016428346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.11.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018220186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319199a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020743092", 
          "https://doi.org/10.1038/319199a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005768-200103000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021864572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005768-200103000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021864572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/ebm.2010.010202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/ebm.2010.010202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.269431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026865323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12864-016-2945-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027460968", 
          "https://doi.org/10.1186/s12864-016-2945-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12864-016-2945-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027460968", 
          "https://doi.org/10.1186/s12864-016-2945-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgt338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029538142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.22186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029955862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-13-111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029984926", 
          "https://doi.org/10.1186/1471-2105-13-111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.9.e45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030834024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.21408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035632725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.21408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035632725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037474082", 
          "https://doi.org/10.1038/nature08832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037474082", 
          "https://doi.org/10.1038/nature08832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-3306.2002.tb05432.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041226181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-3306.2002.tb05432.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041226181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/age.12042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045788458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00993.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048616798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-3306.2010.00299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051199175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-1291fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051982621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-437x(94)90087-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053312978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/aoas-2015-0017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067520631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5713/ajas.16.0865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073083245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1873-3468.12569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074239141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079329367", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079329367", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079385723", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00130.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085292582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/9780851994291.0411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089222648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09466-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232066", 
          "https://doi.org/10.1038/s41598-017-09466-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09466-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232066", 
          "https://doi.org/10.1038/s41598-017-09466-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-09466-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091232066", 
          "https://doi.org/10.1038/s41598-017-09466-w"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Apoptosis plays an important role in the regulation of healthy tissue growth and development as well as in controlling the maintenance of homeostasis in exercising muscles. During an intensive physical effort, the regulation of cell death by apoptosis results in the replacement of unaccustomed muscle cells by new cells that are better suited to exercise. The aim of this study was to determine the expression of two genes (SH3FR1 and SH3RF2) that control apoptosis in muscle tissues during training periods characterized by different intensities. The gene expression levels were estimated using real-time PCR method in skeletal muscle biopsies collected from 15 Arabian horses (untrained, after an intense gallop phase, and at the end of the racing season). An association study was performed on 250 Arabian horses to assess the effect of the SH3RF2:c.796\u00a0T\u2009>\u2009C (p.Ser266Pro) variant on race performance traits in flat gallop-racing.\nRESULTS: A gene expression analysis confirmed a significant decrease (p\u2009<\u20090.01) in the anti-apoptotic SH3RF2 (POSHER) gene during training periods that differed in intensity. The highest SH3RF2 expression level was detected in the muscles of untrained horses, whereas the lowest expression was identified at the end of the racing season in horses that were fully adapted to the exercise. A non-significant decrease in SH3RF1 gene expression following the training periods was observed. Moreover, a serine substitution by proline at amino acid position 266 (CC genotype) was negatively associated with the probability of winning races, the number of races in which a horse occurred and the financial value of the prizes. Horses with the TT genotype achieved the highest financial benefits, both for total winnings and for winnings per race in which the horses participated.\nCONCLUSIONS: The present study showed the supposed regulation mechanism of exercise-induced apoptosis in horses at the molecular level. The identified SH3RF2: c.796\u00a0T\u2009>\u2009C missense variant was associated with selected racing performance traits, which is important information during the evaluation of horses' exercise predisposition. The association results and frequencies of the CT and TT genotypes suggest the possibility of using SH3RF2 variant in selection to improve the racing performance of Arabian horses.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12917-018-1567-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7392077", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1035490", 
        "issn": [
          "1746-6148"
        ], 
        "name": "BMC Veterinary Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Molecular characterization of the apoptosis-related SH3RF1 and SH3RF2 genes and their association with exercise performance in Arabian horses", 
    "pagination": "237", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "af208948dd8d3376119961ce0e9dc3be8d77bae4348084796f9f8d8eb0fb68c2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30107803"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101249759"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12917-018-1567-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106149678"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12917-018-1567-0", 
      "https://app.dimensions.ai/details/publication/pub.1106149678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12917-018-1567-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12917-018-1567-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12917-018-1567-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12917-018-1567-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12917-018-1567-0'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      21 PREDICATES      73 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12917-018-1567-0 schema:about N1a97e623718c4a9e8b39713f07bfb122
2 N28368255d515405599a1c2506bc76714
3 N2c8b409e4caa46c7a3d617554a8948c2
4 N45915c78cb0b48ec850966ce1123013d
5 N7d73a1161af7474ba0bd90778a677fc2
6 N7dff7880ff1c4bda85e64823c34dd070
7 N801ff2c418ae465991b6ddf199b3bd15
8 Na371d3a710f4458283563cad96cf471b
9 Ncfdc9c92a1ff45eca8dd33fe4b8aa15f
10 Nd29544ddb9d447bf9079de450efcf1b5
11 Nd4e581097a0a492f8239c93a1ea2ddac
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Nac013e22d4a04cf3995ef641cbabfc9f
15 schema:citation sg:pub.10.1007/bf03340125
16 sg:pub.10.1038/319199a0
17 sg:pub.10.1038/nature08832
18 sg:pub.10.1038/s41598-017-09466-w
19 sg:pub.10.1186/1471-2105-13-111
20 sg:pub.10.1186/s12864-016-2945-2
21 https://app.dimensions.ai/details/publication/pub.1079329367
22 https://app.dimensions.ai/details/publication/pub.1079385723
23 https://doi.org/10.1002/1873-3468.12569
24 https://doi.org/10.1002/dvdy.22186
25 https://doi.org/10.1002/prot.20441
26 https://doi.org/10.1002/prot.21408
27 https://doi.org/10.1016/0959-437x(94)90087-6
28 https://doi.org/10.1016/j.bbrc.2009.11.123
29 https://doi.org/10.1016/j.cmet.2012.12.012
30 https://doi.org/10.1073/pnas.1232392100
31 https://doi.org/10.1074/jbc.m111.269431
32 https://doi.org/10.1079/9780851994291.0411
33 https://doi.org/10.1089/ars.2013.5773
34 https://doi.org/10.1093/carcin/bgt338
35 https://doi.org/10.1093/nar/29.9.e45
36 https://doi.org/10.1093/nar/gkw937
37 https://doi.org/10.1096/fj.03-1291fje
38 https://doi.org/10.1097/00005768-200103000-00010
39 https://doi.org/10.1111/age.12042
40 https://doi.org/10.1111/j.2042-3306.2002.tb05432.x
41 https://doi.org/10.1111/j.2042-3306.2010.00299.x
42 https://doi.org/10.1152/japplphysiol.00993.2010
43 https://doi.org/10.1152/physiolgenomics.00130.2016
44 https://doi.org/10.1249/00005768-199312000-00004
45 https://doi.org/10.1258/ebm.2010.010202
46 https://doi.org/10.1515/aoas-2015-0017
47 https://doi.org/10.5713/ajas.16.0865
48 schema:datePublished 2018-12
49 schema:datePublishedReg 2018-12-01
50 schema:description BACKGROUND: Apoptosis plays an important role in the regulation of healthy tissue growth and development as well as in controlling the maintenance of homeostasis in exercising muscles. During an intensive physical effort, the regulation of cell death by apoptosis results in the replacement of unaccustomed muscle cells by new cells that are better suited to exercise. The aim of this study was to determine the expression of two genes (SH3FR1 and SH3RF2) that control apoptosis in muscle tissues during training periods characterized by different intensities. The gene expression levels were estimated using real-time PCR method in skeletal muscle biopsies collected from 15 Arabian horses (untrained, after an intense gallop phase, and at the end of the racing season). An association study was performed on 250 Arabian horses to assess the effect of the SH3RF2:c.796 T > C (p.Ser266Pro) variant on race performance traits in flat gallop-racing. RESULTS: A gene expression analysis confirmed a significant decrease (p < 0.01) in the anti-apoptotic SH3RF2 (POSHER) gene during training periods that differed in intensity. The highest SH3RF2 expression level was detected in the muscles of untrained horses, whereas the lowest expression was identified at the end of the racing season in horses that were fully adapted to the exercise. A non-significant decrease in SH3RF1 gene expression following the training periods was observed. Moreover, a serine substitution by proline at amino acid position 266 (CC genotype) was negatively associated with the probability of winning races, the number of races in which a horse occurred and the financial value of the prizes. Horses with the TT genotype achieved the highest financial benefits, both for total winnings and for winnings per race in which the horses participated. CONCLUSIONS: The present study showed the supposed regulation mechanism of exercise-induced apoptosis in horses at the molecular level. The identified SH3RF2: c.796 T > C missense variant was associated with selected racing performance traits, which is important information during the evaluation of horses' exercise predisposition. The association results and frequencies of the CT and TT genotypes suggest the possibility of using SH3RF2 variant in selection to improve the racing performance of Arabian horses.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N4f37badd57964269b7848577d11e5ee7
55 Nb40f1af9708d49c189cd33e2991acc96
56 sg:journal.1035490
57 schema:name Molecular characterization of the apoptosis-related SH3RF1 and SH3RF2 genes and their association with exercise performance in Arabian horses
58 schema:pagination 237
59 schema:productId N12af4590f3294c60a469fa211ff8ac59
60 N1354afe9b6554d55a252f808dfe3c63a
61 N2f2787a87b5140ae8b351f5dcdd165ec
62 N391da7a9805149bca075fc4511b4d5ae
63 N47b44e4813d64904b92602f26241b2d4
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106149678
65 https://doi.org/10.1186/s12917-018-1567-0
66 schema:sdDatePublished 2019-04-10T16:05
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N07b424e0341a49818d4b53905464b8d6
69 schema:url https://link.springer.com/10.1186%2Fs12917-018-1567-0
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N07b424e0341a49818d4b53905464b8d6 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N12af4590f3294c60a469fa211ff8ac59 schema:name nlm_unique_id
76 schema:value 101249759
77 rdf:type schema:PropertyValue
78 N1354afe9b6554d55a252f808dfe3c63a schema:name doi
79 schema:value 10.1186/s12917-018-1567-0
80 rdf:type schema:PropertyValue
81 N1a97e623718c4a9e8b39713f07bfb122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Horses
83 rdf:type schema:DefinedTerm
84 N28368255d515405599a1c2506bc76714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Genotype
86 rdf:type schema:DefinedTerm
87 N2c8b409e4caa46c7a3d617554a8948c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Muscle, Skeletal
89 rdf:type schema:DefinedTerm
90 N2f2787a87b5140ae8b351f5dcdd165ec schema:name dimensions_id
91 schema:value pub.1106149678
92 rdf:type schema:PropertyValue
93 N391da7a9805149bca075fc4511b4d5ae schema:name readcube_id
94 schema:value af208948dd8d3376119961ce0e9dc3be8d77bae4348084796f9f8d8eb0fb68c2
95 rdf:type schema:PropertyValue
96 N45915c78cb0b48ec850966ce1123013d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Physical Fitness
98 rdf:type schema:DefinedTerm
99 N47b44e4813d64904b92602f26241b2d4 schema:name pubmed_id
100 schema:value 30107803
101 rdf:type schema:PropertyValue
102 N4f37badd57964269b7848577d11e5ee7 schema:volumeNumber 14
103 rdf:type schema:PublicationVolume
104 N5a386423a0284cffaf4d81f8b09937bc rdf:first sg:person.01106456037.51
105 rdf:rest N660a9e50ba9a40f1b69cb4609a329b60
106 N660a9e50ba9a40f1b69cb4609a329b60 rdf:first sg:person.01046572754.04
107 rdf:rest Nddc420b695ab47c08b19133f489aecb1
108 N7d73a1161af7474ba0bd90778a677fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Apoptosis Regulatory Proteins
110 rdf:type schema:DefinedTerm
111 N7dff7880ff1c4bda85e64823c34dd070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Polymorphism, Single Nucleotide
113 rdf:type schema:DefinedTerm
114 N801ff2c418ae465991b6ddf199b3bd15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Physical Conditioning, Animal
116 rdf:type schema:DefinedTerm
117 Na371d3a710f4458283563cad96cf471b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Apoptosis
119 rdf:type schema:DefinedTerm
120 Nac013e22d4a04cf3995ef641cbabfc9f rdf:first sg:person.01037576213.51
121 rdf:rest Nb56afd7d283647898141541ac3247af5
122 Nb40f1af9708d49c189cd33e2991acc96 schema:issueNumber 1
123 rdf:type schema:PublicationIssue
124 Nb56afd7d283647898141541ac3247af5 rdf:first sg:person.011637056533.67
125 rdf:rest N5a386423a0284cffaf4d81f8b09937bc
126 Ncfdc9c92a1ff45eca8dd33fe4b8aa15f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Gene Expression
128 rdf:type schema:DefinedTerm
129 Nd29544ddb9d447bf9079de450efcf1b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 Nd4e581097a0a492f8239c93a1ea2ddac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Running
134 rdf:type schema:DefinedTerm
135 Nd63345cfa82940eb982da842202f9e54 schema:name Department of Horse Breeding, Institute of Animal Science, the University of Agriculture in Cracow, Kraków, Poland
136 rdf:type schema:Organization
137 Nddc420b695ab47c08b19133f489aecb1 rdf:first sg:person.01320676240.68
138 rdf:rest rdf:nil
139 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
140 schema:name Biological Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
143 schema:name Genetics
144 rdf:type schema:DefinedTerm
145 sg:grant.7392077 http://pending.schema.org/fundedItem sg:pub.10.1186/s12917-018-1567-0
146 rdf:type schema:MonetaryGrant
147 sg:journal.1035490 schema:issn 1746-6148
148 schema:name BMC Veterinary Research
149 rdf:type schema:Periodical
150 sg:person.01037576213.51 schema:affiliation https://www.grid.ac/institutes/grid.419741.e
151 schema:familyName Ropka-Molik
152 schema:givenName K.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037576213.51
154 rdf:type schema:Person
155 sg:person.01046572754.04 schema:affiliation https://www.grid.ac/institutes/grid.419741.e
156 schema:familyName Szmatoła
157 schema:givenName T.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046572754.04
159 rdf:type schema:Person
160 sg:person.01106456037.51 schema:affiliation https://www.grid.ac/institutes/grid.419741.e
161 schema:familyName Piórkowska
162 schema:givenName K.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106456037.51
164 rdf:type schema:Person
165 sg:person.011637056533.67 schema:affiliation Nd63345cfa82940eb982da842202f9e54
166 schema:familyName Stefaniuk-Szmukier
167 schema:givenName M.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011637056533.67
169 rdf:type schema:Person
170 sg:person.01320676240.68 schema:affiliation https://www.grid.ac/institutes/grid.410701.3
171 schema:familyName Bugno-Poniewierska
172 schema:givenName M.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320676240.68
174 rdf:type schema:Person
175 sg:pub.10.1007/bf03340125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001422678
176 https://doi.org/10.1007/bf03340125
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/319199a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020743092
179 https://doi.org/10.1038/319199a0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nature08832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037474082
182 https://doi.org/10.1038/nature08832
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/s41598-017-09466-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1091232066
185 https://doi.org/10.1038/s41598-017-09466-w
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/1471-2105-13-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029984926
188 https://doi.org/10.1186/1471-2105-13-111
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/s12864-016-2945-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027460968
191 https://doi.org/10.1186/s12864-016-2945-2
192 rdf:type schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079329367 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1079385723 schema:CreativeWork
195 https://doi.org/10.1002/1873-3468.12569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074239141
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/dvdy.22186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029955862
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/prot.20441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005735904
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/prot.21408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035632725
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0959-437x(94)90087-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053312978
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.bbrc.2009.11.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018220186
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.cmet.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016428346
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.1232392100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008847002
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1074/jbc.m111.269431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026865323
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1079/9780851994291.0411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089222648
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1089/ars.2013.5773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015168951
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/carcin/bgt338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029538142
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/nar/gkw937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015021383
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1096/fj.03-1291fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1051982621
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1097/00005768-200103000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021864572
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1111/age.12042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045788458
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.2042-3306.2002.tb05432.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041226181
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/j.2042-3306.2010.00299.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051199175
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1152/japplphysiol.00993.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048616798
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1152/physiolgenomics.00130.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085292582
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1249/00005768-199312000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010936918
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1258/ebm.2010.010202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024606940
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1515/aoas-2015-0017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067520631
242 rdf:type schema:CreativeWork
243 https://doi.org/10.5713/ajas.16.0865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073083245
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.410701.3 schema:alternateName University of Agriculture in Krakow
246 schema:name Institute of Veterinary Sciences University of Agriculture in Krakow, Kraków, Poland
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.419741.e schema:alternateName National Research Institute of Animal Production
249 schema:name Department of Animal Molecular Biology, National Research Institute of Animal Production, Kraków, Poland
250 Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice, Poland
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...