Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue View Full Text


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Article Info

DATE

2018-02-02

AUTHORS

Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan

ABSTRACT

BackgroundCisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmacological properties. The current investigation aimed to assess the protective potential of A. hydaspica polyphenol rich ethyl acetate extract (AHE) against cisplatin (CP) induced pulmonary toxicity.MethodsRats were divided into six groups. Group 1 served as control (saline); Group 2 (drug control) recieved single dose of CP (7.5 mg/kg i.p.) on 1st day; Group 3 (extract control) (400 mg/kg bw, p.o.) received AHE for one week; Group 4 (Post-treated) and Group 5 (pretreated) received AHE (400 mg/kg bw/day, p.o) for 7 days after and before CP (7.5 mg/kg b.w., i.p.) respectively; Group 6 (Standard control) received silymarin (100 mg/kg b.w/7 days) before CP. At the end of dosing rats were sacrificed and pulmonary tissue samples were processed for the evaluation of antioxidant enzymes, oxidative stress markers, genotoxicity and histopathological alterations.ResultsCP caused body weights loss and increase pulmonary tissue weight. The CP significantly increases oxidative stress markers and decreases tissue antioxidant enzyme levels. Furthermore, CP induced deleterious changes in the microanatomy of pulmonary tissue by rupturing the alveolar septa, thickening of alveolar walls, and injuring the cells with subsequent collapse of blood vessels. AHE pretreatment returned MDA, NO, H2O2 production and improved tissue antioxidant enzyme levels to near normalcy. The histological observations evidenced that AHE effectively rescues the lungs from CP-mediated oxidative damage. CP induction in rats also caused DNA fragmentation which was restored by AHE treatment. Our results suggest that pretreatment more significantly improve CP induced deleterious effects compared with post treatment indicating protective effect. Potency of AHE pretreatment is similar to silymarin.ConclusionThese findings demonstrated that A. hydaspica AHE extract might serve as potential adjuvant that prevents CP persuaded pulmonary toxicity due to its intrinsic antioxidant potential and polyphenolic constituents. More... »

PAGES

49

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  • 2015-04-29. Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis in BMC COMPLEMENTARY MEDICINE AND THERAPIES
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    40 Acacia hydaspica R. Parker
    41 CP induction
    42 ConclusionThese findings
    43 DNA damage
    44 DNA fragmentation
    45 H2O2 production
    46 MDA
    47 MethodsRats
    48 Parker
    49 R. Parker
    50 ResultsCP
    51 acetate extract
    52 adjuvant
    53 adverse outcomes
    54 alterations
    55 alveolar septa
    56 alveolar walls
    57 antioxidant enzyme levels
    58 antioxidant enzymes
    59 blood vessels
    60 body weight loss
    61 cells
    62 changes
    63 cisplatin
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    78 enzyme levels
    79 ethyl acetate extract
    80 evaluation
    81 extract
    82 findings
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    84 genotoxicity
    85 group
    86 group 1
    87 group 2
    88 group 3
    89 group 4
    90 group 5
    91 group 6
    92 histological observations
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    94 human malignancies
    95 induction
    96 investigation
    97 levels
    98 loss
    99 lung
    100 malignancy
    101 markers
    102 microanatomy
    103 morphological alterations
    104 natural shrubs
    105 normalcy
    106 observations
    107 outcomes
    108 oxidative damage
    109 oxidative stress
    110 oxidative stress markers
    111 pharmacological properties
    112 platinum compounds
    113 polyphenolic constituents
    114 post treatment
    115 potency
    116 potential
    117 potential adjuvant
    118 pretreatment
    119 production
    120 properties
    121 protective effect
    122 protective potential
    123 pulmonary tissue
    124 pulmonary tissue samples
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    126 rat pulmonary tissue
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    128 results
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    131 shrubs
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