A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean

ABSTRACT

BACKGROUND: A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression: N-acetylcysteine (NAC) and NAC with a combination of nutraceutical agents that may increase mitochondrial biogenesis. METHODS: A three-arm 16-week, double-blind, randomised, placebo-controlled trial, adjunctive to usual treatment, was conducted. Participants (n = 181) with bipolar disorder and current depressive symptoms were randomised to 2000 mg/day NAC (n = 59), 2000 mg/day NAC with the combination nutraceutical treatment (CT, n = 61), or placebo (n = 61). The primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) total score from baseline to week 16. Young Mania Rating Scale, Clinical Global Impression (CGI)-Improvement and CGI-Severity scales, Patient Global Impression scale, Social and Occupational Functioning Assessment Scale (SOFAS), Longitudinal Interval Follow-Up Evaluation - Range of Impaired Functioning Tool (LIFE-RIFT), and Quality of Life Enjoyment, and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) were secondary outcomes. RESULTS: One hundred forty-eight participants had post-randomisation data and were analysed (NAC = 52, CT = 47, Placebo = 49). No between-group differences were found for the rate of change between baseline and 16 weeks on any of the clinical and functioning variables. Improvements in MADRS, BDRS, SOFAS, and LIFE-RIFT scores from baseline to the week 20 post-discontinuation visit were significantly greater in the CT group compared to those in the placebo. At week 20, the CGI-I was significantly lower in the CT group versus placebo. Gastrointestinal symptoms were significantly greater in the NAC than in the placebo group. CONCLUSIONS: These overall negative results, with no significant differences between groups detected at the primary outcome but some positive secondary signals, suggest either delayed benefit of the combination or an improvement of symptoms on withdrawal which warrants further exploration regarding the composition, mechanisms, and application of mitochondrial agents in illnesses characterised by mitochondrial dysfunction. TRIAL REGISTRATION: ANZCTR ( ACTRN12612000830897 ). More... »

PAGES

18

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12916-019-1257-1

DOI

http://dx.doi.org/10.1186/s12916-019-1257-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111662774

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30678686


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Orygen", 
          "id": "https://www.grid.ac/institutes/grid.488501.0", 
          "name": [
            "IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia", 
            "Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia", 
            "Florey Institute for Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, VIC, Australia", 
            "Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berk", 
        "givenName": "Michael", 
        "id": "sg:person.01257261765.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257261765.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia", 
            "Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia", 
            "School of Medicine and Public Health, Faculty of Health and Medicine, the University of Newcastle, Callaghan, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Alyna", 
        "id": "sg:person.0766431042.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766431042.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia", 
            "Academic Department of Psychiatry, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia", 
            "ARCHI, Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malhi", 
        "givenName": "Gin S.", 
        "id": "sg:person.0631757532.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631757532.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Chee H.", 
        "id": "sg:person.01121236011.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121236011.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia", 
            "Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Rd, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cotton", 
        "givenName": "Susan M.", 
        "id": "sg:person.01255032772.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255032772.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia", 
            "Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia", 
            "Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Rd, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dodd", 
        "givenName": "Seetal", 
        "id": "sg:person.01354075132.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354075132.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samuni", 
        "givenName": "Yuval", 
        "id": "sg:person.01063416075.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063416075.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanious", 
        "givenName": "Michelle", 
        "id": "sg:person.01275421041.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275421041.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal North Shore Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412703.3", 
          "name": [
            "CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McAulay", 
        "givenName": "Claire", 
        "id": "sg:person.01041143644.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041143644.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dowling", 
        "givenName": "Nathan", 
        "id": "sg:person.01346403526.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346403526.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Western Sydney University", 
          "id": "https://www.grid.ac/institutes/grid.1029.a", 
          "name": [
            "Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia", 
            "NICM, School of Health and Science, Western Sydney University, Campbelltown, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarris", 
        "givenName": "Jerome", 
        "id": "sg:person.01362145446.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362145446.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Central Lancashire", 
          "id": "https://www.grid.ac/institutes/grid.7943.9", 
          "name": [
            "School of Psychology, University of Central Lancashire, Preston, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Owen", 
        "givenName": "Lauren", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Melbourne Health", 
          "id": "https://www.grid.ac/institutes/grid.429299.d", 
          "name": [
            "Melbourne Health, 300 Grattan St, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waterdrinker", 
        "givenName": "Astrid", 
        "id": "sg:person.01141543633.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141543633.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Deidre", 
        "id": "sg:person.0747375650.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747375650.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia", 
            "Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia", 
            "Florey Institute for Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dean", 
        "givenName": "Olivia M.", 
        "id": "sg:person.0714233410.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714233410.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1590/1516-4446-2013-1341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002117599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0000000000000058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010042909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0000000000000058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010042909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2017.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014781167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2017.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014781167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2015.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018312802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-015-0310-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018347340", 
          "https://doi.org/10.1186/s12916-015-0310-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-015-0310-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018347340", 
          "https://doi.org/10.1186/s12916-015-0310-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023632175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023632175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035983268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037495157", 
          "https://doi.org/10.1038/nrn3229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0004867415585858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051311219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0004867415585858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051311219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2015.12.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053471822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.15m10239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072206630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.15r09984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072206673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2018.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101748509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2018.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101748509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2018.08.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106198685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2018.08.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106198685"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression: N-acetylcysteine (NAC) and NAC with a combination of nutraceutical agents that may increase mitochondrial biogenesis.\nMETHODS: A three-arm 16-week, double-blind, randomised, placebo-controlled trial, adjunctive to usual treatment, was conducted. Participants (n\u2009=\u2009181) with bipolar disorder and current depressive symptoms were randomised to 2000\u2009mg/day NAC (n\u2009=\u200959), 2000\u2009mg/day NAC with the combination nutraceutical treatment (CT, n\u2009=\u200961), or placebo (n\u2009=\u200961). The primary outcome was change in Montgomery-\u00c5sberg Depression Rating Scale (MADRS) total score from baseline to week 16. Young Mania Rating Scale, Clinical Global Impression (CGI)-Improvement and CGI-Severity scales, Patient Global Impression scale, Social and Occupational Functioning Assessment Scale (SOFAS), Longitudinal Interval Follow-Up Evaluation - Range of Impaired Functioning Tool (LIFE-RIFT), and Quality of Life Enjoyment, and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) were secondary outcomes.\nRESULTS: One hundred forty-eight participants had post-randomisation data and were analysed (NAC\u2009=\u200952, CT\u2009=\u200947, Placebo\u2009=\u200949). No between-group differences were found for the rate of change between baseline and 16\u2009weeks on any of the clinical and functioning variables. Improvements in MADRS, BDRS, SOFAS, and LIFE-RIFT scores from baseline to the week 20 post-discontinuation visit were significantly greater in the CT group compared to those in the placebo. At week 20, the CGI-I was significantly lower in the CT group versus placebo. Gastrointestinal symptoms were significantly greater in the NAC than in the placebo group.\nCONCLUSIONS: These overall negative results, with no significant differences between groups detected at the primary outcome but some positive secondary signals, suggest either delayed benefit of the combination or an improvement of symptoms on withdrawal which warrants further exploration regarding the composition, mechanisms, and application of mitochondrial agents in illnesses characterised by mitochondrial dysfunction.\nTRIAL REGISTRATION: ANZCTR ( ACTRN12612000830897 ).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12916-019-1257-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7877829", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6734481", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6727884", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6939291", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6730436", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032885", 
        "issn": [
          "1741-7015"
        ], 
        "name": "BMC Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo", 
    "pagination": "18", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc81d07230f3f1f80fa3e5d6999b32c862c9fd8b013a7427239de76235b80f6f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30678686"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190723"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12916-019-1257-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111662774"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12916-019-1257-1", 
      "https://app.dimensions.ai/details/publication/pub.1111662774"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68481_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12916-019-1257-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-019-1257-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-019-1257-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-019-1257-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-019-1257-1'


 

This table displays all metadata directly associated to this object as RDF triples.

258 TRIPLES      21 PREDICATES      43 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12916-019-1257-1 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nc971eeaaee5f44128813c472b20c1264
4 schema:citation sg:pub.10.1038/nrn3229
5 sg:pub.10.1186/s12916-015-0310-y
6 https://doi.org/10.1016/j.biopsych.2008.04.022
7 https://doi.org/10.1016/j.jpsychires.2015.12.016
8 https://doi.org/10.1016/j.neubiorev.2015.04.015
9 https://doi.org/10.1016/j.neubiorev.2016.06.040
10 https://doi.org/10.1016/j.neubiorev.2017.01.014
11 https://doi.org/10.1016/j.psychres.2018.08.034
12 https://doi.org/10.1016/j.schres.2018.03.012
13 https://doi.org/10.1097/yic.0000000000000058
14 https://doi.org/10.1177/0004867415585858
15 https://doi.org/10.1590/1516-4446-2013-1341
16 https://doi.org/10.4088/jcp.15m10239
17 https://doi.org/10.4088/jcp.15r09984
18 schema:datePublished 2019-12
19 schema:datePublishedReg 2019-12-01
20 schema:description BACKGROUND: A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression: N-acetylcysteine (NAC) and NAC with a combination of nutraceutical agents that may increase mitochondrial biogenesis. METHODS: A three-arm 16-week, double-blind, randomised, placebo-controlled trial, adjunctive to usual treatment, was conducted. Participants (n = 181) with bipolar disorder and current depressive symptoms were randomised to 2000 mg/day NAC (n = 59), 2000 mg/day NAC with the combination nutraceutical treatment (CT, n = 61), or placebo (n = 61). The primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) total score from baseline to week 16. Young Mania Rating Scale, Clinical Global Impression (CGI)-Improvement and CGI-Severity scales, Patient Global Impression scale, Social and Occupational Functioning Assessment Scale (SOFAS), Longitudinal Interval Follow-Up Evaluation - Range of Impaired Functioning Tool (LIFE-RIFT), and Quality of Life Enjoyment, and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) were secondary outcomes. RESULTS: One hundred forty-eight participants had post-randomisation data and were analysed (NAC = 52, CT = 47, Placebo = 49). No between-group differences were found for the rate of change between baseline and 16 weeks on any of the clinical and functioning variables. Improvements in MADRS, BDRS, SOFAS, and LIFE-RIFT scores from baseline to the week 20 post-discontinuation visit were significantly greater in the CT group compared to those in the placebo. At week 20, the CGI-I was significantly lower in the CT group versus placebo. Gastrointestinal symptoms were significantly greater in the NAC than in the placebo group. CONCLUSIONS: These overall negative results, with no significant differences between groups detected at the primary outcome but some positive secondary signals, suggest either delayed benefit of the combination or an improvement of symptoms on withdrawal which warrants further exploration regarding the composition, mechanisms, and application of mitochondrial agents in illnesses characterised by mitochondrial dysfunction. TRIAL REGISTRATION: ANZCTR ( ACTRN12612000830897 ).
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N8cbbf159cc3d46ba9e4b894a89a61e11
25 Nab85179fa2e148f7bee9f47e8abae3a9
26 sg:journal.1032885
27 schema:name A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo
28 schema:pagination 18
29 schema:productId N2aa38f8906df4e78b53441903082fa53
30 N415bbe12489d4ff79649b8305ffc843e
31 N7aabb86eb7b04fefaab73491676f083c
32 Nee89c83ac87646eb95c47c35ff6505ca
33 Nfc32c38ace1d40dc8ea19849351567c6
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111662774
35 https://doi.org/10.1186/s12916-019-1257-1
36 schema:sdDatePublished 2019-04-11T08:59
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N8a8c8eb4ef194bddaf95c0b38ea2d5c2
39 schema:url https://link.springer.com/10.1186%2Fs12916-019-1257-1
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N09fe22b77f054565908bd757215d3d02 rdf:first sg:person.01063416075.78
44 rdf:rest N2a79635610f14c09adf0c541068705ef
45 N0f07354e67314c5589d4b03a151ae7a1 rdf:first N25f9564f3b1a4f87a62ce74e2b15c236
46 rdf:rest N8e64c5b89b36443c8f8d5952d49a60e1
47 N25f9564f3b1a4f87a62ce74e2b15c236 schema:affiliation https://www.grid.ac/institutes/grid.7943.9
48 schema:familyName Owen
49 schema:givenName Lauren
50 rdf:type schema:Person
51 N2a79635610f14c09adf0c541068705ef rdf:first sg:person.01275421041.54
52 rdf:rest N51c453aee40f4e328f231e806cbc1c7e
53 N2aa38f8906df4e78b53441903082fa53 schema:name readcube_id
54 schema:value cc81d07230f3f1f80fa3e5d6999b32c862c9fd8b013a7427239de76235b80f6f
55 rdf:type schema:PropertyValue
56 N3b4bd3cef0804aefacc05265593fdcde rdf:first sg:person.01255032772.00
57 rdf:rest N541dd15955d640db81d3701a19d44929
58 N415bbe12489d4ff79649b8305ffc843e schema:name pubmed_id
59 schema:value 30678686
60 rdf:type schema:PropertyValue
61 N51c453aee40f4e328f231e806cbc1c7e rdf:first sg:person.01041143644.30
62 rdf:rest Nf58fb3ad90ab44c4a52890843d9ad92f
63 N541dd15955d640db81d3701a19d44929 rdf:first sg:person.01354075132.16
64 rdf:rest N09fe22b77f054565908bd757215d3d02
65 N79f0656944eb4d8db3258870c6937baf rdf:first sg:person.0747375650.88
66 rdf:rest Ne1746120a51241838850cab03a22acf1
67 N7aabb86eb7b04fefaab73491676f083c schema:name dimensions_id
68 schema:value pub.1111662774
69 rdf:type schema:PropertyValue
70 N887ee89b74234b3783e7292a450b7573 rdf:first sg:person.01121236011.22
71 rdf:rest N3b4bd3cef0804aefacc05265593fdcde
72 N8a8c8eb4ef194bddaf95c0b38ea2d5c2 schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N8cbbf159cc3d46ba9e4b894a89a61e11 schema:issueNumber 1
75 rdf:type schema:PublicationIssue
76 N8e64c5b89b36443c8f8d5952d49a60e1 rdf:first sg:person.01141543633.31
77 rdf:rest N79f0656944eb4d8db3258870c6937baf
78 Na393cb51a21c4b0d912344df93c5dfce schema:name IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia
79 rdf:type schema:Organization
80 Nab85179fa2e148f7bee9f47e8abae3a9 schema:volumeNumber 17
81 rdf:type schema:PublicationVolume
82 Nc971eeaaee5f44128813c472b20c1264 rdf:first sg:person.01257261765.73
83 rdf:rest Nccb59d0ca0714629b9e6b726cd89c635
84 Nccb59d0ca0714629b9e6b726cd89c635 rdf:first sg:person.0766431042.07
85 rdf:rest Nee6f1f815d5a49f885c437163aa6dc15
86 Ncdfe38e5f6ed4d358096368c69e977a8 schema:name Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia
87 Florey Institute for Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, VIC, Australia
88 IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia
89 rdf:type schema:Organization
90 Ne1746120a51241838850cab03a22acf1 rdf:first sg:person.0714233410.26
91 rdf:rest rdf:nil
92 Nee6f1f815d5a49f885c437163aa6dc15 rdf:first sg:person.0631757532.92
93 rdf:rest N887ee89b74234b3783e7292a450b7573
94 Nee89c83ac87646eb95c47c35ff6505ca schema:name nlm_unique_id
95 schema:value 101190723
96 rdf:type schema:PropertyValue
97 Nf58fb3ad90ab44c4a52890843d9ad92f rdf:first sg:person.01346403526.19
98 rdf:rest Nf7df48765ba245b492719456d3be3186
99 Nf7df48765ba245b492719456d3be3186 rdf:first sg:person.01362145446.25
100 rdf:rest N0f07354e67314c5589d4b03a151ae7a1
101 Nfc32c38ace1d40dc8ea19849351567c6 schema:name doi
102 schema:value 10.1186/s12916-019-1257-1
103 rdf:type schema:PropertyValue
104 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
105 schema:name Medical and Health Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
108 schema:name Clinical Sciences
109 rdf:type schema:DefinedTerm
110 sg:grant.6727884 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-019-1257-1
111 rdf:type schema:MonetaryGrant
112 sg:grant.6730436 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-019-1257-1
113 rdf:type schema:MonetaryGrant
114 sg:grant.6734481 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-019-1257-1
115 rdf:type schema:MonetaryGrant
116 sg:grant.6939291 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-019-1257-1
117 rdf:type schema:MonetaryGrant
118 sg:grant.7877829 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-019-1257-1
119 rdf:type schema:MonetaryGrant
120 sg:journal.1032885 schema:issn 1741-7015
121 schema:name BMC Medicine
122 rdf:type schema:Periodical
123 sg:person.01041143644.30 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
124 schema:familyName McAulay
125 schema:givenName Claire
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041143644.30
127 rdf:type schema:Person
128 sg:person.01063416075.78 schema:affiliation Na393cb51a21c4b0d912344df93c5dfce
129 schema:familyName Samuni
130 schema:givenName Yuval
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063416075.78
132 rdf:type schema:Person
133 sg:person.01121236011.22 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
134 schema:familyName Ng
135 schema:givenName Chee H.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121236011.22
137 rdf:type schema:Person
138 sg:person.01141543633.31 schema:affiliation https://www.grid.ac/institutes/grid.429299.d
139 schema:familyName Waterdrinker
140 schema:givenName Astrid
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141543633.31
142 rdf:type schema:Person
143 sg:person.01255032772.00 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
144 schema:familyName Cotton
145 schema:givenName Susan M.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255032772.00
147 rdf:type schema:Person
148 sg:person.01257261765.73 schema:affiliation https://www.grid.ac/institutes/grid.488501.0
149 schema:familyName Berk
150 schema:givenName Michael
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257261765.73
152 rdf:type schema:Person
153 sg:person.01275421041.54 schema:affiliation https://www.grid.ac/institutes/grid.412703.3
154 schema:familyName Tanious
155 schema:givenName Michelle
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275421041.54
157 rdf:type schema:Person
158 sg:person.01346403526.19 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
159 schema:familyName Dowling
160 schema:givenName Nathan
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346403526.19
162 rdf:type schema:Person
163 sg:person.01354075132.16 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
164 schema:familyName Dodd
165 schema:givenName Seetal
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354075132.16
167 rdf:type schema:Person
168 sg:person.01362145446.25 schema:affiliation https://www.grid.ac/institutes/grid.1029.a
169 schema:familyName Sarris
170 schema:givenName Jerome
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362145446.25
172 rdf:type schema:Person
173 sg:person.0631757532.92 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
174 schema:familyName Malhi
175 schema:givenName Gin S.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631757532.92
177 rdf:type schema:Person
178 sg:person.0714233410.26 schema:affiliation Ncdfe38e5f6ed4d358096368c69e977a8
179 schema:familyName Dean
180 schema:givenName Olivia M.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714233410.26
182 rdf:type schema:Person
183 sg:person.0747375650.88 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
184 schema:familyName Smith
185 schema:givenName Deidre
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747375650.88
187 rdf:type schema:Person
188 sg:person.0766431042.07 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
189 schema:familyName Turner
190 schema:givenName Alyna
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766431042.07
192 rdf:type schema:Person
193 sg:pub.10.1038/nrn3229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037495157
194 https://doi.org/10.1038/nrn3229
195 rdf:type schema:CreativeWork
196 sg:pub.10.1186/s12916-015-0310-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1018347340
197 https://doi.org/10.1186/s12916-015-0310-y
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.biopsych.2008.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035983268
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.jpsychires.2015.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053471822
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.neubiorev.2015.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018312802
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.neubiorev.2016.06.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023632175
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.neubiorev.2017.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014781167
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.psychres.2018.08.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106198685
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.schres.2018.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101748509
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/yic.0000000000000058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010042909
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1177/0004867415585858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051311219
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1590/1516-4446-2013-1341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002117599
218 rdf:type schema:CreativeWork
219 https://doi.org/10.4088/jcp.15m10239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072206630
220 rdf:type schema:CreativeWork
221 https://doi.org/10.4088/jcp.15r09984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072206673
222 rdf:type schema:CreativeWork
223 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
224 schema:name Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Rd, Parkville, VIC, Australia
225 Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia
226 Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia
227 IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia
228 Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia
229 rdf:type schema:Organization
230 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
231 schema:name ARCHI, Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia
232 Academic Department of Psychiatry, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia
233 CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.1029.a schema:alternateName Western Sydney University
236 schema:name Department of Psychiatry, University of Melbourne, the Melbourne Clinic, 130 Church St Richmond, Melbourne, VIC, Australia
237 NICM, School of Health and Science, Western Sydney University, Campbelltown, NSW, Australia
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.266842.c schema:alternateName University of Newcastle Australia
240 schema:name Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia
241 IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia
242 School of Medicine and Public Health, Faculty of Health and Medicine, the University of Newcastle, Callaghan, NSW, Australia
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.412703.3 schema:alternateName Royal North Shore Hospital
245 schema:name CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.429299.d schema:alternateName Melbourne Health
248 schema:name Melbourne Health, 300 Grattan St, Melbourne, VIC, Australia
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.488501.0 schema:alternateName Orygen
251 schema:name Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Level 1 North, Main Block, Parkville, VIC, Australia
252 Florey Institute for Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building, 30 Royal Parade, Parkville, VIC, Australia
253 IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, P.O. Box 291, Geelong, VIC, Australia
254 Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Rd, Parkville, VIC, Australia
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.7943.9 schema:alternateName University of Central Lancashire
257 schema:name School of Psychology, University of Central Lancashire, Preston, UK
258 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...