Acute liver failure associated with Fructus Psoraleae: a case report and literature review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04-11

AUTHORS

Ang Li, Minhong Gao, Na Zhao, Ping Li, Jinguo Zhu, Wenfei Li

ABSTRACT

BACKGROUND: Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qubaibabuqi tablet formula, Fructus Psoraleae plays an important role in the treatment of vitiligo. Fructus Psoraleae has potential hepatotoxicity, thus Qubaibabuqi tablets also have potential liver toxicity. CASE PRESENTATION: A 53-year-old woman who was diagnosed with vitiligo in September 2017 was treated with Qubaibabuqi tablets. After approximately 7 months of treatment, the patient developed a severe, diffuse yellow staining of the skin and sclera in March 2018. On admission, she was diagnosed with acute cholestatic hepatitis associated with Fructus Psoraleae. Despite receiving active treatment, her condition rapidly deteriorated and she died 5 days later due to acute liver failure and multiple organ dysfunction. To the best of our knowledge, there are only six reported cases of liver injury associated with Fructus Psoraleae described in the English language literature; however, cases of acute liver failure associated with the use of Fructus Psoraleae have not been described. CONCLUSION: As a main ingredient in the Qubaibabuqi tablet formula, Fructus Psoraleae has potential hepatotoxicity. This potentially fatal adverse effect should be considered when physicians prescribe Qubaibabuqi tablets. More... »

PAGES

84

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-019-2493-9

DOI

http://dx.doi.org/10.1186/s12906-019-2493-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113377823

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30975110


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208 grid-institutes:grid.260463.5 schema:alternateName Department of Clinical Medicine, Queen Mary School, Medical school, Nanchang University, Nanchang, China
209 schema:name Department of Clinical Medicine, Queen Mary School, Medical school, Nanchang University, Nanchang, China
210 Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014 China
211 Department of Orthopedic Surgery, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
212 rdf:type schema:Organization
213 grid-institutes:grid.27255.37 schema:alternateName Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014 China
214 schema:name Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014 China
215 rdf:type schema:Organization
216 grid-institutes:grid.410638.8 schema:alternateName Department of Clinical Medicine, Taishan Medical College, Tai’an, China
217 schema:name Department of Clinical Medicine, Taishan Medical College, Tai’an, China
218 Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014 China
219 rdf:type schema:Organization
 




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