Modelling the potential of genetic control of malaria mosquitoes at national scale View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ace R. North, Austin Burt, H. Charles J. Godfray

ABSTRACT

BACKGROUND: The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a driving-Y chromosome to suppress vector populations in a 106 km2 area of West Africa including all of Burkina Faso. RESULTS: The consequence of driving-Y introductions is predicted to vary across the landscape, causing elimination of the target species in some regions and suppression in others. We explore how this variation is determined by environmental conditions, mosquito behaviour, and the properties of the gene-drive. Seasonality is particularly important, and we find population elimination is more likely in regions with mild dry seasons whereas suppression is more likely in regions with strong seasonality. CONCLUSIONS: Despite the spatial heterogeneity, we suggest that repeated introductions of modified mosquitoes over a few years into a small fraction of human settlements may be sufficient to substantially reduce the overall number of mosquitoes across the entire geographic area. More... »

PAGES

26

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  • Journal

    TITLE

    BMC Biology

    ISSUE

    1

    VOLUME

    17

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12915-019-0645-5

    DOI

    http://dx.doi.org/10.1186/s12915-019-0645-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113049959

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30922310


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