Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue View Full Text


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Article Info

DATE

2018-02-02

AUTHORS

Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan

ABSTRACT

BackgroundCisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmacological properties. The current investigation aimed to assess the protective potential of A. hydaspica polyphenol rich ethyl acetate extract (AHE) against cisplatin (CP) induced pulmonary toxicity.MethodsRats were divided into six groups. Group 1 served as control (saline); Group 2 (drug control) recieved single dose of CP (7.5 mg/kg i.p.) on 1st day; Group 3 (extract control) (400 mg/kg bw, p.o.) received AHE for one week; Group 4 (Post-treated) and Group 5 (pretreated) received AHE (400 mg/kg bw/day, p.o) for 7 days after and before CP (7.5 mg/kg b.w., i.p.) respectively; Group 6 (Standard control) received silymarin (100 mg/kg b.w/7 days) before CP. At the end of dosing rats were sacrificed and pulmonary tissue samples were processed for the evaluation of antioxidant enzymes, oxidative stress markers, genotoxicity and histopathological alterations.ResultsCP caused body weights loss and increase pulmonary tissue weight. The CP significantly increases oxidative stress markers and decreases tissue antioxidant enzyme levels. Furthermore, CP induced deleterious changes in the microanatomy of pulmonary tissue by rupturing the alveolar septa, thickening of alveolar walls, and injuring the cells with subsequent collapse of blood vessels. AHE pretreatment returned MDA, NO, H2O2 production and improved tissue antioxidant enzyme levels to near normalcy. The histological observations evidenced that AHE effectively rescues the lungs from CP-mediated oxidative damage. CP induction in rats also caused DNA fragmentation which was restored by AHE treatment. Our results suggest that pretreatment more significantly improve CP induced deleterious effects compared with post treatment indicating protective effect. Potency of AHE pretreatment is similar to silymarin.ConclusionThese findings demonstrated that A. hydaspica AHE extract might serve as potential adjuvant that prevents CP persuaded pulmonary toxicity due to its intrinsic antioxidant potential and polyphenolic constituents. More... »

PAGES

49

References to SciGraph publications

  • 1991-07. Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: Stereological studies on rat lungs in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 2016-03-15. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways in SCIENTIFIC REPORTS
  • 2016-07-29. Evaluation of antioxidant, anti-hemolytic and anticancer activity of various solvent extracts of Acacia hydaspica R. Parker aerial parts in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2017-04-24. Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2017-06-12. Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 1968-01. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse in PSYCHOPHARMACOLOGIA
  • 2015-04-11. Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats in PHARMACOLOGICAL REPORTS
  • 2012-02-06. Evaluation of phenolic contents and antioxidant activity of various solvent extracts of Sonchus asper (L.) Hill in BMC CHEMISTRY
  • 2009-03. Acute doxorubicin pulmotoxicity in rats with malignant neoplasm is effectively treated with fullerenol C60(OH)24 through inhibition of oxidative stress in PHARMACOLOGICAL REPORTS
  • 2015-04-29. Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2015-12-15. Antioxidant activity and protection against oxidative-induced damage of Acacia shaffneri and Acacia farnesiana pods extracts: in vitro and in vivo assays in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2014-09-28. Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats in CANCER CELL INTERNATIONAL
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    40 Acacia hydaspica R. Parker
    41 CP induction
    42 ConclusionThese findings
    43 DNA damage
    44 DNA fragmentation
    45 H2O2 production
    46 MDA
    47 MethodsRats
    48 Parker
    49 R. Parker
    50 ResultsCP
    51 acetate extract
    52 adjuvant
    53 adverse outcomes
    54 alterations
    55 alveolar septa
    56 alveolar walls
    57 antioxidant enzyme levels
    58 antioxidant enzymes
    59 blood vessels
    60 body weight loss
    61 cells
    62 changes
    63 cisplatin
    64 collapse
    65 compounds
    66 constituents
    67 control
    68 current investigation
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    70 days
    71 deleterious changes
    72 deleterious effects
    73 dose
    74 drugs
    75 effect
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    77 enzyme
    78 enzyme levels
    79 ethyl acetate extract
    80 evaluation
    81 extract
    82 findings
    83 fragmentation
    84 genotoxicity
    85 group
    86 group 1
    87 group 2
    88 group 3
    89 group 4
    90 group 5
    91 group 6
    92 histological observations
    93 histopathological alterations
    94 human malignancies
    95 induction
    96 investigation
    97 levels
    98 loss
    99 lung
    100 malignancy
    101 markers
    102 microanatomy
    103 morphological alterations
    104 natural shrubs
    105 normalcy
    106 observations
    107 outcomes
    108 oxidative damage
    109 oxidative stress
    110 oxidative stress markers
    111 pharmacological properties
    112 platinum compounds
    113 polyphenolic constituents
    114 post treatment
    115 potency
    116 potential
    117 potential adjuvant
    118 pretreatment
    119 production
    120 properties
    121 protective effect
    122 protective potential
    123 pulmonary tissue
    124 pulmonary tissue samples
    125 pulmonary toxicity
    126 rat pulmonary tissue
    127 rats
    128 results
    129 samples
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    131 shrubs
    132 silymarin
    133 single dose
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