The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-14

AUTHORS

Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena, L.D.A. Menuka Arawwawala

ABSTRACT

BACKGROUND: Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as diarrhea, headache, rash, hypertension, muscular and joint pain. Therefore, there is an urgent need of more effective and safer treatments with fewer side effects. The aim of the present study was to scientifically evaluate the gastroprotective activity of fractions of the hot water extract of Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts with a view to identifying the fraction with the best gastroprotective activity and the possible mechanism/s by which this fraction exert gastroprotection. METHODS: Gastroprotective activity of hexane fraction (HF), ethyl acetate fraction (EF), butanol fraction (BF) and aqueous fraction (AF) were evaluated by the assessment of ability to reduce the ulcer index in ethanol-induced rat model and the mode of action by which the most active fraction mediating gastroprotection. RESULTS: EF showed the maximum gastroprotection effect followed by BF and AF. EF (75 mg/kg) exhibited significantly higher gastroprotection compared to the reference drugs. Further investigations with two lower doses of EF confirmed that EF can mediated a significant and dose dependent gastroprotection. The rats treated with the EF showed significant reduction in free acidity (45%), total acidity (by 48%) in the gastric juice, increased the amount of mucus produced by the rat gastro mucosa and potent antihistamine activity (by 25.6%). EF was also rich in phenolic compounds and flavonoids. CONCLUSION: Gastroprotective mechanism of EF is possibly involves inhibition of acidity, elevation in mucus content, inhibition of histamine and antioxidant mechanisms. More... »

PAGES

312

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-017-1796-y

DOI

http://dx.doi.org/10.1186/s12906-017-1796-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086032444

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28615015


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Juice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Ulcer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trichosanthes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka", 
          "id": "http://www.grid.ac/institutes/grid.415115.5", 
          "name": [
            "Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karunakaran", 
        "givenName": "Ramani", 
        "id": "sg:person.013512251377.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013512251377.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biochemistry, Molecular Biology & Biotechnology, No. 90, Cumaratunga Munidasa Mawatha, Colombo, 03 Sri Lanka", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Biochemistry, Molecular Biology & Biotechnology, No. 90, Cumaratunga Munidasa Mawatha, Colombo, 03 Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thabrew", 
        "givenName": "M. Ira", 
        "id": "sg:person.016605627275.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016605627275.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka", 
          "id": "http://www.grid.ac/institutes/grid.415115.5", 
          "name": [
            "Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thammitiyagodage", 
        "givenName": "G. Mayuri", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry & Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Thallagolla Road, Ragama, Sri Lanka", 
          "id": "http://www.grid.ac/institutes/grid.45202.31", 
          "name": [
            "Department of Biochemistry & Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Thallagolla Road, Ragama, Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galhena", 
        "givenName": "B. Prasanna", 
        "id": "sg:person.015702572777.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015702572777.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, 07 Sri Lanka", 
          "id": "http://www.grid.ac/institutes/grid.473355.3", 
          "name": [
            "Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, 07 Sri Lanka"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arawwawala", 
        "givenName": "L.D.A. Menuka", 
        "id": "sg:person.0623635004.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623635004.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1472-6882-12-247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957716", 
          "https://doi.org/10.1186/1472-6882-12-247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6882-12-s1-p247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034068714", 
          "https://doi.org/10.1186/1472-6882-12-s1-p247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1556/abiol.62.2011.3.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067876480", 
          "https://doi.org/10.1556/abiol.62.2011.3.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.bjp.2015.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015232053", 
          "https://doi.org/10.1016/j.bjp.2015.05.005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-012-0807-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023627371", 
          "https://doi.org/10.1007/s00210-012-0807-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-010-0582-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023401720", 
          "https://doi.org/10.1007/s00210-010-0582-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06-14", 
    "datePublishedReg": "2017-06-14", 
    "description": "BACKGROUND: Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as diarrhea, headache, rash, hypertension, muscular and joint pain. Therefore, there is an urgent need of more effective and safer treatments with fewer side effects. The aim of the present study was to scientifically evaluate the gastroprotective activity of fractions of the hot water extract of Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts with a view to identifying the fraction with the best gastroprotective activity and the possible mechanism/s by which this fraction exert gastroprotection.\nMETHODS: Gastroprotective activity of hexane fraction (HF), ethyl acetate fraction (EF), butanol fraction (BF) and aqueous fraction (AF) were evaluated by the assessment of ability to reduce the ulcer index in ethanol-induced rat model and the mode of action by which the most active fraction mediating gastroprotection.\nRESULTS: EF showed the maximum gastroprotection effect followed by BF and AF. EF (75\u00a0mg/kg) exhibited significantly higher gastroprotection compared to the reference drugs. Further investigations with two lower doses of EF confirmed that EF can mediated a significant and dose dependent gastroprotection. The rats treated with the EF showed significant reduction in free acidity (45%), total acidity (by 48%) in the gastric juice, increased the amount of mucus produced by the rat gastro mucosa and potent antihistamine activity (by 25.6%). EF was also rich in phenolic compounds and flavonoids.\nCONCLUSION: Gastroprotective mechanism of EF is possibly involves inhibition of acidity, elevation in mucus content, inhibition of histamine and antioxidant mechanisms.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12906-017-1796-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1028418", 
        "issn": [
          "1472-6882"
        ], 
        "name": "BMC Complementary Medicine and Therapies", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "ethyl acetate fraction", 
      "gastroprotective activity", 
      "ethanol-induced rat model", 
      "butanol fraction", 
      "histamine H2-receptor antagonists", 
      "possible mechanism/s", 
      "potent antihistamine activity", 
      "Trichosanthes cucumerina Linn", 
      "proton pump inhibitors", 
      "H2-receptor antagonists", 
      "inhibition of histamine", 
      "hot water extract", 
      "acetate fraction", 
      "hexane fraction", 
      "aqueous fraction", 
      "dose-dependent gastroprotection", 
      "amount of mucus", 
      "mechanism/s", 
      "joint pain", 
      "ulcer index", 
      "gastroprotective mechanism", 
      "gastroprotective effect", 
      "anticholinergic drugs", 
      "gastric ulcer", 
      "pump inhibitors", 
      "safe treatment", 
      "rat model", 
      "mucus content", 
      "side effects", 
      "gastroprotection", 
      "low doses", 
      "antihistamine activity", 
      "irreversible proton pump inhibitor", 
      "gastric juice", 
      "water extract", 
      "adverse effects", 
      "reference drug", 
      "mode of action", 
      "antioxidant mechanisms", 
      "drugs", 
      "underlying mechanism", 
      "significant reduction", 
      "further investigation", 
      "present study", 
      "assessment of ability", 
      "treatment", 
      "inhibition", 
      "active fraction", 
      "urgent need", 
      "hypertension", 
      "rash", 
      "pain", 
      "ulcers", 
      "diarrhea", 
      "headache", 
      "antacids", 
      "mucosa", 
      "antagonist", 
      "activity", 
      "rats", 
      "histamine", 
      "doses", 
      "extract", 
      "effect", 
      "mucus", 
      "aerial parts", 
      "inhibitors", 
      "phenolic compounds", 
      "elevation", 
      "mechanism", 
      "flavonoids", 
      "aim", 
      "Linn", 
      "fraction", 
      "assessment", 
      "index", 
      "total acidity", 
      "juice", 
      "free acidity", 
      "study", 
      "action", 
      "reduction", 
      "use", 
      "need", 
      "ability", 
      "investigation", 
      "series", 
      "compounds", 
      "part", 
      "amount", 
      "content", 
      "model", 
      "acidity", 
      "view", 
      "mode", 
      "Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts", 
      "cucumerina Linn (Family: Cucurbitaceae) aerial parts", 
      "Linn (Family: Cucurbitaceae) aerial parts", 
      "best gastroprotective activity", 
      "fraction exert gastroprotection", 
      "exert gastroprotection", 
      "maximum gastroprotection effect", 
      "gastroprotection effect", 
      "higher gastroprotection", 
      "dependent gastroprotection", 
      "rat gastro mucosa", 
      "gastro mucosa", 
      "inhibition of acidity", 
      "cucumerina Linn"
    ], 
    "name": "The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms", 
    "pagination": "312", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1086032444"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12906-017-1796-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28615015"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12906-017-1796-y", 
      "https://app.dimensions.ai/details/publication/pub.1086032444"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_752.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12906-017-1796-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12906-017-1796-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12906-017-1796-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12906-017-1796-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12906-017-1796-y'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      22 PREDICATES      152 URIs      138 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12906-017-1796-y schema:about N341526ca141243699a066fdf94339439
2 N3a2c596629304352ab6b025069adfa36
3 N4a45f67134ab4110a24bd1a4e227bff2
4 N4ac07389121d4e80b619a413db77b3fb
5 N763e4054fa1240be8751120742784c89
6 N8487ca69e051471cbb6b0dace3ce2fd6
7 Na8a06beb31934a48bab09813b5b80244
8 Na93910ce134048fa994c3e08230759ba
9 Nb670ab31d37c411d870a14b8c1611055
10 Nd06b525f2ce943b38268e94a6d055ccf
11 Nf896f32611784a8f9ea1965a82f46623
12 anzsrc-for:11
13 anzsrc-for:1115
14 schema:author Nf8de11f5cf2e497796dfa51e8b44b74e
15 schema:citation sg:pub.10.1007/s00210-010-0582-x
16 sg:pub.10.1007/s00210-012-0807-2
17 sg:pub.10.1016/j.bjp.2015.05.005
18 sg:pub.10.1186/1472-6882-12-247
19 sg:pub.10.1186/1472-6882-12-s1-p247
20 sg:pub.10.1556/abiol.62.2011.3.3
21 schema:datePublished 2017-06-14
22 schema:datePublishedReg 2017-06-14
23 schema:description BACKGROUND: Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as diarrhea, headache, rash, hypertension, muscular and joint pain. Therefore, there is an urgent need of more effective and safer treatments with fewer side effects. The aim of the present study was to scientifically evaluate the gastroprotective activity of fractions of the hot water extract of Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts with a view to identifying the fraction with the best gastroprotective activity and the possible mechanism/s by which this fraction exert gastroprotection. METHODS: Gastroprotective activity of hexane fraction (HF), ethyl acetate fraction (EF), butanol fraction (BF) and aqueous fraction (AF) were evaluated by the assessment of ability to reduce the ulcer index in ethanol-induced rat model and the mode of action by which the most active fraction mediating gastroprotection. RESULTS: EF showed the maximum gastroprotection effect followed by BF and AF. EF (75 mg/kg) exhibited significantly higher gastroprotection compared to the reference drugs. Further investigations with two lower doses of EF confirmed that EF can mediated a significant and dose dependent gastroprotection. The rats treated with the EF showed significant reduction in free acidity (45%), total acidity (by 48%) in the gastric juice, increased the amount of mucus produced by the rat gastro mucosa and potent antihistamine activity (by 25.6%). EF was also rich in phenolic compounds and flavonoids. CONCLUSION: Gastroprotective mechanism of EF is possibly involves inhibition of acidity, elevation in mucus content, inhibition of histamine and antioxidant mechanisms.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N43dd4904a8c54f6f9a4e173e3829fd6e
28 N62935fbf60a1453486c7fc18d769482f
29 sg:journal.1028418
30 schema:keywords H2-receptor antagonists
31 Linn
32 Linn (Family: Cucurbitaceae) aerial parts
33 Trichosanthes cucumerina Linn
34 Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts
35 ability
36 acetate fraction
37 acidity
38 action
39 active fraction
40 activity
41 adverse effects
42 aerial parts
43 aim
44 amount
45 amount of mucus
46 antacids
47 antagonist
48 anticholinergic drugs
49 antihistamine activity
50 antioxidant mechanisms
51 aqueous fraction
52 assessment
53 assessment of ability
54 best gastroprotective activity
55 butanol fraction
56 compounds
57 content
58 cucumerina Linn
59 cucumerina Linn (Family: Cucurbitaceae) aerial parts
60 dependent gastroprotection
61 diarrhea
62 dose-dependent gastroprotection
63 doses
64 drugs
65 effect
66 elevation
67 ethanol-induced rat model
68 ethyl acetate fraction
69 exert gastroprotection
70 extract
71 flavonoids
72 fraction
73 fraction exert gastroprotection
74 free acidity
75 further investigation
76 gastric juice
77 gastric ulcer
78 gastro mucosa
79 gastroprotection
80 gastroprotection effect
81 gastroprotective activity
82 gastroprotective effect
83 gastroprotective mechanism
84 headache
85 hexane fraction
86 higher gastroprotection
87 histamine
88 histamine H2-receptor antagonists
89 hot water extract
90 hypertension
91 index
92 inhibition
93 inhibition of acidity
94 inhibition of histamine
95 inhibitors
96 investigation
97 irreversible proton pump inhibitor
98 joint pain
99 juice
100 low doses
101 maximum gastroprotection effect
102 mechanism
103 mechanism/s
104 mode
105 mode of action
106 model
107 mucosa
108 mucus
109 mucus content
110 need
111 pain
112 part
113 phenolic compounds
114 possible mechanism/s
115 potent antihistamine activity
116 present study
117 proton pump inhibitors
118 pump inhibitors
119 rash
120 rat gastro mucosa
121 rat model
122 rats
123 reduction
124 reference drug
125 safe treatment
126 series
127 side effects
128 significant reduction
129 study
130 total acidity
131 treatment
132 ulcer index
133 ulcers
134 underlying mechanism
135 urgent need
136 use
137 view
138 water extract
139 schema:name The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms
140 schema:pagination 312
141 schema:productId N2db6c693d8224e3bba7471c3b8ead092
142 N91948b9c21624219a0aa7e5624856000
143 Nb379ed6296b5480095d7927d82ce40b5
144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086032444
145 https://doi.org/10.1186/s12906-017-1796-y
146 schema:sdDatePublished 2021-12-01T19:40
147 schema:sdLicense https://scigraph.springernature.com/explorer/license/
148 schema:sdPublisher N1c254fcc859f4b6ea0ba7fd0fae79eb9
149 schema:url https://doi.org/10.1186/s12906-017-1796-y
150 sgo:license sg:explorer/license/
151 sgo:sdDataset articles
152 rdf:type schema:ScholarlyArticle
153 N0dbc9493fd124b7aa9fb93460782cf0b rdf:first N9330fbfee78a4abc8dff532d6a263974
154 rdf:rest Nd919266ccbb44c07ba9b43498edd38a6
155 N11d2d48fa7054a90b346b69ae3662771 rdf:first sg:person.0623635004.64
156 rdf:rest rdf:nil
157 N1c254fcc859f4b6ea0ba7fd0fae79eb9 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N2db6c693d8224e3bba7471c3b8ead092 schema:name dimensions_id
160 schema:value pub.1086032444
161 rdf:type schema:PropertyValue
162 N341526ca141243699a066fdf94339439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Antioxidants
164 rdf:type schema:DefinedTerm
165 N3a2c596629304352ab6b025069adfa36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Male
167 rdf:type schema:DefinedTerm
168 N43dd4904a8c54f6f9a4e173e3829fd6e schema:issueNumber 1
169 rdf:type schema:PublicationIssue
170 N4a45f67134ab4110a24bd1a4e227bff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Protective Agents
172 rdf:type schema:DefinedTerm
173 N4ac07389121d4e80b619a413db77b3fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Gastric Juice
175 rdf:type schema:DefinedTerm
176 N62935fbf60a1453486c7fc18d769482f schema:volumeNumber 17
177 rdf:type schema:PublicationVolume
178 N7225a8d272e146d8b99f63227e107511 rdf:first sg:person.016605627275.40
179 rdf:rest N0dbc9493fd124b7aa9fb93460782cf0b
180 N763e4054fa1240be8751120742784c89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 N8487ca69e051471cbb6b0dace3ce2fd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Stomach Ulcer
185 rdf:type schema:DefinedTerm
186 N91948b9c21624219a0aa7e5624856000 schema:name doi
187 schema:value 10.1186/s12906-017-1796-y
188 rdf:type schema:PropertyValue
189 N9330fbfee78a4abc8dff532d6a263974 schema:affiliation grid-institutes:grid.415115.5
190 schema:familyName Thammitiyagodage
191 schema:givenName G. Mayuri
192 rdf:type schema:Person
193 Na8a06beb31934a48bab09813b5b80244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Rats, Wistar
195 rdf:type schema:DefinedTerm
196 Na93910ce134048fa994c3e08230759ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Animals
198 rdf:type schema:DefinedTerm
199 Nb379ed6296b5480095d7927d82ce40b5 schema:name pubmed_id
200 schema:value 28615015
201 rdf:type schema:PropertyValue
202 Nb670ab31d37c411d870a14b8c1611055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Gastric Mucosa
204 rdf:type schema:DefinedTerm
205 Nd06b525f2ce943b38268e94a6d055ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Plant Extracts
207 rdf:type schema:DefinedTerm
208 Nd919266ccbb44c07ba9b43498edd38a6 rdf:first sg:person.015702572777.12
209 rdf:rest N11d2d48fa7054a90b346b69ae3662771
210 Nf896f32611784a8f9ea1965a82f46623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Trichosanthes
212 rdf:type schema:DefinedTerm
213 Nf8de11f5cf2e497796dfa51e8b44b74e rdf:first sg:person.013512251377.47
214 rdf:rest N7225a8d272e146d8b99f63227e107511
215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
216 schema:name Medical and Health Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
219 schema:name Pharmacology and Pharmaceutical Sciences
220 rdf:type schema:DefinedTerm
221 sg:journal.1028418 schema:issn 1472-6882
222 schema:name BMC Complementary Medicine and Therapies
223 schema:publisher Springer Nature
224 rdf:type schema:Periodical
225 sg:person.013512251377.47 schema:affiliation grid-institutes:grid.415115.5
226 schema:familyName Karunakaran
227 schema:givenName Ramani
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013512251377.47
229 rdf:type schema:Person
230 sg:person.015702572777.12 schema:affiliation grid-institutes:grid.45202.31
231 schema:familyName Galhena
232 schema:givenName B. Prasanna
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015702572777.12
234 rdf:type schema:Person
235 sg:person.016605627275.40 schema:affiliation grid-institutes:None
236 schema:familyName Thabrew
237 schema:givenName M. Ira
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016605627275.40
239 rdf:type schema:Person
240 sg:person.0623635004.64 schema:affiliation grid-institutes:grid.473355.3
241 schema:familyName Arawwawala
242 schema:givenName L.D.A. Menuka
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623635004.64
244 rdf:type schema:Person
245 sg:pub.10.1007/s00210-010-0582-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023401720
246 https://doi.org/10.1007/s00210-010-0582-x
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00210-012-0807-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023627371
249 https://doi.org/10.1007/s00210-012-0807-2
250 rdf:type schema:CreativeWork
251 sg:pub.10.1016/j.bjp.2015.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015232053
252 https://doi.org/10.1016/j.bjp.2015.05.005
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/1472-6882-12-247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045957716
255 https://doi.org/10.1186/1472-6882-12-247
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1472-6882-12-s1-p247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034068714
258 https://doi.org/10.1186/1472-6882-12-s1-p247
259 rdf:type schema:CreativeWork
260 sg:pub.10.1556/abiol.62.2011.3.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067876480
261 https://doi.org/10.1556/abiol.62.2011.3.3
262 rdf:type schema:CreativeWork
263 grid-institutes:None schema:alternateName Institute of Biochemistry, Molecular Biology & Biotechnology, No. 90, Cumaratunga Munidasa Mawatha, Colombo, 03 Sri Lanka
264 schema:name Institute of Biochemistry, Molecular Biology & Biotechnology, No. 90, Cumaratunga Munidasa Mawatha, Colombo, 03 Sri Lanka
265 rdf:type schema:Organization
266 grid-institutes:grid.415115.5 schema:alternateName Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka
267 schema:name Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08 Sri Lanka
268 rdf:type schema:Organization
269 grid-institutes:grid.45202.31 schema:alternateName Department of Biochemistry & Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Thallagolla Road, Ragama, Sri Lanka
270 schema:name Department of Biochemistry & Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Thallagolla Road, Ragama, Sri Lanka
271 rdf:type schema:Organization
272 grid-institutes:grid.473355.3 schema:alternateName Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, 07 Sri Lanka
273 schema:name Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, 07 Sri Lanka
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...