Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sangrak Bae, Kyu Won Lee, Hyun Cheol Jeong, Bong Hee Park, Woong Jin Bae, Chang Hee Han, Sae Woong Kim

ABSTRACT

BACKGROUND: We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO). METHODS: The MO formula consisted of 5 seeds obtained from 5 types of berry plants. Twenty-four Sprague-Dawley rats were randomly assigned to four groups: sham-operated (control), partial urethral obstruction-induced DO (DO group), 0.03 mg/kg solifenacin-treated DO (solifenacin group) and 200 mg/kg MO formula -treated DO (berry mixture). The control and overactive groups were administered distilled water for 4 weeks, and the solifenacin and MO formula groups were treated with the respective medication for 4 weeks. After treatment, cystometrography was performed. At the endo of cystometrography, their bladder tissues were used for identifying the muscarinic receptors, endothelial nitric oxide synthase(eNOS), RhoA, Rock-I & II, 8-hydroxy-2' -deoxyguanosine(8-OHdG), superoxide dismutase(SOD), interleukin-6 &-8(IL-6, IL-8), and tumor necrosis factor-alpha(TNF-a). The tissues were stained and the muscle-to-collagen ratio was identified. RESULTS: The presence of the muscarinic receptors were not significantly different between the solifenacin and MO formula groups. However, significant differences were found between the solifenacin and MO formula groups in terms of eNOS, RhoA, Rock-I and -II levels. The muscle-to-collagen ratio was statistically lower in the DO and solifenacin groups; however, no significant difference was observed between the control and MO formula groups. Under oxidative stress, SOD showed a similar result as 8-OHgG. The MO formula group exhibited anti-inflammatory effects, showing that no significant difference was found between the control and MO formula groups regarding values of IL-6, IL-8, and TNF-a. However, the DO and solifenacin groups showed increased IL-6, IL-8, and TNF-a levels. Cystometrography showed that the OAB and solifenacin groups having a significantly lower value than the control and MO formula groups. The mean contraction interval was shorter in the DO, MO formula, and solifenacin groups and the highest in the control group. CONCLUSIONS: The MO formula exhibited a similar pharmacologic effect to that of solifenacin, with anti-inflammatory and antioxidant effects. Enhancement of the MO formula by the nitric oxide pathway affected DO including BPH-related DO. The MO formula may be one of the alternative choices of anticholinergics, a treatment for DO. More... »

PAGES

64

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-019-2467-y

DOI

http://dx.doi.org/10.1186/s12906-019-2467-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112767820

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30871532


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drugs, Chinese Herbal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Muscarinic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urethral Obstruction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder, Overactive", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bae", 
        "givenName": "Sangrak", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyu Won", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kangdong Sacred Heart Hospital", 
          "id": "https://www.grid.ac/institutes/grid.488451.4", 
          "name": [
            "Kangdong Sacred Heart Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Hyun Cheol", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Bong Hee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bae", 
        "givenName": "Woong Jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Chang Hee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catholic University of Korea", 
          "id": "https://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Urology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sae Woong", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.purol.2013.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000188319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2004.04.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002981892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejogrb.2016.03.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003301982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4111/icu.2016.57.2.84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004320701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5534/wjmh.2015.33.2.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007630726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2009.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009333712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00192-010-1219-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010321425", 
          "https://doi.org/10.1007/s00192-010-1219-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00192-010-1219-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010321425", 
          "https://doi.org/10.1007/s00192-010-1219-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4162/nrp.2014.8.5.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012161226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2014.08.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012852615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1r528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014000790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1r528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014000790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2007.10.077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015445627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nau.22589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015922884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iju.12685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016916441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5534/kja.2011.29.2.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016964419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.3393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018147477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nau.22507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019548527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2042098616659412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019849568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2042098616659412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019849568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023040682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2015.12.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028571642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000277604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031179766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-008-0303-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034379519", 
          "https://doi.org/10.1007/s00345-008-0303-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-008-0303-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034379519", 
          "https://doi.org/10.1007/s00345-008-0303-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1757-5672.2011.00134.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035962832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/rru.s102441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jsm.12261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039933445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5534/wjmh.2013.31.3.254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041937385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2009.02.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044349991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2012.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044790165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2010.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046086541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2007.07310.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046519028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00046.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046833361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2015.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049056520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756287215589238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756287215589238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12906-017-1588-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083870169", 
          "https://doi.org/10.1186/s12906-017-1588-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12906-017-1588-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083870169", 
          "https://doi.org/10.1186/s12906-017-1588-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13880209.2017.1340965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086386025"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO).\nMETHODS: The MO formula consisted of 5 seeds obtained from 5 types of berry plants. Twenty-four Sprague-Dawley rats were randomly assigned to four groups: sham-operated (control), partial urethral obstruction-induced DO (DO group), 0.03\u2009mg/kg solifenacin-treated DO (solifenacin group) and 200\u2009mg/kg MO formula -treated DO (berry mixture). The control and overactive groups were administered distilled water for 4\u2009weeks, and the solifenacin and MO formula groups were treated with the respective medication for 4\u2009weeks. After treatment, cystometrography was performed. At the endo of cystometrography, their bladder tissues were used for identifying the muscarinic receptors, endothelial nitric oxide synthase(eNOS), RhoA, Rock-I & II, 8-hydroxy-2' -deoxyguanosine(8-OHdG), superoxide dismutase(SOD), interleukin-6 &-8(IL-6, IL-8), and tumor necrosis factor-alpha(TNF-a). The tissues were stained and the muscle-to-collagen ratio was identified.\nRESULTS: The presence of the muscarinic receptors were not significantly different between the solifenacin and MO formula groups. However, significant differences were found between the solifenacin and MO formula groups in terms of eNOS, RhoA, Rock-I and -II levels. The muscle-to-collagen ratio was statistically lower in the DO and solifenacin groups; however, no significant difference was observed between the control and MO formula groups. Under oxidative stress, SOD showed a similar result as 8-OHgG. The MO formula group exhibited anti-inflammatory effects, showing that no significant difference was found between the control and MO formula groups regarding values of IL-6, IL-8, and TNF-a. However, the DO and solifenacin groups showed increased IL-6, IL-8, and TNF-a levels. Cystometrography showed that the OAB and solifenacin groups having a significantly lower value than the control and MO formula groups. The mean contraction interval was shorter in the DO, MO formula, and solifenacin groups and the highest in the control group.\nCONCLUSIONS: The MO formula exhibited a similar pharmacologic effect to that of solifenacin, with anti-inflammatory and antioxidant effects. Enhancement of the MO formula by the nitric oxide pathway affected DO including BPH-related DO. The MO formula may be one of the alternative choices of anticholinergics, a treatment for DO.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12906-019-2467-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028418", 
        "issn": [
          "1472-6882"
        ], 
        "name": "BMC Complementary and Alternative Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress", 
    "pagination": "64", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12906-019-2467-y"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e012c54eae314f889ddcbea4d0464c833278e8e794436b3b189cb1573435f82a"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112767820"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101088661"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30871532"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12906-019-2467-y", 
      "https://app.dimensions.ai/details/publication/pub.1112767820"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56173_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12906-019-2467-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2467-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2467-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2467-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2467-y'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      75 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12906-019-2467-y schema:about N1eb3bea0dabe4072ab8f667568a686db
2 N2656b0c1c169419abd61faba52a70750
3 N3181033263634d62969aae2f37a69f4d
4 N3bc7afae4a9a4f0b9950ecbceac74386
5 N59b5bcebecff43c1a4c945efbaef3a04
6 N76ab4607b86344da88544f83cc28823f
7 N8370ba872803442c9accac5c19097938
8 N9a3cf5f74d824d19866e411113158ceb
9 N9e0383779b7d4d5ea0df45775b83fcac
10 Nabb59cf31333433e8dd50ff4ab8c80a9
11 Nb45f2d65f84f41df99016af8c16d4110
12 Nf9212db7439743c5931299d137939252
13 anzsrc-for:11
14 anzsrc-for:1115
15 schema:author N43fd130daefa4badb309d65878a91ab8
16 schema:citation sg:pub.10.1007/s00192-010-1219-9
17 sg:pub.10.1007/s00345-008-0303-y
18 sg:pub.10.1186/s12906-017-1588-4
19 https://doi.org/10.1002/nau.22507
20 https://doi.org/10.1002/nau.22589
21 https://doi.org/10.1002/ptr.3393
22 https://doi.org/10.1016/j.ejogrb.2016.03.024
23 https://doi.org/10.1016/j.eururo.2012.09.006
24 https://doi.org/10.1016/j.eururo.2015.12.048
25 https://doi.org/10.1016/j.foodchem.2007.10.077
26 https://doi.org/10.1016/j.jep.2004.04.028
27 https://doi.org/10.1016/j.jep.2008.08.005
28 https://doi.org/10.1016/j.jep.2009.06.028
29 https://doi.org/10.1016/j.jep.2014.08.029
30 https://doi.org/10.1016/j.jep.2015.12.026
31 https://doi.org/10.1016/j.juro.2009.02.104
32 https://doi.org/10.1016/j.neuint.2010.12.002
33 https://doi.org/10.1016/j.purol.2013.07.005
34 https://doi.org/10.1080/13880209.2017.1340965
35 https://doi.org/10.1111/iju.12685
36 https://doi.org/10.1111/j.1464-410x.2007.07310.x
37 https://doi.org/10.1111/j.1757-5672.2011.00134.x
38 https://doi.org/10.1111/jsm.12261
39 https://doi.org/10.1152/ajpregu.00046.2011
40 https://doi.org/10.1159/000277604
41 https://doi.org/10.1177/1756287215589238
42 https://doi.org/10.1177/2042098616659412
43 https://doi.org/10.1345/aph.1r528
44 https://doi.org/10.2147/rru.s102441
45 https://doi.org/10.4111/icu.2016.57.2.84
46 https://doi.org/10.4162/nrp.2014.8.5.501
47 https://doi.org/10.5534/kja.2011.29.2.91
48 https://doi.org/10.5534/wjmh.2013.31.3.254
49 https://doi.org/10.5534/wjmh.2015.33.2.73
50 schema:datePublished 2019-12
51 schema:datePublishedReg 2019-12-01
52 schema:description BACKGROUND: We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO). METHODS: The MO formula consisted of 5 seeds obtained from 5 types of berry plants. Twenty-four Sprague-Dawley rats were randomly assigned to four groups: sham-operated (control), partial urethral obstruction-induced DO (DO group), 0.03 mg/kg solifenacin-treated DO (solifenacin group) and 200 mg/kg MO formula -treated DO (berry mixture). The control and overactive groups were administered distilled water for 4 weeks, and the solifenacin and MO formula groups were treated with the respective medication for 4 weeks. After treatment, cystometrography was performed. At the endo of cystometrography, their bladder tissues were used for identifying the muscarinic receptors, endothelial nitric oxide synthase(eNOS), RhoA, Rock-I & II, 8-hydroxy-2' -deoxyguanosine(8-OHdG), superoxide dismutase(SOD), interleukin-6 &-8(IL-6, IL-8), and tumor necrosis factor-alpha(TNF-a). The tissues were stained and the muscle-to-collagen ratio was identified. RESULTS: The presence of the muscarinic receptors were not significantly different between the solifenacin and MO formula groups. However, significant differences were found between the solifenacin and MO formula groups in terms of eNOS, RhoA, Rock-I and -II levels. The muscle-to-collagen ratio was statistically lower in the DO and solifenacin groups; however, no significant difference was observed between the control and MO formula groups. Under oxidative stress, SOD showed a similar result as 8-OHgG. The MO formula group exhibited anti-inflammatory effects, showing that no significant difference was found between the control and MO formula groups regarding values of IL-6, IL-8, and TNF-a. However, the DO and solifenacin groups showed increased IL-6, IL-8, and TNF-a levels. Cystometrography showed that the OAB and solifenacin groups having a significantly lower value than the control and MO formula groups. The mean contraction interval was shorter in the DO, MO formula, and solifenacin groups and the highest in the control group. CONCLUSIONS: The MO formula exhibited a similar pharmacologic effect to that of solifenacin, with anti-inflammatory and antioxidant effects. Enhancement of the MO formula by the nitric oxide pathway affected DO including BPH-related DO. The MO formula may be one of the alternative choices of anticholinergics, a treatment for DO.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N4f87f34b6e354f3d9128b1f22387cb85
57 Nda9520d0286845d19c847b27d0588c7b
58 sg:journal.1028418
59 schema:name Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress
60 schema:pagination 64
61 schema:productId N0b6f2af997dc4a90a7d79e542019052c
62 N196e62465d1341b6828e6a9f4e13533c
63 N1c33e0acb69147ea9c01e7be6edcb63d
64 N9261a9b9904941ceac2b6563e86cace8
65 Nd3ef457cec734b3fb66104b3e03de7ba
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112767820
67 https://doi.org/10.1186/s12906-019-2467-y
68 schema:sdDatePublished 2019-04-15T09:18
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N4076e9cae5244052bd0e62675826962a
71 schema:url https://link.springer.com/10.1186%2Fs12906-019-2467-y
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0b6f2af997dc4a90a7d79e542019052c schema:name readcube_id
76 schema:value e012c54eae314f889ddcbea4d0464c833278e8e794436b3b189cb1573435f82a
77 rdf:type schema:PropertyValue
78 N11cad71b418d4f098c2bf2ed3ea69a9a schema:affiliation https://www.grid.ac/institutes/grid.411947.e
79 schema:familyName Kim
80 schema:givenName Sae Woong
81 rdf:type schema:Person
82 N196e62465d1341b6828e6a9f4e13533c schema:name pubmed_id
83 schema:value 30871532
84 rdf:type schema:PropertyValue
85 N1c33e0acb69147ea9c01e7be6edcb63d schema:name doi
86 schema:value 10.1186/s12906-019-2467-y
87 rdf:type schema:PropertyValue
88 N1eb3bea0dabe4072ab8f667568a686db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Receptors, Muscarinic
90 rdf:type schema:DefinedTerm
91 N25696323d68344fa85654226fd59c0d1 schema:affiliation https://www.grid.ac/institutes/grid.411947.e
92 schema:familyName Park
93 schema:givenName Bong Hee
94 rdf:type schema:Person
95 N2656b0c1c169419abd61faba52a70750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Drugs, Chinese Herbal
97 rdf:type schema:DefinedTerm
98 N3181033263634d62969aae2f37a69f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Urinary Bladder
100 rdf:type schema:DefinedTerm
101 N329ca4a20e80424b98dc13349f498b77 rdf:first Nf02e7a6e744e409c9a983f08ea3008a5
102 rdf:rest Nf0c54006a858407292eef8145bc8b26b
103 N3bc7afae4a9a4f0b9950ecbceac74386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Oxidative Stress
105 rdf:type schema:DefinedTerm
106 N4076e9cae5244052bd0e62675826962a schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N43fd130daefa4badb309d65878a91ab8 rdf:first N96a26cbe41294e53a5943497d18ebb24
109 rdf:rest Nf15dcb0748eb459cb6f291497f7e7128
110 N4f87f34b6e354f3d9128b1f22387cb85 schema:volumeNumber 19
111 rdf:type schema:PublicationVolume
112 N59b5bcebecff43c1a4c945efbaef3a04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Urinary Bladder, Overactive
114 rdf:type schema:DefinedTerm
115 N5daaa4fc087647bbb411def2423352d9 schema:affiliation https://www.grid.ac/institutes/grid.411947.e
116 schema:familyName Bae
117 schema:givenName Woong Jin
118 rdf:type schema:Person
119 N72765f5b7c9549289954aed58738b2f7 rdf:first N7678452b7ef84239bc935c96ea477fa2
120 rdf:rest Nc83b4a689e43445884ff8302c372817e
121 N7678452b7ef84239bc935c96ea477fa2 schema:affiliation https://www.grid.ac/institutes/grid.488451.4
122 schema:familyName Jeong
123 schema:givenName Hyun Cheol
124 rdf:type schema:Person
125 N76ab4607b86344da88544f83cc28823f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Urethral Obstruction
127 rdf:type schema:DefinedTerm
128 N789a4ae3694742a7aebb260e4cd1cb8d rdf:first N5daaa4fc087647bbb411def2423352d9
129 rdf:rest N329ca4a20e80424b98dc13349f498b77
130 N8370ba872803442c9accac5c19097938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 N9261a9b9904941ceac2b6563e86cace8 schema:name nlm_unique_id
134 schema:value 101088661
135 rdf:type schema:PropertyValue
136 N96a26cbe41294e53a5943497d18ebb24 schema:affiliation https://www.grid.ac/institutes/grid.411947.e
137 schema:familyName Bae
138 schema:givenName Sangrak
139 rdf:type schema:Person
140 N97c26b13054f4df4901dd14d9f0d4e9a schema:affiliation https://www.grid.ac/institutes/grid.411947.e
141 schema:familyName Lee
142 schema:givenName Kyu Won
143 rdf:type schema:Person
144 N9a3cf5f74d824d19866e411113158ceb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 N9e0383779b7d4d5ea0df45775b83fcac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Anti-Inflammatory Agents
149 rdf:type schema:DefinedTerm
150 Nabb59cf31333433e8dd50ff4ab8c80a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Rats, Sprague-Dawley
152 rdf:type schema:DefinedTerm
153 Nb45f2d65f84f41df99016af8c16d4110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Rats
155 rdf:type schema:DefinedTerm
156 Nc83b4a689e43445884ff8302c372817e rdf:first N25696323d68344fa85654226fd59c0d1
157 rdf:rest N789a4ae3694742a7aebb260e4cd1cb8d
158 Nd3ef457cec734b3fb66104b3e03de7ba schema:name dimensions_id
159 schema:value pub.1112767820
160 rdf:type schema:PropertyValue
161 Nda9520d0286845d19c847b27d0588c7b schema:issueNumber 1
162 rdf:type schema:PublicationIssue
163 Nf02e7a6e744e409c9a983f08ea3008a5 schema:affiliation https://www.grid.ac/institutes/grid.411947.e
164 schema:familyName Han
165 schema:givenName Chang Hee
166 rdf:type schema:Person
167 Nf0c54006a858407292eef8145bc8b26b rdf:first N11cad71b418d4f098c2bf2ed3ea69a9a
168 rdf:rest rdf:nil
169 Nf15dcb0748eb459cb6f291497f7e7128 rdf:first N97c26b13054f4df4901dd14d9f0d4e9a
170 rdf:rest N72765f5b7c9549289954aed58738b2f7
171 Nf9212db7439743c5931299d137939252 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Nitric Oxide
173 rdf:type schema:DefinedTerm
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
178 schema:name Pharmacology and Pharmaceutical Sciences
179 rdf:type schema:DefinedTerm
180 sg:journal.1028418 schema:issn 1472-6882
181 schema:name BMC Complementary and Alternative Medicine
182 rdf:type schema:Periodical
183 sg:pub.10.1007/s00192-010-1219-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010321425
184 https://doi.org/10.1007/s00192-010-1219-9
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s00345-008-0303-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034379519
187 https://doi.org/10.1007/s00345-008-0303-y
188 rdf:type schema:CreativeWork
189 sg:pub.10.1186/s12906-017-1588-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083870169
190 https://doi.org/10.1186/s12906-017-1588-4
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/nau.22507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019548527
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/nau.22589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015922884
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/ptr.3393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018147477
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.ejogrb.2016.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003301982
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.eururo.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044790165
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.eururo.2015.12.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028571642
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.foodchem.2007.10.077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015445627
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.jep.2004.04.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002981892
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.jep.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023040682
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.jep.2009.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009333712
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.jep.2014.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012852615
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.jep.2015.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049056520
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.juro.2009.02.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044349991
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.neuint.2010.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046086541
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.purol.2013.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000188319
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1080/13880209.2017.1340965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086386025
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/iju.12685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016916441
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1111/j.1464-410x.2007.07310.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046519028
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/j.1757-5672.2011.00134.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035962832
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/jsm.12261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039933445
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1152/ajpregu.00046.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046833361
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1159/000277604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031179766
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1177/1756287215589238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064077007
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1177/2042098616659412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019849568
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1345/aph.1r528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014000790
241 rdf:type schema:CreativeWork
242 https://doi.org/10.2147/rru.s102441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576705
243 rdf:type schema:CreativeWork
244 https://doi.org/10.4111/icu.2016.57.2.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004320701
245 rdf:type schema:CreativeWork
246 https://doi.org/10.4162/nrp.2014.8.5.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012161226
247 rdf:type schema:CreativeWork
248 https://doi.org/10.5534/kja.2011.29.2.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016964419
249 rdf:type schema:CreativeWork
250 https://doi.org/10.5534/wjmh.2013.31.3.254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041937385
251 rdf:type schema:CreativeWork
252 https://doi.org/10.5534/wjmh.2015.33.2.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007630726
253 rdf:type schema:CreativeWork
254 https://www.grid.ac/institutes/grid.411947.e schema:alternateName Catholic University of Korea
255 schema:name Department of Urology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
256 Department of Urology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.488451.4 schema:alternateName Kangdong Sacred Heart Hospital
259 schema:name Kangdong Sacred Heart Hospital, Seoul, Republic of Korea
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...