Effect of housing arrangement on fecal-oral transmission of avian hepatitis E virus in chicken flocks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-07

AUTHORS

Baoyuan Liu, Yani Sun, Yiyang Chen, Taofeng Du, Yuchen Nan, Xinjie Wang, Huixia Li, Baicheng Huang, Gaiping Zhang, En-Min Zhou, Qin Zhao

ABSTRACT

BackgroundAvian hepatitis E virus (HEV) infection is common in chicken flocks in China, as currently no measures exist to prevent the spread of the disease. In this study, we analyzed the effect of caged versus cage-free housing arrangements on avian HEV transmission. First, 127 serum and 110 clinical fecal samples were collected from 4 chicken flocks including the two arrangements in Shaanxi Province, China and tested for HEV antibodies and/or virus. Concurrently, 36 specific-pathogen-free chickens were divided equally into four experimental living arrangement groups, designated cage-free (Inoculated), caged (Inoculated), cage-free (Negative) and caged (Negative) groups. In caged groups, three cages contained 3 chickens each. Three chickens each from cage-free (Inoculated) and caged (Inoculated) groups (one chicken of each cage) were inoculated by cutaneous ulnar vein with the same dose of avian HEV, respectively. The cage-free (Negative) and caged (Negative) groups served as negative control. Serum and fecal samples were collected at 1 to 7 weeks post-inoculation (wpi) and liver lesions were scored at 7 wpi.ResultsThe results of serology showed that the avian HEV infection rate (54.10%) of the cage-free chickens was significantly higher than the one (12.12%) for caged chickens (P < 0.05). Also, the rate of detection of avian HEV RNA in the clinical fecal samples was significantly higher in the cage-free (22.80%, 13/57) than caged birds (5.66%, 3/53). Moreover, under experimental conditions, the infected number of uninoculated cage-free chickens (6) was significantly higher than the one for the uninoculated caged birds (2), as evidenced by seroconversion, fecal virus shedding, viremia and gross and microscopic liver lesions.ConclusionsThese results suggest that reduction of contact with feces as seen in the caged arrangement of housing chickens can reduce avian HEV transmission. This study provides insights for prevention and control of avian HEV infection in chicken flocks. More... »

PAGES

282

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12917-017-1203-4

DOI

http://dx.doi.org/10.1186/s12917-017-1203-4

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https://app.dimensions.ai/details/publication/pub.1091501005

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28882185


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62 fecal samples
63 fecal virus shedding
64 fecal-oral transmission
65 feces
66 flocks
67 free chickens
68 group
69 hepatitis E virus
70 hepatitis E virus infection
71 housing arrangements
72 housing chickens
73 infected number
74 infection
75 infection rate
76 insights
77 lesions
78 liver lesions
79 measures
80 microscopic liver lesions
81 negative control
82 number
83 one
84 prevention
85 rate
86 rate of detection
87 reduction
88 reduction of contact
89 results
90 same dose
91 samples
92 seroconversion
93 serology
94 serum
95 shedding
96 spread
97 study
98 transmission
99 ulnar vein
100 vein
101 viremia
102 virus
103 virus infection
104 virus shedding
105 weeks
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