Systematic target function annotation of human transcription factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yong Fuga Li, Russ B. Altman

ABSTRACT

BACKGROUND: Transcription factors (TFs), the key players in transcriptional regulation, have attracted great experimental attention, yet the functions of most human TFs remain poorly understood. Recent capabilities in genome-wide protein binding profiling have stimulated systematic studies of the hierarchical organization of human gene regulatory network and DNA-binding specificity of TFs, shedding light on combinatorial gene regulation. We show here that these data also enable a systematic annotation of the biological functions and functional diversity of TFs. RESULT: We compiled a human gene regulatory network for 384 TFs covering the 146,096 TF-target gene (TF-TG) relationships, extracted from over 850 ChIP-seq experiments as well as the literature. By integrating this network of TF-TF and TF-TG relationships with 3715 functional concepts from six sources of gene function annotations, we obtained over 9000 confident functional annotations for 279 TFs. We observe extensive connectivity between TFs and Mendelian diseases, GWAS phenotypes, and pharmacogenetic pathways. Further, we show that TFs link apparently unrelated functions, even when the two functions do not share common genes. Finally, we analyze the pleiotropic functions of TFs and suggest that the increased number of upstream regulators contributes to the functional pleiotropy of TFs. CONCLUSION: Our computational approach is complementary to focused experimental studies on TF functions, and the resulting knowledge can guide experimental design for the discovery of unknown roles of TFs in human disease and drug response. More... »

PAGES

4

References to SciGraph publications

  • 2000-05. Gene Ontology: tool for the unification of biology in NATURE GENETICS
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 1989-07. Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2011-02. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-11. FOXO transcription factors at the interface between longevity and tumor suppression in ONCOGENE
  • 2005-09. Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides in HUMAN GENETICS
  • 2011-06. Coffee consumption modifies risk of estrogen-receptor negative breast cancer in BREAST CANCER RESEARCH
  • 2015-05. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption in MOLECULAR PSYCHIATRY
  • 2012-12. HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions in BMC GENOMICS
  • 2002-10. Dec1 and Dec2 are regulators of the mammalian molecular clock in NATURE
  • 2005-07. Controlling nuclear receptors: the circular logic of cofactor cycles in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-02. SOX10 mutations in patients with Waardenburg-Hirschsprung disease in NATURE GENETICS
  • 2008-01. Reprogramming of human somatic cells to pluripotency with defined factors in NATURE
  • 2004-04. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) in NATURE GENETICS
  • 2009-04. A census of human transcription factors: function, expression and evolution in NATURE REVIEWS GENETICS
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2010-12. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data in BMC BIOINFORMATICS
  • 2010-05. GREAT improves functional interpretation of cis-regulatory regions in NATURE BIOTECHNOLOGY
  • 2009-12. BayesPeak: Bayesian analysis of ChIP-seq data in BMC BIOINFORMATICS
  • 2008-08. Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation in NATURE REVIEWS GENETICS
  • 1998-11. A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients in NATURE GENETICS
  • 2007-05-24. Stability and flexibility of epigenetic gene regulation in mammalian development in NATURE
  • 2009-12. Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators in HUMAN GENETICS
  • 2012-09. Architecture of the human regulatory network derived from ENCODE data in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2007-10. The NCBI dbGaP database of genotypes and phenotypes in NATURE GENETICS
  • 2012-03. The Transcription Factor Encyclopedia in GENOME BIOLOGY
  • 1982-08. Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line in NATURE
  • 2012-11. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2013-01. Bardet–Biedl syndrome in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 1991-10. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour in NATURE
  • 2010-08. Biological, clinical and population relevance of 95 loci for blood lipids in NATURE
  • 2012-12. ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions in NATURE REVIEWS GENETICS
  • 2007-09. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study in BMC MEDICAL GENETICS
  • 2015-11. DNA-dependent formation of transcription factor pairs alters their binding specificity in NATURE
  • 2012-04. Metazoan promoters: emerging characteristics and insights into transcriptional regulation in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12915-017-0469-0

    DOI

    http://dx.doi.org/10.1186/s12915-017-0469-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100302267

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29325558


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