Circadian oscillator proteins across the kingdoms of life: structural aspects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Reena Saini, Mariusz Jaskolski, Seth J. Davis

ABSTRACT

Circadian oscillators are networks of biochemical feedback loops that generate 24-hour rhythms in organisms from bacteria to animals. These periodic rhythms result from a complex interplay among clock components that are specific to the organism, but share molecular mechanisms across kingdoms. A full understanding of these processes requires detailed knowledge, not only of the biochemical properties of clock proteins and their interactions, but also of the three-dimensional structure of clockwork components. Posttranslational modifications and protein-protein interactions have become a recent focus, in particular the complex interactions mediated by the phosphorylation of clock proteins and the formation of multimeric protein complexes that regulate clock genes at transcriptional and translational levels. This review covers the structural aspects of circadian oscillators, and serves as a primer for this exciting realm of structural biology. More... »

PAGES

13

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12915-018-0623-3

    DOI

    http://dx.doi.org/10.1186/s12915-018-0623-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112215650

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30777051


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