A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Mahen Wijesuriya, Nikolaos Fountoulakis, Nicola Guess, Sarath Banneheka, Laksha Vasantharajah, Martin Gulliford, Giancarlo Viberti, Luigi Gnudi, Janaka Karalliedde

ABSTRACT

BACKGROUND: There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-intensive 12-monthly control LSM (C-LSM) intervention on a primary composite endpoint of predictors of cardio-metabolic disease (new onset T2DM, hypertension, impaired glucose tolerance (IGT), impaired fasting glycaemia (IFG) and markers of cardio-renal disease) in participants aged 5-40 years with risk factors for T2DM. METHODS: This was a randomised controlled trial performed at the National Diabetes Centre, Sri-Lanka. We individually randomised 4672 participants at risk of T2DM, of whom 3539 (mean age 22.5 (range 6-40 years, 48% males) received either trimonthly (P-LSM n = 1726) or 12-monthly (C-LSM n = 1813) peer educator advice aimed at reducing weight, improving diet, reducing psychological stress and increasing physical activity. RESULTS: During a median follow-up of 3 years, the cumulative incidence of the primary endpoint was n = 479 in P-LSM (74 per 1000 person years) vs. 561 in C-LSM (96 per 1000 person years), with an incident rate ratio (IRR) of 0.89 (95% CI 0.83-0.96, P = 0.02). In post hoc analyses, new onset dysglycaemia (T2DM, IFG and IGT), was the major contributor to the composite and was significantly reduced by P-LSM (IRR 0.9, 95% CI 0.83-0.97, P = 0.01). A significant impact of P-LSM on the incidence of the composite endpoint was noted in 1725 participants (P-LSM n = 850, C-LSM n = 875) aged below 18; P-LSM n = 140 (48 per 1000 person years) versus C-LSM n = 174 (55.4 per 1000 person years), with an IRR of 0.83 (95% CI 0.73-0.94, P = 0.004). CONCLUSIONS: In a young at-risk South-Asian population, a pragmatic LSM programme significantly reduces the incidence of predictors of cardio-metabolic disease. Our results highlight the importance of early intervention in young at-risk subjects. TRIAL REGISTRATION: World Health Organization international clinical trial registry platform ( SLCTR/2008/003 ). Registration Date: March 28, 2008. Retrospectively registered. More... »

PAGES

146

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12916-017-0905-6

DOI

http://dx.doi.org/10.1186/s12916-017-0905-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091018133

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28851373


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asian Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Intolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Life Style", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sri Lanka", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urban Population", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Diabetes Association of Sri Lanka, Colombo, Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wijesuriya", 
        "givenName": "Mahen", 
        "id": "sg:person.01241100351.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241100351.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Cardiovascular Division, Faculty of Life Science & Medicine, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fountoulakis", 
        "givenName": "Nikolaos", 
        "id": "sg:person.015265765765.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015265765765.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Diabetes and Nutritional Sciences Division, Faculty of Life Science & Medicine, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guess", 
        "givenName": "Nicola", 
        "id": "sg:person.01327363707.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327363707.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Diabetes Association of Sri Lanka, Colombo, Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banneheka", 
        "givenName": "Sarath", 
        "id": "sg:person.01252243517.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252243517.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Diabetes Association of Sri Lanka, Colombo, Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasantharajah", 
        "givenName": "Laksha", 
        "id": "sg:person.0706511336.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706511336.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Primary Care and Public Health Sciences, King\u2019s College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gulliford", 
        "givenName": "Martin", 
        "id": "sg:person.0723000442.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723000442.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Cardiovascular Division, Faculty of Life Science & Medicine, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viberti", 
        "givenName": "Giancarlo", 
        "id": "sg:person.01007414541.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007414541.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Cardiovascular Division, Faculty of Life Science & Medicine, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gnudi", 
        "givenName": "Luigi", 
        "id": "sg:person.01107742454.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107742454.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Cardiovascular Division, Faculty of Life Science & Medicine, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karalliedde", 
        "givenName": "Janaka", 
        "id": "sg:person.01014264451.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014264451.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa012512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001036745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)61457-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011910033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60766-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015125310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2008.02523.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016302569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-0097-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020980576", 
          "https://doi.org/10.1007/s00125-005-0097-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-0097-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020980576", 
          "https://doi.org/10.1007/s00125-005-0097-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-005-0097-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020980576", 
          "https://doi.org/10.1007/s00125-005-0097-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc13-1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023483560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6215-12-209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027715022", 
          "https://doi.org/10.1186/1745-6215-12-209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.2007.s5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029719438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61301-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030177848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme0807625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032946607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60937-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034133188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200105033441801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034342241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035160335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035160335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4278/0890-1171-12.1.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035349442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4278/0890-1171-12.1.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035349442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.28.4.888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035690379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00707.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037865910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199806043382302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041842101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-8587(14)70057-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043561975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3132/dvdr.2008.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045907423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3132/dvdr.2008.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045907423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.12.3230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046786445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.08.080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049004851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052535061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dcs15-3001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053445531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0029-1240975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057207221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2013-2886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064294546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.20.4.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082667031", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-intensive 12-monthly control LSM (C-LSM) intervention on a primary composite endpoint of predictors of cardio-metabolic disease (new onset T2DM, hypertension, impaired glucose tolerance (IGT), impaired fasting glycaemia (IFG) and markers of cardio-renal disease) in participants aged 5-40 years with risk factors for T2DM.\nMETHODS: This was a randomised controlled trial performed at the National Diabetes Centre, Sri-Lanka. We individually randomised 4672 participants at risk of T2DM, of whom 3539 (mean age 22.5 (range 6-40 years, 48% males) received either trimonthly (P-LSM n\u2009=\u20091726) or 12-monthly (C-LSM n\u2009=\u20091813) peer educator advice aimed at reducing weight, improving diet, reducing psychological stress and increasing physical activity.\nRESULTS: During a median follow-up of 3\u00a0years, the cumulative incidence of the primary endpoint was n\u2009=\u2009479 in P-LSM (74 per 1000 person years) vs. 561 in C-LSM (96 per 1000 person years), with an incident rate ratio (IRR) of 0.89 (95% CI 0.83-0.96, P\u2009=\u20090.02). In post hoc analyses, new onset dysglycaemia (T2DM, IFG and IGT), was the major contributor to the composite and was significantly reduced by P-LSM (IRR 0.9, 95% CI 0.83-0.97, P\u2009=\u20090.01). A significant impact of P-LSM on the incidence of the composite endpoint was noted in 1725 participants (P-LSM n\u2009=\u2009850, C-LSM n\u2009=\u2009875) aged below 18; P-LSM n\u2009=\u2009140 (48 per 1000 person years) versus C-LSM n\u2009=\u2009174 (55.4 per 1000 person years), with an IRR of 0.83 (95% CI 0.73-0.94, P\u2009=\u20090.004).\nCONCLUSIONS: In a young at-risk South-Asian population, a pragmatic LSM programme significantly reduces the incidence of predictors of cardio-metabolic disease. Our results highlight the importance of early intervention in young at-risk subjects.\nTRIAL REGISTRATION: World Health Organization international clinical trial registry platform ( SLCTR/2008/003 ). Registration Date: March 28, 2008. Retrospectively registered.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12916-017-0905-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032885", 
        "issn": [
          "1741-7015"
        ], 
        "name": "BMC Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial", 
    "pagination": "146", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7b68951a78bd144a51d7e54e7d26b6c3c8bf4ae548547f16ed0559164d632fae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28851373"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190723"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12916-017-0905-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091018133"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12916-017-0905-6", 
      "https://app.dimensions.ai/details/publication/pub.1091018133"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000484.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12916-017-0905-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0905-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0905-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0905-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0905-6'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      73 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12916-017-0905-6 schema:about N01b1f30ab16a44f2b4d356b521eb4629
2 N0231b865666e428c8f9dbae922f57a5f
3 N1b56c9b183b64fc2bb782e3235041560
4 N1d996b27d3f34c4cb35e1ef8919efdcd
5 N27dfdb85854d483fbd97d792b0d24456
6 N31f67dbd551a48c7b7641fbf52e3f83c
7 N39e6e025c3a64ce49b4ab542fd4d85ac
8 N62439eb4b1fc4f3aa86ffa888cb5a81d
9 N6b272d0b843248e48a9db7c29e10c187
10 N6cd38ab65b6145fda8aae4dd55d182d5
11 N744a84b165cf4b24bbfdf59bb20341d4
12 N7adfcba03cc2415cb45928ab1aac32a2
13 N9ce9b38595994c35a23ca07e21605c3c
14 Na494ef3f93a54e0c94da7c8336323b19
15 Nabc0548143934a62947692efaea30dec
16 Nae89114c9f074d338ca6b604e3144565
17 Nc971d84d6d4a426e9d81518720a57294
18 anzsrc-for:11
19 anzsrc-for:1117
20 schema:author N9f7931c1e1fb4fe0a2fc8018f00fcca0
21 schema:citation sg:pub.10.1007/s00125-005-0097-z
22 sg:pub.10.1186/1745-6215-12-209
23 https://app.dimensions.ai/details/publication/pub.1082667031
24 https://doi.org/10.1016/j.jacc.2011.08.080
25 https://doi.org/10.1016/s0140-6736(08)60766-7
26 https://doi.org/10.1016/s0140-6736(09)60937-5
27 https://doi.org/10.1016/s0140-6736(09)61457-4
28 https://doi.org/10.1016/s0140-6736(12)61301-4
29 https://doi.org/10.1016/s2213-8587(14)70057-9
30 https://doi.org/10.1055/s-0029-1240975
31 https://doi.org/10.1056/nejm199806043382302
32 https://doi.org/10.1056/nejm200105033441801
33 https://doi.org/10.1056/nejme0807625
34 https://doi.org/10.1056/nejmoa012512
35 https://doi.org/10.1111/j.1464-5491.2008.02523.x
36 https://doi.org/10.1152/japplphysiol.00707.2003
37 https://doi.org/10.1161/cir.0000000000000094
38 https://doi.org/10.1210/jc.2013-2886
39 https://doi.org/10.1371/journal.pone.0031309
40 https://doi.org/10.2337/dc13-1954
41 https://doi.org/10.2337/dcs15-3001
42 https://doi.org/10.2337/diacare.20.4.537
43 https://doi.org/10.2337/diacare.26.12.3230
44 https://doi.org/10.2337/diacare.26.2007.s5
45 https://doi.org/10.2337/diacare.28.4.888
46 https://doi.org/10.3132/dvdr.2008.005
47 https://doi.org/10.4278/0890-1171-12.1.38
48 schema:datePublished 2017-12
49 schema:datePublishedReg 2017-12-01
50 schema:description BACKGROUND: There is an increasing incidence of type 2 diabetes mellitus (T2DM) in young urban South-Asians. We tested the effect of a pragmatic trimonthly lifestyle modification (LSM) programme (P-LSM) versus a less-intensive 12-monthly control LSM (C-LSM) intervention on a primary composite endpoint of predictors of cardio-metabolic disease (new onset T2DM, hypertension, impaired glucose tolerance (IGT), impaired fasting glycaemia (IFG) and markers of cardio-renal disease) in participants aged 5-40 years with risk factors for T2DM. METHODS: This was a randomised controlled trial performed at the National Diabetes Centre, Sri-Lanka. We individually randomised 4672 participants at risk of T2DM, of whom 3539 (mean age 22.5 (range 6-40 years, 48% males) received either trimonthly (P-LSM n = 1726) or 12-monthly (C-LSM n = 1813) peer educator advice aimed at reducing weight, improving diet, reducing psychological stress and increasing physical activity. RESULTS: During a median follow-up of 3 years, the cumulative incidence of the primary endpoint was n = 479 in P-LSM (74 per 1000 person years) vs. 561 in C-LSM (96 per 1000 person years), with an incident rate ratio (IRR) of 0.89 (95% CI 0.83-0.96, P = 0.02). In post hoc analyses, new onset dysglycaemia (T2DM, IFG and IGT), was the major contributor to the composite and was significantly reduced by P-LSM (IRR 0.9, 95% CI 0.83-0.97, P = 0.01). A significant impact of P-LSM on the incidence of the composite endpoint was noted in 1725 participants (P-LSM n = 850, C-LSM n = 875) aged below 18; P-LSM n = 140 (48 per 1000 person years) versus C-LSM n = 174 (55.4 per 1000 person years), with an IRR of 0.83 (95% CI 0.73-0.94, P = 0.004). CONCLUSIONS: In a young at-risk South-Asian population, a pragmatic LSM programme significantly reduces the incidence of predictors of cardio-metabolic disease. Our results highlight the importance of early intervention in young at-risk subjects. TRIAL REGISTRATION: World Health Organization international clinical trial registry platform ( SLCTR/2008/003 ). Registration Date: March 28, 2008. Retrospectively registered.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf Ne32051aad5b74cf8a9c2b6005fe5c3b9
55 Necc2744504b2476eaa3f8f11db1be243
56 sg:journal.1032885
57 schema:name A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial
58 schema:pagination 146
59 schema:productId N029967897e0a4902bf410afe96e09e6a
60 N216bbbc336554db7b24bf85f3fb3eb8a
61 N6114916c386e49c8b5eb66e19341fd4a
62 N8412e204f8d940929c0faf41d9605794
63 Na943430a46434c1d808aca7e3b662b92
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091018133
65 https://doi.org/10.1186/s12916-017-0905-6
66 schema:sdDatePublished 2019-04-10T13:06
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Ncf1bcfcca2c74f96a517a049ad806376
69 schema:url http://link.springer.com/10.1186/s12916-017-0905-6
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N01b1f30ab16a44f2b4d356b521eb4629 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Child
75 rdf:type schema:DefinedTerm
76 N0231b865666e428c8f9dbae922f57a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Sri Lanka
78 rdf:type schema:DefinedTerm
79 N029967897e0a4902bf410afe96e09e6a schema:name dimensions_id
80 schema:value pub.1091018133
81 rdf:type schema:PropertyValue
82 N1b56c9b183b64fc2bb782e3235041560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Adult
84 rdf:type schema:DefinedTerm
85 N1d996b27d3f34c4cb35e1ef8919efdcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Female
87 rdf:type schema:DefinedTerm
88 N216bbbc336554db7b24bf85f3fb3eb8a schema:name doi
89 schema:value 10.1186/s12916-017-0905-6
90 rdf:type schema:PropertyValue
91 N27dfdb85854d483fbd97d792b0d24456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Young Adult
93 rdf:type schema:DefinedTerm
94 N2d357a7f8c064b76bb7c6bbf3567f4f4 schema:name Diabetes Association of Sri Lanka, Colombo, Sri Lanka
95 rdf:type schema:Organization
96 N31f67dbd551a48c7b7641fbf52e3f83c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Life Style
98 rdf:type schema:DefinedTerm
99 N39e6e025c3a64ce49b4ab542fd4d85ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Glucose Intolerance
101 rdf:type schema:DefinedTerm
102 N561f26b6af714d458ad389660b1c205a rdf:first sg:person.01107742454.63
103 rdf:rest Nb0f713d7259f4d5794818bbe7078ce65
104 N6114916c386e49c8b5eb66e19341fd4a schema:name pubmed_id
105 schema:value 28851373
106 rdf:type schema:PropertyValue
107 N62439eb4b1fc4f3aa86ffa888cb5a81d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N6b272d0b843248e48a9db7c29e10c187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Risk Factors
112 rdf:type schema:DefinedTerm
113 N6cd38ab65b6145fda8aae4dd55d182d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Child, Preschool
115 rdf:type schema:DefinedTerm
116 N744a84b165cf4b24bbfdf59bb20341d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Treatment Outcome
118 rdf:type schema:DefinedTerm
119 N7adfcba03cc2415cb45928ab1aac32a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Male
121 rdf:type schema:DefinedTerm
122 N8412e204f8d940929c0faf41d9605794 schema:name nlm_unique_id
123 schema:value 101190723
124 rdf:type schema:PropertyValue
125 N935aa9e5131947adbed763a668eee091 rdf:first sg:person.01007414541.83
126 rdf:rest N561f26b6af714d458ad389660b1c205a
127 N9ce9b38595994c35a23ca07e21605c3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Incidence
129 rdf:type schema:DefinedTerm
130 N9f7931c1e1fb4fe0a2fc8018f00fcca0 rdf:first sg:person.01241100351.30
131 rdf:rest Ncb3abea3f1834a5da4a6042491f7584e
132 Na494ef3f93a54e0c94da7c8336323b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Diabetes Mellitus, Type 2
134 rdf:type schema:DefinedTerm
135 Na943430a46434c1d808aca7e3b662b92 schema:name readcube_id
136 schema:value 7b68951a78bd144a51d7e54e7d26b6c3c8bf4ae548547f16ed0559164d632fae
137 rdf:type schema:PropertyValue
138 Nabc0548143934a62947692efaea30dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Asian Continental Ancestry Group
140 rdf:type schema:DefinedTerm
141 Nae89114c9f074d338ca6b604e3144565 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adolescent
143 rdf:type schema:DefinedTerm
144 Nb0f713d7259f4d5794818bbe7078ce65 rdf:first sg:person.01014264451.29
145 rdf:rest rdf:nil
146 Nb47b2d2f5f7348e7a7374d4ddc520009 schema:name Diabetes Association of Sri Lanka, Colombo, Sri Lanka
147 rdf:type schema:Organization
148 Nb4b3609c257c4aefa92f52f3aa5e868c rdf:first sg:person.0723000442.22
149 rdf:rest N935aa9e5131947adbed763a668eee091
150 Nc4f5ca9c51a947629f14abe9ed52058b rdf:first sg:person.0706511336.27
151 rdf:rest Nb4b3609c257c4aefa92f52f3aa5e868c
152 Nc971d84d6d4a426e9d81518720a57294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Urban Population
154 rdf:type schema:DefinedTerm
155 Ncb3abea3f1834a5da4a6042491f7584e rdf:first sg:person.015265765765.82
156 rdf:rest Ndeb7e53486d947be8e646dc923e774d4
157 Ncf1bcfcca2c74f96a517a049ad806376 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 Ndeb7e53486d947be8e646dc923e774d4 rdf:first sg:person.01327363707.91
160 rdf:rest Ndf6dc53585ca4893aa096f9274342ebb
161 Ndf6dc53585ca4893aa096f9274342ebb rdf:first sg:person.01252243517.49
162 rdf:rest Nc4f5ca9c51a947629f14abe9ed52058b
163 Ne32051aad5b74cf8a9c2b6005fe5c3b9 schema:issueNumber 1
164 rdf:type schema:PublicationIssue
165 Ne5e906af4dfb4777b3bec6cccdbf50dc schema:name Diabetes Association of Sri Lanka, Colombo, Sri Lanka
166 rdf:type schema:Organization
167 Necc2744504b2476eaa3f8f11db1be243 schema:volumeNumber 15
168 rdf:type schema:PublicationVolume
169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical and Health Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
173 schema:name Public Health and Health Services
174 rdf:type schema:DefinedTerm
175 sg:journal.1032885 schema:issn 1741-7015
176 schema:name BMC Medicine
177 rdf:type schema:Periodical
178 sg:person.01007414541.83 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
179 schema:familyName Viberti
180 schema:givenName Giancarlo
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007414541.83
182 rdf:type schema:Person
183 sg:person.01014264451.29 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
184 schema:familyName Karalliedde
185 schema:givenName Janaka
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014264451.29
187 rdf:type schema:Person
188 sg:person.01107742454.63 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
189 schema:familyName Gnudi
190 schema:givenName Luigi
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107742454.63
192 rdf:type schema:Person
193 sg:person.01241100351.30 schema:affiliation Nb47b2d2f5f7348e7a7374d4ddc520009
194 schema:familyName Wijesuriya
195 schema:givenName Mahen
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241100351.30
197 rdf:type schema:Person
198 sg:person.01252243517.49 schema:affiliation N2d357a7f8c064b76bb7c6bbf3567f4f4
199 schema:familyName Banneheka
200 schema:givenName Sarath
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252243517.49
202 rdf:type schema:Person
203 sg:person.01327363707.91 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
204 schema:familyName Guess
205 schema:givenName Nicola
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327363707.91
207 rdf:type schema:Person
208 sg:person.015265765765.82 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
209 schema:familyName Fountoulakis
210 schema:givenName Nikolaos
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015265765765.82
212 rdf:type schema:Person
213 sg:person.0706511336.27 schema:affiliation Ne5e906af4dfb4777b3bec6cccdbf50dc
214 schema:familyName Vasantharajah
215 schema:givenName Laksha
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706511336.27
217 rdf:type schema:Person
218 sg:person.0723000442.22 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
219 schema:familyName Gulliford
220 schema:givenName Martin
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723000442.22
222 rdf:type schema:Person
223 sg:pub.10.1007/s00125-005-0097-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020980576
224 https://doi.org/10.1007/s00125-005-0097-z
225 rdf:type schema:CreativeWork
226 sg:pub.10.1186/1745-6215-12-209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027715022
227 https://doi.org/10.1186/1745-6215-12-209
228 rdf:type schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1082667031 schema:CreativeWork
230 https://doi.org/10.1016/j.jacc.2011.08.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049004851
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0140-6736(08)60766-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015125310
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0140-6736(09)60937-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034133188
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0140-6736(09)61457-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011910033
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0140-6736(12)61301-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030177848
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s2213-8587(14)70057-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043561975
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1055/s-0029-1240975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057207221
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejm199806043382302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041842101
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejm200105033441801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034342241
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejme0807625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032946607
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1056/nejmoa012512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001036745
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1464-5491.2008.02523.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016302569
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1152/japplphysiol.00707.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037865910
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/cir.0000000000000094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035160335
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1210/jc.2013-2886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064294546
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1371/journal.pone.0031309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052535061
261 rdf:type schema:CreativeWork
262 https://doi.org/10.2337/dc13-1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023483560
263 rdf:type schema:CreativeWork
264 https://doi.org/10.2337/dcs15-3001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053445531
265 rdf:type schema:CreativeWork
266 https://doi.org/10.2337/diacare.20.4.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747641
267 rdf:type schema:CreativeWork
268 https://doi.org/10.2337/diacare.26.12.3230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046786445
269 rdf:type schema:CreativeWork
270 https://doi.org/10.2337/diacare.26.2007.s5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029719438
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2337/diacare.28.4.888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035690379
273 rdf:type schema:CreativeWork
274 https://doi.org/10.3132/dvdr.2008.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045907423
275 rdf:type schema:CreativeWork
276 https://doi.org/10.4278/0890-1171-12.1.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035349442
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
279 schema:name Cardiovascular Division, Faculty of Life Science & Medicine, King’s College London, London, UK
280 Department of Primary Care and Public Health Sciences, King’s College, London, UK
281 Diabetes and Nutritional Sciences Division, Faculty of Life Science & Medicine, King’s College London, London, UK
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...