Geographical and temporal trends and seasonal relapse in Plasmodium ovale spp. and Plasmodium malariae infections imported to the UK between ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Laura E. B. Nabarro, Debbie Nolder, Claire Broderick, Behzad Nadjm, Valerie Smith, Marie Blaze, Anna M. Checkley, Peter L. Chiodini, Colin J. Sutherland, Christopher J. M. Whitty

ABSTRACT

BACKGROUND: Plasmodium ovale spp. and P. malariae cause illness in endemic regions and returning travellers. Far less is known about these species than P. falciparum and P. vivax. METHODS: The UK national surveillance data, collected 1987 to 2015, were collated with the International Passenger Survey and climatic data to determine geographical, temporal and seasonal trends of imported P. ovale spp. and P. malariae infection. RESULTS: Of 52,242 notified cases of malaria, 6.04% (3157) were caused by P. ovale spp. and 1.61% (841) by P. malariae; mortality was 0.03% (1) and 0.12% (1), respectively. Almost all travellers acquired infection in West or East Africa. Infection rate per travel episode fell fivefold during the study period. The median latency of P. malariae and P. ovale spp. was 18 and 76 days, respectively; delayed presentation occurred with both species. The latency of P. ovale spp. infection imported from West Africa was significantly shorter in those arriving in the UK during the West African peak malarial season compared to those arriving outside it (44 days vs 94 days, p < 0.0001), implying that relapse synchronises with the period of high malarial transmission. This trend was not seen in P. ovale spp. imported from East Africa nor in P. malariae. CONCLUSION: In West Africa, where malaria transmission is highly seasonal, P. ovale spp. may have evolved to relapse during the malarial high transmission season. This has public health implications. Deaths are very rare, supporting current guidelines emphasising outpatient treatment. However, late presentations do occur. More... »

PAGES

218

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12916-018-1204-6

DOI

http://dx.doi.org/10.1186/s12916-018-1204-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110193516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30477484


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium malariae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium ovale", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Travel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United Kingdom", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nabarro", 
        "givenName": "Laura E. B.", 
        "id": "sg:person.01230172573.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230172573.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nolder", 
        "givenName": "Debbie", 
        "id": "sg:person.01311775150.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311775150.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Tropical Diseases", 
          "id": "https://www.grid.ac/institutes/grid.439634.f", 
          "name": [
            "The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broderick", 
        "givenName": "Claire", 
        "id": "sg:person.0622564076.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622564076.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK", 
            "Oxford University Clinical Research Unit, Hanoi, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nadjm", 
        "givenName": "Behzad", 
        "id": "sg:person.01063367761.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063367761.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Valerie", 
        "id": "sg:person.01224556455.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224556455.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blaze", 
        "givenName": "Marie", 
        "id": "sg:person.01272671655.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272671655.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Tropical Diseases", 
          "id": "https://www.grid.ac/institutes/grid.439634.f", 
          "name": [
            "The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Checkley", 
        "givenName": "Anna M.", 
        "id": "sg:person.0635651241.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635651241.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Tropical Diseases", 
          "id": "https://www.grid.ac/institutes/grid.439634.f", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK", 
            "The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiodini", 
        "givenName": "Peter L.", 
        "id": "sg:person.01126001404.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126001404.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sutherland", 
        "givenName": "Colin J.", 
        "id": "sg:person.0666107610.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666107610.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Tropical Diseases", 
          "id": "https://www.grid.ac/institutes/grid.439634.f", 
          "name": [
            "Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK", 
            "The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whitty", 
        "givenName": "Christopher J. M.", 
        "id": "sg:person.0735017030.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735017030.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)68264-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001418225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02316-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004637459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3399/bjgp12x657017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009837131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2007.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010613537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0035-9203(03)80023-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011502607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2006.01640.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016730802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2003.130745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018030825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(93)90050-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019696782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(93)90050-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019696782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-016-1251-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023369940", 
          "https://doi.org/10.1186/s12936-016-1251-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpddr.2013.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024404951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.e2116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028480150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030129103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.h1703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030548712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031148912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2013-002711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033673983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ofid/ofu034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035301348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2011.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039513092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/652240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042915696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-4453(83)97088-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044183180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-4453(83)97088-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044183180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2016.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047501341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2016.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052107825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268809991130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053793334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268809991130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053793334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2005.72.229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077023176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2006.75.588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077308793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078415237", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Plasmodium ovale spp. and P. malariae cause illness in endemic regions and returning travellers. Far less is known about these species than P. falciparum and P. vivax.\nMETHODS: The UK national surveillance data, collected 1987 to 2015, were collated with the International Passenger Survey and climatic data to determine geographical, temporal and seasonal trends of imported P. ovale spp. and P. malariae infection.\nRESULTS: Of 52,242 notified cases of malaria, 6.04% (3157) were caused by P. ovale spp. and 1.61% (841) by P. malariae; mortality was 0.03% (1) and 0.12% (1), respectively. Almost all travellers acquired infection in West or East Africa. Infection rate per travel episode fell fivefold during the study period. The median latency of P. malariae and P. ovale spp. was 18 and 76\u00a0days, respectively; delayed presentation occurred with both species. The latency of P. ovale spp. infection imported from West Africa was significantly shorter in those arriving in the UK during the West African peak malarial season compared to those arriving outside it (44\u00a0days vs 94\u00a0days, p\u00a0<\u20090.0001), implying that relapse synchronises with the period of high malarial transmission. This trend was not seen in P. ovale spp. imported from East Africa nor in P. malariae.\nCONCLUSION: In West Africa, where malaria transmission is highly seasonal, P. ovale spp. may have evolved to relapse during the malarial high transmission season. This has public health implications. Deaths are very rare, supporting current guidelines emphasising outpatient treatment. However, late presentations do occur.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12916-018-1204-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3560586", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032885", 
        "issn": [
          "1741-7015"
        ], 
        "name": "BMC Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Geographical and temporal trends and seasonal relapse in Plasmodium ovale spp. and Plasmodium malariae infections imported to the UK between 1987 and 2015", 
    "pagination": "218", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12916-018-1204-6"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8cd74b011ef070c914b801100ff5cdebe9f1e9c2789186c539d4bfa664172cc7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110193516"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190723"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30477484"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12916-018-1204-6", 
      "https://app.dimensions.ai/details/publication/pub.1110193516"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119727_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12916-018-1204-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1204-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1204-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1204-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1204-6'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      63 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12916-018-1204-6 schema:about N4a1b5ee5d14142198311f2d0a955c36c
2 N4a909a2def9a40feb58bd349c02284ba
3 N5ca921458d3c407087b8b11d8a0b55b8
4 N6176c5b3779b4708b9e633dd1df20a2f
5 N84b19176756a464c8b484540d4013a83
6 Nc3e03634e6964a18b5afbc2de86034c9
7 Nc5898daaa7bf4d34b4ba1dad1506ec64
8 Nccc11b25c2f64f35bf23465db6ddfd53
9 Nfa04abca27eb4a52a7b7ad32b38cfb88
10 anzsrc-for:11
11 anzsrc-for:1117
12 schema:author N63239da46a10403eadefc8031f83ee63
13 schema:citation sg:pub.10.1186/s12936-016-1251-4
14 https://app.dimensions.ai/details/publication/pub.1078415237
15 https://doi.org/10.1016/0166-6851(93)90050-8
16 https://doi.org/10.1016/j.ijpara.2011.01.004
17 https://doi.org/10.1016/j.ijpddr.2013.01.001
18 https://doi.org/10.1016/j.jinf.2016.02.001
19 https://doi.org/10.1016/j.pt.2007.04.009
20 https://doi.org/10.1016/j.pt.2016.07.001
21 https://doi.org/10.1016/s0035-9203(03)80023-8
22 https://doi.org/10.1016/s0140-6736(06)68264-0
23 https://doi.org/10.1016/s0163-4453(83)97088-3
24 https://doi.org/10.1017/s0950268809991130
25 https://doi.org/10.1086/652240
26 https://doi.org/10.1093/ofid/ofu034
27 https://doi.org/10.1111/j.1365-3156.2006.01640.x
28 https://doi.org/10.1128/jcm.02316-06
29 https://doi.org/10.1136/bmj.e2116
30 https://doi.org/10.1136/bmj.h1703
31 https://doi.org/10.1136/bmjopen-2013-002711
32 https://doi.org/10.1371/journal.pntd.0004068
33 https://doi.org/10.1371/journal.pntd.0004195
34 https://doi.org/10.3201/eid2003.130745
35 https://doi.org/10.3399/bjgp12x657017
36 https://doi.org/10.4269/ajtmh.2005.72.229
37 https://doi.org/10.4269/ajtmh.2006.75.588
38 schema:datePublished 2018-12
39 schema:datePublishedReg 2018-12-01
40 schema:description BACKGROUND: Plasmodium ovale spp. and P. malariae cause illness in endemic regions and returning travellers. Far less is known about these species than P. falciparum and P. vivax. METHODS: The UK national surveillance data, collected 1987 to 2015, were collated with the International Passenger Survey and climatic data to determine geographical, temporal and seasonal trends of imported P. ovale spp. and P. malariae infection. RESULTS: Of 52,242 notified cases of malaria, 6.04% (3157) were caused by P. ovale spp. and 1.61% (841) by P. malariae; mortality was 0.03% (1) and 0.12% (1), respectively. Almost all travellers acquired infection in West or East Africa. Infection rate per travel episode fell fivefold during the study period. The median latency of P. malariae and P. ovale spp. was 18 and 76 days, respectively; delayed presentation occurred with both species. The latency of P. ovale spp. infection imported from West Africa was significantly shorter in those arriving in the UK during the West African peak malarial season compared to those arriving outside it (44 days vs 94 days, p < 0.0001), implying that relapse synchronises with the period of high malarial transmission. This trend was not seen in P. ovale spp. imported from East Africa nor in P. malariae. CONCLUSION: In West Africa, where malaria transmission is highly seasonal, P. ovale spp. may have evolved to relapse during the malarial high transmission season. This has public health implications. Deaths are very rare, supporting current guidelines emphasising outpatient treatment. However, late presentations do occur.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N0b03eecb8bbd41eaa2e36eb93cd41c30
45 N5f61dc36a05f4f2e9d030de90ab63321
46 sg:journal.1032885
47 schema:name Geographical and temporal trends and seasonal relapse in Plasmodium ovale spp. and Plasmodium malariae infections imported to the UK between 1987 and 2015
48 schema:pagination 218
49 schema:productId N3fca8847ae334669a0e4a2e99626afd9
50 N77dd06cd603b4291b70868c247cfbced
51 N7b41febdaade4df785a8cb3a7052e63c
52 N8d129078996c468280c73605a0a0f283
53 Na571e677fd7e4ec5a58ffca032b32579
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110193516
55 https://doi.org/10.1186/s12916-018-1204-6
56 schema:sdDatePublished 2019-04-15T08:50
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher Nad1edecaf4b749ca9437b094cbd526de
59 schema:url https://link.springer.com/10.1186%2Fs12916-018-1204-6
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0b03eecb8bbd41eaa2e36eb93cd41c30 schema:volumeNumber 16
64 rdf:type schema:PublicationVolume
65 N2910b31c7cac4e66a67906afe2808796 rdf:first sg:person.01126001404.10
66 rdf:rest N77e49e1ab3a04ffc8224fa584aff3ed8
67 N335ae2ed0066406c8c9714faf6936785 rdf:first sg:person.01224556455.49
68 rdf:rest N788b194ccb844307b513207568368d97
69 N3fca8847ae334669a0e4a2e99626afd9 schema:name pubmed_id
70 schema:value 30477484
71 rdf:type schema:PropertyValue
72 N4a1b5ee5d14142198311f2d0a955c36c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Malaria
74 rdf:type schema:DefinedTerm
75 N4a909a2def9a40feb58bd349c02284ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Travel
77 rdf:type schema:DefinedTerm
78 N5ca921458d3c407087b8b11d8a0b55b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name United Kingdom
80 rdf:type schema:DefinedTerm
81 N5f61dc36a05f4f2e9d030de90ab63321 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N6176c5b3779b4708b9e633dd1df20a2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Male
85 rdf:type schema:DefinedTerm
86 N63239da46a10403eadefc8031f83ee63 rdf:first sg:person.01230172573.10
87 rdf:rest Nc4f501c691624fea9a0fb1f05fb25774
88 N77dd06cd603b4291b70868c247cfbced schema:name nlm_unique_id
89 schema:value 101190723
90 rdf:type schema:PropertyValue
91 N77e49e1ab3a04ffc8224fa584aff3ed8 rdf:first sg:person.0666107610.46
92 rdf:rest Ndaa9facf3f0e4a0aa83f072c909aa8a4
93 N788b194ccb844307b513207568368d97 rdf:first sg:person.01272671655.71
94 rdf:rest Na07c616a0aa74325bf82858fe6da9f61
95 N7b41febdaade4df785a8cb3a7052e63c schema:name doi
96 schema:value 10.1186/s12916-018-1204-6
97 rdf:type schema:PropertyValue
98 N84b19176756a464c8b484540d4013a83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Plasmodium malariae
100 rdf:type schema:DefinedTerm
101 N8606ab6ca0ee466183ae9196545e4af2 rdf:first sg:person.0622564076.48
102 rdf:rest N9d1b2d69f38540a59653c52d11a126b6
103 N8d129078996c468280c73605a0a0f283 schema:name readcube_id
104 schema:value 8cd74b011ef070c914b801100ff5cdebe9f1e9c2789186c539d4bfa664172cc7
105 rdf:type schema:PropertyValue
106 N9d1b2d69f38540a59653c52d11a126b6 rdf:first sg:person.01063367761.22
107 rdf:rest N335ae2ed0066406c8c9714faf6936785
108 Na07c616a0aa74325bf82858fe6da9f61 rdf:first sg:person.0635651241.67
109 rdf:rest N2910b31c7cac4e66a67906afe2808796
110 Na571e677fd7e4ec5a58ffca032b32579 schema:name dimensions_id
111 schema:value pub.1110193516
112 rdf:type schema:PropertyValue
113 Nad1edecaf4b749ca9437b094cbd526de schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Nc3e03634e6964a18b5afbc2de86034c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Plasmodium ovale
117 rdf:type schema:DefinedTerm
118 Nc4f501c691624fea9a0fb1f05fb25774 rdf:first sg:person.01311775150.55
119 rdf:rest N8606ab6ca0ee466183ae9196545e4af2
120 Nc5898daaa7bf4d34b4ba1dad1506ec64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Chronic Disease
122 rdf:type schema:DefinedTerm
123 Nccc11b25c2f64f35bf23465db6ddfd53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 Ndaa9facf3f0e4a0aa83f072c909aa8a4 rdf:first sg:person.0735017030.99
127 rdf:rest rdf:nil
128 Nfa04abca27eb4a52a7b7ad32b38cfb88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
132 schema:name Medical and Health Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
135 schema:name Public Health and Health Services
136 rdf:type schema:DefinedTerm
137 sg:grant.3560586 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-018-1204-6
138 rdf:type schema:MonetaryGrant
139 sg:journal.1032885 schema:issn 1741-7015
140 schema:name BMC Medicine
141 rdf:type schema:Periodical
142 sg:person.01063367761.22 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
143 schema:familyName Nadjm
144 schema:givenName Behzad
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063367761.22
146 rdf:type schema:Person
147 sg:person.01126001404.10 schema:affiliation https://www.grid.ac/institutes/grid.439634.f
148 schema:familyName Chiodini
149 schema:givenName Peter L.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126001404.10
151 rdf:type schema:Person
152 sg:person.01224556455.49 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
153 schema:familyName Smith
154 schema:givenName Valerie
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224556455.49
156 rdf:type schema:Person
157 sg:person.01230172573.10 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
158 schema:familyName Nabarro
159 schema:givenName Laura E. B.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230172573.10
161 rdf:type schema:Person
162 sg:person.01272671655.71 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
163 schema:familyName Blaze
164 schema:givenName Marie
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272671655.71
166 rdf:type schema:Person
167 sg:person.01311775150.55 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
168 schema:familyName Nolder
169 schema:givenName Debbie
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311775150.55
171 rdf:type schema:Person
172 sg:person.0622564076.48 schema:affiliation https://www.grid.ac/institutes/grid.439634.f
173 schema:familyName Broderick
174 schema:givenName Claire
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622564076.48
176 rdf:type schema:Person
177 sg:person.0635651241.67 schema:affiliation https://www.grid.ac/institutes/grid.439634.f
178 schema:familyName Checkley
179 schema:givenName Anna M.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635651241.67
181 rdf:type schema:Person
182 sg:person.0666107610.46 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
183 schema:familyName Sutherland
184 schema:givenName Colin J.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666107610.46
186 rdf:type schema:Person
187 sg:person.0735017030.99 schema:affiliation https://www.grid.ac/institutes/grid.439634.f
188 schema:familyName Whitty
189 schema:givenName Christopher J. M.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735017030.99
191 rdf:type schema:Person
192 sg:pub.10.1186/s12936-016-1251-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023369940
193 https://doi.org/10.1186/s12936-016-1251-4
194 rdf:type schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1078415237 schema:CreativeWork
196 https://doi.org/10.1016/0166-6851(93)90050-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019696782
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.ijpara.2011.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039513092
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.ijpddr.2013.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024404951
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.jinf.2016.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052107825
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.pt.2007.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010613537
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.pt.2016.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047501341
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0035-9203(03)80023-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011502607
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0140-6736(06)68264-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001418225
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0163-4453(83)97088-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044183180
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1017/s0950268809991130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053793334
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1086/652240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042915696
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/ofid/ofu034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035301348
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/j.1365-3156.2006.01640.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016730802
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1128/jcm.02316-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004637459
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1136/bmj.e2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028480150
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1136/bmj.h1703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030548712
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1136/bmjopen-2013-002711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033673983
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1371/journal.pntd.0004068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031148912
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1371/journal.pntd.0004195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030129103
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3201/eid2003.130745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018030825
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3399/bjgp12x657017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009837131
237 rdf:type schema:CreativeWork
238 https://doi.org/10.4269/ajtmh.2005.72.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077023176
239 rdf:type schema:CreativeWork
240 https://doi.org/10.4269/ajtmh.2006.75.588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077308793
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.412433.3 schema:alternateName Oxford University Clinical Research Unit
243 schema:name Oxford University Clinical Research Unit, Hanoi, Vietnam
244 The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.439634.f schema:alternateName Hospital for Tropical Diseases
247 schema:name Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
248 The Hospital for Tropical Diseases, Mortimer Market Capper Street, WC1E 6JD, London, UK
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.8991.9 schema:alternateName London School of Hygiene & Tropical Medicine
251 schema:name Public Health England Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...