Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Lamprini Karygianni, Manuel Cecere, Aikaterini Argyropoulou, Elmar Hellwig, Alexios Leandros Skaltsounis, Annette Wittmer, Jörg Philipp Tchorz, Ali Al-Ahmad

ABSTRACT

BACKGROUND: In view of the increasing antibiotic resistance, the introduction of natural anti-infective agents has brought a new era in the treatment of bacterially derived oral diseases. METHODS: The aim of this study was to investigate the antimicrobial potential of five natural constituents of Olea europaea (oleuropein, maslinic acid, hydroxytyrosol, oleocanthal, oleacein) and three compounds of Pistacia lentiscus (24Z-isomasticadienolic acid, oleanolic acid, oleanonic aldehyde) against ten representative oral bacterial species and a Candida albicans strain. After the isolation and quality control of natural compounds, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assay were performed. RESULTS: Among all O. europaea-derived constituents, maslinic acid was the most active (MIC = 4.9-312 μg mL- 1, MBC = 9.8-25 μg mL- 1) one against oral streptococci and anaerobic pathogenic bacteria (Porphyromonas gingivalis, Fusobacterium nucleatum, Parvimonas micra), while oleuropein, hydroxytyrosol, oleocanthal and oleacein showed milder, yet significant effects against P. gingivalis and F. nucleatum. Among all P. lentiscus compounds, oleanolic acid was the most effective one against almost all microorganisms with MIC values ranging from 9.8 μg mL- 1 (P. gingivalis) to 625 μg mL- 1 (F. nucleatum, P. micra). In the presence of 24Z-isomasticadienolic acid, a mean inhibitory concentration range of 2.4 μg mL- 1 to 625 μg mL- 1 was observed for strict anaerobia. The MIC value for 24Z-isomasticadienolic acid was estimated between 39 μg mL- 1 (Streptococcus sobrinus, Streptococcus oralis) and 78 μg mL- 1 (Streptococcus mutans). All tested compounds showed no effects against Prevotella intermedia. CONCLUSIONS: Overall, maslinic acid and oleanolic acid exerted the most significant inhibitory activity against the tested oral pathogens, especially streptococci and anaerobic oral microorganisms. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-019-2461-4

DOI

http://dx.doi.org/10.1186/s12906-019-2461-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112391827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30808354


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Infective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candida albicans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dental Caries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbial Sensitivity Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Olea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pistacia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Clinic for Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karygianni", 
        "givenName": "Lamprini", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cecere", 
        "givenName": "Manuel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece", 
            "PharmaGnose S.A., Papathanasiou 24, 34100, Chalkida, Euboea, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Argyropoulou", 
        "givenName": "Aikaterini", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellwig", 
        "givenName": "Elmar", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National and Kapodistrian University of Athens", 
          "id": "https://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skaltsounis", 
        "givenName": "Alexios Leandros", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Institute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wittmer", 
        "givenName": "Annette", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danube Private University", 
          "id": "https://www.grid.ac/institutes/grid.465811.f", 
          "name": [
            "Department of Operative Dentistry, Periodontology and Endodontology, University of Dental Medicine and Oral Health, Danube Private University (DPU), Krems, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tchorz", 
        "givenName": "J\u00f6rg Philipp", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Ahmad", 
        "givenName": "Ali", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1021/acs.jnatprod.5b01055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000619475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-011-3169-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000907783", 
          "https://doi.org/10.1007/s00253-011-3169-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkl519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003733498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/jr9560004150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004239014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e32835a2b70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005082594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e32835a2b70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005082594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2012.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007633459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00394-013-0609-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008173701", 
          "https://doi.org/10.1007/s00394-013-0609-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985815595517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008219480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985815595517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008219480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1517-83822013005000061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009147472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0023045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009258727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010228120", 
          "https://doi.org/10.1038/35081161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010228120", 
          "https://doi.org/10.1038/35081161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35081161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010228120", 
          "https://doi.org/10.1038/35081161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.02490-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010506952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dku570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012729858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/431021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013233203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11274-012-1036-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013985019", 
          "https://doi.org/10.1007/s11274-012-1036-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0022034509351812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014693421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0022034509351812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014693421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-015-0759-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017080966", 
          "https://doi.org/10.1186/s13059-015-0759-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.2010.00360.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017445409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.2010.00360.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017445409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joen.2013.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018275648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/znc-2007-9-1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018426634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022430209", 
          "https://doi.org/10.1038/nature13178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joen.2013.07.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025257412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-0711-13-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027129310", 
          "https://doi.org/10.1186/1476-0711-13-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0973-7847.162101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027895637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/pathogens4010137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028607338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0022034513504950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030410805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0022034513504950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030410805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2015.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030460889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0064449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031555632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00642-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032133519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rcm.2507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032763513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2011.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033693234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2013.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033721910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/839019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034785908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2012.07.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035846612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2015.00618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036085217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jprot.2013.02.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036559834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tplants.2011.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036995675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micres.2013.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037588740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/mehd.v26.23289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039737403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms151018508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040211560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2005.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040755357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2014.07.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040823802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3np20120a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041565362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2014.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042151489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3841.2011.02365.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043401457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms10083400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043907100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2014.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044567322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biortech.2009.12.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045431200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0137751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047197938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000327250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047659096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0047722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047973466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-051x.2009.01425.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050655981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-051x.2009.01425.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050655981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2013.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051780067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053128946", 
          "https://doi.org/10.1038/nrmicro1556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053128946", 
          "https://doi.org/10.1038/nrmicro1556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np401010x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056232562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol052106a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056247050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol052106a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056247050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol052106a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056247050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0035-1558111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057343104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2000-9601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057405377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2002-26749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057414382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/fpd.2009.0412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059261759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jmf.2014.0021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059283359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/jmm.0.008391-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060390861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986713805219136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069162908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612820666141007141137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069170085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1573406411006030174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069209758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077531219", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: In view of the increasing antibiotic resistance, the introduction of natural anti-infective agents has brought a new era in the treatment of bacterially derived oral diseases.\nMETHODS: The aim of this study was to investigate the antimicrobial potential of five natural constituents of Olea europaea (oleuropein, maslinic acid, hydroxytyrosol, oleocanthal, oleacein) and three compounds of Pistacia lentiscus (24Z-isomasticadienolic acid, oleanolic acid, oleanonic aldehyde) against ten representative oral bacterial species and a Candida albicans strain. After the isolation and quality control of natural compounds, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assay were performed.\nRESULTS: Among all O. europaea-derived constituents, maslinic acid was the most active (MIC\u2009=\u20094.9-312\u2009\u03bcg\u2009mL-\u20091, MBC\u2009=\u20099.8-25\u2009\u03bcg\u2009mL-\u20091) one against oral streptococci and anaerobic pathogenic bacteria (Porphyromonas gingivalis, Fusobacterium nucleatum, Parvimonas micra), while oleuropein, hydroxytyrosol, oleocanthal and oleacein showed milder, yet significant effects against P. gingivalis and F. nucleatum. Among all P. lentiscus compounds, oleanolic acid was the most effective one against almost all microorganisms with MIC values ranging from 9.8\u2009\u03bcg\u2009mL-\u20091 (P. gingivalis) to 625\u2009\u03bcg\u2009mL-\u20091 (F. nucleatum, P. micra). In the presence of 24Z-isomasticadienolic acid, a mean inhibitory concentration range of 2.4\u2009\u03bcg\u2009mL-\u20091 to 625\u2009\u03bcg\u2009mL-\u20091 was observed for strict anaerobia. The MIC value for 24Z-isomasticadienolic acid was estimated between 39\u2009\u03bcg\u2009mL-\u20091 (Streptococcus sobrinus, Streptococcus oralis) and 78\u2009\u03bcg\u2009mL-\u20091 (Streptococcus mutans). All tested compounds showed no effects against Prevotella intermedia.\nCONCLUSIONS: Overall, maslinic acid and oleanolic acid exerted the most significant inhibitory activity against the tested oral pathogens, especially streptococci and anaerobic oral microorganisms.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12906-019-2461-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028418", 
        "issn": [
          "1472-6882"
        ], 
        "name": "BMC Complementary and Alternative Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth", 
    "pagination": "51", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6054a365266aa01ef0041d299aef68c220a17059031fb056f7855cad5ddf1737"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30808354"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101088661"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12906-019-2461-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112391827"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12906-019-2461-4", 
      "https://app.dimensions.ai/details/publication/pub.1112391827"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72839_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12906-019-2461-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2461-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2461-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2461-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12906-019-2461-4'


 

This table displays all metadata directly associated to this object as RDF triples.

365 TRIPLES      21 PREDICATES      105 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12906-019-2461-4 schema:about N15c92317b469437fabddbbc838412f91
2 N1a387a856c2c488f8d81688ad5f4767d
3 N3a1096eb955f4b00a96518b2019262d0
4 N79a5739a84464282ab2425be58eb95fd
5 N84205946b7da4808a8d8b03407ba69d1
6 N855e567a7b334d9fab1b23b7fb6f2e79
7 Nc7e214c3ead64e14a1f38497de7f61a6
8 Nd6d19711aa18416cbc51bfa3a6d3d1b1
9 Ne0528fa47e4047f0a7faabcbee1483fb
10 Nf9379a1db1ee44a092d6869263b38691
11 anzsrc-for:06
12 anzsrc-for:0605
13 schema:author N420866d1ad414749b3fddafd59b25900
14 schema:citation sg:pub.10.1007/s00253-011-3169-7
15 sg:pub.10.1007/s00394-013-0609-4
16 sg:pub.10.1007/s11274-012-1036-z
17 sg:pub.10.1038/35081161
18 sg:pub.10.1038/nature13178
19 sg:pub.10.1038/nrmicro1556
20 sg:pub.10.1186/1476-0711-13-24
21 sg:pub.10.1186/s13059-015-0759-1
22 https://app.dimensions.ai/details/publication/pub.1077531219
23 https://doi.org/10.1002/rcm.2507
24 https://doi.org/10.1016/j.abb.2014.03.006
25 https://doi.org/10.1016/j.bcp.2012.07.029
26 https://doi.org/10.1016/j.biortech.2009.12.052
27 https://doi.org/10.1016/j.fitote.2013.07.012
28 https://doi.org/10.1016/j.foodchem.2014.07.105
29 https://doi.org/10.1016/j.foodchem.2014.08.007
30 https://doi.org/10.1016/j.foodchem.2015.03.018
31 https://doi.org/10.1016/j.joen.2013.07.023
32 https://doi.org/10.1016/j.joen.2013.10.005
33 https://doi.org/10.1016/j.jprot.2013.02.031
34 https://doi.org/10.1016/j.lfs.2012.09.012
35 https://doi.org/10.1016/j.mib.2005.06.008
36 https://doi.org/10.1016/j.micres.2013.12.009
37 https://doi.org/10.1016/j.phymed.2011.12.009
38 https://doi.org/10.1016/j.phymed.2013.05.002
39 https://doi.org/10.1016/j.tplants.2011.11.002
40 https://doi.org/10.1021/acs.jnatprod.5b01055
41 https://doi.org/10.1021/np401010x
42 https://doi.org/10.1021/ol052106a
43 https://doi.org/10.1039/c3np20120a
44 https://doi.org/10.1039/jr9560004150
45 https://doi.org/10.1055/s-0035-1558111
46 https://doi.org/10.1055/s-2000-9601
47 https://doi.org/10.1055/s-2002-26749
48 https://doi.org/10.1089/fpd.2009.0412
49 https://doi.org/10.1089/jmf.2014.0021
50 https://doi.org/10.1093/jac/dkl519
51 https://doi.org/10.1093/jac/dku570
52 https://doi.org/10.1097/meg.0b013e32835a2b70
53 https://doi.org/10.1099/jmm.0.008391-0
54 https://doi.org/10.1111/j.1600-051x.2009.01425.x
55 https://doi.org/10.1111/j.1600-0757.2010.00360.x
56 https://doi.org/10.1111/j.1750-3841.2011.02365.x
57 https://doi.org/10.1128/aac.00642-06
58 https://doi.org/10.1128/aem.02490-14
59 https://doi.org/10.1155/2011/431021
60 https://doi.org/10.1155/2014/839019
61 https://doi.org/10.1159/000327250
62 https://doi.org/10.1177/0022034509351812
63 https://doi.org/10.1177/0022034513504950
64 https://doi.org/10.1177/0300985815595517
65 https://doi.org/10.1371/journal.pone.0023045
66 https://doi.org/10.1371/journal.pone.0047722
67 https://doi.org/10.1371/journal.pone.0064449
68 https://doi.org/10.1371/journal.pone.0137751
69 https://doi.org/10.1515/znc-2007-9-1007
70 https://doi.org/10.1590/s1517-83822013005000061
71 https://doi.org/10.2174/092986713805219136
72 https://doi.org/10.2174/1381612820666141007141137
73 https://doi.org/10.2174/1573406411006030174
74 https://doi.org/10.3389/fmicb.2015.00618
75 https://doi.org/10.3390/ijms10083400
76 https://doi.org/10.3390/ijms151018508
77 https://doi.org/10.3390/pathogens4010137
78 https://doi.org/10.3402/mehd.v26.23289
79 https://doi.org/10.4103/0973-7847.162101
80 schema:datePublished 2019-12
81 schema:datePublishedReg 2019-12-01
82 schema:description BACKGROUND: In view of the increasing antibiotic resistance, the introduction of natural anti-infective agents has brought a new era in the treatment of bacterially derived oral diseases. METHODS: The aim of this study was to investigate the antimicrobial potential of five natural constituents of Olea europaea (oleuropein, maslinic acid, hydroxytyrosol, oleocanthal, oleacein) and three compounds of Pistacia lentiscus (24Z-isomasticadienolic acid, oleanolic acid, oleanonic aldehyde) against ten representative oral bacterial species and a Candida albicans strain. After the isolation and quality control of natural compounds, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assay were performed. RESULTS: Among all O. europaea-derived constituents, maslinic acid was the most active (MIC = 4.9-312 μg mL- 1, MBC = 9.8-25 μg mL- 1) one against oral streptococci and anaerobic pathogenic bacteria (Porphyromonas gingivalis, Fusobacterium nucleatum, Parvimonas micra), while oleuropein, hydroxytyrosol, oleocanthal and oleacein showed milder, yet significant effects against P. gingivalis and F. nucleatum. Among all P. lentiscus compounds, oleanolic acid was the most effective one against almost all microorganisms with MIC values ranging from 9.8 μg mL- 1 (P. gingivalis) to 625 μg mL- 1 (F. nucleatum, P. micra). In the presence of 24Z-isomasticadienolic acid, a mean inhibitory concentration range of 2.4 μg mL- 1 to 625 μg mL- 1 was observed for strict anaerobia. The MIC value for 24Z-isomasticadienolic acid was estimated between 39 μg mL- 1 (Streptococcus sobrinus, Streptococcus oralis) and 78 μg mL- 1 (Streptococcus mutans). All tested compounds showed no effects against Prevotella intermedia. CONCLUSIONS: Overall, maslinic acid and oleanolic acid exerted the most significant inhibitory activity against the tested oral pathogens, especially streptococci and anaerobic oral microorganisms.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree true
86 schema:isPartOf N1b6af3a936f44945aeccdabc5f1c8f78
87 N4bba3a6114f441df948dca9f26650512
88 sg:journal.1028418
89 schema:name Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth
90 schema:pagination 51
91 schema:productId N0aad38a665fd40c5bc015e1523dd7f73
92 N15c120fa97274018a563fcd7b182b601
93 N642936f3da36431bad62bcf68d2e2f1d
94 Nc871dc084fd947dfb9b815812168b92f
95 Ne72d5aa874fd4fb09c018471b0cca98e
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112391827
97 https://doi.org/10.1186/s12906-019-2461-4
98 schema:sdDatePublished 2019-04-11T12:53
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N6cb89e8b3c1d47ef9586090a011d6c95
101 schema:url https://link.springer.com/10.1186%2Fs12906-019-2461-4
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0aad38a665fd40c5bc015e1523dd7f73 schema:name pubmed_id
106 schema:value 30808354
107 rdf:type schema:PropertyValue
108 N15c120fa97274018a563fcd7b182b601 schema:name readcube_id
109 schema:value 6054a365266aa01ef0041d299aef68c220a17059031fb056f7855cad5ddf1737
110 rdf:type schema:PropertyValue
111 N15c92317b469437fabddbbc838412f91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Olea
113 rdf:type schema:DefinedTerm
114 N1a387a856c2c488f8d81688ad5f4767d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Microbial Sensitivity Tests
116 rdf:type schema:DefinedTerm
117 N1b6af3a936f44945aeccdabc5f1c8f78 schema:volumeNumber 19
118 rdf:type schema:PublicationVolume
119 N280055c389344cb9a7ceacb5c610119d rdf:first Nac5056f264fb49e9a85c3f59c387e671
120 rdf:rest N527a049a57a74389b8141ddfdfe56340
121 N3a1096eb955f4b00a96518b2019262d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Dental Caries
123 rdf:type schema:DefinedTerm
124 N4178fca668ea467a9b394c6f03cfcebb rdf:first N7ab837a06361420a863dcaa7ede05c27
125 rdf:rest Nc3ee7d6a7eff4919b086d5610f9665bf
126 N420866d1ad414749b3fddafd59b25900 rdf:first Nfd5568a9df814e7b99d0aeae586df338
127 rdf:rest N507e3234bc06472a8745ddcc41fbd557
128 N4bba3a6114f441df948dca9f26650512 schema:issueNumber 1
129 rdf:type schema:PublicationIssue
130 N5071dc7868c74b05a5848707b09301fa schema:affiliation https://www.grid.ac/institutes/grid.5963.9
131 schema:familyName Wittmer
132 schema:givenName Annette
133 rdf:type schema:Person
134 N507e3234bc06472a8745ddcc41fbd557 rdf:first Ne994decbec014a50b522b44419ae7c3e
135 rdf:rest N280055c389344cb9a7ceacb5c610119d
136 N527a049a57a74389b8141ddfdfe56340 rdf:first Nc3b96e6ea6504cb984200917fcd9c886
137 rdf:rest N89539eb716564456b851521873a4bc68
138 N642936f3da36431bad62bcf68d2e2f1d schema:name doi
139 schema:value 10.1186/s12906-019-2461-4
140 rdf:type schema:PropertyValue
141 N696ecc22b78146b092ca5c5af4b86a5a schema:affiliation https://www.grid.ac/institutes/grid.5963.9
142 schema:familyName Al-Ahmad
143 schema:givenName Ali
144 rdf:type schema:Person
145 N6cb89e8b3c1d47ef9586090a011d6c95 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N79a5739a84464282ab2425be58eb95fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Anti-Infective Agents
149 rdf:type schema:DefinedTerm
150 N7ab837a06361420a863dcaa7ede05c27 schema:affiliation https://www.grid.ac/institutes/grid.465811.f
151 schema:familyName Tchorz
152 schema:givenName Jörg Philipp
153 rdf:type schema:Person
154 N84205946b7da4808a8d8b03407ba69d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Pistacia
156 rdf:type schema:DefinedTerm
157 N855e567a7b334d9fab1b23b7fb6f2e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Bacteria
159 rdf:type schema:DefinedTerm
160 N89539eb716564456b851521873a4bc68 rdf:first Ne869ce41b63944bdbb79e2539ca7583c
161 rdf:rest Naa5788f7d5ab4d9097d87fd7739caf82
162 Naa5788f7d5ab4d9097d87fd7739caf82 rdf:first N5071dc7868c74b05a5848707b09301fa
163 rdf:rest N4178fca668ea467a9b394c6f03cfcebb
164 Nac5056f264fb49e9a85c3f59c387e671 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
165 schema:familyName Argyropoulou
166 schema:givenName Aikaterini
167 rdf:type schema:Person
168 Nc3b96e6ea6504cb984200917fcd9c886 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
169 schema:familyName Hellwig
170 schema:givenName Elmar
171 rdf:type schema:Person
172 Nc3ee7d6a7eff4919b086d5610f9665bf rdf:first N696ecc22b78146b092ca5c5af4b86a5a
173 rdf:rest rdf:nil
174 Nc7e214c3ead64e14a1f38497de7f61a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Candida albicans
176 rdf:type schema:DefinedTerm
177 Nc871dc084fd947dfb9b815812168b92f schema:name nlm_unique_id
178 schema:value 101088661
179 rdf:type schema:PropertyValue
180 Nd6d19711aa18416cbc51bfa3a6d3d1b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 Ne0528fa47e4047f0a7faabcbee1483fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Plant Extracts
185 rdf:type schema:DefinedTerm
186 Ne72d5aa874fd4fb09c018471b0cca98e schema:name dimensions_id
187 schema:value pub.1112391827
188 rdf:type schema:PropertyValue
189 Ne869ce41b63944bdbb79e2539ca7583c schema:affiliation https://www.grid.ac/institutes/grid.5216.0
190 schema:familyName Skaltsounis
191 schema:givenName Alexios Leandros
192 rdf:type schema:Person
193 Ne994decbec014a50b522b44419ae7c3e schema:affiliation https://www.grid.ac/institutes/grid.5963.9
194 schema:familyName Cecere
195 schema:givenName Manuel
196 rdf:type schema:Person
197 Nf9379a1db1ee44a092d6869263b38691 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Mouth
199 rdf:type schema:DefinedTerm
200 Nfd5568a9df814e7b99d0aeae586df338 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
201 schema:familyName Karygianni
202 schema:givenName Lamprini
203 rdf:type schema:Person
204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biological Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
208 schema:name Microbiology
209 rdf:type schema:DefinedTerm
210 sg:journal.1028418 schema:issn 1472-6882
211 schema:name BMC Complementary and Alternative Medicine
212 rdf:type schema:Periodical
213 sg:pub.10.1007/s00253-011-3169-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000907783
214 https://doi.org/10.1007/s00253-011-3169-7
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s00394-013-0609-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008173701
217 https://doi.org/10.1007/s00394-013-0609-4
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s11274-012-1036-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1013985019
220 https://doi.org/10.1007/s11274-012-1036-z
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/35081161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010228120
223 https://doi.org/10.1038/35081161
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature13178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022430209
226 https://doi.org/10.1038/nature13178
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nrmicro1556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053128946
229 https://doi.org/10.1038/nrmicro1556
230 rdf:type schema:CreativeWork
231 sg:pub.10.1186/1476-0711-13-24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027129310
232 https://doi.org/10.1186/1476-0711-13-24
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/s13059-015-0759-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017080966
235 https://doi.org/10.1186/s13059-015-0759-1
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1077531219 schema:CreativeWork
238 https://doi.org/10.1002/rcm.2507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032763513
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.abb.2014.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042151489
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.bcp.2012.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035846612
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.biortech.2009.12.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045431200
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.fitote.2013.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033721910
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.foodchem.2014.07.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040823802
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.foodchem.2014.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044567322
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.foodchem.2015.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030460889
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.joen.2013.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025257412
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.joen.2013.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018275648
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.jprot.2013.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036559834
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.lfs.2012.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007633459
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.mib.2005.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040755357
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.micres.2013.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037588740
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.phymed.2011.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033693234
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.phymed.2013.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051780067
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.tplants.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036995675
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1021/acs.jnatprod.5b01055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000619475
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1021/np401010x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056232562
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1021/ol052106a schema:sameAs https://app.dimensions.ai/details/publication/pub.1056247050
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1039/c3np20120a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041565362
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1039/jr9560004150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004239014
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1055/s-0035-1558111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057343104
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1055/s-2000-9601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057405377
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1055/s-2002-26749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057414382
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1089/fpd.2009.0412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059261759
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1089/jmf.2014.0021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059283359
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/jac/dkl519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003733498
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/jac/dku570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012729858
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/meg.0b013e32835a2b70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005082594
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1099/jmm.0.008391-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060390861
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/j.1600-051x.2009.01425.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050655981
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/j.1600-0757.2010.00360.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017445409
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1750-3841.2011.02365.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043401457
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1128/aac.00642-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032133519
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1128/aem.02490-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010506952
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1155/2011/431021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013233203
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1155/2014/839019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034785908
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1159/000327250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047659096
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1177/0022034509351812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014693421
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1177/0022034513504950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030410805
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1177/0300985815595517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008219480
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pone.0023045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009258727
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pone.0047722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047973466
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1371/journal.pone.0064449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031555632
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pone.0137751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047197938
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1515/znc-2007-9-1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018426634
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1590/s1517-83822013005000061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009147472
333 rdf:type schema:CreativeWork
334 https://doi.org/10.2174/092986713805219136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162908
335 rdf:type schema:CreativeWork
336 https://doi.org/10.2174/1381612820666141007141137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069170085
337 rdf:type schema:CreativeWork
338 https://doi.org/10.2174/1573406411006030174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069209758
339 rdf:type schema:CreativeWork
340 https://doi.org/10.3389/fmicb.2015.00618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036085217
341 rdf:type schema:CreativeWork
342 https://doi.org/10.3390/ijms10083400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043907100
343 rdf:type schema:CreativeWork
344 https://doi.org/10.3390/ijms151018508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040211560
345 rdf:type schema:CreativeWork
346 https://doi.org/10.3390/pathogens4010137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028607338
347 rdf:type schema:CreativeWork
348 https://doi.org/10.3402/mehd.v26.23289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039737403
349 rdf:type schema:CreativeWork
350 https://doi.org/10.4103/0973-7847.162101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027895637
351 rdf:type schema:CreativeWork
352 https://www.grid.ac/institutes/grid.465811.f schema:alternateName Danube Private University
353 schema:name Department of Operative Dentistry, Periodontology and Endodontology, University of Dental Medicine and Oral Health, Danube Private University (DPU), Krems, Austria
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
356 schema:name Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
357 PharmaGnose S.A., Papathanasiou 24, 34100, Chalkida, Euboea, Greece
358 rdf:type schema:Organization
359 https://www.grid.ac/institutes/grid.5963.9 schema:alternateName University of Freiburg
360 schema:name Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
361 Institute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
364 schema:name Clinic for Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zürich, Switzerland
365 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...