Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Nicholas J. Gay

ABSTRACT

A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 that cause immunodeficiency are unable to form these structures. By contrast a somatic mutant that promotes the survival of tumour cells forms oligomers much more readily than the wild-type protein. These findings suggest that assembly of oligomeric MyD88 is critical for the regulation of inflammatory signalling. More... »

PAGES

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12915-019-0637-5

DOI

http://dx.doi.org/10.1186/s12915-019-0637-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112259601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30786893


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