The renin–angiotensin system: a possible new target for depression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-01

AUTHORS

João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk, Brisa S. Fernandes

ABSTRACT

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin–angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin–angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment. More... »

PAGES

144

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12916-017-0916-3

    DOI

    http://dx.doi.org/10.1186/s12916-017-0916-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090940768

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28760142


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