Antioxidant and vasorelaxant activities induced by northeastern Brazilian fermented grape skins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-28

AUTHORS

José George F. Albuquerque, Valéria L. Assis, Arthur J. P. O. Almeida, Ionaldo J. L. D. Basílio, Melissa N. Luciano, Bruno R. L. A. Meireles, Ângela M. T. M. Cordeiro, Islânia G. A. Araújo, Robson C. Veras, Thaís P. Ribeiro, Isac A. Medeiros

ABSTRACT

BACKGROUND: In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from pomace, described as fermented (FGS), and fresh, unfermented (UGS) grape skins to show the relevant brand's composition upon the first maceration in winemaking. METHODS: The use of in vitro testing such as Folin-Ciocalteu's, DPPH free radical scavenger and HPLC methods were performed to evidence antioxidant effect and phenolic compounds. Additionally, vascular reactivity studies were performed in third-order branches of rat superior mesenteric arteries, which were obtained and placed in organ baths containing Krebs-Henseleit solution, maintained at 37 °C, gassed with a mixture of 95% O2 and 5% CO2, and maintained at pH 7.4. The in situ formation of reactive oxygen species (ROS) was evaluated in small mesenteric rings using oxidative fluorescent dihydroethidium dye. RESULTS: We found higher phenolic content and antioxidant activity in FGS when compared to UGS. HPLC analyses identified a significant number of phenolic compounds with antioxidant potential in both samples. The vasorelaxant effect induced by FGS was more potent than that induced by UGS, and the activity was attenuated after removal of vascular endothelium or by blockade of endothelium-derived relaxing factors, such as NO and EDHF. CONCLUSIONS: The FGS extract may be a great source of natural polyphenol products with potent antioxidant effects and endothelium-dependent vasodilatory actions involving NO and EDHF pathways. More... »

PAGES

376

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-017-1881-2

DOI

http://dx.doi.org/10.1186/s12906-017-1881-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090913842

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28754099


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27 schema:description BACKGROUND: In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from pomace, described as fermented (FGS), and fresh, unfermented (UGS) grape skins to show the relevant brand's composition upon the first maceration in winemaking. METHODS: The use of in vitro testing such as Folin-Ciocalteu's, DPPH free radical scavenger and HPLC methods were performed to evidence antioxidant effect and phenolic compounds. Additionally, vascular reactivity studies were performed in third-order branches of rat superior mesenteric arteries, which were obtained and placed in organ baths containing Krebs-Henseleit solution, maintained at 37 °C, gassed with a mixture of 95% O<sub>2</sub> and 5% CO<sub>2</sub>, and maintained at pH 7.4. The in situ formation of reactive oxygen species (ROS) was evaluated in small mesenteric rings using oxidative fluorescent dihydroethidium dye. RESULTS: We found higher phenolic content and antioxidant activity in FGS when compared to UGS. HPLC analyses identified a significant number of phenolic compounds with antioxidant potential in both samples. The vasorelaxant effect induced by FGS was more potent than that induced by UGS, and the activity was attenuated after removal of vascular endothelium or by blockade of endothelium-derived relaxing factors, such as NO and EDHF. CONCLUSIONS: The FGS extract may be a great source of natural polyphenol products with potent antioxidant effects and endothelium-dependent vasodilatory actions involving NO and EDHF pathways.
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45 NO
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54 artery
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67 endothelium
68 endothelium-dependent vasodilatory actions
69 endothelium-derived relaxing factors
70 evidence antioxidant effect
71 extract
72 factors
73 first maceration
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75 formation
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77 grape pomace
78 grape skins
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81 lyophilized extract
82 maceration
83 mesenteric artery
84 mesenteric rings
85 method
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88 northeastern Brazil
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93 oxygen species
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109 relaxing factors
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125 unfermented (UGS) grape skins
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