Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-01-11

AUTHORS

Emmanouil Bouras, Ville Karhunen, Dipender Gill, Jian Huang, Philip C. Haycock, Marc J. Gunter, Mattias Johansson, Paul Brennan, Tim Key, Sarah J. Lewis, Richard M. Martin, Neil Murphy, Elizabeth A. Platz, Ruth Travis, James Yarmolinsky, Verena Zuber, Paul Martin, Michail Katsoulis, Heinz Freisling, Therese Haugdahl Nøst, Matthias B. Schulze, Laure Dossus, Rayjean J. Hung, Christopher I. Amos, Ari Ahola-Olli, Saranya Palaniswamy, Minna Männikkö, Juha Auvinen, Karl-Heinz Herzig, Sirkka Keinänen-Kiukaanniemi, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Marko Salmi, Sirpa Jalkanen, Marjo-Riitta Jarvelin, Abbas Dehghan, Konstantinos K. Tsilidis

ABSTRACT

BackgroundEpidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis.MethodsUp to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer).ResultsThere was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses.ConclusionsOur study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention. More... »

PAGES

3

References to SciGraph publications

  • 2020-10-16. Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals in NATURE METABOLISM
  • 2020-09-01. Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of breast cancer in NPJ PRECISION ONCOLOGY
  • 2016-05-16. Detection and interpretation of shared genetic influences on 42 human traits in NATURE GENETICS
  • 2006-06. Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2017-03-27. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer in NATURE GENETICS
  • 2020-06-26. Genetic drug target validation using Mendelian randomisation in NATURE COMMUNICATIONS
  • 2020-09-17. Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer in CELL DEATH & DISEASE
  • 2014-01-29. Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects in BMC CANCER
  • 2006-10. Drugs, their targets and the nature and number of drug targets in NATURE REVIEWS DRUG DISCOVERY
  • 2018-02-19. CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer in MOLECULAR CANCER
  • 2018-08-09. Identification of nine new susceptibility loci for endometrial cancer in NATURE COMMUNICATIONS
  • 2018-06-11. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci in NATURE GENETICS
  • 2015-07-23. Biomarkers of Inflammation and Immune Function and Risk of Colorectal Cancer in CURRENT COLORECTAL CANCER REPORTS
  • 2020-09-07. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases in NATURE GENETICS
  • 2009-07-13. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion in NATURE CELL BIOLOGY
  • 2020-01-06. Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme in NPJ PRECISION ONCOLOGY
  • 2015-09-22. lnflammation-induced epigenetic switches in cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2020-05-18. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses in NATURE GENETICS
  • 2017-10-12. Genetic effects on gene expression across human tissues in NATURE
  • 2018-06-06. Genomic atlas of the human plasma proteome in NATURE
  • 2017-06-12. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes in NATURE GENETICS
  • 2009-07-14. Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer in BMC CANCER
  • Journal

    TITLE

    BMC Medicine

    ISSUE

    1

    VOLUME

    20

    Author Affiliations

  • Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
  • Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland
  • Clinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George’s, University of London, London, UK
  • Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
  • Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
  • Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
  • Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
  • Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
  • National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK
  • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
  • MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
  • Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
  • School of Biochemistry, University of Bristol, Bristol, UK
  • Health Data Research UK, London, UK
  • K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
  • Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
  • Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
  • Baylor College of Medicine, Texas, USA
  • Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
  • Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
  • Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
  • Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland
  • Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
  • Finnish Institute for Health and Welfare, Helsinki, Finland
  • Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
  • Institute of Biomedicine, University of Turku, Turku, Finland
  • Unit of Primary Care, Oulu University Hospital, Oulu, Finland
  • UK Dementia Research Institute at Imperial College London, London, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12916-021-02193-0

    DOI

    http://dx.doi.org/10.1186/s12916-021-02193-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1144561176

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35012533


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mendelian Randomization Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Meta-Analysis as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ovarian Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece", 
              "id": "http://www.grid.ac/institutes/grid.9594.1", 
              "name": [
                "Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouras", 
            "givenName": "Emmanouil", 
            "id": "sg:person.013743611175.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013743611175.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.10858.34", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
                "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland", 
                "Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karhunen", 
            "givenName": "Ville", 
            "id": "sg:person.015154651745.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015154651745.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George\u2019s, University of London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.4464.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
                "Novo Nordisk Research Centre Oxford, Old Road Campus, Oxford, UK", 
                "Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George\u2019s University Hospitals NHS Foundation Trust, London, UK", 
                "Clinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George\u2019s, University of London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gill", 
            "givenName": "Dipender", 
            "id": "sg:person.01221541237.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221541237.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore", 
              "id": "http://www.grid.ac/institutes/grid.452264.3", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
                "Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Jian", 
            "id": "sg:person.011470704047.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011470704047.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK", 
                "Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haycock", 
            "givenName": "Philip C.", 
            "id": "sg:person.0774615111.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774615111.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gunter", 
            "givenName": "Marc J.", 
            "id": "sg:person.015307142637.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johansson", 
            "givenName": "Mattias", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brennan", 
            "givenName": "Paul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Key", 
            "givenName": "Tim", 
            "id": "sg:person.010714076422.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK", 
                "Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lewis", 
            "givenName": "Sarah J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK", 
                "Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK", 
                "National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin", 
            "givenName": "Richard M.", 
            "id": "sg:person.0601161247.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601161247.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murphy", 
            "givenName": "Neil", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Platz", 
            "givenName": "Elizabeth A.", 
            "id": "sg:person.01155264157.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155264157.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Travis", 
            "givenName": "Ruth", 
            "id": "sg:person.0761344604.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761344604.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yarmolinsky", 
            "givenName": "James", 
            "id": "sg:person.012361217621.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012361217621.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zuber", 
            "givenName": "Verena", 
            "id": "sg:person.01207324316.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207324316.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Biochemistry, University of Bristol, Bristol, UK", 
              "id": "http://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "School of Biochemistry, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin", 
            "givenName": "Paul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Health Data Research UK, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.507332.0", 
              "name": [
                "Institute of Health Informatics, University College London, London, UK", 
                "Health Data Research UK, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katsoulis", 
            "givenName": "Michail", 
            "id": "sg:person.01016225525.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016225525.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Freisling", 
            "givenName": "Heinz", 
            "id": "sg:person.01027072723.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027072723.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway", 
              "id": "http://www.grid.ac/institutes/grid.5947.f", 
              "name": [
                "Department of Community Medicine, Faculty of Health Sciences, Arctic University of Norway, Troms\u00f8, Norway", 
                "K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "N\u00f8st", 
            "givenName": "Therese Haugdahl", 
            "id": "sg:person.0663744543.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663744543.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nutritional Science, University of Potsdam, Potsdam, Germany", 
              "id": "http://www.grid.ac/institutes/grid.11348.3f", 
              "name": [
                "Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutehtal, Germany", 
                "Institute of Nutritional Science, University of Potsdam, Potsdam, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schulze", 
            "givenName": "Matthias B.", 
            "id": "sg:person.01125230241.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125230241.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dossus", 
            "givenName": "Laure", 
            "id": "sg:person.01143450544.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dalla Lana School of Public Health, University of Toronto, Toronto, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health System, Toronto, Canada", 
                "Dalla Lana School of Public Health, University of Toronto, Toronto, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hung", 
            "givenName": "Rayjean J.", 
            "id": "sg:person.01014657100.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014657100.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Baylor College of Medicine, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amos", 
            "givenName": "Christopher I.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.452494.a", 
              "name": [
                "The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA", 
                "Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahola-Olli", 
            "givenName": "Ari", 
            "id": "sg:person.01207641006.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207641006.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palaniswamy", 
            "givenName": "Saranya", 
            "id": "sg:person.01134753455.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134753455.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.10858.34", 
              "name": [
                "Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e4nnikk\u00f6", 
            "givenName": "Minna", 
            "id": "sg:person.01044710762.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044710762.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.10858.34", 
              "name": [
                "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Auvinen", 
            "givenName": "Juha", 
            "id": "sg:person.01170527776.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170527776.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.10858.34", 
              "name": [
                "Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herzig", 
            "givenName": "Karl-Heinz", 
            "id": "sg:person.0736422041.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736422041.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.10858.34", 
              "name": [
                "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kein\u00e4nen-Kiukaanniemi", 
            "givenName": "Sirkka", 
            "id": "sg:person.01174025532.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174025532.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland", 
              "id": "http://www.grid.ac/institutes/grid.502801.e", 
              "name": [
                "Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lehtim\u00e4ki", 
            "givenName": "Terho", 
            "id": "sg:person.0654341265.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Finnish Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Finnish Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salomaa", 
            "givenName": "Veikko", 
            "id": "sg:person.01022740164.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.410552.7", 
              "name": [
                "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland", 
                "Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raitakari", 
            "givenName": "Olli", 
            "id": "sg:person.01267360065.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biomedicine, University of Turku, Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "MediCity Research Laboratory, University of Turku, Turku, Finland", 
                "Institute of Biomedicine, University of Turku, Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salmi", 
            "givenName": "Marko", 
            "id": "sg:person.01143473026.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143473026.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Biomedicine, University of Turku, Turku, Finland", 
              "id": "http://www.grid.ac/institutes/grid.1374.1", 
              "name": [
                "MediCity Research Laboratory, University of Turku, Turku, Finland", 
                "Institute of Biomedicine, University of Turku, Turku, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jalkanen", 
            "givenName": "Sirpa", 
            "id": "sg:person.0763611336.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763611336.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Primary Care, Oulu University Hospital, Oulu, Finland", 
              "id": "http://www.grid.ac/institutes/grid.412326.0", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
                "Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland", 
                "Unit of Primary Care, Oulu University Hospital, Oulu, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jarvelin", 
            "givenName": "Marjo-Riitta", 
            "id": "sg:person.015301404517.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015301404517.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UK Dementia Research Institute at Imperial College London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
                "Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK", 
                "UK Dementia Research Institute at Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dehghan", 
            "givenName": "Abbas", 
            "id": "sg:person.01333534554.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333534554.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece", 
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary\u2019s Campus, W2 1PG, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsilidis", 
            "givenName": "Konstantinos K.", 
            "id": "sg:person.01311243771.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311243771.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrd2132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027454893", 
              "https://doi.org/10.1038/nrd2132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-020-16969-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1128766997", 
              "https://doi.org/10.1038/s41467-020-16969-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11888-015-0282-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036357529", 
              "https://doi.org/10.1007/s11888-015-0282-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008470674", 
              "https://doi.org/10.1038/ncb1909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085984210", 
              "https://doi.org/10.1038/ng.3892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0175-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104306669", 
              "https://doi.org/10.1038/s41586-018-0175-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031947374", 
              "https://doi.org/10.1038/ng.3570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-015-2045-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052996789", 
              "https://doi.org/10.1007/s00018-015-2045-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-05427-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105993563", 
              "https://doi.org/10.1038/s41467-018-05427-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129162", 
              "https://doi.org/10.1038/ng.3826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-9-230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000141217", 
              "https://doi.org/10.1186/1471-2407-9-230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41698-020-00131-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130476805", 
              "https://doi.org/10.1038/s41698-020-00131-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42255-020-00287-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1131771940", 
              "https://doi.org/10.1038/s42255-020-00287-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006206828", 
              "https://doi.org/10.1186/1471-2407-14-48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-020-0609-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127687077", 
              "https://doi.org/10.1038/s41588-020-0609-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-4-48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017282335", 
              "https://doi.org/10.1186/1479-5876-4-48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-020-0682-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130642727", 
              "https://doi.org/10.1038/s41588-020-0682-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0142-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104478461", 
              "https://doi.org/10.1038/s41588-018-0142-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41698-019-0106-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123827222", 
              "https://doi.org/10.1038/s41698-019-0106-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-020-02992-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1130896903", 
              "https://doi.org/10.1038/s41419-020-02992-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092152730", 
              "https://doi.org/10.1038/nature24277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-018-0787-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101066788", 
              "https://doi.org/10.1186/s12943-018-0787-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-01-11", 
        "datePublishedReg": "2022-01-11", 
        "description": "BackgroundEpidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis.MethodsUp to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer).ResultsThere was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses.ConclusionsOur study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12916-021-02193-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5050517", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7147305", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8531082", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4293719", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7879493", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6504068", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8964467", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9521295", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4246589", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2774591", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9959093", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8840422", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5050691", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.9425823", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3804705", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705367", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7085434", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1032885", 
            "issn": [
              "1741-7015"
            ], 
            "name": "BMC Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "keywords": [
          "endometrial cancer", 
          "lung cancer", 
          "cancer etiology", 
          "two-sample Mendelian randomisation analysis", 
          "interleukin-1 receptor antagonist", 
          "macrophage migration inhibitory factor", 
          "specific inflammatory biomarkers", 
          "cutaneous T-cell", 
          "single nucleotide polymorphisms", 
          "migration inhibitory factor", 
          "false discovery rate correction", 
          "Mendelian randomisation analysis", 
          "genome-wide association studies", 
          "Mendelian randomization analysis", 
          "lifestyle targets", 
          "inflammatory biomarkers", 
          "interleukin-18", 
          "chronic inflammation", 
          "inflammatory cytokines", 
          "cancer outcomes", 
          "receptor antagonist", 
          "inverse association", 
          "ovarian cancer", 
          "breast cancer", 
          "T cells", 
          "cancer prevention", 
          "gamma interferon", 
          "primary analysis", 
          "cytokines", 
          "inhibitory factor", 
          "ConclusionsOur study", 
          "cancer", 
          "cancer development", 
          "biomarker pathways", 
          "randomisation analysis", 
          "randomization analysis", 
          "European descent", 
          "positive association", 
          "etiology", 
          "multiple comparisons", 
          "further validation", 
          "association", 
          "rate correction", 
          "current knowledge", 
          "colocalization analysis", 
          "nucleotide polymorphisms", 
          "MR assumptions", 
          "summary data", 
          "association studies", 
          "inflammation", 
          "RANTES", 
          "chemokines", 
          "ResultsThere", 
          "monokine", 
          "antagonist", 
          "interferon", 
          "subtypes", 
          "pharmacological", 
          "MethodsUp", 
          "biomarkers", 
          "prevention", 
          "evidence", 
          "outcomes", 
          "risk", 
          "study", 
          "polymorphism", 
          "MR", 
          "pathway", 
          "individuals", 
          "GWAS summary data", 
          "analysis", 
          "target", 
          "experimental evidence", 
          "factors", 
          "sensitivity analysis", 
          "genes", 
          "role", 
          "sensitivity", 
          "concentration", 
          "instrumental variables", 
          "data", 
          "development", 
          "descent", 
          "variables", 
          "knowledge", 
          "correction", 
          "bias", 
          "potential", 
          "comparison", 
          "validation", 
          "order", 
          "assumption"
        ], 
        "name": "Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis", 
        "pagination": "3", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1144561176"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12916-021-02193-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35012533"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12916-021-02193-0", 
          "https://app.dimensions.ai/details/publication/pub.1144561176"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_920.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12916-021-02193-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-021-02193-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-021-02193-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-021-02193-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-021-02193-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    659 TRIPLES      21 PREDICATES      149 URIs      119 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12916-021-02193-0 schema:about N15198a51bb14417eaea322733d5a3c72
    2 N306b4b0ca3fd4ab9a992e7f68d5ed5af
    3 N5394c267189e4450addf63e7b8da80bc
    4 N6bd3c5cc08024f5290419f5aeee0d3a8
    5 N70e600baa2ec45109e6af405b051fe56
    6 N9576983097f440ef92542fc2038468e1
    7 Na08d18fb51d34d3fb92aa0a277d88253
    8 Nab4f7ff537064981a0d70a23ab98d4cf
    9 Nb4042da752454fc09539e6de552734df
    10 Nb64e54de5f6048adb4dcdac437c4d53e
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author N326b51190e00452498a02dbc64021e2a
    14 schema:citation sg:pub.10.1007/s00018-015-2045-5
    15 sg:pub.10.1007/s11888-015-0282-5
    16 sg:pub.10.1038/nature24277
    17 sg:pub.10.1038/ncb1909
    18 sg:pub.10.1038/ng.3570
    19 sg:pub.10.1038/ng.3826
    20 sg:pub.10.1038/ng.3892
    21 sg:pub.10.1038/nrd2132
    22 sg:pub.10.1038/s41419-020-02992-y
    23 sg:pub.10.1038/s41467-018-05427-7
    24 sg:pub.10.1038/s41467-020-16969-0
    25 sg:pub.10.1038/s41586-018-0175-2
    26 sg:pub.10.1038/s41588-018-0142-8
    27 sg:pub.10.1038/s41588-020-0609-2
    28 sg:pub.10.1038/s41588-020-0682-6
    29 sg:pub.10.1038/s41698-019-0106-1
    30 sg:pub.10.1038/s41698-020-00131-6
    31 sg:pub.10.1038/s42255-020-00287-2
    32 sg:pub.10.1186/1471-2407-14-48
    33 sg:pub.10.1186/1471-2407-9-230
    34 sg:pub.10.1186/1479-5876-4-48
    35 sg:pub.10.1186/s12943-018-0787-z
    36 schema:datePublished 2022-01-11
    37 schema:datePublishedReg 2022-01-11
    38 schema:description BackgroundEpidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis.MethodsUp to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer).ResultsThere was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses.ConclusionsOur study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention.
    39 schema:genre article
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N0402d9f1614b45288a1b440a90720bce
    42 N2cb8eb295523457c8c0d7ee5a1c7f018
    43 sg:journal.1032885
    44 schema:keywords ConclusionsOur study
    45 European descent
    46 GWAS summary data
    47 MR
    48 MR assumptions
    49 Mendelian randomisation analysis
    50 Mendelian randomization analysis
    51 MethodsUp
    52 RANTES
    53 ResultsThere
    54 T cells
    55 analysis
    56 antagonist
    57 association
    58 association studies
    59 assumption
    60 bias
    61 biomarker pathways
    62 biomarkers
    63 breast cancer
    64 cancer
    65 cancer development
    66 cancer etiology
    67 cancer outcomes
    68 cancer prevention
    69 chemokines
    70 chronic inflammation
    71 colocalization analysis
    72 comparison
    73 concentration
    74 correction
    75 current knowledge
    76 cutaneous T-cell
    77 cytokines
    78 data
    79 descent
    80 development
    81 endometrial cancer
    82 etiology
    83 evidence
    84 experimental evidence
    85 factors
    86 false discovery rate correction
    87 further validation
    88 gamma interferon
    89 genes
    90 genome-wide association studies
    91 individuals
    92 inflammation
    93 inflammatory biomarkers
    94 inflammatory cytokines
    95 inhibitory factor
    96 instrumental variables
    97 interferon
    98 interleukin-1 receptor antagonist
    99 interleukin-18
    100 inverse association
    101 knowledge
    102 lifestyle targets
    103 lung cancer
    104 macrophage migration inhibitory factor
    105 migration inhibitory factor
    106 monokine
    107 multiple comparisons
    108 nucleotide polymorphisms
    109 order
    110 outcomes
    111 ovarian cancer
    112 pathway
    113 pharmacological
    114 polymorphism
    115 positive association
    116 potential
    117 prevention
    118 primary analysis
    119 randomisation analysis
    120 randomization analysis
    121 rate correction
    122 receptor antagonist
    123 risk
    124 role
    125 sensitivity
    126 sensitivity analysis
    127 single nucleotide polymorphisms
    128 specific inflammatory biomarkers
    129 study
    130 subtypes
    131 summary data
    132 target
    133 two-sample Mendelian randomisation analysis
    134 validation
    135 variables
    136 schema:name Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
    137 schema:pagination 3
    138 schema:productId N22f2c1d3f2f0421aafe7a37a070ffd15
    139 N542872ea7b2449f7b5a5479d7891f951
    140 N5c4baa48b3854b45885993bff7f7e087
    141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1144561176
    142 https://doi.org/10.1186/s12916-021-02193-0
    143 schema:sdDatePublished 2022-11-24T21:08
    144 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    145 schema:sdPublisher N34f5660796e3404588b30f698afddf2b
    146 schema:url https://doi.org/10.1186/s12916-021-02193-0
    147 sgo:license sg:explorer/license/
    148 sgo:sdDataset articles
    149 rdf:type schema:ScholarlyArticle
    150 N0402d9f1614b45288a1b440a90720bce schema:volumeNumber 20
    151 rdf:type schema:PublicationVolume
    152 N06cf800d93cb420590ece1a6939c1968 schema:affiliation grid-institutes:grid.5337.2
    153 schema:familyName Lewis
    154 schema:givenName Sarah J.
    155 rdf:type schema:Person
    156 N0dccfaba8a12469b9005e1b7d81aabe4 rdf:first N0e988b438a464d8cb8c7f845a03f3080
    157 rdf:rest Nd11a1f9710fd430cae975ae262e243e7
    158 N0e988b438a464d8cb8c7f845a03f3080 schema:affiliation grid-institutes:grid.17703.32
    159 schema:familyName Brennan
    160 schema:givenName Paul
    161 rdf:type schema:Person
    162 N15198a51bb14417eaea322733d5a3c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Polymorphism, Single Nucleotide
    164 rdf:type schema:DefinedTerm
    165 N1bc52558e218417ca9bae9da6b054a9f schema:affiliation grid-institutes:grid.17703.32
    166 schema:familyName Johansson
    167 schema:givenName Mattias
    168 rdf:type schema:Person
    169 N1d22afe136124aed9ad9083031d1c179 schema:affiliation grid-institutes:grid.5337.2
    170 schema:familyName Martin
    171 schema:givenName Paul
    172 rdf:type schema:Person
    173 N22f2c1d3f2f0421aafe7a37a070ffd15 schema:name doi
    174 schema:value 10.1186/s12916-021-02193-0
    175 rdf:type schema:PropertyValue
    176 N27e513520c3144bcb31821de331e529a rdf:first Nf72840fdb0bd45d083666054ac88ade6
    177 rdf:rest N90b696836bfc4f28bd968e8bca2f1760
    178 N2cb8eb295523457c8c0d7ee5a1c7f018 schema:issueNumber 1
    179 rdf:type schema:PublicationIssue
    180 N2e6ff48536c64bc6a3add7b8e66946bf rdf:first sg:person.011470704047.81
    181 rdf:rest Na3b591933af44b6eb1de5eff0ee9bba0
    182 N306b4b0ca3fd4ab9a992e7f68d5ed5af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Ovarian Neoplasms
    184 rdf:type schema:DefinedTerm
    185 N326b51190e00452498a02dbc64021e2a rdf:first sg:person.013743611175.64
    186 rdf:rest Nc1a24be741144ec8a38f89d85836b1a1
    187 N34f5660796e3404588b30f698afddf2b schema:name Springer Nature - SN SciGraph project
    188 rdf:type schema:Organization
    189 N49c2996227ee4d7eb32ea3968de9e9e9 rdf:first N1d22afe136124aed9ad9083031d1c179
    190 rdf:rest N8c7c5a5493144a38883347c0d049faba
    191 N5394c267189e4450addf63e7b8da80bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Risk Factors
    193 rdf:type schema:DefinedTerm
    194 N542872ea7b2449f7b5a5479d7891f951 schema:name pubmed_id
    195 schema:value 35012533
    196 rdf:type schema:PropertyValue
    197 N5a1c16c99f0f4b78b7d4e5212e14890f schema:affiliation grid-institutes:grid.39382.33
    198 schema:familyName Amos
    199 schema:givenName Christopher I.
    200 rdf:type schema:Person
    201 N5c4baa48b3854b45885993bff7f7e087 schema:name dimensions_id
    202 schema:value pub.1144561176
    203 rdf:type schema:PropertyValue
    204 N61a053fc63a84a458721948feb036fd1 rdf:first N1bc52558e218417ca9bae9da6b054a9f
    205 rdf:rest N0dccfaba8a12469b9005e1b7d81aabe4
    206 N643c04044e424e7fa4ff051ec3ee3828 rdf:first sg:person.0761344604.66
    207 rdf:rest Na062d03ea74043c5bb110de47e17cdbc
    208 N6bd3c5cc08024f5290419f5aeee0d3a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Meta-Analysis as Topic
    210 rdf:type schema:DefinedTerm
    211 N6e5c9ee2d1214e0baefa1ce0d15c5e6f rdf:first N5a1c16c99f0f4b78b7d4e5212e14890f
    212 rdf:rest Na3b7dbfa15ec4e478816b22f2bd14e91
    213 N70e600baa2ec45109e6af405b051fe56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Genome-Wide Association Study
    215 rdf:type schema:DefinedTerm
    216 N85d601401d60454e980556c5c721dadf rdf:first sg:person.01221541237.33
    217 rdf:rest N2e6ff48536c64bc6a3add7b8e66946bf
    218 N8851f2949ab84feaa4f22b96fc41f840 rdf:first sg:person.01143473026.43
    219 rdf:rest Na348bd7df29d4e5abca6e6d1c89db023
    220 N885feecf04c44618be329567505cd7c3 rdf:first sg:person.01125230241.05
    221 rdf:rest N9198ad479cdf4b2ab0830b2e6a5f2497
    222 N8adec2770a3b478e9c321aace3f4aa0b rdf:first sg:person.015301404517.88
    223 rdf:rest N94a85495684547a1ae2f7ce2cb049d5b
    224 N8c7c5a5493144a38883347c0d049faba rdf:first sg:person.01016225525.25
    225 rdf:rest Nfcb730f1dd934d12b060194840c42034
    226 N90b696836bfc4f28bd968e8bca2f1760 rdf:first sg:person.01155264157.72
    227 rdf:rest N643c04044e424e7fa4ff051ec3ee3828
    228 N9198ad479cdf4b2ab0830b2e6a5f2497 rdf:first sg:person.01143450544.32
    229 rdf:rest Nd54a7ba0e96a4726821824bac1ed6080
    230 N94a85495684547a1ae2f7ce2cb049d5b rdf:first sg:person.01333534554.85
    231 rdf:rest Nc7fa83c3d22241e5ba078cd650366b15
    232 N94ccf33841b148e7b7d6b762f54a69b2 rdf:first sg:person.015307142637.30
    233 rdf:rest N61a053fc63a84a458721948feb036fd1
    234 N9576983097f440ef92542fc2038468e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Mendelian Randomization Analysis
    236 rdf:type schema:DefinedTerm
    237 N9b4f6c41ab0b43cfbacda0abec424ac2 rdf:first sg:person.01022740164.96
    238 rdf:rest Nc8c7fb80897a46d4b1fd8f602baa25e5
    239 Na062d03ea74043c5bb110de47e17cdbc rdf:first sg:person.012361217621.88
    240 rdf:rest Nff70579facf940fda71b1cfe70bbbc10
    241 Na08d18fb51d34d3fb92aa0a277d88253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Male
    243 rdf:type schema:DefinedTerm
    244 Na2e35909dc9a41eab0f585e0a1730504 rdf:first sg:person.0654341265.88
    245 rdf:rest N9b4f6c41ab0b43cfbacda0abec424ac2
    246 Na348bd7df29d4e5abca6e6d1c89db023 rdf:first sg:person.0763611336.50
    247 rdf:rest N8adec2770a3b478e9c321aace3f4aa0b
    248 Na3b591933af44b6eb1de5eff0ee9bba0 rdf:first sg:person.0774615111.82
    249 rdf:rest N94ccf33841b148e7b7d6b762f54a69b2
    250 Na3b7dbfa15ec4e478816b22f2bd14e91 rdf:first sg:person.01207641006.00
    251 rdf:rest Nbf71cf5f0fba4bb2a70bd7f633190738
    252 Nab4f7ff537064981a0d70a23ab98d4cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Female
    254 rdf:type schema:DefinedTerm
    255 Nb4042da752454fc09539e6de552734df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Humans
    257 rdf:type schema:DefinedTerm
    258 Nb64e54de5f6048adb4dcdac437c4d53e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Cytokines
    260 rdf:type schema:DefinedTerm
    261 Nbacff9084b8e46c785541b9f68c41635 rdf:first N06cf800d93cb420590ece1a6939c1968
    262 rdf:rest Nfd4aec49ad6840c0bda707173c0ed613
    263 Nbc4fc97ef40a44d891a806961d0ad77b rdf:first sg:person.0663744543.42
    264 rdf:rest N885feecf04c44618be329567505cd7c3
    265 Nbe823db80f204cdeb79700b288591cd5 rdf:first sg:person.01044710762.13
    266 rdf:rest Nf4e19285286f4ab8acb30a990b2e4ab5
    267 Nbf71cf5f0fba4bb2a70bd7f633190738 rdf:first sg:person.01134753455.33
    268 rdf:rest Nbe823db80f204cdeb79700b288591cd5
    269 Nc1a24be741144ec8a38f89d85836b1a1 rdf:first sg:person.015154651745.75
    270 rdf:rest N85d601401d60454e980556c5c721dadf
    271 Nc7fa83c3d22241e5ba078cd650366b15 rdf:first sg:person.01311243771.83
    272 rdf:rest rdf:nil
    273 Nc8c7fb80897a46d4b1fd8f602baa25e5 rdf:first sg:person.01267360065.55
    274 rdf:rest N8851f2949ab84feaa4f22b96fc41f840
    275 Nd11a1f9710fd430cae975ae262e243e7 rdf:first sg:person.010714076422.15
    276 rdf:rest Nbacff9084b8e46c785541b9f68c41635
    277 Nd54a7ba0e96a4726821824bac1ed6080 rdf:first sg:person.01014657100.55
    278 rdf:rest N6e5c9ee2d1214e0baefa1ce0d15c5e6f
    279 Nf21dc43224854572b692e05010ee6edc rdf:first sg:person.0736422041.58
    280 rdf:rest Nff58bae68cb949e3bc8f8cd72ae6d84a
    281 Nf4e19285286f4ab8acb30a990b2e4ab5 rdf:first sg:person.01170527776.64
    282 rdf:rest Nf21dc43224854572b692e05010ee6edc
    283 Nf72840fdb0bd45d083666054ac88ade6 schema:affiliation grid-institutes:grid.17703.32
    284 schema:familyName Murphy
    285 schema:givenName Neil
    286 rdf:type schema:Person
    287 Nfcb730f1dd934d12b060194840c42034 rdf:first sg:person.01027072723.97
    288 rdf:rest Nbc4fc97ef40a44d891a806961d0ad77b
    289 Nfd4aec49ad6840c0bda707173c0ed613 rdf:first sg:person.0601161247.00
    290 rdf:rest N27e513520c3144bcb31821de331e529a
    291 Nff58bae68cb949e3bc8f8cd72ae6d84a rdf:first sg:person.01174025532.44
    292 rdf:rest Na2e35909dc9a41eab0f585e0a1730504
    293 Nff70579facf940fda71b1cfe70bbbc10 rdf:first sg:person.01207324316.12
    294 rdf:rest N49c2996227ee4d7eb32ea3968de9e9e9
    295 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    296 schema:name Medical and Health Sciences
    297 rdf:type schema:DefinedTerm
    298 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    299 schema:name Oncology and Carcinogenesis
    300 rdf:type schema:DefinedTerm
    301 sg:grant.2705367 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    302 rdf:type schema:MonetaryGrant
    303 sg:grant.2774591 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    304 rdf:type schema:MonetaryGrant
    305 sg:grant.3804705 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    306 rdf:type schema:MonetaryGrant
    307 sg:grant.4246589 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    308 rdf:type schema:MonetaryGrant
    309 sg:grant.4293719 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    310 rdf:type schema:MonetaryGrant
    311 sg:grant.5050517 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    312 rdf:type schema:MonetaryGrant
    313 sg:grant.5050691 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    314 rdf:type schema:MonetaryGrant
    315 sg:grant.6504068 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    316 rdf:type schema:MonetaryGrant
    317 sg:grant.7085434 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    318 rdf:type schema:MonetaryGrant
    319 sg:grant.7147305 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    320 rdf:type schema:MonetaryGrant
    321 sg:grant.7879493 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    322 rdf:type schema:MonetaryGrant
    323 sg:grant.8531082 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    324 rdf:type schema:MonetaryGrant
    325 sg:grant.8840422 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    326 rdf:type schema:MonetaryGrant
    327 sg:grant.8964467 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    328 rdf:type schema:MonetaryGrant
    329 sg:grant.9425823 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    330 rdf:type schema:MonetaryGrant
    331 sg:grant.9521295 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    332 rdf:type schema:MonetaryGrant
    333 sg:grant.9959093 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-021-02193-0
    334 rdf:type schema:MonetaryGrant
    335 sg:journal.1032885 schema:issn 1741-7015
    336 schema:name BMC Medicine
    337 schema:publisher Springer Nature
    338 rdf:type schema:Periodical
    339 sg:person.01014657100.55 schema:affiliation grid-institutes:grid.17063.33
    340 schema:familyName Hung
    341 schema:givenName Rayjean J.
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014657100.55
    343 rdf:type schema:Person
    344 sg:person.01016225525.25 schema:affiliation grid-institutes:grid.507332.0
    345 schema:familyName Katsoulis
    346 schema:givenName Michail
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016225525.25
    348 rdf:type schema:Person
    349 sg:person.01022740164.96 schema:affiliation grid-institutes:grid.14758.3f
    350 schema:familyName Salomaa
    351 schema:givenName Veikko
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022740164.96
    353 rdf:type schema:Person
    354 sg:person.01027072723.97 schema:affiliation grid-institutes:grid.17703.32
    355 schema:familyName Freisling
    356 schema:givenName Heinz
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027072723.97
    358 rdf:type schema:Person
    359 sg:person.01044710762.13 schema:affiliation grid-institutes:grid.10858.34
    360 schema:familyName Männikkö
    361 schema:givenName Minna
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044710762.13
    363 rdf:type schema:Person
    364 sg:person.010714076422.15 schema:affiliation grid-institutes:grid.4991.5
    365 schema:familyName Key
    366 schema:givenName Tim
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15
    368 rdf:type schema:Person
    369 sg:person.01125230241.05 schema:affiliation grid-institutes:grid.11348.3f
    370 schema:familyName Schulze
    371 schema:givenName Matthias B.
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125230241.05
    373 rdf:type schema:Person
    374 sg:person.01134753455.33 schema:affiliation grid-institutes:grid.7445.2
    375 schema:familyName Palaniswamy
    376 schema:givenName Saranya
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134753455.33
    378 rdf:type schema:Person
    379 sg:person.01143450544.32 schema:affiliation grid-institutes:grid.17703.32
    380 schema:familyName Dossus
    381 schema:givenName Laure
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32
    383 rdf:type schema:Person
    384 sg:person.01143473026.43 schema:affiliation grid-institutes:grid.1374.1
    385 schema:familyName Salmi
    386 schema:givenName Marko
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143473026.43
    388 rdf:type schema:Person
    389 sg:person.011470704047.81 schema:affiliation grid-institutes:grid.452264.3
    390 schema:familyName Huang
    391 schema:givenName Jian
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011470704047.81
    393 rdf:type schema:Person
    394 sg:person.01155264157.72 schema:affiliation grid-institutes:grid.21107.35
    395 schema:familyName Platz
    396 schema:givenName Elizabeth A.
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155264157.72
    398 rdf:type schema:Person
    399 sg:person.01170527776.64 schema:affiliation grid-institutes:grid.10858.34
    400 schema:familyName Auvinen
    401 schema:givenName Juha
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170527776.64
    403 rdf:type schema:Person
    404 sg:person.01174025532.44 schema:affiliation grid-institutes:grid.10858.34
    405 schema:familyName Keinänen-Kiukaanniemi
    406 schema:givenName Sirkka
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174025532.44
    408 rdf:type schema:Person
    409 sg:person.01207324316.12 schema:affiliation grid-institutes:grid.7445.2
    410 schema:familyName Zuber
    411 schema:givenName Verena
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207324316.12
    413 rdf:type schema:Person
    414 sg:person.01207641006.00 schema:affiliation grid-institutes:grid.452494.a
    415 schema:familyName Ahola-Olli
    416 schema:givenName Ari
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207641006.00
    418 rdf:type schema:Person
    419 sg:person.01221541237.33 schema:affiliation grid-institutes:grid.4464.2
    420 schema:familyName Gill
    421 schema:givenName Dipender
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221541237.33
    423 rdf:type schema:Person
    424 sg:person.012361217621.88 schema:affiliation grid-institutes:grid.5337.2
    425 schema:familyName Yarmolinsky
    426 schema:givenName James
    427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012361217621.88
    428 rdf:type schema:Person
    429 sg:person.01267360065.55 schema:affiliation grid-institutes:grid.410552.7
    430 schema:familyName Raitakari
    431 schema:givenName Olli
    432 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55
    433 rdf:type schema:Person
    434 sg:person.01311243771.83 schema:affiliation grid-institutes:grid.7445.2
    435 schema:familyName Tsilidis
    436 schema:givenName Konstantinos K.
    437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311243771.83
    438 rdf:type schema:Person
    439 sg:person.01333534554.85 schema:affiliation grid-institutes:grid.7445.2
    440 schema:familyName Dehghan
    441 schema:givenName Abbas
    442 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333534554.85
    443 rdf:type schema:Person
    444 sg:person.013743611175.64 schema:affiliation grid-institutes:grid.9594.1
    445 schema:familyName Bouras
    446 schema:givenName Emmanouil
    447 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013743611175.64
    448 rdf:type schema:Person
    449 sg:person.015154651745.75 schema:affiliation grid-institutes:grid.10858.34
    450 schema:familyName Karhunen
    451 schema:givenName Ville
    452 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015154651745.75
    453 rdf:type schema:Person
    454 sg:person.015301404517.88 schema:affiliation grid-institutes:grid.412326.0
    455 schema:familyName Jarvelin
    456 schema:givenName Marjo-Riitta
    457 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015301404517.88
    458 rdf:type schema:Person
    459 sg:person.015307142637.30 schema:affiliation grid-institutes:grid.17703.32
    460 schema:familyName Gunter
    461 schema:givenName Marc J.
    462 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30
    463 rdf:type schema:Person
    464 sg:person.0601161247.00 schema:affiliation grid-institutes:grid.5337.2
    465 schema:familyName Martin
    466 schema:givenName Richard M.
    467 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601161247.00
    468 rdf:type schema:Person
    469 sg:person.0654341265.88 schema:affiliation grid-institutes:grid.502801.e
    470 schema:familyName Lehtimäki
    471 schema:givenName Terho
    472 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88
    473 rdf:type schema:Person
    474 sg:person.0663744543.42 schema:affiliation grid-institutes:grid.5947.f
    475 schema:familyName Nøst
    476 schema:givenName Therese Haugdahl
    477 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663744543.42
    478 rdf:type schema:Person
    479 sg:person.0736422041.58 schema:affiliation grid-institutes:grid.10858.34
    480 schema:familyName Herzig
    481 schema:givenName Karl-Heinz
    482 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736422041.58
    483 rdf:type schema:Person
    484 sg:person.0761344604.66 schema:affiliation grid-institutes:grid.4991.5
    485 schema:familyName Travis
    486 schema:givenName Ruth
    487 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761344604.66
    488 rdf:type schema:Person
    489 sg:person.0763611336.50 schema:affiliation grid-institutes:grid.1374.1
    490 schema:familyName Jalkanen
    491 schema:givenName Sirpa
    492 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763611336.50
    493 rdf:type schema:Person
    494 sg:person.0774615111.82 schema:affiliation grid-institutes:grid.5337.2
    495 schema:familyName Haycock
    496 schema:givenName Philip C.
    497 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774615111.82
    498 rdf:type schema:Person
    499 sg:pub.10.1007/s00018-015-2045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052996789
    500 https://doi.org/10.1007/s00018-015-2045-5
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1007/s11888-015-0282-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036357529
    503 https://doi.org/10.1007/s11888-015-0282-5
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/nature24277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092152730
    506 https://doi.org/10.1038/nature24277
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/ncb1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008470674
    509 https://doi.org/10.1038/ncb1909
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/ng.3570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031947374
    512 https://doi.org/10.1038/ng.3570
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/ng.3826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129162
    515 https://doi.org/10.1038/ng.3826
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/ng.3892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085984210
    518 https://doi.org/10.1038/ng.3892
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/nrd2132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027454893
    521 https://doi.org/10.1038/nrd2132
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/s41419-020-02992-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1130896903
    524 https://doi.org/10.1038/s41419-020-02992-y
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/s41467-018-05427-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105993563
    527 https://doi.org/10.1038/s41467-018-05427-7
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/s41467-020-16969-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128766997
    530 https://doi.org/10.1038/s41467-020-16969-0
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1038/s41586-018-0175-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104306669
    533 https://doi.org/10.1038/s41586-018-0175-2
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1038/s41588-018-0142-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104478461
    536 https://doi.org/10.1038/s41588-018-0142-8
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1038/s41588-020-0609-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127687077
    539 https://doi.org/10.1038/s41588-020-0609-2
    540 rdf:type schema:CreativeWork
    541 sg:pub.10.1038/s41588-020-0682-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130642727
    542 https://doi.org/10.1038/s41588-020-0682-6
    543 rdf:type schema:CreativeWork
    544 sg:pub.10.1038/s41698-019-0106-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123827222
    545 https://doi.org/10.1038/s41698-019-0106-1
    546 rdf:type schema:CreativeWork
    547 sg:pub.10.1038/s41698-020-00131-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130476805
    548 https://doi.org/10.1038/s41698-020-00131-6
    549 rdf:type schema:CreativeWork
    550 sg:pub.10.1038/s42255-020-00287-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131771940
    551 https://doi.org/10.1038/s42255-020-00287-2
    552 rdf:type schema:CreativeWork
    553 sg:pub.10.1186/1471-2407-14-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006206828
    554 https://doi.org/10.1186/1471-2407-14-48
    555 rdf:type schema:CreativeWork
    556 sg:pub.10.1186/1471-2407-9-230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000141217
    557 https://doi.org/10.1186/1471-2407-9-230
    558 rdf:type schema:CreativeWork
    559 sg:pub.10.1186/1479-5876-4-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017282335
    560 https://doi.org/10.1186/1479-5876-4-48
    561 rdf:type schema:CreativeWork
    562 sg:pub.10.1186/s12943-018-0787-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101066788
    563 https://doi.org/10.1186/s12943-018-0787-z
    564 rdf:type schema:CreativeWork
    565 grid-institutes:grid.10858.34 schema:alternateName Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
    566 Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
    567 Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland
    568 Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland
    569 schema:name Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
    570 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    571 Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland
    572 Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland
    573 Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland
    574 rdf:type schema:Organization
    575 grid-institutes:grid.11348.3f schema:alternateName Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    576 schema:name Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutehtal, Germany
    577 Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    578 rdf:type schema:Organization
    579 grid-institutes:grid.1374.1 schema:alternateName Institute of Biomedicine, University of Turku, Turku, Finland
    580 schema:name Institute of Biomedicine, University of Turku, Turku, Finland
    581 MediCity Research Laboratory, University of Turku, Turku, Finland
    582 rdf:type schema:Organization
    583 grid-institutes:grid.14758.3f schema:alternateName Finnish Institute for Health and Welfare, Helsinki, Finland
    584 schema:name Finnish Institute for Health and Welfare, Helsinki, Finland
    585 rdf:type schema:Organization
    586 grid-institutes:grid.17063.33 schema:alternateName Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    587 schema:name Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    588 Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health System, Toronto, Canada
    589 rdf:type schema:Organization
    590 grid-institutes:grid.17703.32 schema:alternateName Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
    591 Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
    592 schema:name Genomics Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
    593 Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
    594 rdf:type schema:Organization
    595 grid-institutes:grid.21107.35 schema:alternateName Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    596 schema:name Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    597 rdf:type schema:Organization
    598 grid-institutes:grid.39382.33 schema:alternateName Baylor College of Medicine, Texas, USA
    599 schema:name Baylor College of Medicine, Texas, USA
    600 rdf:type schema:Organization
    601 grid-institutes:grid.410552.7 schema:alternateName Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    602 schema:name Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    603 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    604 rdf:type schema:Organization
    605 grid-institutes:grid.412326.0 schema:alternateName Unit of Primary Care, Oulu University Hospital, Oulu, Finland
    606 schema:name Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
    607 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    608 Unit of Primary Care, Oulu University Hospital, Oulu, Finland
    609 rdf:type schema:Organization
    610 grid-institutes:grid.4464.2 schema:alternateName Clinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George’s, University of London, London, UK
    611 schema:name Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George’s University Hospitals NHS Foundation Trust, London, UK
    612 Clinical Pharmacology and Therapeutics Section, Institute for Infection and Immunity, St George’s, University of London, London, UK
    613 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    614 Novo Nordisk Research Centre Oxford, Old Road Campus, Oxford, UK
    615 rdf:type schema:Organization
    616 grid-institutes:grid.452264.3 schema:alternateName Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
    617 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    618 Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
    619 rdf:type schema:Organization
    620 grid-institutes:grid.452494.a schema:alternateName Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    621 schema:name Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
    622 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
    623 The Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    624 rdf:type schema:Organization
    625 grid-institutes:grid.4991.5 schema:alternateName Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
    626 schema:name Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
    627 rdf:type schema:Organization
    628 grid-institutes:grid.502801.e schema:alternateName Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
    629 schema:name Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
    630 rdf:type schema:Organization
    631 grid-institutes:grid.507332.0 schema:alternateName Health Data Research UK, London, UK
    632 schema:name Health Data Research UK, London, UK
    633 Institute of Health Informatics, University College London, London, UK
    634 rdf:type schema:Organization
    635 grid-institutes:grid.5337.2 schema:alternateName Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
    636 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
    637 National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK
    638 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
    639 School of Biochemistry, University of Bristol, Bristol, UK
    640 schema:name Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
    641 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
    642 National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK
    643 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
    644 School of Biochemistry, University of Bristol, Bristol, UK
    645 rdf:type schema:Organization
    646 grid-institutes:grid.5947.f schema:alternateName K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
    647 schema:name Department of Community Medicine, Faculty of Health Sciences, Arctic University of Norway, Tromsø, Norway
    648 K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway
    649 rdf:type schema:Organization
    650 grid-institutes:grid.7445.2 schema:alternateName Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    651 UK Dementia Research Institute at Imperial College London, London, UK
    652 schema:name Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
    653 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary’s Campus, W2 1PG, London, UK
    654 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    655 UK Dementia Research Institute at Imperial College London, London, UK
    656 rdf:type schema:Organization
    657 grid-institutes:grid.9594.1 schema:alternateName Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    658 schema:name Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    659 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...