Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-08

AUTHORS

Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. Van Gils, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A. Merritt, Elio Riboli, Rudolf Kaaks

ABSTRACT

BackgroundCirculating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.MethodsA case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER–, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.ResultsThe associations between OPG and ER+ and ER– breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER– breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24–3.02]; ptrend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER– disease did not differ by menopausal status at blood collection (phet = 0.97), and we observed no heterogeneity by HT use at blood collection (phet ≥ 0.43) or age at breast cancer diagnosis (phet ≥ 0.30).ConclusionsThis study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER– breast cancer. More... »

PAGES

26

References to SciGraph publications

  • 2005-02-08. Arterial osteoprotegerin: increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-α in DIABETOLOGIA
  • 2010-09-29. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis in NATURE
  • 2012-08-17. Breast Cancer Proteome Takes More Than Two to Tango on TRAIL: Beat Them at Their Own Game in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2015-06-10. Osteoprotegerin in breast cancer: beyond bone remodeling in MOLECULAR CANCER
  • 2014-01-30. Reproductive risk factors and breast cancer subtypes: a review of the literature in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-11-25. Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis in BMC CANCER
  • 2010-06-10. Progesterone induces adult mammary stem cell expansion in NATURE
  • 2002-08. Differential Gene Expression of TGF-β Family Members and Osteopontin in Breast Tumor Tissue: Analysis by Real-Time Quantitative PCR in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-12-01. Association of osteoprotegerin with impaired glucose regulation and microalbuminuria: the REACTION study in BMC ENDOCRINE DISORDERS
  • 2003-05. Osteoclast differentiation and activation in NATURE
  • 2004-06-22. Prolactin acts as a potent survival factor for human breast cancer cell lines in BRITISH JOURNAL OF CANCER
  • 2014-07-10. RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-12-02. Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2002-05. Correlates of Osteoprotegerin Levels in Women and Men in OSTEOPOROSIS INTERNATIONAL
  • 2008-02-12. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-08-12. Progestin effects on cell proliferation pathways in the postmenopausal mammary gland in BREAST CANCER RESEARCH
  • 2016-06-20. RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers in NATURE MEDICINE
  • 2009-02-25. Decreased TGFβ signaling and increased COX2 expression in high risk women with increased mammographic breast density in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-09-29. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer in NATURE
  • 2005-08. Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival? in BREAST CANCER RESEARCH AND TREATMENT
  • Journal

    TITLE

    BMC Medicine

    ISSUE

    1

    VOLUME

    15

    Author Affiliations

  • Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany
  • Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
  • Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
  • Gustave Roussy, F-94805, Villejuif, France
  • Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
  • Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
  • Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
  • Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
  • Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
  • Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
  • Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
  • Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
  • Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
  • Public Health Directorate, Asturias, Spain
  • Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
  • CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
  • IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
  • Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
  • Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
  • International Agency for Research on Cancer, Lyon, France
  • Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8

    DOI

    http://dx.doi.org/10.1186/s12916-017-0786-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083508265

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28173834


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteoprotegerin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fortner", 
            "givenName": "Ren\u00e9e T.", 
            "id": "sg:person.01046601661.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601661.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sarink", 
            "givenName": "Danja", 
            "id": "sg:person.01311572120.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311572120.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schock", 
            "givenName": "Helena", 
            "id": "sg:person.01276573557.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276573557.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Theron", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tj\u00f8nneland", 
            "givenName": "Anne", 
            "id": "sg:person.01346230170.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230170.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olsen", 
            "givenName": "Anja", 
            "id": "sg:person.01027705103.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027705103.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Overvad", 
            "givenName": "Kim", 
            "id": "sg:person.01335307124.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335307124.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805, Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Affret", 
            "givenName": "Aur\u00e9lie", 
            "id": "sg:person.01031554217.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031554217.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805, Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "His", 
            "givenName": "Mathilde", 
            "id": "sg:person.01161713144.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161713144.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gustave Roussy, F-94805, Villejuif, France", 
              "id": "http://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Universit\u00e9 Paris-Saclay, Universit\u00e9 Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France", 
                "Gustave Roussy, F-94805, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boutron-Ruault", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.011104534765.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104534765.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany", 
              "id": "http://www.grid.ac/institutes/grid.418213.d", 
              "name": [
                "Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boeing", 
            "givenName": "Heiner", 
            "id": "sg:person.0625660524.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625660524.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trichopoulou", 
            "givenName": "Antonia", 
            "id": "sg:person.01017060476.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017060476.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naska", 
            "givenName": "Androniki", 
            "id": "sg:person.0650023362.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650023362.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece", 
              "id": "http://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Hellenic Health Foundation, Athens, Greece", 
                "WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Orfanos", 
            "givenName": "Philippos", 
            "id": "sg:person.0740214435.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740214435.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417623.5", 
              "name": [
                "Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute \u2013 ISPO, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palli", 
            "givenName": "Domenico", 
            "id": "sg:person.010014537677.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sieri", 
            "givenName": "Sabina", 
            "id": "sg:person.0744006030.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744006030.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy", 
              "id": "http://www.grid.ac/institutes/grid.4691.a", 
              "name": [
                "Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattiello", 
            "givenName": "Amalia", 
            "id": "sg:person.01254612334.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254612334.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Cancer Registry and Histopathology Unit, \u201cCivic - M.p.Arezzo\u201d Hospital, ASP Ragusa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tumino", 
            "givenName": "Rosario", 
            "id": "sg:person.01024135334.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024135334.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7605.4", 
              "name": [
                "Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy", 
                "Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ricceri", 
            "givenName": "Fulvio", 
            "id": "sg:person.01075056726.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075056726.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia", 
              "id": "http://www.grid.ac/institutes/grid.10347.31", 
              "name": [
                "Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands", 
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
                "Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bueno-de-Mesquita", 
            "givenName": "H. Bas", 
            "id": "sg:person.01301037165.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301037165.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands", 
                "MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peeters", 
            "givenName": "Petra H. M.", 
            "id": "sg:person.0710337377.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710337377.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.7692.a", 
              "name": [
                "Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Gils", 
            "givenName": "Carla H.", 
            "id": "sg:person.01172774244.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172774244.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.428673.c", 
              "name": [
                "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway", 
                "Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway", 
                "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden", 
                "Genetic Epidemiology Group, Folkh\u00e4lsan Research Center, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiderpass", 
            "givenName": "Elisabete", 
            "id": "sg:person.01317176547.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317176547.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway", 
              "id": "http://www.grid.ac/institutes/grid.10919.30", 
              "name": [
                "Department of Community Medicine, Faculty of Health Sciences, University of Troms\u00f8, The Arctic University of Norway, Troms\u00f8, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lund", 
            "givenName": "Eiliv", 
            "id": "sg:person.01147471116.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147471116.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Public Health Directorate, Asturias, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Public Health Directorate, Asturias, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quir\u00f3s", 
            "givenName": "J. Ram\u00f3n", 
            "id": "sg:person.01046135645.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046135645.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.418284.3", 
              "name": [
                "Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L\u2019Hospitalet de Llobregat, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agudo", 
            "givenName": "Antonio", 
            "id": "sg:person.01332611452.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332611452.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.466571.7", 
              "name": [
                "Escuela Andaluza de Salud P\u00fablica. Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain", 
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez", 
            "givenName": "Maria-Jos\u00e9", 
            "id": "sg:person.01206565027.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206565027.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10586.3a", 
              "name": [
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
                "Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain", 
                "Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chirlaque", 
            "givenName": "Mar\u00eda-Dolores", 
            "id": "sg:person.014110204647.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110204647.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.508840.1", 
              "name": [
                "CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain", 
                "Navarra Public Health Institute, Pamplona, Spain", 
                "IdiSNA, Navarra Institute for Health Research, Pamplona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ardanaz", 
            "givenName": "Eva", 
            "id": "sg:person.01005017746.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005017746.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain", 
              "id": "http://www.grid.ac/institutes/grid.432380.e", 
              "name": [
                "Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dorronsoro", 
            "givenName": "Miren", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Department of Population Health, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Population Health, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Key", 
            "givenName": "Tim", 
            "id": "sg:person.010714076422.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khaw", 
            "givenName": "Kay-Tee", 
            "id": "sg:person.015521617657.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521617657.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rinaldi", 
            "givenName": "Sabina", 
            "id": "sg:person.01305543702.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dossus", 
            "givenName": "Laure", 
            "id": "sg:person.01143450544.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "International Agency for Research on Cancer, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.17703.32", 
              "name": [
                "International Agency for Research on Cancer, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gunter", 
            "givenName": "Marc", 
            "id": "sg:person.015307142637.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merritt", 
            "givenName": "Melissa A.", 
            "id": "sg:person.01371677602.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371677602.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riboli", 
            "givenName": "Elio", 
            "id": "sg:person.01253670741.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaaks", 
            "givenName": "Rudolf", 
            "id": "sg:person.015420102437.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature09495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028032153", 
              "https://doi.org/10.1038/nature09495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00232-012-9490-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052427537", 
              "https://doi.org/10.1007/s00232-012-9490-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010449747", 
              "https://doi.org/10.1038/nature09091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038971688", 
              "https://doi.org/10.1186/bcr3456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001980200045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035334352", 
              "https://doi.org/10.1007/s001980200045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025264215", 
              "https://doi.org/10.1038/nm.4118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-2852-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025842663", 
              "https://doi.org/10.1007/s10549-014-2852-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019910253", 
              "https://doi.org/10.1038/nature01658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-014-9975-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048139987", 
              "https://doi.org/10.1007/s10654-014-9975-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1652-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040864632", 
              "https://doi.org/10.1007/s00125-004-1652-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-014-3049-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043974543", 
              "https://doi.org/10.1007/s10549-014-3049-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-005-2419-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008264217", 
              "https://doi.org/10.1007/s10549-005-2419-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1837-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024268280", 
              "https://doi.org/10.1186/s12885-015-1837-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006526014", 
              "https://doi.org/10.1038/sj.bjc.6601947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016339120506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043199963", 
              "https://doi.org/10.1023/a:1016339120506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039295960", 
              "https://doi.org/10.1038/nature09387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-015-0390-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024011568", 
              "https://doi.org/10.1186/s12943-015-0390-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0350-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043212667", 
              "https://doi.org/10.1007/s10549-009-0350-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-9924-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004175549", 
              "https://doi.org/10.1007/s10549-008-9924-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12902-015-0067-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014098214", 
              "https://doi.org/10.1186/s12902-015-0067-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-02-08", 
        "datePublishedReg": "2017-02-08", 
        "description": "BackgroundCirculating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.MethodsA case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n\u2009=\u20091622; ER\u2013, n\u2009=\u2009386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.ResultsThe associations between OPG and ER+ and ER\u2013 breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER\u2013 breast cancer (top vs. bottom tertile RR\u2009=\u20091.93 [95% CI 1.24\u20133.02]; ptrend\u2009=\u20090.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER\u2013 disease did not differ by menopausal status at blood collection (phet\u2009=\u20090.97), and we observed no heterogeneity by HT use at blood collection (phet\u2009\u2265\u20090.43) or age at breast cancer diagnosis (phet\u2009\u2265\u20090.30).ConclusionsThis study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER\u2013 breast cancer.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12916-017-0786-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2774057", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2755349", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5072449", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3866507", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1032885", 
            "issn": [
              "1741-7015"
            ], 
            "name": "BMC Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "keywords": [
          "breast cancer risk", 
          "ER- breast cancer", 
          "case-control study", 
          "hormone receptor subtype", 
          "tumor necrosis factor-related apoptosis-inducing ligand", 
          "cancer risk", 
          "blood collection", 
          "hormone therapy", 
          "relative risk", 
          "receptor subtypes", 
          "incident invasive breast cancer cases", 
          "RANK ligand", 
          "MethodsA case\u2013control study", 
          "invasive breast cancer cases", 
          "nuclear factor-kappa B (NF-\u03baB) axis", 
          "suggestive inverse association", 
          "postmenopausal hormone therapy", 
          "European Prospective Investigation", 
          "novel risk factors", 
          "confidence intervals", 
          "conditional logistic regression", 
          "first prospective data", 
          "breast cancer cases", 
          "necrosis factor-related apoptosis-inducing ligand", 
          "factor-related apoptosis-inducing ligand", 
          "breast cancer diagnosis", 
          "apoptosis-inducing ligand", 
          "ER- disease", 
          "Nutrition Cohort", 
          "postmenopausal women", 
          "serum OPG", 
          "menopausal status", 
          "HT use", 
          "EPIC cohort", 
          "Prospective Investigation", 
          "prospective data", 
          "inverse association", 
          "risk factors", 
          "cancer cases", 
          "receptor activator", 
          "decoy receptor", 
          "logistic regression", 
          "cancer", 
          "OPG", 
          "ConclusionsThis study", 
          "cancer diagnosis", 
          "electrochemiluminescence assay", 
          "women", 
          "risk", 
          "cohort", 
          "subtypes", 
          "association", 
          "prior studies", 
          "therapy", 
          "osteoprotegerin", 
          "study", 
          "disease", 
          "diagnosis", 
          "receptors", 
          "high concentrations", 
          "age", 
          "total", 
          "status", 
          "assays", 
          "regression", 
          "activator", 
          "interval", 
          "factors", 
          "control", 
          "cases", 
          "role", 
          "collection", 
          "heterogeneity", 
          "ligands", 
          "concentration", 
          "use", 
          "axis", 
          "data", 
          "members", 
          "investigation", 
          "analysis", 
          "results", 
          "users"
        ], 
        "name": "Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort", 
        "pagination": "26", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083508265"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12916-017-0786-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28173834"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12916-017-0786-8", 
          "https://app.dimensions.ai/details/publication/pub.1083508265"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_739.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12916-017-0786-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12916-017-0786-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    612 TRIPLES      22 PREDICATES      138 URIs      110 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12916-017-0786-8 schema:about N0514da8079c744478c8fe5cd3273d9ab
    2 N35824f0012994d9c86e54405cef47b87
    3 N5d343993f69a4126a23f376215733634
    4 N60aa1a59674346f9a1da84ebc4e961cf
    5 N740ea799eaba46978fbe44303b5b7e2c
    6 N7b5807c3c53b432d9580f92068eaaafe
    7 N9f849a7ca1cd4fdab0cb4437d0812a85
    8 Nb362f772c319489c8f331a6f760e68d6
    9 Ne7e3815ecbb24fe5a2686085a397c8fe
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N58213f56ed644c6185cf1220c68dd367
    13 schema:citation sg:pub.10.1007/s00125-004-1652-8
    14 sg:pub.10.1007/s001980200045
    15 sg:pub.10.1007/s00232-012-9490-y
    16 sg:pub.10.1007/s10549-005-2419-8
    17 sg:pub.10.1007/s10549-008-9924-5
    18 sg:pub.10.1007/s10549-009-0350-0
    19 sg:pub.10.1007/s10549-014-2852-7
    20 sg:pub.10.1007/s10549-014-3049-9
    21 sg:pub.10.1007/s10654-014-9975-3
    22 sg:pub.10.1023/a:1016339120506
    23 sg:pub.10.1038/nature01658
    24 sg:pub.10.1038/nature09091
    25 sg:pub.10.1038/nature09387
    26 sg:pub.10.1038/nature09495
    27 sg:pub.10.1038/nm.4118
    28 sg:pub.10.1038/sj.bjc.6601947
    29 sg:pub.10.1186/bcr3456
    30 sg:pub.10.1186/s12885-015-1837-1
    31 sg:pub.10.1186/s12902-015-0067-5
    32 sg:pub.10.1186/s12943-015-0390-5
    33 schema:datePublished 2017-02-08
    34 schema:datePublishedReg 2017-02-08
    35 schema:description BackgroundCirculating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.MethodsA case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER–, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.ResultsThe associations between OPG and ER+ and ER– breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER– breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24–3.02]; ptrend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER– disease did not differ by menopausal status at blood collection (phet = 0.97), and we observed no heterogeneity by HT use at blood collection (phet ≥ 0.43) or age at breast cancer diagnosis (phet ≥ 0.30).ConclusionsThis study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER– breast cancer.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree true
    39 schema:isPartOf Nb4b57b59f525477fa8db0c8a360b8cce
    40 Nee233a3a41994dbfaf73032e907bfd7d
    41 sg:journal.1032885
    42 schema:keywords ConclusionsThis study
    43 EPIC cohort
    44 ER- breast cancer
    45 ER- disease
    46 European Prospective Investigation
    47 HT use
    48 MethodsA case–control study
    49 Nutrition Cohort
    50 OPG
    51 Prospective Investigation
    52 RANK ligand
    53 activator
    54 age
    55 analysis
    56 apoptosis-inducing ligand
    57 assays
    58 association
    59 axis
    60 blood collection
    61 breast cancer cases
    62 breast cancer diagnosis
    63 breast cancer risk
    64 cancer
    65 cancer cases
    66 cancer diagnosis
    67 cancer risk
    68 case-control study
    69 cases
    70 cohort
    71 collection
    72 concentration
    73 conditional logistic regression
    74 confidence intervals
    75 control
    76 data
    77 decoy receptor
    78 diagnosis
    79 disease
    80 electrochemiluminescence assay
    81 factor-related apoptosis-inducing ligand
    82 factors
    83 first prospective data
    84 heterogeneity
    85 high concentrations
    86 hormone receptor subtype
    87 hormone therapy
    88 incident invasive breast cancer cases
    89 interval
    90 invasive breast cancer cases
    91 inverse association
    92 investigation
    93 ligands
    94 logistic regression
    95 members
    96 menopausal status
    97 necrosis factor-related apoptosis-inducing ligand
    98 novel risk factors
    99 nuclear factor-kappa B (NF-κB) axis
    100 osteoprotegerin
    101 postmenopausal hormone therapy
    102 postmenopausal women
    103 prior studies
    104 prospective data
    105 receptor activator
    106 receptor subtypes
    107 receptors
    108 regression
    109 relative risk
    110 results
    111 risk
    112 risk factors
    113 role
    114 serum OPG
    115 status
    116 study
    117 subtypes
    118 suggestive inverse association
    119 therapy
    120 total
    121 tumor necrosis factor-related apoptosis-inducing ligand
    122 use
    123 users
    124 women
    125 schema:name Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
    126 schema:pagination 26
    127 schema:productId N82361d2a98014bdaa2641a8165ff7553
    128 N981ca109430547c0b625ef5f545a3ae5
    129 Nac6489c523554c58a53174c5a6fd6cda
    130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083508265
    131 https://doi.org/10.1186/s12916-017-0786-8
    132 schema:sdDatePublished 2022-05-10T10:17
    133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    134 schema:sdPublisher Ne9230578f3d540b5a571c59f1c42dd03
    135 schema:url https://doi.org/10.1186/s12916-017-0786-8
    136 sgo:license sg:explorer/license/
    137 sgo:sdDataset articles
    138 rdf:type schema:ScholarlyArticle
    139 N0514da8079c744478c8fe5cd3273d9ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Cohort Studies
    141 rdf:type schema:DefinedTerm
    142 N0a693d4ef2df4f4b8b45858bc23e2e0d rdf:first sg:person.015307142637.30
    143 rdf:rest Naf590f0ee6e143ba99354ef8ae55d57c
    144 N0dec0e3677b74e20b2d9730a88640e47 rdf:first sg:person.01024135334.78
    145 rdf:rest Ncba511e489ee4c4cbd717bf125ba2250
    146 N11112b49714d4cfb98c1895c38e01127 rdf:first sg:person.01046135645.03
    147 rdf:rest N70c97901f20e42bc8596b2885a4cedc3
    148 N20518d7689cd4be7b935ad9c032bda0b rdf:first sg:person.01346230170.69
    149 rdf:rest Nce6266f7f9764bfbab28b66b30f09665
    150 N231bdc8e9ac64c25a5f888693f9cb30d rdf:first sg:person.015420102437.43
    151 rdf:rest rdf:nil
    152 N239cdeb7db8b4eccbe2193cf261c33ad rdf:first Neb34d37ed6d0499385b236c1a0e8d126
    153 rdf:rest N20518d7689cd4be7b935ad9c032bda0b
    154 N2b079d397ff449d69d1046b1b09ef374 rdf:first sg:person.011104534765.43
    155 rdf:rest N5da434ea71ff4defadaa7c128d29b3b1
    156 N2d8e16fe27ef435b9bf2b91b89be6fa5 rdf:first sg:person.01161713144.12
    157 rdf:rest N2b079d397ff449d69d1046b1b09ef374
    158 N35824f0012994d9c86e54405cef47b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Case-Control Studies
    160 rdf:type schema:DefinedTerm
    161 N521770ecfab64b3fadfc09a9752d639f rdf:first sg:person.01254612334.90
    162 rdf:rest N0dec0e3677b74e20b2d9730a88640e47
    163 N576e9ac597774b29b9e69295899e0f33 rdf:first sg:person.0650023362.59
    164 rdf:rest Na41c7d50ddb54027bbe9669ef0c488fc
    165 N58213f56ed644c6185cf1220c68dd367 rdf:first sg:person.01046601661.53
    166 rdf:rest Nb8578e73ba7246ee81e7c83864d4e736
    167 N5b74e1adb6474a9ca8205ee89bc3328a rdf:first sg:person.01305543702.17
    168 rdf:rest Nda17f4f337be4bec85d522ced266e234
    169 N5d343993f69a4126a23f376215733634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Risk Factors
    171 rdf:type schema:DefinedTerm
    172 N5da434ea71ff4defadaa7c128d29b3b1 rdf:first sg:person.0625660524.69
    173 rdf:rest N7e79acaffac94b1394e9cb19f501ee40
    174 N5ecb098590764d88b9962f7db91ad6fc rdf:first sg:person.0710337377.75
    175 rdf:rest Nf528ca53b9bb4b388e6609e10798ebfd
    176 N60aa1a59674346f9a1da84ebc4e961cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Female
    178 rdf:type schema:DefinedTerm
    179 N6bc0073fb54e4917b793baa5e349fe5e schema:affiliation grid-institutes:grid.432380.e
    180 schema:familyName Dorronsoro
    181 schema:givenName Miren
    182 rdf:type schema:Person
    183 N70c97901f20e42bc8596b2885a4cedc3 rdf:first sg:person.01332611452.48
    184 rdf:rest Nf330ee260f2040009ba12ad426c6a131
    185 N735f20d11f4e4fd0814b1bb2ac039084 rdf:first sg:person.01253670741.91
    186 rdf:rest N231bdc8e9ac64c25a5f888693f9cb30d
    187 N740ea799eaba46978fbe44303b5b7e2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Osteoprotegerin
    189 rdf:type schema:DefinedTerm
    190 N7b5807c3c53b432d9580f92068eaaafe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Humans
    192 rdf:type schema:DefinedTerm
    193 N7b6a9a9c146b408b9dfaf24ef09df22a rdf:first sg:person.014110204647.37
    194 rdf:rest N8a899ed9690241eba49af36793aa687e
    195 N7bd7d6adb24e4a6b9ef6a47a81e9ec91 rdf:first sg:person.01276573557.19
    196 rdf:rest N239cdeb7db8b4eccbe2193cf261c33ad
    197 N7e79acaffac94b1394e9cb19f501ee40 rdf:first sg:person.01017060476.31
    198 rdf:rest N576e9ac597774b29b9e69295899e0f33
    199 N82361d2a98014bdaa2641a8165ff7553 schema:name pubmed_id
    200 schema:value 28173834
    201 rdf:type schema:PropertyValue
    202 N8a899ed9690241eba49af36793aa687e rdf:first sg:person.01005017746.37
    203 rdf:rest Na56e993d106a470dbae94559c73a2993
    204 N93cdd6a96b8e445ebad6dbbebfe99ee7 rdf:first sg:person.01335307124.43
    205 rdf:rest Nb0ef9fe1268b4a7e86c53f8223d83e1c
    206 N981ca109430547c0b625ef5f545a3ae5 schema:name doi
    207 schema:value 10.1186/s12916-017-0786-8
    208 rdf:type schema:PropertyValue
    209 N9e301793c4ad4fba91e8703f02fc6811 rdf:first sg:person.010014537677.09
    210 rdf:rest Nb3433b885ac545f4a77abb15e9ed4260
    211 N9f849a7ca1cd4fdab0cb4437d0812a85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Breast Neoplasms
    213 rdf:type schema:DefinedTerm
    214 Na41c7d50ddb54027bbe9669ef0c488fc rdf:first sg:person.0740214435.52
    215 rdf:rest N9e301793c4ad4fba91e8703f02fc6811
    216 Na56e993d106a470dbae94559c73a2993 rdf:first N6bc0073fb54e4917b793baa5e349fe5e
    217 rdf:rest Nb665a19ecb1b4b9d810e961fa7bfc226
    218 Nac6489c523554c58a53174c5a6fd6cda schema:name dimensions_id
    219 schema:value pub.1083508265
    220 rdf:type schema:PropertyValue
    221 Naf590f0ee6e143ba99354ef8ae55d57c rdf:first sg:person.01371677602.75
    222 rdf:rest N735f20d11f4e4fd0814b1bb2ac039084
    223 Nb0ef9fe1268b4a7e86c53f8223d83e1c rdf:first sg:person.01031554217.11
    224 rdf:rest N2d8e16fe27ef435b9bf2b91b89be6fa5
    225 Nb3433b885ac545f4a77abb15e9ed4260 rdf:first sg:person.0744006030.52
    226 rdf:rest N521770ecfab64b3fadfc09a9752d639f
    227 Nb362f772c319489c8f331a6f760e68d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Prospective Studies
    229 rdf:type schema:DefinedTerm
    230 Nb4b57b59f525477fa8db0c8a360b8cce schema:issueNumber 1
    231 rdf:type schema:PublicationIssue
    232 Nb665a19ecb1b4b9d810e961fa7bfc226 rdf:first sg:person.010714076422.15
    233 rdf:rest Nd6978ac376c8447c880d98769bc5e6db
    234 Nb8578e73ba7246ee81e7c83864d4e736 rdf:first sg:person.01311572120.03
    235 rdf:rest N7bd7d6adb24e4a6b9ef6a47a81e9ec91
    236 Ncba511e489ee4c4cbd717bf125ba2250 rdf:first sg:person.01075056726.24
    237 rdf:rest Ncd226d7b27994b0e98328e73b9ef2103
    238 Ncd226d7b27994b0e98328e73b9ef2103 rdf:first sg:person.01301037165.21
    239 rdf:rest N5ecb098590764d88b9962f7db91ad6fc
    240 Nce6266f7f9764bfbab28b66b30f09665 rdf:first sg:person.01027705103.14
    241 rdf:rest N93cdd6a96b8e445ebad6dbbebfe99ee7
    242 Nd6978ac376c8447c880d98769bc5e6db rdf:first sg:person.015521617657.37
    243 rdf:rest N5b74e1adb6474a9ca8205ee89bc3328a
    244 Nd9b8fa9ec3bd4af1b5d2e0e3e18c3c12 rdf:first sg:person.01147471116.91
    245 rdf:rest N11112b49714d4cfb98c1895c38e01127
    246 Nda17f4f337be4bec85d522ced266e234 rdf:first sg:person.01143450544.32
    247 rdf:rest N0a693d4ef2df4f4b8b45858bc23e2e0d
    248 Ne7e3815ecbb24fe5a2686085a397c8fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Middle Aged
    250 rdf:type schema:DefinedTerm
    251 Ne9230578f3d540b5a571c59f1c42dd03 schema:name Springer Nature - SN SciGraph project
    252 rdf:type schema:Organization
    253 Neb34d37ed6d0499385b236c1a0e8d126 schema:affiliation grid-institutes:grid.7497.d
    254 schema:familyName Johnson
    255 schema:givenName Theron
    256 rdf:type schema:Person
    257 Nee233a3a41994dbfaf73032e907bfd7d schema:volumeNumber 15
    258 rdf:type schema:PublicationVolume
    259 Nf330ee260f2040009ba12ad426c6a131 rdf:first sg:person.01206565027.91
    260 rdf:rest N7b6a9a9c146b408b9dfaf24ef09df22a
    261 Nf528ca53b9bb4b388e6609e10798ebfd rdf:first sg:person.01172774244.59
    262 rdf:rest Nfaa714d6b2a543b29e6478b0dedf2493
    263 Nfaa714d6b2a543b29e6478b0dedf2493 rdf:first sg:person.01317176547.68
    264 rdf:rest Nd9b8fa9ec3bd4af1b5d2e0e3e18c3c12
    265 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    266 schema:name Medical and Health Sciences
    267 rdf:type schema:DefinedTerm
    268 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    269 schema:name Oncology and Carcinogenesis
    270 rdf:type schema:DefinedTerm
    271 sg:grant.2755349 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    272 rdf:type schema:MonetaryGrant
    273 sg:grant.2774057 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.3866507 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.5072449 http://pending.schema.org/fundedItem sg:pub.10.1186/s12916-017-0786-8
    278 rdf:type schema:MonetaryGrant
    279 sg:journal.1032885 schema:issn 1741-7015
    280 schema:name BMC Medicine
    281 schema:publisher Springer Nature
    282 rdf:type schema:Periodical
    283 sg:person.010014537677.09 schema:affiliation grid-institutes:grid.417623.5
    284 schema:familyName Palli
    285 schema:givenName Domenico
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09
    287 rdf:type schema:Person
    288 sg:person.01005017746.37 schema:affiliation grid-institutes:grid.508840.1
    289 schema:familyName Ardanaz
    290 schema:givenName Eva
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005017746.37
    292 rdf:type schema:Person
    293 sg:person.01017060476.31 schema:affiliation grid-institutes:grid.5216.0
    294 schema:familyName Trichopoulou
    295 schema:givenName Antonia
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017060476.31
    297 rdf:type schema:Person
    298 sg:person.01024135334.78 schema:affiliation grid-institutes:None
    299 schema:familyName Tumino
    300 schema:givenName Rosario
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024135334.78
    302 rdf:type schema:Person
    303 sg:person.01027705103.14 schema:affiliation grid-institutes:grid.417390.8
    304 schema:familyName Olsen
    305 schema:givenName Anja
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027705103.14
    307 rdf:type schema:Person
    308 sg:person.01031554217.11 schema:affiliation grid-institutes:grid.14925.3b
    309 schema:familyName Affret
    310 schema:givenName Aurélie
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031554217.11
    312 rdf:type schema:Person
    313 sg:person.01046135645.03 schema:affiliation grid-institutes:None
    314 schema:familyName Quirós
    315 schema:givenName J. Ramón
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046135645.03
    317 rdf:type schema:Person
    318 sg:person.01046601661.53 schema:affiliation grid-institutes:grid.7497.d
    319 schema:familyName Fortner
    320 schema:givenName Renée T.
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046601661.53
    322 rdf:type schema:Person
    323 sg:person.010714076422.15 schema:affiliation grid-institutes:grid.4991.5
    324 schema:familyName Key
    325 schema:givenName Tim
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010714076422.15
    327 rdf:type schema:Person
    328 sg:person.01075056726.24 schema:affiliation grid-institutes:grid.7605.4
    329 schema:familyName Ricceri
    330 schema:givenName Fulvio
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075056726.24
    332 rdf:type schema:Person
    333 sg:person.011104534765.43 schema:affiliation grid-institutes:grid.14925.3b
    334 schema:familyName Boutron-Ruault
    335 schema:givenName Marie-Christine
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011104534765.43
    337 rdf:type schema:Person
    338 sg:person.01143450544.32 schema:affiliation grid-institutes:grid.17703.32
    339 schema:familyName Dossus
    340 schema:givenName Laure
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143450544.32
    342 rdf:type schema:Person
    343 sg:person.01147471116.91 schema:affiliation grid-institutes:grid.10919.30
    344 schema:familyName Lund
    345 schema:givenName Eiliv
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147471116.91
    347 rdf:type schema:Person
    348 sg:person.01161713144.12 schema:affiliation grid-institutes:grid.14925.3b
    349 schema:familyName His
    350 schema:givenName Mathilde
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161713144.12
    352 rdf:type schema:Person
    353 sg:person.01172774244.59 schema:affiliation grid-institutes:grid.7692.a
    354 schema:familyName Van Gils
    355 schema:givenName Carla H.
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172774244.59
    357 rdf:type schema:Person
    358 sg:person.01206565027.91 schema:affiliation grid-institutes:grid.466571.7
    359 schema:familyName Sánchez
    360 schema:givenName Maria-José
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206565027.91
    362 rdf:type schema:Person
    363 sg:person.01253670741.91 schema:affiliation grid-institutes:grid.7445.2
    364 schema:familyName Riboli
    365 schema:givenName Elio
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253670741.91
    367 rdf:type schema:Person
    368 sg:person.01254612334.90 schema:affiliation grid-institutes:grid.4691.a
    369 schema:familyName Mattiello
    370 schema:givenName Amalia
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254612334.90
    372 rdf:type schema:Person
    373 sg:person.01276573557.19 schema:affiliation grid-institutes:grid.7497.d
    374 schema:familyName Schock
    375 schema:givenName Helena
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276573557.19
    377 rdf:type schema:Person
    378 sg:person.01301037165.21 schema:affiliation grid-institutes:grid.10347.31
    379 schema:familyName Bueno-de-Mesquita
    380 schema:givenName H. Bas
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301037165.21
    382 rdf:type schema:Person
    383 sg:person.01305543702.17 schema:affiliation grid-institutes:grid.17703.32
    384 schema:familyName Rinaldi
    385 schema:givenName Sabina
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305543702.17
    387 rdf:type schema:Person
    388 sg:person.01311572120.03 schema:affiliation grid-institutes:grid.7497.d
    389 schema:familyName Sarink
    390 schema:givenName Danja
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311572120.03
    392 rdf:type schema:Person
    393 sg:person.01317176547.68 schema:affiliation grid-institutes:grid.428673.c
    394 schema:familyName Weiderpass
    395 schema:givenName Elisabete
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317176547.68
    397 rdf:type schema:Person
    398 sg:person.01332611452.48 schema:affiliation grid-institutes:grid.418284.3
    399 schema:familyName Agudo
    400 schema:givenName Antonio
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332611452.48
    402 rdf:type schema:Person
    403 sg:person.01335307124.43 schema:affiliation grid-institutes:grid.7048.b
    404 schema:familyName Overvad
    405 schema:givenName Kim
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335307124.43
    407 rdf:type schema:Person
    408 sg:person.01346230170.69 schema:affiliation grid-institutes:grid.417390.8
    409 schema:familyName Tjønneland
    410 schema:givenName Anne
    411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346230170.69
    412 rdf:type schema:Person
    413 sg:person.01371677602.75 schema:affiliation grid-institutes:grid.7445.2
    414 schema:familyName Merritt
    415 schema:givenName Melissa A.
    416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371677602.75
    417 rdf:type schema:Person
    418 sg:person.014110204647.37 schema:affiliation grid-institutes:grid.10586.3a
    419 schema:familyName Chirlaque
    420 schema:givenName María-Dolores
    421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014110204647.37
    422 rdf:type schema:Person
    423 sg:person.015307142637.30 schema:affiliation grid-institutes:grid.17703.32
    424 schema:familyName Gunter
    425 schema:givenName Marc
    426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015307142637.30
    427 rdf:type schema:Person
    428 sg:person.015420102437.43 schema:affiliation grid-institutes:grid.7497.d
    429 schema:familyName Kaaks
    430 schema:givenName Rudolf
    431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015420102437.43
    432 rdf:type schema:Person
    433 sg:person.015521617657.37 schema:affiliation grid-institutes:grid.5335.0
    434 schema:familyName Khaw
    435 schema:givenName Kay-Tee
    436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015521617657.37
    437 rdf:type schema:Person
    438 sg:person.0625660524.69 schema:affiliation grid-institutes:grid.418213.d
    439 schema:familyName Boeing
    440 schema:givenName Heiner
    441 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625660524.69
    442 rdf:type schema:Person
    443 sg:person.0650023362.59 schema:affiliation grid-institutes:grid.5216.0
    444 schema:familyName Naska
    445 schema:givenName Androniki
    446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650023362.59
    447 rdf:type schema:Person
    448 sg:person.0710337377.75 schema:affiliation grid-institutes:grid.7445.2
    449 schema:familyName Peeters
    450 schema:givenName Petra H. M.
    451 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710337377.75
    452 rdf:type schema:Person
    453 sg:person.0740214435.52 schema:affiliation grid-institutes:grid.5216.0
    454 schema:familyName Orfanos
    455 schema:givenName Philippos
    456 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740214435.52
    457 rdf:type schema:Person
    458 sg:person.0744006030.52 schema:affiliation grid-institutes:grid.417893.0
    459 schema:familyName Sieri
    460 schema:givenName Sabina
    461 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744006030.52
    462 rdf:type schema:Person
    463 sg:pub.10.1007/s00125-004-1652-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040864632
    464 https://doi.org/10.1007/s00125-004-1652-8
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1007/s001980200045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035334352
    467 https://doi.org/10.1007/s001980200045
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1007/s00232-012-9490-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052427537
    470 https://doi.org/10.1007/s00232-012-9490-y
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1007/s10549-005-2419-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008264217
    473 https://doi.org/10.1007/s10549-005-2419-8
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1007/s10549-008-9924-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004175549
    476 https://doi.org/10.1007/s10549-008-9924-5
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1007/s10549-009-0350-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043212667
    479 https://doi.org/10.1007/s10549-009-0350-0
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1007/s10549-014-2852-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025842663
    482 https://doi.org/10.1007/s10549-014-2852-7
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1007/s10549-014-3049-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043974543
    485 https://doi.org/10.1007/s10549-014-3049-9
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1007/s10654-014-9975-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048139987
    488 https://doi.org/10.1007/s10654-014-9975-3
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1023/a:1016339120506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043199963
    491 https://doi.org/10.1023/a:1016339120506
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/nature01658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019910253
    494 https://doi.org/10.1038/nature01658
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/nature09091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010449747
    497 https://doi.org/10.1038/nature09091
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/nature09387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039295960
    500 https://doi.org/10.1038/nature09387
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/nature09495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028032153
    503 https://doi.org/10.1038/nature09495
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/nm.4118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025264215
    506 https://doi.org/10.1038/nm.4118
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/sj.bjc.6601947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006526014
    509 https://doi.org/10.1038/sj.bjc.6601947
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1186/bcr3456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038971688
    512 https://doi.org/10.1186/bcr3456
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1186/s12885-015-1837-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268280
    515 https://doi.org/10.1186/s12885-015-1837-1
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1186/s12902-015-0067-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014098214
    518 https://doi.org/10.1186/s12902-015-0067-5
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1186/s12943-015-0390-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024011568
    521 https://doi.org/10.1186/s12943-015-0390-5
    522 rdf:type schema:CreativeWork
    523 grid-institutes:None schema:alternateName Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
    524 Public Health Directorate, Asturias, Spain
    525 schema:name Cancer Registry and Histopathology Unit, “Civic - M.p.Arezzo” Hospital, ASP Ragusa, Italy
    526 Public Health Directorate, Asturias, Spain
    527 rdf:type schema:Organization
    528 grid-institutes:grid.10347.31 schema:alternateName Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    529 schema:name Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
    530 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    531 Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    532 rdf:type schema:Organization
    533 grid-institutes:grid.10586.3a schema:alternateName Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
    534 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    535 Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
    536 Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
    537 rdf:type schema:Organization
    538 grid-institutes:grid.10919.30 schema:alternateName Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    539 schema:name Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    540 rdf:type schema:Organization
    541 grid-institutes:grid.14925.3b schema:alternateName Gustave Roussy, F-94805, Villejuif, France
    542 schema:name Gustave Roussy, F-94805, Villejuif, France
    543 Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France
    544 rdf:type schema:Organization
    545 grid-institutes:grid.17703.32 schema:alternateName International Agency for Research on Cancer, Lyon, France
    546 schema:name International Agency for Research on Cancer, Lyon, France
    547 rdf:type schema:Organization
    548 grid-institutes:grid.417390.8 schema:alternateName Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
    549 schema:name Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
    550 rdf:type schema:Organization
    551 grid-institutes:grid.417623.5 schema:alternateName Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
    552 schema:name Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
    553 rdf:type schema:Organization
    554 grid-institutes:grid.417893.0 schema:alternateName Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    555 schema:name Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    556 rdf:type schema:Organization
    557 grid-institutes:grid.418213.d schema:alternateName Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
    558 schema:name Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
    559 rdf:type schema:Organization
    560 grid-institutes:grid.418284.3 schema:alternateName Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
    561 schema:name Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L’Hospitalet de Llobregat, Barcelona, Spain
    562 rdf:type schema:Organization
    563 grid-institutes:grid.428673.c schema:alternateName Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
    564 schema:name Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
    565 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    566 Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway
    567 Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland
    568 rdf:type schema:Organization
    569 grid-institutes:grid.432380.e schema:alternateName Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
    570 schema:name Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain
    571 rdf:type schema:Organization
    572 grid-institutes:grid.466571.7 schema:alternateName CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    573 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    574 Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
    575 rdf:type schema:Organization
    576 grid-institutes:grid.4691.a schema:alternateName Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
    577 schema:name Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
    578 rdf:type schema:Organization
    579 grid-institutes:grid.4991.5 schema:alternateName Nuffield Department of Population Health, University of Oxford, Oxford, UK
    580 schema:name Nuffield Department of Population Health, University of Oxford, Oxford, UK
    581 rdf:type schema:Organization
    582 grid-institutes:grid.508840.1 schema:alternateName IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
    583 schema:name CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
    584 IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
    585 Navarra Public Health Institute, Pamplona, Spain
    586 rdf:type schema:Organization
    587 grid-institutes:grid.5216.0 schema:alternateName WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
    588 schema:name Hellenic Health Foundation, Athens, Greece
    589 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
    590 rdf:type schema:Organization
    591 grid-institutes:grid.5335.0 schema:alternateName Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
    592 schema:name Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK
    593 rdf:type schema:Organization
    594 grid-institutes:grid.7048.b schema:alternateName Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
    595 schema:name Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
    596 rdf:type schema:Organization
    597 grid-institutes:grid.7445.2 schema:alternateName Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    598 MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
    599 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    600 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    601 MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK
    602 rdf:type schema:Organization
    603 grid-institutes:grid.7497.d schema:alternateName Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany
    604 schema:name Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany
    605 rdf:type schema:Organization
    606 grid-institutes:grid.7605.4 schema:alternateName Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
    607 schema:name Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
    608 Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy
    609 rdf:type schema:Organization
    610 grid-institutes:grid.7692.a schema:alternateName Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    611 schema:name Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    612 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...