Ontology type: schema:ScholarlyArticle Open Access: True
2017-02-08
AUTHORSRenée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. Van Gils, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A. Merritt, Elio Riboli, Rudolf Kaaks
ABSTRACTBackgroundCirculating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.MethodsA case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER–, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.ResultsThe associations between OPG and ER+ and ER– breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER– breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24–3.02]; ptrend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER– disease did not differ by menopausal status at blood collection (phet = 0.97), and we observed no heterogeneity by HT use at blood collection (phet ≥ 0.43) or age at breast cancer diagnosis (phet ≥ 0.30).ConclusionsThis study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER– breast cancer. More... »
PAGES26
http://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8
DOIhttp://dx.doi.org/10.1186/s12916-017-0786-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1083508265
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28173834
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Case-Control Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteoprotegerin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7497.d",
"name": [
"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Fortner",
"givenName": "Ren\u00e9e T.",
"id": "sg:person.01046601661.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601661.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7497.d",
"name": [
"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Sarink",
"givenName": "Danja",
"id": "sg:person.01311572120.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311572120.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7497.d",
"name": [
"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Schock",
"givenName": "Helena",
"id": "sg:person.01276573557.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276573557.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7497.d",
"name": [
"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Johnson",
"givenName": "Theron",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark",
"id": "http://www.grid.ac/institutes/grid.417390.8",
"name": [
"Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Tj\u00f8nneland",
"givenName": "Anne",
"id": "sg:person.01346230170.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230170.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark",
"id": "http://www.grid.ac/institutes/grid.417390.8",
"name": [
"Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Olsen",
"givenName": "Anja",
"id": "sg:person.01027705103.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027705103.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark",
"id": "http://www.grid.ac/institutes/grid.7048.b",
"name": [
"Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Overvad",
"givenName": "Kim",
"id": "sg:person.01335307124.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335307124.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gustave Roussy, F-94805, Villejuif, France",
"id": "http://www.grid.ac/institutes/grid.14925.3b",
"name": [
"Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France",
"Gustave Roussy, F-94805, Villejuif, France"
],
"type": "Organization"
},
"familyName": "Affret",
"givenName": "Aur\u00e9lie",
"id": "sg:person.01031554217.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031554217.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gustave Roussy, F-94805, Villejuif, France",
"id": "http://www.grid.ac/institutes/grid.14925.3b",
"name": [
"Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France",
"Gustave Roussy, F-94805, Villejuif, France"
],
"type": "Organization"
},
"familyName": "His",
"givenName": "Mathilde",
"id": "sg:person.01161713144.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161713144.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gustave Roussy, F-94805, Villejuif, France",
"id": "http://www.grid.ac/institutes/grid.14925.3b",
"name": [
"Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France",
"Gustave Roussy, F-94805, Villejuif, France"
],
"type": "Organization"
},
"familyName": "Boutron-Ruault",
"givenName": "Marie-Christine",
"id": "sg:person.011104534765.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104534765.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany",
"id": "http://www.grid.ac/institutes/grid.418213.d",
"name": [
"Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"
],
"type": "Organization"
},
"familyName": "Boeing",
"givenName": "Heiner",
"id": "sg:person.0625660524.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625660524.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece",
"id": "http://www.grid.ac/institutes/grid.5216.0",
"name": [
"Hellenic Health Foundation, Athens, Greece",
"WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Trichopoulou",
"givenName": "Antonia",
"id": "sg:person.01017060476.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017060476.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece",
"id": "http://www.grid.ac/institutes/grid.5216.0",
"name": [
"Hellenic Health Foundation, Athens, Greece",
"WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Naska",
"givenName": "Androniki",
"id": "sg:person.0650023362.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650023362.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece",
"id": "http://www.grid.ac/institutes/grid.5216.0",
"name": [
"Hellenic Health Foundation, Athens, Greece",
"WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
],
"type": "Organization"
},
"familyName": "Orfanos",
"givenName": "Philippos",
"id": "sg:person.0740214435.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740214435.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy",
"id": "http://www.grid.ac/institutes/grid.417623.5",
"name": [
"Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy"
],
"type": "Organization"
},
"familyName": "Palli",
"givenName": "Domenico",
"id": "sg:person.010014537677.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy",
"id": "http://www.grid.ac/institutes/grid.417893.0",
"name": [
"Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Sieri",
"givenName": "Sabina",
"id": "sg:person.0744006030.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744006030.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy",
"id": "http://www.grid.ac/institutes/grid.4691.a",
"name": [
"Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy"
],
"type": "Organization"
},
"familyName": "Mattiello",
"givenName": "Amalia",
"id": "sg:person.01254612334.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254612334.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy"
],
"type": "Organization"
},
"familyName": "Tumino",
"givenName": "Rosario",
"id": "sg:person.01024135334.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024135334.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy",
"id": "http://www.grid.ac/institutes/grid.7605.4",
"name": [
"Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy",
"Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy"
],
"type": "Organization"
},
"familyName": "Ricceri",
"givenName": "Fulvio",
"id": "sg:person.01075056726.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075056726.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia",
"id": "http://www.grid.ac/institutes/grid.10347.31",
"name": [
"Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands",
"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK",
"Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"
],
"type": "Organization"
},
"familyName": "Bueno-de-Mesquita",
"givenName": "H. Bas",
"id": "sg:person.01301037165.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301037165.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands",
"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK"
],
"type": "Organization"
},
"familyName": "Peeters",
"givenName": "Petra H. M.",
"id": "sg:person.0710337377.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710337377.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands",
"id": "http://www.grid.ac/institutes/grid.7692.a",
"name": [
"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands"
],
"type": "Organization"
},
"familyName": "Van Gils",
"givenName": "Carla H.",
"id": "sg:person.01172774244.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172774244.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland",
"id": "http://www.grid.ac/institutes/grid.428673.c",
"name": [
"Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway",
"Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway",
"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden",
"Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland"
],
"type": "Organization"
},
"familyName": "Weiderpass",
"givenName": "Elisabete",
"id": "sg:person.01317176547.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317176547.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway",
"id": "http://www.grid.ac/institutes/grid.10919.30",
"name": [
"Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway"
],
"type": "Organization"
},
"familyName": "Lund",
"givenName": "Eiliv",
"id": "sg:person.01147471116.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147471116.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Public Health Directorate, Asturias, Spain",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Public Health Directorate, Asturias, Spain"
],
"type": "Organization"
},
"familyName": "Quir\u00f3s",
"givenName": "J. Ram\u00f3n",
"id": "sg:person.01046135645.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046135645.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain",
"id": "http://www.grid.ac/institutes/grid.418284.3",
"name": [
"Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain"
],
"type": "Organization"
},
"familyName": "Agudo",
"givenName": "Antonio",
"id": "sg:person.01332611452.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332611452.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.466571.7",
"name": [
"Escuela Andaluza de Salud P\u00fablica. Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain",
"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"
],
"type": "Organization"
},
"familyName": "S\u00e1nchez",
"givenName": "Maria-Jos\u00e9",
"id": "sg:person.01206565027.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206565027.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain",
"id": "http://www.grid.ac/institutes/grid.10586.3a",
"name": [
"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain",
"Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain",
"Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain"
],
"type": "Organization"
},
"familyName": "Chirlaque",
"givenName": "Mar\u00eda-Dolores",
"id": "sg:person.014110204647.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110204647.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain",
"id": "http://www.grid.ac/institutes/grid.508840.1",
"name": [
"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain",
"Navarra Public Health Institute, Pamplona, Spain",
"IdiSNA, Navarra Institute for Health Research, Pamplona, Spain"
],
"type": "Organization"
},
"familyName": "Ardanaz",
"givenName": "Eva",
"id": "sg:person.01005017746.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005017746.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain",
"id": "http://www.grid.ac/institutes/grid.432380.e",
"name": [
"Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain"
],
"type": "Organization"
},
"familyName": "Dorronsoro",
"givenName": "Miren",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nuffield Department of Population Health, University of Oxford, Oxford, UK",
"id": "http://www.grid.ac/institutes/grid.4991.5",
"name": [
"Nuffield Department of Population Health, University of Oxford, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Key",
"givenName": "Tim",
"id": "sg:person.010714076422.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK",
"id": "http://www.grid.ac/institutes/grid.5335.0",
"name": [
"Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK"
],
"type": "Organization"
},
"familyName": "Khaw",
"givenName": "Kay-Tee",
"id": "sg:person.015521617657.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521617657.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "International Agency for Research on Cancer, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.17703.32",
"name": [
"International Agency for Research on Cancer, Lyon, France"
],
"type": "Organization"
},
"familyName": "Rinaldi",
"givenName": "Sabina",
"id": "sg:person.01305543702.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "International Agency for Research on Cancer, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.17703.32",
"name": [
"International Agency for Research on Cancer, Lyon, France"
],
"type": "Organization"
},
"familyName": "Dossus",
"givenName": "Laure",
"id": "sg:person.01143450544.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "International Agency for Research on Cancer, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.17703.32",
"name": [
"International Agency for Research on Cancer, Lyon, France"
],
"type": "Organization"
},
"familyName": "Gunter",
"givenName": "Marc",
"id": "sg:person.015307142637.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
],
"type": "Organization"
},
"familyName": "Merritt",
"givenName": "Melissa A.",
"id": "sg:person.01371677602.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371677602.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
],
"type": "Organization"
},
"familyName": "Riboli",
"givenName": "Elio",
"id": "sg:person.01253670741.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7497.d",
"name": [
"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Kaaks",
"givenName": "Rudolf",
"id": "sg:person.015420102437.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature09495",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028032153",
"https://doi.org/10.1038/nature09495"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00232-012-9490-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052427537",
"https://doi.org/10.1007/s00232-012-9490-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010449747",
"https://doi.org/10.1038/nature09091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr3456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038971688",
"https://doi.org/10.1186/bcr3456"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001980200045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035334352",
"https://doi.org/10.1007/s001980200045"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.4118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025264215",
"https://doi.org/10.1038/nm.4118"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-2852-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025842663",
"https://doi.org/10.1007/s10549-014-2852-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01658",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019910253",
"https://doi.org/10.1038/nature01658"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10654-014-9975-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048139987",
"https://doi.org/10.1007/s10654-014-9975-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-004-1652-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040864632",
"https://doi.org/10.1007/s00125-004-1652-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-3049-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043974543",
"https://doi.org/10.1007/s10549-014-3049-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-005-2419-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008264217",
"https://doi.org/10.1007/s10549-005-2419-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12885-015-1837-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024268280",
"https://doi.org/10.1186/s12885-015-1837-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6601947",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006526014",
"https://doi.org/10.1038/sj.bjc.6601947"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1016339120506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043199963",
"https://doi.org/10.1023/a:1016339120506"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039295960",
"https://doi.org/10.1038/nature09387"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12943-015-0390-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024011568",
"https://doi.org/10.1186/s12943-015-0390-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-009-0350-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043212667",
"https://doi.org/10.1007/s10549-009-0350-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-008-9924-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004175549",
"https://doi.org/10.1007/s10549-008-9924-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12902-015-0067-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014098214",
"https://doi.org/10.1186/s12902-015-0067-5"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-02-08",
"datePublishedReg": "2017-02-08",
"description": "BackgroundCirculating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.MethodsA case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n\u2009=\u20091622; ER\u2013, n\u2009=\u2009386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.ResultsThe associations between OPG and ER+ and ER\u2013 breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER\u2013 breast cancer (top vs. bottom tertile RR\u2009=\u20091.93 [95% CI 1.24\u20133.02]; ptrend\u2009=\u20090.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER\u2013 disease did not differ by menopausal status at blood collection (phet\u2009=\u20090.97), and we observed no heterogeneity by HT use at blood collection (phet\u2009\u2265\u20090.43) or age at breast cancer diagnosis (phet\u2009\u2265\u20090.30).ConclusionsThis study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER\u2013 breast cancer.",
"genre": "article",
"id": "sg:pub.10.1186/s12916-017-0786-8",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2774057",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2755349",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5072449",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3866507",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1032885",
"issn": [
"1741-7015"
],
"name": "BMC Medicine",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "15"
}
],
"keywords": [
"breast cancer risk",
"ER- breast cancer",
"case-control study",
"hormone receptor subtype",
"tumor necrosis factor-related apoptosis-inducing ligand",
"cancer risk",
"blood collection",
"hormone therapy",
"relative risk",
"receptor subtypes",
"incident invasive breast cancer cases",
"RANK ligand",
"MethodsA case\u2013control study",
"invasive breast cancer cases",
"nuclear factor-kappa B (NF-\u03baB) axis",
"suggestive inverse association",
"postmenopausal hormone therapy",
"European Prospective Investigation",
"novel risk factors",
"confidence intervals",
"conditional logistic regression",
"first prospective data",
"breast cancer cases",
"necrosis factor-related apoptosis-inducing ligand",
"factor-related apoptosis-inducing ligand",
"breast cancer diagnosis",
"apoptosis-inducing ligand",
"ER- disease",
"Nutrition Cohort",
"postmenopausal women",
"serum OPG",
"menopausal status",
"HT use",
"EPIC cohort",
"Prospective Investigation",
"prospective data",
"inverse association",
"risk factors",
"cancer cases",
"receptor activator",
"decoy receptor",
"logistic regression",
"cancer",
"OPG",
"ConclusionsThis study",
"cancer diagnosis",
"electrochemiluminescence assay",
"women",
"risk",
"cohort",
"subtypes",
"association",
"prior studies",
"therapy",
"osteoprotegerin",
"study",
"disease",
"diagnosis",
"receptors",
"high concentrations",
"age",
"total",
"status",
"assays",
"regression",
"activator",
"interval",
"factors",
"control",
"cases",
"role",
"collection",
"heterogeneity",
"ligands",
"concentration",
"use",
"axis",
"data",
"members",
"investigation",
"analysis",
"results",
"users"
],
"name": "Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort",
"pagination": "26",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1083508265"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12916-017-0786-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28173834"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12916-017-0786-8",
"https://app.dimensions.ai/details/publication/pub.1083508265"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_739.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12916-017-0786-8"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'
This table displays all metadata directly associated to this object as RDF triples.
612 TRIPLES
22 PREDICATES
138 URIs
110 LITERALS
16 BLANK NODES