The protective effects of Resveratrol against radiation-induced intestinal injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Heng Zhang, Hao Yan, Xiaoliang Zhou, Huaqing Wang, Yiling Yang, Junling Zhang, Hui Wang

ABSTRACT

BACKGROUND: Intestinal injury is a potential cause of death after high-dose radiation exposure. The aim of the present study was to investigate the protective effects of resveratrol against radiation-induced small intestine injury. METHODS: C57BL/6 N mice were irradiated and treated with resveratrol and/or Ex527 (a potent Sirt1 inhibitor), and subsequent examining intestinal morphological changes, and crypt cell apoptosis. Then, the expression and enzyme activity of SOD2 in the small intestine were examined. Furthermore, Sirt1 and acetylated p53 expression was analysed. RESULTS: Compared to the vehicle control, treatment with resveratrol improved intestinal morphology, decreased apoptosis of crypt cells, maintained cell regeneration, and ameliorated SOD2 expression and activity. Resveratrol also regulated Sirt1 and acetylated p53 expression perturbed by irradiation in the small intestine. The protective effect of resveratrol against ionizing radiation induced small intestine injury was significantly inhibited by Ex527. CONCLUSION: Our results suggest that resveratrol decreases the effects of radiation on intestinal injury at least partly via activation of Sirt1. More... »

PAGES

410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-017-1915-9

DOI

http://dx.doi.org/10.1186/s12906-017-1915-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091206656

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28814292


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