Clinical trial registration and reporting: a survey of academic organizations in the United States View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Evan Mayo-Wilson, James Heyward, Anthony Keyes, Jesse Reynolds, Sarah White, Nidhi Atri, G. Caleb Alexander, Audrey Omar, Daniel E. Ford, on behalf of the National Clinical Trials Registration and Results Reporting Taskforce Survey Subcommittee

ABSTRACT

BACKGROUND: Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, "The Final Rule" (compliance date April 18, 2017) and a National Institutes of Health policy clarified and expanded trial registration and results reporting requirements. We sought to identify policies, procedures, and resources to support trial registration and reporting at academic organizations. METHODS: We conducted an online survey from November 21, 2016 to March 1, 2017, before organizations were expected to comply with The Final Rule. We included active Protocol Registration and Results System (PRS) accounts classified by ClinicalTrials.gov as a "University/Organization" in the USA. PRS administrators manage information on ClinicalTrials.gov. We invited one PRS administrator to complete the survey for each organization account, which was the unit of analysis. RESULTS: Eligible organization accounts (N = 783) included 47,701 records (e.g., studies) in August 2016. Participating organizations (366/783; 47%) included 40,351/47,701 (85%) records. Compared with other organizations, Clinical and Translational Science Award (CTSA) holders, cancer centers, and large organizations were more likely to participate. A minority of accounts have a registration (156/366; 43%) or results reporting policy (129/366; 35%). Of those with policies, 15/156 (11%) and 49/156 (35%) reported that trials must be registered before institutional review board approval is granted or before beginning enrollment, respectively. Few organizations use computer software to monitor compliance (68/366; 19%). One organization had penalized an investigator for non-compliance. Among the 287/366 (78%) accounts reporting that they allocate staff to fulfill ClinicalTrials.gov registration and reporting requirements, the median number of full-time equivalent staff is 0.08 (interquartile range = 0.02-0.25). Because of non-response and social desirability, this could be a "best case" scenario. CONCLUSIONS: Before the compliance date for The Final Rule, some academic organizations had policies and resources that facilitate clinical trial registration and reporting. Most organizations appear to be unprepared to meet the new requirements. Organizations could enact the following: adopt policies that require trial registration and reporting, allocate resources (e.g., staff, software) to support registration and reporting, and ensure there are consequences for investigators who do not follow standards for clinical research. More... »

PAGES

60

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12916-018-1042-6

DOI

http://dx.doi.org/10.1186/s12916-018-1042-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103705291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29716585


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Academies and Institutes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Report", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E6036, 21205, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayo-Wilson", 
        "givenName": "Evan", 
        "id": "sg:person.01126746307.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126746307.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E6036, 21205, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heyward", 
        "givenName": "James", 
        "id": "sg:person.01125472503.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125472503.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Clinical Research Projects, Johns Hopkins University School of Medicine, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keyes", 
        "givenName": "Anthony", 
        "id": "sg:person.010262543722.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010262543722.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Yale Center for Analytical Studies, New Haven, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reynolds", 
        "givenName": "Jesse", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Partners HealthCare", 
          "id": "https://www.grid.ac/institutes/grid.452687.a", 
          "name": [
            "Human Research Quality Improvement Program, Partners HealthCare, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "White", 
        "givenName": "Sarah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins University School of Medicine, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atri", 
        "givenName": "Nidhi", 
        "id": "sg:person.012453065322.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012453065322.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Departments of Epidemiology and Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alexander", 
        "givenName": "G. Caleb", 
        "id": "sg:person.014240163354.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240163354.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Yale Center for Analytical Studies, New Haven, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omar", 
        "givenName": "Audrey", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Johns Hopkins University School of Medicine, Baltimore, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ford", 
        "givenName": "Daniel E.", 
        "id": "sg:person.0652225203.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652225203.91"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "on behalf of the National Clinical Trials Registration and Results Reporting Taskforce Survey Subcommittee", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/14651858.mr000030.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004189933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cts.12235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004621928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-015-0520-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005653311", 
          "https://doi.org/10.1186/s12916-015-0520-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsa1012065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006441835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(88)90002-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006664249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(88)90002-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006664249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d7292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007208571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.h3572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007370515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsa1409364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008476253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1505965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008501135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0133718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010902258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d8141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014587913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0050217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015312889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018628062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0084727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018992912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.f6104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020904721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.mr000031.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022629508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.39590.732037.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024128110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197701132960214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025025817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025168872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.4230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025227037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)62228-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026123782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/ccp0000115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027017996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)62296-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029210049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1990.03440100121018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030067890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.i637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034284002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034466779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-015-0430-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034690267", 
          "https://doi.org/10.1186/s12916-015-0430-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.g3510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036120604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr1611785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036947123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jclinepi.2015.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038125111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.14668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038654719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.292.11.1363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038781092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d7202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040754266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1377/hlthaff.2011.0172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043273878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jclinepi.2016.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047748213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.293.23.jed50037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051801365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.g5579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052536125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.290.4.516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053060153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d7373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053448664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2016-0223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067831544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta14080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071139135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr1601330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074216004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079330209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1986.4.10.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079937181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083847538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083847538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cct.2017.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084820323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085247252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j1726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085247252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamainternmed.2017.1313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085413373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2017.6514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085885852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j2490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.j2490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942091"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, \"The Final Rule\" (compliance date April 18, 2017) and a National Institutes of Health policy clarified and expanded trial registration and results reporting requirements. We sought to identify policies, procedures, and resources to support trial registration and reporting at academic organizations.\nMETHODS: We conducted an online survey from November 21, 2016 to March 1, 2017, before organizations were expected to comply with The Final Rule. We included active Protocol Registration and Results System (PRS) accounts classified by ClinicalTrials.gov as a \"University/Organization\" in the USA. PRS administrators manage information on ClinicalTrials.gov. We invited one PRS administrator to complete the survey for each organization account, which was the unit of analysis.\nRESULTS: Eligible organization accounts (N\u00a0=\u2009783) included 47,701 records (e.g., studies) in August 2016. Participating organizations (366/783; 47%) included 40,351/47,701 (85%) records. Compared with other organizations, Clinical and Translational Science Award (CTSA) holders, cancer centers, and large organizations were more likely to participate. A minority of accounts have a registration (156/366; 43%) or results reporting policy (129/366; 35%). Of those with policies, 15/156 (11%) and 49/156 (35%) reported that trials must be registered before institutional review board approval is granted or before beginning enrollment, respectively. Few organizations use computer software to monitor compliance (68/366; 19%). One organization had penalized an investigator for non-compliance. Among the 287/366 (78%) accounts reporting that they allocate staff to fulfill ClinicalTrials.gov registration and reporting requirements, the median number of full-time equivalent staff is 0.08 (interquartile range\u2009=\u20090.02-0.25). Because of non-response and social desirability, this could be a \"best case\" scenario.\nCONCLUSIONS: Before the compliance date for The Final Rule, some academic organizations had policies and resources that facilitate clinical trial registration and reporting. Most organizations appear to be unprepared to meet the new requirements. Organizations could enact the following: adopt policies that require trial registration and reporting, allocate resources (e.g., staff, software) to support registration and reporting, and ensure there are consequences for investigators who do not follow standards for clinical research.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12916-018-1042-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5475983", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705248", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535987", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705252", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032885", 
        "issn": [
          "1741-7015"
        ], 
        "name": "BMC Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Clinical trial registration and reporting: a survey of academic organizations in the United States", 
    "pagination": "60", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fbe1a924f93f9caf301484d5e51a3c0ecbb086d2da0a82e2a0ca3033c6ff0361"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29716585"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190723"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12916-018-1042-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103705291"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12916-018-1042-6", 
      "https://app.dimensions.ai/details/publication/pub.1103705291"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78938_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12916-018-1042-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1042-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1042-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1042-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-018-1042-6'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      84 URIs      26 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12916-018-1042-6 schema:about N0d9e5a3683b24bf49965088e7d874cb1
2 N50d937f7bcd1416fabd8138e593db75c
3 N8b66056135c84e988604d2742d38a0f4
4 Ncc565441feff40dd8070c838313f83ad
5 Nd17eb4a153ef45dbac91cafd145d612e
6 anzsrc-for:11
7 anzsrc-for:1117
8 schema:author N7d117c426f354ea7bc587fcf51380b2d
9 schema:citation sg:pub.10.1186/s12916-015-0430-4
10 sg:pub.10.1186/s12916-015-0520-3
11 https://app.dimensions.ai/details/publication/pub.1079330209
12 https://doi.org/10.1001/jama.1990.03440100121018
13 https://doi.org/10.1001/jama.2012.4230
14 https://doi.org/10.1001/jama.2016.14668
15 https://doi.org/10.1001/jama.2017.6514
16 https://doi.org/10.1001/jama.290.4.516
17 https://doi.org/10.1001/jama.292.11.1363
18 https://doi.org/10.1001/jama.293.23.jed50037
19 https://doi.org/10.1001/jamainternmed.2017.1313
20 https://doi.org/10.1002/14651858.mr000030.pub2
21 https://doi.org/10.1002/14651858.mr000031.pub2
22 https://doi.org/10.1016/0197-2456(88)90002-5
23 https://doi.org/10.1016/j.cct.2017.04.002
24 https://doi.org/10.1016/j.jclinepi.2015.07.007
25 https://doi.org/10.1016/j.jclinepi.2016.01.017
26 https://doi.org/10.1016/s0140-6736(13)62228-x
27 https://doi.org/10.1016/s0140-6736(13)62296-5
28 https://doi.org/10.1037/ccp0000115
29 https://doi.org/10.1056/nejm197701132960214
30 https://doi.org/10.1056/nejmc1505965
31 https://doi.org/10.1056/nejmsa1012065
32 https://doi.org/10.1056/nejmsa1409364
33 https://doi.org/10.1056/nejmsr1601330
34 https://doi.org/10.1056/nejmsr1611785
35 https://doi.org/10.1111/cts.12235
36 https://doi.org/10.1136/bmj.39590.732037.47
37 https://doi.org/10.1136/bmj.d7202
38 https://doi.org/10.1136/bmj.d7292
39 https://doi.org/10.1136/bmj.d7373
40 https://doi.org/10.1136/bmj.d8141
41 https://doi.org/10.1136/bmj.f6104
42 https://doi.org/10.1136/bmj.g3510
43 https://doi.org/10.1136/bmj.g5579
44 https://doi.org/10.1136/bmj.h3572
45 https://doi.org/10.1136/bmj.i637
46 https://doi.org/10.1136/bmj.j1726
47 https://doi.org/10.1136/bmj.j2490
48 https://doi.org/10.1136/bmj.j448
49 https://doi.org/10.1200/jco.1986.4.10.1529
50 https://doi.org/10.1371/journal.pmed.0050217
51 https://doi.org/10.1371/journal.pmed.1000144
52 https://doi.org/10.1371/journal.pone.0025258
53 https://doi.org/10.1371/journal.pone.0066844
54 https://doi.org/10.1371/journal.pone.0084727
55 https://doi.org/10.1371/journal.pone.0133718
56 https://doi.org/10.1377/hlthaff.2011.0172
57 https://doi.org/10.1542/peds.2016-0223
58 https://doi.org/10.3310/hta14080
59 schema:datePublished 2018-12
60 schema:datePublishedReg 2018-12-01
61 schema:description BACKGROUND: Many clinical trials conducted by academic organizations are not published, or are not published completely. Following the US Food and Drug Administration Amendments Act of 2007, "The Final Rule" (compliance date April 18, 2017) and a National Institutes of Health policy clarified and expanded trial registration and results reporting requirements. We sought to identify policies, procedures, and resources to support trial registration and reporting at academic organizations. METHODS: We conducted an online survey from November 21, 2016 to March 1, 2017, before organizations were expected to comply with The Final Rule. We included active Protocol Registration and Results System (PRS) accounts classified by ClinicalTrials.gov as a "University/Organization" in the USA. PRS administrators manage information on ClinicalTrials.gov. We invited one PRS administrator to complete the survey for each organization account, which was the unit of analysis. RESULTS: Eligible organization accounts (N = 783) included 47,701 records (e.g., studies) in August 2016. Participating organizations (366/783; 47%) included 40,351/47,701 (85%) records. Compared with other organizations, Clinical and Translational Science Award (CTSA) holders, cancer centers, and large organizations were more likely to participate. A minority of accounts have a registration (156/366; 43%) or results reporting policy (129/366; 35%). Of those with policies, 15/156 (11%) and 49/156 (35%) reported that trials must be registered before institutional review board approval is granted or before beginning enrollment, respectively. Few organizations use computer software to monitor compliance (68/366; 19%). One organization had penalized an investigator for non-compliance. Among the 287/366 (78%) accounts reporting that they allocate staff to fulfill ClinicalTrials.gov registration and reporting requirements, the median number of full-time equivalent staff is 0.08 (interquartile range = 0.02-0.25). Because of non-response and social desirability, this could be a "best case" scenario. CONCLUSIONS: Before the compliance date for The Final Rule, some academic organizations had policies and resources that facilitate clinical trial registration and reporting. Most organizations appear to be unprepared to meet the new requirements. Organizations could enact the following: adopt policies that require trial registration and reporting, allocate resources (e.g., staff, software) to support registration and reporting, and ensure there are consequences for investigators who do not follow standards for clinical research.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf Na9190b5aeac94bf89ec0b6e59bc40eeb
66 Nb044ef37e4244cdbbedd6400d69bb3dc
67 sg:journal.1032885
68 schema:name Clinical trial registration and reporting: a survey of academic organizations in the United States
69 schema:pagination 60
70 schema:productId N10b73e2de7a94e94bad967d69d7d5aa5
71 N3bcabf8cb4d64f6690f2586f284071b1
72 N4b0e158659744fa2bc1b3a316330f947
73 N80a3f3bdb0a34c85a5449e954e63e929
74 N8ba3fd9ea09a4f8ba9f460fa9ac071aa
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103705291
76 https://doi.org/10.1186/s12916-018-1042-6
77 schema:sdDatePublished 2019-04-11T13:17
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N1bf3feacbdc84d4b9bb3a478d3caa590
80 schema:url https://link.springer.com/10.1186%2Fs12916-018-1042-6
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N06b8edb4db804052a2faf6233f3a7772 rdf:first sg:person.014240163354.75
85 rdf:rest Nc6728043eec44759b800317e4b2a4cec
86 N0d9e5a3683b24bf49965088e7d874cb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Academies and Institutes
88 rdf:type schema:DefinedTerm
89 N10b73e2de7a94e94bad967d69d7d5aa5 schema:name doi
90 schema:value 10.1186/s12916-018-1042-6
91 rdf:type schema:PropertyValue
92 N121f6d3598d94b5e9863c5c5e82d34a6 schema:name Yale Center for Analytical Studies, New Haven, USA
93 rdf:type schema:Organization
94 N1bda5c8529f948ce90140b70896127f6 rdf:first Ndf042ff8f7f54876b560dfecedf3993b
95 rdf:rest N259bbaa352c346e9a9d83abe0b982485
96 N1bf3feacbdc84d4b9bb3a478d3caa590 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N259bbaa352c346e9a9d83abe0b982485 rdf:first Nbb6bc115b4b3497ea66488446040a9bb
99 rdf:rest Ne2486db9344f4daba9fe91286650ebc3
100 N3bcabf8cb4d64f6690f2586f284071b1 schema:name pubmed_id
101 schema:value 29716585
102 rdf:type schema:PropertyValue
103 N3e5045686f9c41cebc478a82a7e47375 rdf:first sg:person.010262543722.73
104 rdf:rest N1bda5c8529f948ce90140b70896127f6
105 N4b0e158659744fa2bc1b3a316330f947 schema:name dimensions_id
106 schema:value pub.1103705291
107 rdf:type schema:PropertyValue
108 N50d937f7bcd1416fabd8138e593db75c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Research Report
110 rdf:type schema:DefinedTerm
111 N656c90165c474538acf46ffa7c48d0fd schema:name Yale Center for Analytical Studies, New Haven, USA
112 rdf:type schema:Organization
113 N7714e68d22104c7c8e27124700521a05 schema:familyName on behalf of the National Clinical Trials Registration and Results Reporting Taskforce Survey Subcommittee
114 rdf:type schema:Person
115 N7d117c426f354ea7bc587fcf51380b2d rdf:first sg:person.01126746307.44
116 rdf:rest Na0a15f97a4a54b7fb591632f0dc72f7a
117 N80a3f3bdb0a34c85a5449e954e63e929 schema:name readcube_id
118 schema:value fbe1a924f93f9caf301484d5e51a3c0ecbb086d2da0a82e2a0ca3033c6ff0361
119 rdf:type schema:PropertyValue
120 N8b66056135c84e988604d2742d38a0f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name United States
122 rdf:type schema:DefinedTerm
123 N8ba3fd9ea09a4f8ba9f460fa9ac071aa schema:name nlm_unique_id
124 schema:value 101190723
125 rdf:type schema:PropertyValue
126 Na0a15f97a4a54b7fb591632f0dc72f7a rdf:first sg:person.01125472503.01
127 rdf:rest N3e5045686f9c41cebc478a82a7e47375
128 Na9190b5aeac94bf89ec0b6e59bc40eeb schema:issueNumber 1
129 rdf:type schema:PublicationIssue
130 Nb044ef37e4244cdbbedd6400d69bb3dc schema:volumeNumber 16
131 rdf:type schema:PublicationVolume
132 Nbb6bc115b4b3497ea66488446040a9bb schema:affiliation https://www.grid.ac/institutes/grid.452687.a
133 schema:familyName White
134 schema:givenName Sarah
135 rdf:type schema:Person
136 Nc6728043eec44759b800317e4b2a4cec rdf:first Nd1fcde92cd1047cd9dae861c2525db9f
137 rdf:rest Nf2ff0e4a7ecb4acc9c5218ef329f3c1c
138 Ncc565441feff40dd8070c838313f83ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 Nd17eb4a153ef45dbac91cafd145d612e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Surveys and Questionnaires
143 rdf:type schema:DefinedTerm
144 Nd1fcde92cd1047cd9dae861c2525db9f schema:affiliation N656c90165c474538acf46ffa7c48d0fd
145 schema:familyName Omar
146 schema:givenName Audrey
147 rdf:type schema:Person
148 Ndf042ff8f7f54876b560dfecedf3993b schema:affiliation N121f6d3598d94b5e9863c5c5e82d34a6
149 schema:familyName Reynolds
150 schema:givenName Jesse
151 rdf:type schema:Person
152 Ne2486db9344f4daba9fe91286650ebc3 rdf:first sg:person.012453065322.15
153 rdf:rest N06b8edb4db804052a2faf6233f3a7772
154 Nf1265e2787a04860a3a45f6a07c8f90e rdf:first N7714e68d22104c7c8e27124700521a05
155 rdf:rest rdf:nil
156 Nf2ff0e4a7ecb4acc9c5218ef329f3c1c rdf:first sg:person.0652225203.91
157 rdf:rest Nf1265e2787a04860a3a45f6a07c8f90e
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
162 schema:name Public Health and Health Services
163 rdf:type schema:DefinedTerm
164 sg:grant.2705248 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-018-1042-6
165 rdf:type schema:MonetaryGrant
166 sg:grant.2705252 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-018-1042-6
167 rdf:type schema:MonetaryGrant
168 sg:grant.3535987 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-018-1042-6
169 rdf:type schema:MonetaryGrant
170 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-018-1042-6
171 rdf:type schema:MonetaryGrant
172 sg:journal.1032885 schema:issn 1741-7015
173 schema:name BMC Medicine
174 rdf:type schema:Periodical
175 sg:person.010262543722.73 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
176 schema:familyName Keyes
177 schema:givenName Anthony
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010262543722.73
179 rdf:type schema:Person
180 sg:person.01125472503.01 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
181 schema:familyName Heyward
182 schema:givenName James
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125472503.01
184 rdf:type schema:Person
185 sg:person.01126746307.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
186 schema:familyName Mayo-Wilson
187 schema:givenName Evan
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126746307.44
189 rdf:type schema:Person
190 sg:person.012453065322.15 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
191 schema:familyName Atri
192 schema:givenName Nidhi
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012453065322.15
194 rdf:type schema:Person
195 sg:person.014240163354.75 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
196 schema:familyName Alexander
197 schema:givenName G. Caleb
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240163354.75
199 rdf:type schema:Person
200 sg:person.0652225203.91 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
201 schema:familyName Ford
202 schema:givenName Daniel E.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652225203.91
204 rdf:type schema:Person
205 sg:pub.10.1186/s12916-015-0430-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034690267
206 https://doi.org/10.1186/s12916-015-0430-4
207 rdf:type schema:CreativeWork
208 sg:pub.10.1186/s12916-015-0520-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005653311
209 https://doi.org/10.1186/s12916-015-0520-3
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1079330209 schema:CreativeWork
212 https://doi.org/10.1001/jama.1990.03440100121018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030067890
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1001/jama.2012.4230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025227037
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1001/jama.2016.14668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038654719
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/jama.2017.6514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085885852
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1001/jama.290.4.516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053060153
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1001/jama.292.11.1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038781092
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1001/jama.293.23.jed50037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051801365
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1001/jamainternmed.2017.1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085413373
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/14651858.mr000030.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004189933
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/14651858.mr000031.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022629508
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0197-2456(88)90002-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006664249
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.cct.2017.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084820323
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.jclinepi.2015.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038125111
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.jclinepi.2016.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047748213
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0140-6736(13)62228-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026123782
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0140-6736(13)62296-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029210049
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1037/ccp0000115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027017996
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejm197701132960214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025025817
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmc1505965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008501135
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1056/nejmsa1012065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006441835
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejmsa1409364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008476253
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1056/nejmsr1601330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074216004
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejmsr1611785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036947123
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/cts.12235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004621928
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1136/bmj.39590.732037.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024128110
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1136/bmj.d7202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040754266
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1136/bmj.d7292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007208571
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1136/bmj.d7373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053448664
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1136/bmj.d8141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014587913
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1136/bmj.f6104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020904721
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1136/bmj.g3510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036120604
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1136/bmj.g5579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052536125
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1136/bmj.h3572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007370515
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1136/bmj.i637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034284002
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1136/bmj.j1726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085247252
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1136/bmj.j2490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942091
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1136/bmj.j448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083847538
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1200/jco.1986.4.10.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079937181
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1371/journal.pmed.0050217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015312889
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1371/journal.pmed.1000144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018628062
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1371/journal.pone.0025258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025168872
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1371/journal.pone.0066844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034466779
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1371/journal.pone.0084727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018992912
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1371/journal.pone.0133718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010902258
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1377/hlthaff.2011.0172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043273878
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1542/peds.2016-0223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067831544
303 rdf:type schema:CreativeWork
304 https://doi.org/10.3310/hta14080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139135
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
307 schema:name Clinical Research Projects, Johns Hopkins University School of Medicine, Baltimore, USA
308 Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E6036, 21205, Baltimore, MD, USA
309 Departments of Epidemiology and Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA
310 Johns Hopkins University School of Medicine, Baltimore, USA
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.452687.a schema:alternateName Partners HealthCare
313 schema:name Human Research Quality Improvement Program, Partners HealthCare, Boston, USA
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...