Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-08

AUTHORS

Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. Van Gils, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A. Merritt, Elio Riboli, Rudolf Kaaks

ABSTRACT

BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. METHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. RESULTS: The associations between OPG and ER+ and ER- breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER- breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p trend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER- disease did not differ by menopausal status at blood collection (p het = 0.97), and we observed no heterogeneity by HT use at blood collection (p het ≥ 0.43) or age at breast cancer diagnosis (p het ≥ 0.30). CONCLUSIONS: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER- breast cancer. More... »

PAGES

26

References to SciGraph publications

  • 2005-02-08. Arterial osteoprotegerin: increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-α in DIABETOLOGIA
  • 2010-09-29. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis in NATURE
  • 2012-08-17. Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own Game in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2015-06-10. Osteoprotegerin in breast cancer: beyond bone remodeling in MOLECULAR CANCER
  • 2014-01-30. Reproductive risk factors and breast cancer subtypes: a review of the literature in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-11-25. Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis in BMC CANCER
  • 2010-06-10. Progesterone induces adult mammary stem cell expansion in NATURE
  • 2002-08. Differential Gene Expression of TGF-β Family Members and Osteopontin in Breast Tumor Tissue: Analysis by Real-Time Quantitative PCR in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-12-01. Association of osteoprotegerin with impaired glucose regulation and microalbuminuria: the REACTION study in BMC ENDOCRINE DISORDERS
  • 2003-05. Osteoclast differentiation and activation in NATURE
  • 2004-06-22. Prolactin acts as a potent survival factor for human breast cancer cell lines in BRITISH JOURNAL OF CANCER
  • 2014-07-10. RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-12-02. Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2002-05. Correlates of Osteoprotegerin Levels in Women and Men in OSTEOPOROSIS INTERNATIONAL
  • 2008-02-12. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-08-12. Progestin effects on cell proliferation pathways in the postmenopausal mammary gland in BREAST CANCER RESEARCH
  • 2016-06-20. RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers in NATURE MEDICINE
  • 2009-02-25. Decreased TGFβ signaling and increased COX2 expression in high risk women with increased mammographic breast density in BREAST CANCER RESEARCH AND TREATMENT
  • 2005-08. Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival? in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-09-29. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer in NATURE
  • Journal

    TITLE

    BMC Medicine

    ISSUE

    1

    VOLUME

    15

    Author Affiliations

  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
  • Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
  • Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
  • Gustave Roussy, F-94805 Villejuif, France
  • Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
  • Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
  • Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
  • Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
  • Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
  • Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
  • Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
  • Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
  • Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
  • Public Health Directorate, Asturias, Spain
  • Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
  • CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
  • IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
  • Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
  • Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
  • International Agency for Research on Cancer, Lyon, France
  • Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8

    DOI

    http://dx.doi.org/10.1186/s12916-017-0786-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083508265

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28173834


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoprotegerin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fortner", 
            "givenName": "Ren\u00e9e T.", 
            "id": "sg:person.01046601661.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601661.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sarink", 
            "givenName": "Danja", 
            "id": "sg:person.01311572120.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311572120.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schock", 
            "givenName": "Helena", 
            "id": "sg:person.01276573557.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276573557.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Theron", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tj\u00f8nneland", 
            "givenName": "Anne", 
            "id": "sg:person.01346230170.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230170.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olsen", 
            "givenName": "Anja", 
            "id": "sg:person.01027705103.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027705103.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Overvad", 
            "givenName": "Kim", 
            "id": "sg:person.01335307124.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335307124.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805 Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805 Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Affret", 
            "givenName": "Aur\u00e9lie", 
            "id": "sg:person.01031554217.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031554217.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805 Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805 Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "His", 
            "givenName": "Mathilde", 
            "id": "sg:person.01161713144.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161713144.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805 Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805 Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boutron-Ruault", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.011104534765.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104534765.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418213.d", 
              "name": [
                "Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boeing", 
            "givenName": "Heiner", 
            "id": "sg:person.0625660524.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625660524.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trichopoulou", 
            "givenName": "Antonia", 
            "id": "sg:person.01017060476.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017060476.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naska", 
            "givenName": "Androniki", 
            "id": "sg:person.0650023362.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650023362.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Orfanos", 
            "givenName": "Philippos", 
            "id": "sg:person.0740214435.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740214435.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417623.5", 
              "name": [
                "Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palli", 
            "givenName": "Domenico", 
            "id": "sg:person.010014537677.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sieri", 
            "givenName": "Sabina", 
            "id": "sg:person.0744006030.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744006030.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy", 
              "id": "http://www.grid.ac/institutes/grid.4691.a", 
              "name": [
                "Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattiello", 
            "givenName": "Amalia", 
            "id": "sg:person.01254612334.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254612334.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tumino", 
            "givenName": "Rosario", 
            "id": "sg:person.01024135334.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024135334.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7605.4", 
              "name": [
                "Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy", 
                "Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ricceri", 
            "givenName": "Fulvio", 
            "id": "sg:person.01075056726.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075056726.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia", 
              "id": "http://www.grid.ac/institutes/grid.10347.31", 
              "name": [
                "Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands", 
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
                "Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bueno-de-Mesquita", 
            "givenName": "H. Bas", 
            "id": "sg:person.01301037165.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301037165.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands", 
                "MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peeters", 
            "givenName": "Petra H. M.", 
            "id": "sg:person.0710337377.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710337377.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7692.a", 
              "name": [
                "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Gils", 
            "givenName": "Carla H.", 
            "id": "sg:person.01172774244.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172774244.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.428673.c", 
              "name": [
                "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway", 
                "Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway", 
                "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden", 
                "Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiderpass", 
            "givenName": "Elisabete", 
            "id": "sg:person.01317176547.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317176547.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway", 
              "id": "http://www.grid.ac/institutes/grid.10919.30", 
              "name": [
                "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lund", 
            "givenName": "Eiliv", 
            "id": "sg:person.01147471116.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147471116.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Public Health Directorate, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Public Health Directorate, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quir\u00f3s", 
            "givenName": "J. Ram\u00f3n", 
            "id": "sg:person.01046135645.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046135645.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.417656.7", 
              "name": [
                "Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agudo", 
            "givenName": "Antonio", 
            "id": "sg:person.01332611452.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332611452.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Escuela Andaluza de Salud P\u00fablica. Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain", 
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez", 
            "givenName": "Maria-Jos\u00e9", 
            "id": "sg:person.01206565027.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206565027.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10586.3a", 
              "name": [
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
                "Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain", 
                "Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chirlaque", 
            "givenName": "Mar\u00eda-Dolores", 
            "id": "sg:person.014110204647.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110204647.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.508840.1", 
              "name": [
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
                "Navarra Public Health Institute, Pamplona, Spain", 
                "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ardanaz", 
            "givenName": "Eva", 
            "id": "sg:person.01005017746.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005017746.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain", 
              "id": "http://www.grid.ac/institutes/grid.432380.e", 
              "name": [
                "Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dorronsoro", 
            "givenName": "Miren", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Population Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Population Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Key", 
            "givenName": "Tim", 
            "id": "sg:person.010714076422.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khaw", 
            "givenName": "Kay-Tee", 
            "id": "sg:person.015521617657.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521617657.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rinaldi", 
            "givenName": "Sabina", 
            "id": "sg:person.01305543702.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dossus", 
            "givenName": "Laure", 
            "id": "sg:person.01143450544.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gunter", 
            "givenName": "Marc", 
            "id": "sg:person.015307142637.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merritt", 
            "givenName": "Melissa A.", 
            "id": "sg:person.01371677602.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371677602.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riboli", 
            "givenName": "Elio", 
            "id": "sg:person.01253670741.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaaks", 
            "givenName": "Rudolf", 
            "id": "sg:person.015420102437.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm.4118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025264215", 
              "https://doi.org/10.1038/nm.4118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038971688", 
              "https://doi.org/10.1186/bcr3456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019910253", 
              "https://doi.org/10.1038/nature01658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039295960", 
              "https://doi.org/10.1038/nature09387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010449747", 
              "https://doi.org/10.1038/nature09091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-3049-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043974543", 
              "https://doi.org/10.1007/s10549-014-3049-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-015-0390-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024011568", 
              "https://doi.org/10.1186/s12943-015-0390-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1652-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040864632", 
              "https://doi.org/10.1007/s00125-004-1652-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-2852-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025842663", 
              "https://doi.org/10.1007/s10549-014-2852-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-014-9975-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048139987", 
              "https://doi.org/10.1007/s10654-014-9975-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016339120506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043199963", 
              "https://doi.org/10.1023/a:1016339120506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028032153", 
              "https://doi.org/10.1038/nature09495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-9924-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004175549", 
              "https://doi.org/10.1007/s10549-008-9924-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0350-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043212667", 
              "https://doi.org/10.1007/s10549-009-0350-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12902-015-0067-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014098214", 
              "https://doi.org/10.1186/s12902-015-0067-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1837-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024268280", 
              "https://doi.org/10.1186/s12885-015-1837-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980200045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035334352", 
              "https://doi.org/10.1007/s001980200045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006526014", 
              "https://doi.org/10.1038/sj.bjc.6601947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00232-012-9490-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052427537", 
              "https://doi.org/10.1007/s00232-012-9490-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-005-2419-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008264217", 
              "https://doi.org/10.1007/s10549-005-2419-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-02-08", 
        "datePublishedReg": "2017-02-08", 
        "description": "BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.\nMETHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n\u2009=\u20091622; ER-, n\u2009=\u2009386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.\nRESULTS: The associations between OPG and ER+ and ER- breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER- breast cancer (top vs. bottom tertile RR\u2009=\u20091.93 [95% CI 1.24-3.02]; p trend\u2009=\u20090.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER- disease did not differ by menopausal status at blood collection (p het\u2009=\u20090.97), and we observed no heterogeneity by HT use at blood collection (p het\u2009\u2265\u20090.43) or age at breast cancer diagnosis (p het\u2009\u2265\u20090.30).\nCONCLUSIONS: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER- breast cancer.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12916-017-0786-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5072449", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2755349", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2774057", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3866507", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1032885", 
            "issn": [
              "1741-7015"
            ], 
            "name": "BMC Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "keywords": [
          "breast cancer risk", 
          "ER- breast cancer", 
          "case-control study", 
          "tumor necrosis factor-related apoptosis-inducing ligand", 
          "hormone receptor subtype", 
          "cancer risk", 
          "blood collection", 
          "hormone therapy", 
          "receptor subtypes", 
          "relative risk", 
          "incident invasive breast cancer cases", 
          "RANK ligand", 
          "invasive breast cancer cases", 
          "postmenopausal hormone therapy", 
          "suggestive inverse association", 
          "European Prospective Investigation", 
          "novel risk factors", 
          "confidence intervals", 
          "conditional logistic regression", 
          "breast cancer cases", 
          "first prospective data", 
          "necrosis factor-related apoptosis-inducing ligand", 
          "nuclear factor kappa", 
          "factor-related apoptosis-inducing ligand", 
          "breast cancer diagnosis", 
          "apoptosis-inducing ligand", 
          "serum OPG", 
          "ER- disease", 
          "Nutrition Cohort", 
          "postmenopausal women", 
          "menopausal status", 
          "HT use", 
          "EPIC cohort", 
          "Prospective Investigation", 
          "prospective data", 
          "inverse association", 
          "risk factors", 
          "cancer cases", 
          "factor kappa", 
          "receptor activator", 
          "decoy receptor", 
          "logistic regression", 
          "OPG", 
          "cancer", 
          "cancer diagnosis", 
          "electrochemiluminescence assay", 
          "women", 
          "risk", 
          "cohort", 
          "subtypes", 
          "association", 
          "prior studies", 
          "therapy", 
          "osteoprotegerin", 
          "study", 
          "disease", 
          "diagnosis", 
          "high concentrations", 
          "receptors", 
          "age", 
          "total", 
          "kappa", 
          "status", 
          "assays", 
          "regression", 
          "activator", 
          "intervals", 
          "factors", 
          "control", 
          "cases", 
          "role", 
          "collection", 
          "ligands", 
          "heterogeneity", 
          "concentration", 
          "use", 
          "data", 
          "members", 
          "axis", 
          "investigation", 
          "analysis", 
          "results", 
          "users"
        ], 
        "name": "Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort", 
        "pagination": "26", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083508265"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12916-017-0786-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28173834"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12916-017-0786-8", 
          "https://app.dimensions.ai/details/publication/pub.1083508265"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_751.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12916-017-0786-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    612 TRIPLES      22 PREDICATES      138 URIs      110 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12916-017-0786-8 schema:about N3115d8d905a346af9f85e4e844a36157
    2 N3e2ec390b97d4a4aacfce6c3f6d70cf4
    3 N7412942ae6d94ebfbb88097658e05fee
    4 N85d222cc67fa40dfbbf756189c77f5d0
    5 N8c97a806d7394321ae8d774b9fa7e399
    6 N8d710a8e73aa402aadcba92e7f92304d
    7 N8ed658b3b71447dd843b8f8a4c9359d2
    8 N927e751d323e4c96aef82bca0df3e8d2
    9 Neffa115f5bcf4efe91d1fca5aa07f036
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N0dc40ddda987450c8891b208bc49a146
    13 schema:citation sg:pub.10.1007/s00125-004-1652-8
    14 sg:pub.10.1007/s001980200045
    15 sg:pub.10.1007/s00232-012-9490-y
    16 sg:pub.10.1007/s10549-005-2419-8
    17 sg:pub.10.1007/s10549-008-9924-5
    18 sg:pub.10.1007/s10549-009-0350-0
    19 sg:pub.10.1007/s10549-014-2852-7
    20 sg:pub.10.1007/s10549-014-3049-9
    21 sg:pub.10.1007/s10654-014-9975-3
    22 sg:pub.10.1023/a:1016339120506
    23 sg:pub.10.1038/nature01658
    24 sg:pub.10.1038/nature09091
    25 sg:pub.10.1038/nature09387
    26 sg:pub.10.1038/nature09495
    27 sg:pub.10.1038/nm.4118
    28 sg:pub.10.1038/sj.bjc.6601947
    29 sg:pub.10.1186/bcr3456
    30 sg:pub.10.1186/s12885-015-1837-1
    31 sg:pub.10.1186/s12902-015-0067-5
    32 sg:pub.10.1186/s12943-015-0390-5
    33 schema:datePublished 2017-02-08
    34 schema:datePublishedReg 2017-02-08
    35 schema:description BACKGROUND: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. METHODS: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. RESULTS: The associations between OPG and ER+ and ER- breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER- breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p <sub>trend</sub> = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER- disease did not differ by menopausal status at blood collection (p <sub>het</sub> = 0.97), and we observed no heterogeneity by HT use at blood collection (p <sub>het</sub> ≥ 0.43) or age at breast cancer diagnosis (p <sub>het</sub> ≥ 0.30). CONCLUSIONS: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER- breast cancer.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree true
    39 schema:isPartOf N1da42ab6fc5e4a1a8ed815cfeffbb347
    40 Nc91e4e98681c4273b42201241b1714b1
    41 sg:journal.1032885
    42 schema:keywords EPIC cohort
    43 ER- breast cancer
    44 ER- disease
    45 European Prospective Investigation
    46 HT use
    47 Nutrition Cohort
    48 OPG
    49 Prospective Investigation
    50 RANK ligand
    51 activator
    52 age
    53 analysis
    54 apoptosis-inducing ligand
    55 assays
    56 association
    57 axis
    58 blood collection
    59 breast cancer cases
    60 breast cancer diagnosis
    61 breast cancer risk
    62 cancer
    63 cancer cases
    64 cancer diagnosis
    65 cancer risk
    66 case-control study
    67 cases
    68 cohort
    69 collection
    70 concentration
    71 conditional logistic regression
    72 confidence intervals
    73 control
    74 data
    75 decoy receptor
    76 diagnosis
    77 disease
    78 electrochemiluminescence assay
    79 factor kappa
    80 factor-related apoptosis-inducing ligand
    81 factors
    82 first prospective data
    83 heterogeneity
    84 high concentrations
    85 hormone receptor subtype
    86 hormone therapy
    87 incident invasive breast cancer cases
    88 intervals
    89 invasive breast cancer cases
    90 inverse association
    91 investigation
    92 kappa
    93 ligands
    94 logistic regression
    95 members
    96 menopausal status
    97 necrosis factor-related apoptosis-inducing ligand
    98 novel risk factors
    99 nuclear factor kappa
    100 osteoprotegerin
    101 postmenopausal hormone therapy
    102 postmenopausal women
    103 prior studies
    104 prospective data
    105 receptor activator
    106 receptor subtypes
    107 receptors
    108 regression
    109 relative risk
    110 results
    111 risk
    112 risk factors
    113 role
    114 serum OPG
    115 status
    116 study
    117 subtypes
    118 suggestive inverse association
    119 therapy
    120 total
    121 tumor necrosis factor-related apoptosis-inducing ligand
    122 use
    123 users
    124 women
    125 schema:name Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
    126 schema:pagination 26
    127 schema:productId N38c118ce162844909257809e63ccb908
    128 Nc02a1675d3754a43b67d80fe469edf41
    129 Nd9de209c202a417fb9c6cf688c21c7db
    130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083508265
    131 https://doi.org/10.1186/s12916-017-0786-8
    132 schema:sdDatePublished 2022-01-01T18:46
    133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    134 schema:sdPublisher Nbb5ab6e9dbdb488581b08a8c2f575e95
    135 schema:url https://doi.org/10.1186/s12916-017-0786-8
    136 sgo:license sg:explorer/license/
    137 sgo:sdDataset articles
    138 rdf:type schema:ScholarlyArticle
    139 N048e9d4008bf44c287ae94c6f4f004ef rdf:first sg:person.01161713144.12
    140 rdf:rest Ncc51190baa0b4dbd986843d35d8f6a67
    141 N0dc40ddda987450c8891b208bc49a146 rdf:first sg:person.01046601661.53
    142 rdf:rest Ncb166d6c24c24b85a4dd70f906b37afe
    143 N1807f13589554e82ac4a7771bcb04e21 rdf:first sg:person.014110204647.37
    144 rdf:rest N411658052f194c258eabb696820d3ab0
    145 N1da42ab6fc5e4a1a8ed815cfeffbb347 schema:issueNumber 1
    146 rdf:type schema:PublicationIssue
    147 N1e863170afc449958e703299f6cb5781 rdf:first sg:person.01206565027.91
    148 rdf:rest N1807f13589554e82ac4a7771bcb04e21
    149 N2b0bf96f7af84faf9073206b328eaa2d rdf:first sg:person.010714076422.15
    150 rdf:rest N84da7d28e54d4ba3b9836ad860d5162b
    151 N2c90c12bfb134ced94fe0aadc2be0bc5 rdf:first sg:person.010014537677.09
    152 rdf:rest N40f7f67817b2401dbf2cf35bfa633e92
    153 N3115d8d905a346af9f85e4e844a36157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Middle Aged
    155 rdf:type schema:DefinedTerm
    156 N315f61d7fd12453a9a6404bb4b3f5b4b rdf:first sg:person.01046135645.03
    157 rdf:rest Ne01ac0277f924f939f323aff8795c31d
    158 N38c118ce162844909257809e63ccb908 schema:name dimensions_id
    159 schema:value pub.1083508265
    160 rdf:type schema:PropertyValue
    161 N3cac33aa17264a528d371ddd3b4f7040 rdf:first sg:person.01027705103.14
    162 rdf:rest N4b60981affea42af98d7eebd5eddd682
    163 N3e2ec390b97d4a4aacfce6c3f6d70cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Breast Neoplasms
    165 rdf:type schema:DefinedTerm
    166 N40f7f67817b2401dbf2cf35bfa633e92 rdf:first sg:person.0744006030.52
    167 rdf:rest N491b361ea7d14a44a311814bf1d1dcd5
    168 N411658052f194c258eabb696820d3ab0 rdf:first sg:person.01005017746.37
    169 rdf:rest N9eb7cf64ba9e4993b493b4ccfb33dada
    170 N491b361ea7d14a44a311814bf1d1dcd5 rdf:first sg:person.01254612334.90
    171 rdf:rest N50778ccd5eb648f68d6773838150abcd
    172 N4b60981affea42af98d7eebd5eddd682 rdf:first sg:person.01335307124.43
    173 rdf:rest Nede3dd0f2414475abd6f0600b267a5ab
    174 N50778ccd5eb648f68d6773838150abcd rdf:first sg:person.01024135334.78
    175 rdf:rest N7dcb3714cbef49dc9933f91f41e6f0db
    176 N5b9ee55fee674bf5b86602d04582de9b rdf:first N7965a33ee40f4a33a3c10ed2091c2357
    177 rdf:rest Nd0a657a62b4f4c499c7a23d193e4be01
    178 N616760e29be74490bafe02422f4374cb rdf:first sg:person.01147471116.91
    179 rdf:rest N315f61d7fd12453a9a6404bb4b3f5b4b
    180 N6c2e45541b8947fa8c02e38c2f6876bc rdf:first sg:person.01172774244.59
    181 rdf:rest N9e8d04f35e5c4487a0365e2f298dc979
    182 N7412942ae6d94ebfbb88097658e05fee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Case-Control Studies
    184 rdf:type schema:DefinedTerm
    185 N7965a33ee40f4a33a3c10ed2091c2357 schema:affiliation grid-institutes:grid.7497.d
    186 schema:familyName Johnson
    187 schema:givenName Theron
    188 rdf:type schema:Person
    189 N7dcb3714cbef49dc9933f91f41e6f0db rdf:first sg:person.01075056726.24
    190 rdf:rest N84446d9aaf4147e5aa2e223513ae7207
    191 N83b248cc18984b22a9c553d35b2aed7f schema:affiliation grid-institutes:grid.432380.e
    192 schema:familyName Dorronsoro
    193 schema:givenName Miren
    194 rdf:type schema:Person
    195 N84446d9aaf4147e5aa2e223513ae7207 rdf:first sg:person.01301037165.21
    196 rdf:rest Nd16c63554b4a443e93a35b515212f591
    197 N84da7d28e54d4ba3b9836ad860d5162b rdf:first sg:person.015521617657.37
    198 rdf:rest N8c05a72290e747a3baa14ae7b701d0f0
    199 N851c6087b3f74f33b9c0344cff87f1c7 rdf:first sg:person.0740214435.52
    200 rdf:rest N2c90c12bfb134ced94fe0aadc2be0bc5
    201 N85d222cc67fa40dfbbf756189c77f5d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Prospective Studies
    203 rdf:type schema:DefinedTerm
    204 N8621ab488de844c5a47e6280db6345cc rdf:first sg:person.0650023362.59
    205 rdf:rest N851c6087b3f74f33b9c0344cff87f1c7
    206 N8c05a72290e747a3baa14ae7b701d0f0 rdf:first sg:person.01305543702.17
    207 rdf:rest Nb28be1d3d4eb4527ab198e95b159e162
    208 N8c97a806d7394321ae8d774b9fa7e399 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Humans
    210 rdf:type schema:DefinedTerm
    211 N8d710a8e73aa402aadcba92e7f92304d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Risk Factors
    213 rdf:type schema:DefinedTerm
    214 N8ed658b3b71447dd843b8f8a4c9359d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Cohort Studies
    216 rdf:type schema:DefinedTerm
    217 N91c27842bfb34b1996bf6c108d17e2f6 rdf:first sg:person.0625660524.69
    218 rdf:rest Nfadcddf4302e46adac401f5c3de9e395
    219 N927e751d323e4c96aef82bca0df3e8d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Female
    221 rdf:type schema:DefinedTerm
    222 N9e8d04f35e5c4487a0365e2f298dc979 rdf:first sg:person.01317176547.68
    223 rdf:rest N616760e29be74490bafe02422f4374cb
    224 N9eb7cf64ba9e4993b493b4ccfb33dada rdf:first N83b248cc18984b22a9c553d35b2aed7f
    225 rdf:rest N2b0bf96f7af84faf9073206b328eaa2d
    226 Nb28be1d3d4eb4527ab198e95b159e162 rdf:first sg:person.01143450544.32
    227 rdf:rest Nee9833888ba54ebab8061a2b13825a01
    228 Nbb5ab6e9dbdb488581b08a8c2f575e95 schema:name Springer Nature - SN SciGraph project
    229 rdf:type schema:Organization
    230 Nc02a1675d3754a43b67d80fe469edf41 schema:name pubmed_id
    231 schema:value 28173834
    232 rdf:type schema:PropertyValue
    233 Nc6127a2b26194d78af897ec49bb60c5a rdf:first sg:person.015420102437.43
    234 rdf:rest rdf:nil
    235 Nc91e4e98681c4273b42201241b1714b1 schema:volumeNumber 15
    236 rdf:type schema:PublicationVolume
    237 Ncb166d6c24c24b85a4dd70f906b37afe rdf:first sg:person.01311572120.03
    238 rdf:rest Nea207e3021de425dadbe77d9131bf190
    239 Ncc51190baa0b4dbd986843d35d8f6a67 rdf:first sg:person.011104534765.43
    240 rdf:rest N91c27842bfb34b1996bf6c108d17e2f6
    241 Nd0a657a62b4f4c499c7a23d193e4be01 rdf:first sg:person.01346230170.69
    242 rdf:rest N3cac33aa17264a528d371ddd3b4f7040
    243 Nd16c63554b4a443e93a35b515212f591 rdf:first sg:person.0710337377.75
    244 rdf:rest N6c2e45541b8947fa8c02e38c2f6876bc
    245 Nd9de209c202a417fb9c6cf688c21c7db schema:name doi
    246 schema:value 10.1186/s12916-017-0786-8
    247 rdf:type schema:PropertyValue
    248 Ne01ac0277f924f939f323aff8795c31d rdf:first sg:person.01332611452.48
    249 rdf:rest N1e863170afc449958e703299f6cb5781
    250 Nea207e3021de425dadbe77d9131bf190 rdf:first sg:person.01276573557.19
    251 rdf:rest N5b9ee55fee674bf5b86602d04582de9b
    252 Nede3dd0f2414475abd6f0600b267a5ab rdf:first sg:person.01031554217.11
    253 rdf:rest N048e9d4008bf44c287ae94c6f4f004ef
    254 Nee9833888ba54ebab8061a2b13825a01 rdf:first sg:person.015307142637.30
    255 rdf:rest Nf1ed5fd292e24552a73627091defcb74
    256 Neffa115f5bcf4efe91d1fca5aa07f036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Osteoprotegerin
    258 rdf:type schema:DefinedTerm
    259 Nf1ed5fd292e24552a73627091defcb74 rdf:first sg:person.01371677602.75
    260 rdf:rest Nfd6ad7ae3f344f3e80392d92b9e80f25
    261 Nfadcddf4302e46adac401f5c3de9e395 rdf:first sg:person.01017060476.31
    262 rdf:rest N8621ab488de844c5a47e6280db6345cc
    263 Nfd6ad7ae3f344f3e80392d92b9e80f25 rdf:first sg:person.01253670741.91
    264 rdf:rest Nc6127a2b26194d78af897ec49bb60c5a
    265 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    266 schema:name Medical and Health Sciences
    267 rdf:type schema:DefinedTerm
    268 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    269 schema:name Oncology and Carcinogenesis
    270 rdf:type schema:DefinedTerm
    271 sg:grant.2755349 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    272 rdf:type schema:MonetaryGrant
    273 sg:grant.2774057 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.3866507 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.5072449 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    278 rdf:type schema:MonetaryGrant
    279 sg:journal.1032885 schema:issn 1741-7015
    280 schema:name BMC Medicine
    281 schema:publisher Springer Nature
    282 rdf:type schema:Periodical
    283 sg:person.010014537677.09 schema:affiliation grid-institutes:grid.417623.5
    284 schema:familyName Palli
    285 schema:givenName Domenico
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09
    287 rdf:type schema:Person
    288 sg:person.01005017746.37 schema:affiliation grid-institutes:grid.508840.1
    289 schema:familyName Ardanaz
    290 schema:givenName Eva
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005017746.37
    292 rdf:type schema:Person
    293 sg:person.01017060476.31 schema:affiliation grid-institutes:grid.5216.0
    294 schema:familyName Trichopoulou
    295 schema:givenName Antonia
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017060476.31
    297 rdf:type schema:Person
    298 sg:person.01024135334.78 schema:affiliation grid-institutes:None
    299 schema:familyName Tumino
    300 schema:givenName Rosario
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024135334.78
    302 rdf:type schema:Person
    303 sg:person.01027705103.14 schema:affiliation grid-institutes:grid.417390.8
    304 schema:familyName Olsen
    305 schema:givenName Anja
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027705103.14
    307 rdf:type schema:Person
    308 sg:person.01031554217.11 schema:affiliation grid-institutes:grid.14925.3b
    309 schema:familyName Affret
    310 schema:givenName Aurélie
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031554217.11
    312 rdf:type schema:Person
    313 sg:person.01046135645.03 schema:affiliation grid-institutes:None
    314 schema:familyName Quirós
    315 schema:givenName J. Ramón
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046135645.03
    317 rdf:type schema:Person
    318 sg:person.01046601661.53 schema:affiliation grid-institutes:grid.7497.d
    319 schema:familyName Fortner
    320 schema:givenName Renée T.
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601661.53
    322 rdf:type schema:Person
    323 sg:person.010714076422.15 schema:affiliation grid-institutes:grid.4991.5
    324 schema:familyName Key
    325 schema:givenName Tim
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15
    327 rdf:type schema:Person
    328 sg:person.01075056726.24 schema:affiliation grid-institutes:grid.7605.4
    329 schema:familyName Ricceri
    330 schema:givenName Fulvio
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075056726.24
    332 rdf:type schema:Person
    333 sg:person.011104534765.43 schema:affiliation grid-institutes:grid.14925.3b
    334 schema:familyName Boutron-Ruault
    335 schema:givenName Marie-Christine
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104534765.43
    337 rdf:type schema:Person
    338 sg:person.01143450544.32 schema:affiliation grid-institutes:grid.17703.32
    339 schema:familyName Dossus
    340 schema:givenName Laure
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32
    342 rdf:type schema:Person
    343 sg:person.01147471116.91 schema:affiliation grid-institutes:grid.10919.30
    344 schema:familyName Lund
    345 schema:givenName Eiliv
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147471116.91
    347 rdf:type schema:Person
    348 sg:person.01161713144.12 schema:affiliation grid-institutes:grid.14925.3b
    349 schema:familyName His
    350 schema:givenName Mathilde
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161713144.12
    352 rdf:type schema:Person
    353 sg:person.01172774244.59 schema:affiliation grid-institutes:grid.7692.a
    354 schema:familyName Van Gils
    355 schema:givenName Carla H.
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172774244.59
    357 rdf:type schema:Person
    358 sg:person.01206565027.91 schema:affiliation grid-institutes:grid.413448.e
    359 schema:familyName Sánchez
    360 schema:givenName Maria-José
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206565027.91
    362 rdf:type schema:Person
    363 sg:person.01253670741.91 schema:affiliation grid-institutes:grid.7445.2
    364 schema:familyName Riboli
    365 schema:givenName Elio
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91
    367 rdf:type schema:Person
    368 sg:person.01254612334.90 schema:affiliation grid-institutes:grid.4691.a
    369 schema:familyName Mattiello
    370 schema:givenName Amalia
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254612334.90
    372 rdf:type schema:Person
    373 sg:person.01276573557.19 schema:affiliation grid-institutes:grid.7497.d
    374 schema:familyName Schock
    375 schema:givenName Helena
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276573557.19
    377 rdf:type schema:Person
    378 sg:person.01301037165.21 schema:affiliation grid-institutes:grid.10347.31
    379 schema:familyName Bueno-de-Mesquita
    380 schema:givenName H. Bas
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301037165.21
    382 rdf:type schema:Person
    383 sg:person.01305543702.17 schema:affiliation grid-institutes:grid.17703.32
    384 schema:familyName Rinaldi
    385 schema:givenName Sabina
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17
    387 rdf:type schema:Person
    388 sg:person.01311572120.03 schema:affiliation grid-institutes:grid.7497.d
    389 schema:familyName Sarink
    390 schema:givenName Danja
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311572120.03
    392 rdf:type schema:Person
    393 sg:person.01317176547.68 schema:affiliation grid-institutes:grid.428673.c
    394 schema:familyName Weiderpass
    395 schema:givenName Elisabete
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317176547.68
    397 rdf:type schema:Person
    398 sg:person.01332611452.48 schema:affiliation grid-institutes:grid.417656.7
    399 schema:familyName Agudo
    400 schema:givenName Antonio
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332611452.48
    402 rdf:type schema:Person
    403 sg:person.01335307124.43 schema:affiliation grid-institutes:grid.7048.b
    404 schema:familyName Overvad
    405 schema:givenName Kim
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335307124.43
    407 rdf:type schema:Person
    408 sg:person.01346230170.69 schema:affiliation grid-institutes:grid.417390.8
    409 schema:familyName Tjønneland
    410 schema:givenName Anne
    411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230170.69
    412 rdf:type schema:Person
    413 sg:person.01371677602.75 schema:affiliation grid-institutes:grid.7445.2
    414 schema:familyName Merritt
    415 schema:givenName Melissa A.
    416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371677602.75
    417 rdf:type schema:Person
    418 sg:person.014110204647.37 schema:affiliation grid-institutes:grid.10586.3a
    419 schema:familyName Chirlaque
    420 schema:givenName María-Dolores
    421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110204647.37
    422 rdf:type schema:Person
    423 sg:person.015307142637.30 schema:affiliation grid-institutes:grid.17703.32
    424 schema:familyName Gunter
    425 schema:givenName Marc
    426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30
    427 rdf:type schema:Person
    428 sg:person.015420102437.43 schema:affiliation grid-institutes:grid.7497.d
    429 schema:familyName Kaaks
    430 schema:givenName Rudolf
    431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43
    432 rdf:type schema:Person
    433 sg:person.015521617657.37 schema:affiliation grid-institutes:grid.5335.0
    434 schema:familyName Khaw
    435 schema:givenName Kay-Tee
    436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521617657.37
    437 rdf:type schema:Person
    438 sg:person.0625660524.69 schema:affiliation grid-institutes:grid.418213.d
    439 schema:familyName Boeing
    440 schema:givenName Heiner
    441 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625660524.69
    442 rdf:type schema:Person
    443 sg:person.0650023362.59 schema:affiliation grid-institutes:grid.5216.0
    444 schema:familyName Naska
    445 schema:givenName Androniki
    446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650023362.59
    447 rdf:type schema:Person
    448 sg:person.0710337377.75 schema:affiliation grid-institutes:grid.7445.2
    449 schema:familyName Peeters
    450 schema:givenName Petra H. M.
    451 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710337377.75
    452 rdf:type schema:Person
    453 sg:person.0740214435.52 schema:affiliation grid-institutes:grid.5216.0
    454 schema:familyName Orfanos
    455 schema:givenName Philippos
    456 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740214435.52
    457 rdf:type schema:Person
    458 sg:person.0744006030.52 schema:affiliation grid-institutes:grid.417893.0
    459 schema:familyName Sieri
    460 schema:givenName Sabina
    461 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744006030.52
    462 rdf:type schema:Person
    463 sg:pub.10.1007/s00125-004-1652-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040864632
    464 https://doi.org/10.1007/s00125-004-1652-8
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1007/s001980200045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035334352
    467 https://doi.org/10.1007/s001980200045
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1007/s00232-012-9490-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052427537
    470 https://doi.org/10.1007/s00232-012-9490-y
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1007/s10549-005-2419-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008264217
    473 https://doi.org/10.1007/s10549-005-2419-8
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1007/s10549-008-9924-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004175549
    476 https://doi.org/10.1007/s10549-008-9924-5
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1007/s10549-009-0350-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043212667
    479 https://doi.org/10.1007/s10549-009-0350-0
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1007/s10549-014-2852-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025842663
    482 https://doi.org/10.1007/s10549-014-2852-7
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1007/s10549-014-3049-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043974543
    485 https://doi.org/10.1007/s10549-014-3049-9
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1007/s10654-014-9975-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048139987
    488 https://doi.org/10.1007/s10654-014-9975-3
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1023/a:1016339120506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043199963
    491 https://doi.org/10.1023/a:1016339120506
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/nature01658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019910253
    494 https://doi.org/10.1038/nature01658
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/nature09091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010449747
    497 https://doi.org/10.1038/nature09091
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/nature09387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039295960
    500 https://doi.org/10.1038/nature09387
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/nature09495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028032153
    503 https://doi.org/10.1038/nature09495
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/nm.4118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025264215
    506 https://doi.org/10.1038/nm.4118
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/sj.bjc.6601947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006526014
    509 https://doi.org/10.1038/sj.bjc.6601947
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1186/bcr3456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038971688
    512 https://doi.org/10.1186/bcr3456
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1186/s12885-015-1837-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268280
    515 https://doi.org/10.1186/s12885-015-1837-1
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1186/s12902-015-0067-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014098214
    518 https://doi.org/10.1186/s12902-015-0067-5
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1186/s12943-015-0390-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024011568
    521 https://doi.org/10.1186/s12943-015-0390-5
    522 rdf:type schema:CreativeWork
    523 grid-institutes:None schema:alternateName Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
    524 Public Health Directorate, Asturias, Spain
    525 schema:name Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
    526 Public Health Directorate, Asturias, Spain
    527 rdf:type schema:Organization
    528 grid-institutes:grid.10347.31 schema:alternateName Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    529 schema:name Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
    530 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    531 Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    532 rdf:type schema:Organization
    533 grid-institutes:grid.10586.3a schema:alternateName Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
    534 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    535 Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
    536 Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
    537 rdf:type schema:Organization
    538 grid-institutes:grid.10919.30 schema:alternateName Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    539 schema:name Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    540 rdf:type schema:Organization
    541 grid-institutes:grid.14925.3b schema:alternateName Gustave Roussy, F-94805 Villejuif, France
    542 schema:name Gustave Roussy, F-94805 Villejuif, France
    543 Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France
    544 rdf:type schema:Organization
    545 grid-institutes:grid.17703.32 schema:alternateName International Agency for Research on Cancer, Lyon, France
    546 schema:name International Agency for Research on Cancer, Lyon, France
    547 rdf:type schema:Organization
    548 grid-institutes:grid.413448.e schema:alternateName CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    549 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    550 Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
    551 rdf:type schema:Organization
    552 grid-institutes:grid.417390.8 schema:alternateName Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
    553 schema:name Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
    554 rdf:type schema:Organization
    555 grid-institutes:grid.417623.5 schema:alternateName Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
    556 schema:name Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
    557 rdf:type schema:Organization
    558 grid-institutes:grid.417656.7 schema:alternateName Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
    559 schema:name Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
    560 rdf:type schema:Organization
    561 grid-institutes:grid.417893.0 schema:alternateName Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    562 schema:name Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    563 rdf:type schema:Organization
    564 grid-institutes:grid.418213.d schema:alternateName Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
    565 schema:name Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
    566 rdf:type schema:Organization
    567 grid-institutes:grid.428673.c schema:alternateName Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
    568 schema:name Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    569 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    570 Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
    571 Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
    572 rdf:type schema:Organization
    573 grid-institutes:grid.432380.e schema:alternateName Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
    574 schema:name Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
    575 rdf:type schema:Organization
    576 grid-institutes:grid.4691.a schema:alternateName Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
    577 schema:name Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
    578 rdf:type schema:Organization
    579 grid-institutes:grid.4991.5 schema:alternateName Nuffield Department of Population Health, University of Oxford, Oxford, UK
    580 schema:name Nuffield Department of Population Health, University of Oxford, Oxford, UK
    581 rdf:type schema:Organization
    582 grid-institutes:grid.508840.1 schema:alternateName IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
    583 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    584 IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
    585 Navarra Public Health Institute, Pamplona, Spain
    586 rdf:type schema:Organization
    587 grid-institutes:grid.5216.0 schema:alternateName WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
    588 schema:name Hellenic Health Foundation, Athens, Greece
    589 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
    590 rdf:type schema:Organization
    591 grid-institutes:grid.5335.0 schema:alternateName Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
    592 schema:name Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
    593 rdf:type schema:Organization
    594 grid-institutes:grid.7048.b schema:alternateName Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
    595 schema:name Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
    596 rdf:type schema:Organization
    597 grid-institutes:grid.7445.2 schema:alternateName Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    598 MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
    599 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    600 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    601 MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
    602 rdf:type schema:Organization
    603 grid-institutes:grid.7497.d schema:alternateName Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    604 schema:name Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    605 rdf:type schema:Organization
    606 grid-institutes:grid.7605.4 schema:alternateName Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
    607 schema:name Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
    608 Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy
    609 rdf:type schema:Organization
    610 grid-institutes:grid.7692.a schema:alternateName Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    611 schema:name Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    612 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...