Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Woan Sean Tan, Palanisamy Arulselvan, Shiow-Fern Ng, Che Norma Mat Taib, Murni Nazira Sarian, Sharida Fakurazi

ABSTRACT

BACKGROUND: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Vicenin-2 (VCN-2) has been reported to contain prospective anti-oxidant and anti-inflammatory properties that enhance cell proliferation and migration. Sodium Alginate (SA) is a natural polysaccharide that possesses gel forming properties and has biodegradable and biocompatible characteristics. Therefore, the objective of this study is to evaluate the effect of SA wound dressings containing VCN-2 on diabetic wounds. METHODS: Wounds were inflicted in type-1 diabetic-streptozotocin (STZ) induced male Sprague Dawley rats. Subsequently, relevant groups were topically treated with the indicated concentrations (12.5, 25 and 50 μM) of VCN-2 hydrocolloid film over the study duration (14 days). The control group was treated with vehicle dressing (blank or allantoin). Wounded tissues and blood serum were collected on 0, 7 and 14 days prior to sacrifice. Appropriate wound assessments such as histological tests, nitric oxide assays, enzyme-linked immunosorbent assays (ELISA) and immunoblotting assays were conducted to confirm wound healing efficacy in the in vivo model. One-way Analysis of Variance (ANOVA) was used for statistical analysis. RESULTS: Results showed that hydrocolloid film was recapitulated with VCN-2 enhanced diabetic wound healing in a dose-dependent manner. VCN-2 reduced pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), mediators (iNOS and COX-2), and nitric oxide (NO) via the NF-κB pathway. Data suggests that the VCN-2 film facilitated healing in hyperglycemic conditions by releasing growth factors such as (VEGF and TGF-β) to enhance cell proliferation, migration, and wound contraction via the VEGF and TGF-β mechanism pathways. CONCLUSIONS: This study's findings suggest that VCN-2 may possess wound healing potential since topical treatment with VCN-2 hydrocolloid films effectively enhanced wound healing in hyperglycemic conditions. More... »

PAGES

20

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-018-2427-y

DOI

http://dx.doi.org/10.1186/s12906-018-2427-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111499625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30654793


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universiti Putra Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11142.37", 
          "name": [
            "Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Woan Sean", 
        "id": "sg:person.01156311117.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156311117.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Putra Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11142.37", 
          "name": [
            "Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arulselvan", 
        "givenName": "Palanisamy", 
        "id": "sg:person.0701276576.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701276576.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.412113.4", 
          "name": [
            "Centre of Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Shiow-Fern", 
        "id": "sg:person.0662531463.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662531463.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Putra Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11142.37", 
          "name": [
            "Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mat Taib", 
        "givenName": "Che Norma", 
        "id": "sg:person.01100506604.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100506604.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Putra Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11142.37", 
          "name": [
            "Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarian", 
        "givenName": "Murni Nazira", 
        "id": "sg:person.013435260537.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013435260537.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Putra Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11142.37", 
          "name": [
            "Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia", 
            "Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fakurazi", 
        "givenName": "Sharida", 
        "id": "sg:person.0606554720.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606554720.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pone.0055456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000236658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-481x.2011.00924.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000350785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000223120.26394.7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001991667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000223120.26394.7d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001991667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.memsci.2006.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002100056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2000.00029.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002429506", 
          "https://doi.org/10.1046/j.1523-1747.2000.00029.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2016.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002631097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2006.06.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003860610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/etp.12008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004898213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s96968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007044180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jcmm.12164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008031880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-355x(97)00010-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008279054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s79885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008913427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-475x.2012.00772.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011853840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-016-2268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012262705", 
          "https://doi.org/10.1007/s00018-016-2268-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-016-2268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012262705", 
          "https://doi.org/10.1007/s00018-016-2268-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.avsg.2013.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013121912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/974580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014216266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2014.03.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015328968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-475x.2008.00410.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016786299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-475x.2008.00410.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016786299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000102937.50486.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017896639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000102937.50486.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017896639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5455/jice.20160201055629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018940822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1517847112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019954538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67698-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021686568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67698-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021686568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14653249.2010.512632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022522829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2013.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025123510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4172/2157-7099.1000294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027188118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-475x.2012.00851.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028911789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/720171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029245625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.25328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031025790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(02)00815-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031717838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2012.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032012605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1524-475x.1996.40404.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032614631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2008.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033945769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034114372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxrep.2014.10.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037393937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2011.02.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037495194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2012.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037907243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2013.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038415446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2014.10.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038544747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.3.667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040256432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12906-016-1128-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041047689", 
          "https://doi.org/10.1186/s12906-016-1128-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2013.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041275498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iwj.12225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041749796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdiacomp.2013.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042514149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0055899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043569838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044548324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1067-1927.2005.130108.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045261731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0973-1296.172961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049410919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/2897656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049785671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.envres.2016.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049935332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iwj.12181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051823240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/msg.2001.111167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053064371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/dmt.15.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053480048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100937e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100937e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2016-013037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062809930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2016-013037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062809930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070913488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074993161", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.2003.83.3.835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075310758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078053858", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12659/msm.902859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083395568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/bir-1997-34205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092049512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18122766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099885613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2018/3142073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101116379"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Vicenin-2 (VCN-2) has been reported to contain prospective anti-oxidant and anti-inflammatory properties that enhance cell proliferation and migration. Sodium Alginate (SA) is a natural polysaccharide that possesses gel forming properties and has biodegradable and biocompatible characteristics. Therefore, the objective of this study is to evaluate the effect of SA wound dressings containing VCN-2 on diabetic wounds.\nMETHODS: Wounds were inflicted in type-1 diabetic-streptozotocin (STZ) induced male Sprague Dawley rats. Subsequently, relevant groups were topically treated with the indicated concentrations (12.5, 25 and 50\u2009\u03bcM) of VCN-2 hydrocolloid film over the study duration (14\u2009days). The control group was treated with vehicle dressing (blank or allantoin). Wounded tissues and blood serum were collected on 0, 7 and 14\u2009days prior to sacrifice. Appropriate wound assessments such as histological tests, nitric oxide assays, enzyme-linked immunosorbent assays (ELISA) and immunoblotting assays were conducted to confirm wound healing efficacy in the in vivo model. One-way Analysis of Variance (ANOVA) was used for statistical analysis.\nRESULTS: Results showed that hydrocolloid film was recapitulated with VCN-2 enhanced diabetic wound healing in a dose-dependent manner. VCN-2 reduced pro-inflammatory cytokines (IL-1\u03b2, IL-6 and TNF-\u03b1), mediators (iNOS and COX-2), and nitric oxide (NO) via the NF-\u03baB pathway. Data suggests that the VCN-2 film facilitated healing in hyperglycemic conditions by releasing growth factors such as (VEGF and TGF-\u03b2) to enhance cell proliferation, migration, and wound contraction via the VEGF and TGF-\u03b2 mechanism pathways.\nCONCLUSIONS: This study's findings suggest that VCN-2 may possess wound healing potential since topical treatment with VCN-2 hydrocolloid films effectively enhanced wound healing in hyperglycemic conditions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12906-018-2427-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028418", 
        "issn": [
          "1472-6882"
        ], 
        "name": "BMC Complementary and Alternative Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats", 
    "pagination": "20", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a2a118cf65d1723fb9128a379dedfc3f3dbfa0cf59b11fdae7aeaa9990814f09"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30654793"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101088661"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12906-018-2427-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111499625"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12906-018-2427-y", 
      "https://app.dimensions.ai/details/publication/pub.1111499625"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000325_0000000325/records_100782_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12906-018-2427-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12906-018-2427-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12906-018-2427-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12906-018-2427-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12906-018-2427-y'


 

This table displays all metadata directly associated to this object as RDF triples.

297 TRIPLES      21 PREDICATES      92 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12906-018-2427-y schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nfabafbc6a1304b478699f4a6bb94710d
4 schema:citation sg:pub.10.1007/s00018-016-2268-0
5 sg:pub.10.1046/j.1523-1747.2000.00029.x
6 sg:pub.10.1186/s12906-016-1128-7
7 https://app.dimensions.ai/details/publication/pub.1074993161
8 https://app.dimensions.ai/details/publication/pub.1078053858
9 https://doi.org/10.1002/jcp.21503
10 https://doi.org/10.1002/jcp.25328
11 https://doi.org/10.1016/j.avsg.2013.01.011
12 https://doi.org/10.1016/j.bbadis.2013.10.009
13 https://doi.org/10.1016/j.biomaterials.2011.02.042
14 https://doi.org/10.1016/j.envres.2016.10.021
15 https://doi.org/10.1016/j.fct.2014.03.042
16 https://doi.org/10.1016/j.fitote.2008.11.005
17 https://doi.org/10.1016/j.fitote.2012.08.013
18 https://doi.org/10.1016/j.fitote.2013.12.024
19 https://doi.org/10.1016/j.ijpharm.2012.05.044
20 https://doi.org/10.1016/j.jdiacomp.2013.05.002
21 https://doi.org/10.1016/j.jss.2006.06.034
22 https://doi.org/10.1016/j.jss.2014.10.019
23 https://doi.org/10.1016/j.lfs.2013.04.001
24 https://doi.org/10.1016/j.lfs.2016.04.017
25 https://doi.org/10.1016/j.memsci.2006.01.002
26 https://doi.org/10.1016/j.toxrep.2014.10.022
27 https://doi.org/10.1016/s0002-9610(02)00815-2
28 https://doi.org/10.1016/s0006-355x(97)00010-3
29 https://doi.org/10.1016/s0140-6736(05)67698-2
30 https://doi.org/10.1021/np100937e
31 https://doi.org/10.1038/sj.emboj.7601579
32 https://doi.org/10.1046/j.1524-475x.1996.40404.x
33 https://doi.org/10.1067/msg.2001.111167
34 https://doi.org/10.1073/pnas.1517847112
35 https://doi.org/10.1097/01.shk.0000223120.26394.7d
36 https://doi.org/10.1111/etp.12008
37 https://doi.org/10.1111/iwj.12181
38 https://doi.org/10.1111/iwj.12225
39 https://doi.org/10.1111/j.1067-1927.2005.130108.x
40 https://doi.org/10.1111/j.1524-475x.2008.00410.x
41 https://doi.org/10.1111/j.1524-475x.2012.00772.x
42 https://doi.org/10.1111/j.1524-475x.2012.00851.x
43 https://doi.org/10.1111/j.1742-481x.2011.00924.x
44 https://doi.org/10.1111/jcmm.12164
45 https://doi.org/10.1136/bmjopen-2016-013037
46 https://doi.org/10.1152/physrev.2003.83.3.835
47 https://doi.org/10.1155/2013/974580
48 https://doi.org/10.1155/2015/720171
49 https://doi.org/10.1155/2016/2897656
50 https://doi.org/10.1155/2018/3142073
51 https://doi.org/10.1161/01.res.0000102937.50486.1b
52 https://doi.org/10.1172/jci32169
53 https://doi.org/10.12659/msm.902859
54 https://doi.org/10.1371/journal.pone.0055456
55 https://doi.org/10.1371/journal.pone.0055899
56 https://doi.org/10.2147/dddt.s79885
57 https://doi.org/10.2147/dddt.s96968
58 https://doi.org/10.2217/dmt.15.44
59 https://doi.org/10.2337/diabetes.50.3.667
60 https://doi.org/10.2741/1184
61 https://doi.org/10.3109/14653249.2010.512632
62 https://doi.org/10.3233/bir-1997-34205
63 https://doi.org/10.3390/ijms18122766
64 https://doi.org/10.4103/0973-1296.172961
65 https://doi.org/10.4172/2157-7099.1000294
66 https://doi.org/10.5455/jice.20160201055629
67 schema:datePublished 2019-12
68 schema:datePublishedReg 2019-12-01
69 schema:description BACKGROUND: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Vicenin-2 (VCN-2) has been reported to contain prospective anti-oxidant and anti-inflammatory properties that enhance cell proliferation and migration. Sodium Alginate (SA) is a natural polysaccharide that possesses gel forming properties and has biodegradable and biocompatible characteristics. Therefore, the objective of this study is to evaluate the effect of SA wound dressings containing VCN-2 on diabetic wounds. METHODS: Wounds were inflicted in type-1 diabetic-streptozotocin (STZ) induced male Sprague Dawley rats. Subsequently, relevant groups were topically treated with the indicated concentrations (12.5, 25 and 50 μM) of VCN-2 hydrocolloid film over the study duration (14 days). The control group was treated with vehicle dressing (blank or allantoin). Wounded tissues and blood serum were collected on 0, 7 and 14 days prior to sacrifice. Appropriate wound assessments such as histological tests, nitric oxide assays, enzyme-linked immunosorbent assays (ELISA) and immunoblotting assays were conducted to confirm wound healing efficacy in the in vivo model. One-way Analysis of Variance (ANOVA) was used for statistical analysis. RESULTS: Results showed that hydrocolloid film was recapitulated with VCN-2 enhanced diabetic wound healing in a dose-dependent manner. VCN-2 reduced pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), mediators (iNOS and COX-2), and nitric oxide (NO) via the NF-κB pathway. Data suggests that the VCN-2 film facilitated healing in hyperglycemic conditions by releasing growth factors such as (VEGF and TGF-β) to enhance cell proliferation, migration, and wound contraction via the VEGF and TGF-β mechanism pathways. CONCLUSIONS: This study's findings suggest that VCN-2 may possess wound healing potential since topical treatment with VCN-2 hydrocolloid films effectively enhanced wound healing in hyperglycemic conditions.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N392a54010252404081eea7c39a41bf13
74 N6c698eb7d3254845ad3ba0a2ecf3380d
75 sg:journal.1028418
76 schema:name Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats
77 schema:pagination 20
78 schema:productId N380cf611c2054a408ce37febeec1a437
79 N3e12cc2e4efe41e5a1f07252651274ae
80 N5affe72f991a444c92b44948962aa3e9
81 N78cd6d86b78c4580a2358d2459741e15
82 Nfb743f3d9298441f98ab9c4d03dd197f
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111499625
84 https://doi.org/10.1186/s12906-018-2427-y
85 schema:sdDatePublished 2019-04-11T08:55
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N0b7282e4929e4991a9af181f2759c921
88 schema:url https://link.springer.com/10.1186%2Fs12906-018-2427-y
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0b7282e4929e4991a9af181f2759c921 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N1ef6698a94d04bae9f48f46279a5c481 rdf:first sg:person.0701276576.19
95 rdf:rest N55b1ca6254564ef884e4199089578e71
96 N380cf611c2054a408ce37febeec1a437 schema:name nlm_unique_id
97 schema:value 101088661
98 rdf:type schema:PropertyValue
99 N392a54010252404081eea7c39a41bf13 schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 N3e12cc2e4efe41e5a1f07252651274ae schema:name dimensions_id
102 schema:value pub.1111499625
103 rdf:type schema:PropertyValue
104 N4543fe0525984692a39e974425988cfd rdf:first sg:person.013435260537.15
105 rdf:rest N6479f25427ed4ee0858283647cd72732
106 N55b1ca6254564ef884e4199089578e71 rdf:first sg:person.0662531463.66
107 rdf:rest Nf4cd8100134b43938429e77e8fd754dd
108 N5affe72f991a444c92b44948962aa3e9 schema:name doi
109 schema:value 10.1186/s12906-018-2427-y
110 rdf:type schema:PropertyValue
111 N6479f25427ed4ee0858283647cd72732 rdf:first sg:person.0606554720.54
112 rdf:rest rdf:nil
113 N6c698eb7d3254845ad3ba0a2ecf3380d schema:volumeNumber 19
114 rdf:type schema:PublicationVolume
115 N78cd6d86b78c4580a2358d2459741e15 schema:name readcube_id
116 schema:value a2a118cf65d1723fb9128a379dedfc3f3dbfa0cf59b11fdae7aeaa9990814f09
117 rdf:type schema:PropertyValue
118 Nf4cd8100134b43938429e77e8fd754dd rdf:first sg:person.01100506604.16
119 rdf:rest N4543fe0525984692a39e974425988cfd
120 Nfabafbc6a1304b478699f4a6bb94710d rdf:first sg:person.01156311117.46
121 rdf:rest N1ef6698a94d04bae9f48f46279a5c481
122 Nfb743f3d9298441f98ab9c4d03dd197f schema:name pubmed_id
123 schema:value 30654793
124 rdf:type schema:PropertyValue
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
129 schema:name Clinical Sciences
130 rdf:type schema:DefinedTerm
131 sg:journal.1028418 schema:issn 1472-6882
132 schema:name BMC Complementary and Alternative Medicine
133 rdf:type schema:Periodical
134 sg:person.01100506604.16 schema:affiliation https://www.grid.ac/institutes/grid.11142.37
135 schema:familyName Mat Taib
136 schema:givenName Che Norma
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100506604.16
138 rdf:type schema:Person
139 sg:person.01156311117.46 schema:affiliation https://www.grid.ac/institutes/grid.11142.37
140 schema:familyName Tan
141 schema:givenName Woan Sean
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156311117.46
143 rdf:type schema:Person
144 sg:person.013435260537.15 schema:affiliation https://www.grid.ac/institutes/grid.11142.37
145 schema:familyName Sarian
146 schema:givenName Murni Nazira
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013435260537.15
148 rdf:type schema:Person
149 sg:person.0606554720.54 schema:affiliation https://www.grid.ac/institutes/grid.11142.37
150 schema:familyName Fakurazi
151 schema:givenName Sharida
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606554720.54
153 rdf:type schema:Person
154 sg:person.0662531463.66 schema:affiliation https://www.grid.ac/institutes/grid.412113.4
155 schema:familyName Ng
156 schema:givenName Shiow-Fern
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662531463.66
158 rdf:type schema:Person
159 sg:person.0701276576.19 schema:affiliation https://www.grid.ac/institutes/grid.11142.37
160 schema:familyName Arulselvan
161 schema:givenName Palanisamy
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701276576.19
163 rdf:type schema:Person
164 sg:pub.10.1007/s00018-016-2268-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012262705
165 https://doi.org/10.1007/s00018-016-2268-0
166 rdf:type schema:CreativeWork
167 sg:pub.10.1046/j.1523-1747.2000.00029.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002429506
168 https://doi.org/10.1046/j.1523-1747.2000.00029.x
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/s12906-016-1128-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041047689
171 https://doi.org/10.1186/s12906-016-1128-7
172 rdf:type schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1074993161 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1078053858 schema:CreativeWork
175 https://doi.org/10.1002/jcp.21503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034114372
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/jcp.25328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031025790
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.avsg.2013.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013121912
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.bbadis.2013.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041275498
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.biomaterials.2011.02.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037495194
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.envres.2016.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049935332
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.fct.2014.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015328968
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.fitote.2008.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033945769
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.fitote.2012.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032012605
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.fitote.2013.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025123510
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.ijpharm.2012.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037907243
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.jdiacomp.2013.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042514149
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.jss.2006.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003860610
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.jss.2014.10.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038544747
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.lfs.2013.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038415446
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.lfs.2016.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002631097
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.memsci.2006.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002100056
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.toxrep.2014.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037393937
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0002-9610(02)00815-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031717838
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0006-355x(97)00010-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008279054
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0140-6736(05)67698-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021686568
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1021/np100937e schema:sameAs https://app.dimensions.ai/details/publication/pub.1056231505
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1038/sj.emboj.7601579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044548324
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1046/j.1524-475x.1996.40404.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032614631
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1067/msg.2001.111167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053064371
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.1517847112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019954538
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/01.shk.0000223120.26394.7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1001991667
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/etp.12008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004898213
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1111/iwj.12181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051823240
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/iwj.12225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041749796
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1067-1927.2005.130108.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045261731
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1524-475x.2008.00410.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016786299
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1524-475x.2012.00772.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853840
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/j.1524-475x.2012.00851.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028911789
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1742-481x.2011.00924.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000350785
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/jcmm.12164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008031880
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1136/bmjopen-2016-013037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062809930
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1152/physrev.2003.83.3.835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075310758
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1155/2013/974580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014216266
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1155/2015/720171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029245625
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1155/2016/2897656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049785671
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1155/2018/3142073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101116379
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1161/01.res.0000102937.50486.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1017896639
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1172/jci32169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028037015
262 rdf:type schema:CreativeWork
263 https://doi.org/10.12659/msm.902859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083395568
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0055456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000236658
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1371/journal.pone.0055899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043569838
268 rdf:type schema:CreativeWork
269 https://doi.org/10.2147/dddt.s79885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008913427
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2147/dddt.s96968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007044180
272 rdf:type schema:CreativeWork
273 https://doi.org/10.2217/dmt.15.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053480048
274 rdf:type schema:CreativeWork
275 https://doi.org/10.2337/diabetes.50.3.667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040256432
276 rdf:type schema:CreativeWork
277 https://doi.org/10.2741/1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913488
278 rdf:type schema:CreativeWork
279 https://doi.org/10.3109/14653249.2010.512632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022522829
280 rdf:type schema:CreativeWork
281 https://doi.org/10.3233/bir-1997-34205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092049512
282 rdf:type schema:CreativeWork
283 https://doi.org/10.3390/ijms18122766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099885613
284 rdf:type schema:CreativeWork
285 https://doi.org/10.4103/0973-1296.172961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049410919
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4172/2157-7099.1000294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027188118
288 rdf:type schema:CreativeWork
289 https://doi.org/10.5455/jice.20160201055629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018940822
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.11142.37 schema:alternateName Universiti Putra Malaysia
292 schema:name Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
293 Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.412113.4 schema:alternateName National University of Malaysia
296 schema:name Centre of Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
297 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...