Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats View Full Text


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Article Info

DATE

2017-06-12

AUTHORS

Tayyaba Afsar, Suhail Razak, Ali almajwal, Muhammad Rashid khan

ABSTRACT

BackgroundCisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity.MethodsRats were randomly separated into six groups (n = 6). Group 1 (control) received distilled water orally for 21 days. Groups 2 (CP control) received a single dose of CP (7.5 mg/kg bw, i.p) on day 16, group 3 (Plant control) received AHE (400 mg/kg b.w, oral) for 21 days, group 4 (post treated group); CP received on day 16 and AHE (400 mg/kg b.w/day, p.o.) was administered after CP till day 21, Group 5 (pretreated group) received AHE (400 mg/kg b.w/day, p.o.) for 21 days and CP (7.5 mg/kg b.w., i.p.) on day 16, group 6 (Silymarin + CP) received 100 mg/kg b.w., p.o. (11 doses/21 days) and CP (7.5 mg/kg b.w., i.p.) on day 16. Lipid profile, liver functional tests, oxidative stress markers, antioxidant enzymes status and histopathological changes were examined.ResultsThe present study revealed that CP caused body weights loss and increase liver index. CP significantly increased serum total lipid, triglycerides and LDL-cholesterol levels. Conversely, it significantly decreased serum HDL-cholesterol level. CP induced marked deteriorations in serum liver function biomarkers, reduced antioxidant enzymes in tissue, while elevated tissue oxidative stress markers along with morphological injuries compared to control rats. Treatment with AHE ameliorated CP induced alterations in lipid profile, serum ALT, AST, ALP and total bilirubin levels and liver weight. Furthermore AHE treatment improved the total protein and antioxidant enzymes levels while decreased the level of MDA, H2O2, and NO. The altered parameters were returned to the control level with AHE pretreatment. Histopathological analysis also supported the biochemical findings. Pretreatment seems to be more effective compared to post treatment indicating protective effect.ConclusionThese results reveal that treatment of AHE may be useful in the prevention of CP induced hepatotoxicity due to its antioxidant potential and polyphenolic constituents. More... »

PAGES

307

References to SciGraph publications

  • 2016-03-15. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways in SCIENTIFIC REPORTS
  • 2016-07-29. Evaluation of antioxidant, anti-hemolytic and anticancer activity of various solvent extracts of Acacia hydaspica R. Parker aerial parts in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2017-04-24. Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2001. Anticancer Drug—Induced Kidney Disorders in DRUG SAFETY
  • 2015-05. Hepatoprotective effect of Ficus religiosa latex on cisplatin induced liver injury in Wistar rats in REVISTA BRASILEIRA DE FARMACOGNOSIA
  • 2014-12-24. Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats in LABORATORY ANIMAL RESEARCH
  • 2006-02-17. Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats in ARCHIVES OF TOXICOLOGY
  • 2006-06-05. Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats in ASIAN JOURNAL OF ANDROLOGY
  • 2015-04-29. Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2015-12-15. Antioxidant activity and protection against oxidative-induced damage of Acacia shaffneri and Acacia farnesiana pods extracts: in vitro and in vivo assays in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2014-09-28. Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats in CANCER CELL INTERNATIONAL
  • 2010-09-14. Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway in INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
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    http://scigraph.springernature.com/pub.10.1186/s12906-017-1824-y

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    http://dx.doi.org/10.1186/s12906-017-1824-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085982465

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28606074


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    31 schema:description BackgroundCisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity.MethodsRats were randomly separated into six groups (n = 6). Group 1 (control) received distilled water orally for 21 days. Groups 2 (CP control) received a single dose of CP (7.5 mg/kg bw, i.p) on day 16, group 3 (Plant control) received AHE (400 mg/kg b.w, oral) for 21 days, group 4 (post treated group); CP received on day 16 and AHE (400 mg/kg b.w/day, p.o.) was administered after CP till day 21, Group 5 (pretreated group) received AHE (400 mg/kg b.w/day, p.o.) for 21 days and CP (7.5 mg/kg b.w., i.p.) on day 16, group 6 (Silymarin + CP) received 100 mg/kg b.w., p.o. (11 doses/21 days) and CP (7.5 mg/kg b.w., i.p.) on day 16. Lipid profile, liver functional tests, oxidative stress markers, antioxidant enzymes status and histopathological changes were examined.ResultsThe present study revealed that CP caused body weights loss and increase liver index. CP significantly increased serum total lipid, triglycerides and LDL-cholesterol levels. Conversely, it significantly decreased serum HDL-cholesterol level. CP induced marked deteriorations in serum liver function biomarkers, reduced antioxidant enzymes in tissue, while elevated tissue oxidative stress markers along with morphological injuries compared to control rats. Treatment with AHE ameliorated CP induced alterations in lipid profile, serum ALT, AST, ALP and total bilirubin levels and liver weight. Furthermore AHE treatment improved the total protein and antioxidant enzymes levels while decreased the level of MDA, H2O2, and NO. The altered parameters were returned to the control level with AHE pretreatment. Histopathological analysis also supported the biochemical findings. Pretreatment seems to be more effective compared to post treatment indicating protective effect.ConclusionThese results reveal that treatment of AHE may be useful in the prevention of CP induced hepatotoxicity due to its antioxidant potential and polyphenolic constituents.
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    38 ALT
    39 AST
    40 Acacia hydaspica
    41 Alps
    42 BackgroundCisplatin
    43 CP
    44 ConclusionThese results
    45 H2O2
    46 HDL cholesterol levels
    47 LDL cholesterol levels
    48 MDA
    49 MethodsRats
    50 aberrations
    51 acetate extract
    52 activity
    53 adverse effects
    54 agents
    55 alterations
    56 altered parameters
    57 analysis
    58 antioxidant enzyme status
    59 antioxidant enzymes
    60 bilirubin levels
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    67 constituents
    68 control levels
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    71 day 21
    72 days
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    78 enzyme
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    84 functional tests
    85 group
    86 group 1
    87 group 2
    88 group 3
    89 group 4
    90 group 5
    91 group 6
    92 hepatic injury
    93 hepatotoxicity
    94 histopathological analysis
    95 histopathological changes
    96 index
    97 influence
    98 injury
    99 levels
    100 levels of MDA
    101 lipid profile
    102 lipids
    103 liver function biomarkers
    104 liver functional tests
    105 liver index
    106 liver weight
    107 loss
    108 marked deterioration
    109 markers
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    112 outcomes
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    114 parameters
    115 pharmacological activities
    116 phytochemicals
    117 polyphenolic constituents
    118 present study
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    120 prevention
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    123 protein
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    131 single dose
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    133 status
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    139 total bilirubin levels
    140 total lipids
    141 total protein
    142 treatment
    143 triglycerides
    144 tumors
    145 usage outcomes
    146 water
    147 weight
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