Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-29

AUTHORS

Tayyaba Afsar, Muhammad Rashid Khan, Suhail Razak, Shafi Ullah, Bushra Mirza

ABSTRACT

BackgroundInflammation and pain underlies several pathological conditions. Synthetic drugs used for the management of these conditions carry severe toxic effects. Globally efforts are ongoing to introduce novel medicinal plants to develop effective, economic and innocuous drugs. The current study was aimed at investigating the antipyretic, anti-inflammatory and analgesic activity of methanol extract of A. hydaspica aerial parts (AHM) and its active fraction. Furthermore identification and isolation of polyphenolic compounds was carried out to identify the active principles.MethodsYeast induced pyrexia, Paw edema, acetic acid-induced writhing and hot plate test were carried out in vivo. HPLC-DAD analysis and combination of different chromatographic techniques, involving vacuum liquid chromatography (VLC) and flash chromatography (FC) were carried out for chemical characterization. The structural heterogeneity of flavanols was characterized by ESI- MS, 1H NMR, 13C NMR and 2D NMR spectroscopic analyses, and also by comparison with reported literature.ResultsOral administration of A. hydaspica methanol extract (AHM) and A. hydaspica ethyl acetate fraction (AHE), showed dose and time dependent decrease in body temperature in yeast induced pyrexia, comparable to standard, Paracetamol. AHM and AHE (150 mg/kg) significantly (p < 0.001) inhibit pain sensation in various pain models, i.e. acetic acid induced writhing and hot plate test. Similarly AHM and AHE demonstrated an anti-inflammatory effect in carrageenan-induced paw edema in rats and 150 mg/kg dose being distinctly more effective (91.92% inhibition). When studied on prostaglandin E2 (PGE2) induced edema in rats, AHM and AHE showed maximum inhibition of edema at 150 mg/kg after 4 h. HPLC chromatogram of AHM revealed the presence of gallic acid, catechin, rutin and caffeic acid. Chromatographic separation and structure characterization of AHE, has led to the identification of three flavan-3-ol derivative including 7-O-galloyl catechin, +catechin and methyl gallate, which have been reported for the first time in A. hydaspica.ConclusionThese results revealed that the presence of bioactive compounds in A. hydaspica might be responsible for the pharmacological activities, confirming the indigenous utility of A. hydaspica against inflammatory disorders. More... »

PAGES

136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12906-015-0658-8

DOI

http://dx.doi.org/10.1186/s12906-015-0658-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027258357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25928288


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102 hot plate test
103 identification
104 inflammatory disorders
105 inhibition
106 innocuous drug
107 isolation
108 liquid chromatography
109 literature
110 management
111 maximum inhibition
112 medicinal plants
113 methanol extract
114 methyl gallate
115 model
116 novel medicinal plants
117 pain
118 pain model
119 pain sensation
120 paracetamol
121 part
122 pathological conditions
123 paw edema
124 pharmacological activities
125 phytochemical analysis
126 plants
127 plate test
128 polyphenolic compounds
129 presence
130 principles
131 prostaglandin E2
132 pyrexia
133 rats
134 results
135 rutin
136 sensation
137 separation
138 severe toxic effects
139 spectroscopic analysis
140 standards
141 structural heterogeneity
142 structure characterization
143 study
144 synthetic drugs
145 technique
146 temperature
147 test
148 time
149 time-dependent decrease
150 toxic effects
151 utility
152 vacuum liquid chromatography
153 vivo
154 writhing
155 yeast
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