Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-21

AUTHORS

Sarwat Jahan, Asma Munawar, Suhail Razak, Sara Anam, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Mahmoud Abulmeaty, Ali Almajwal

ABSTRACT

BackgroundCisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats.Methods28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7 mg/kg) on day first and received saline for next 13 days. Third group received i.p injection of cisplatin at day one and treated with rutin (75 mg/kg) orally for next 13 days. Fourth group was treated with rutin orally for 13 days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters.ResultsCisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues, and change of the intra-testicular testosterone concentrations. Rutin co-treatment resulted in reversing cisplatin effect on DNA damage, sperm count, histological and biochemical parameters.ConclusionThese results indicated that rutin co-treatment could ameliorate cisplatin-induced reproductive toxicity in male rats. More... »

PAGES

107

References to SciGraph publications

  • 2013-01-02. Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2014-02-13. Effects of rutin on acrylamide-induced neurotoxicity in DARU JOURNAL OF PHARMACEUTICAL SCIENCES
  • 2012-01-03. Development of a novel 96-microwell assay with high throughput for determination of olmesartan medoxomil in its tablets in BMC CHEMISTRY
  • 2011-06-17. Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-09. Pharmacokinetic study of rutin and quercetin in rats after oral administration of total flavones of mulberry leaf extract in REVISTA BRASILEIRA DE FARMACOGNOSIA
  • 2015-06-11. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats in BIOLOGICAL RESEARCH
  • 2012-01-12. Any difference? Use of a CAM provider among cancer patients, coronary heart disease (CHD) patients and individuals with no cancer/CHD in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2012-02-06. Evaluation of phenolic contents and antioxidant activity of various solvent extracts of Sonchus asper (L.) Hill in BMC CHEMISTRY
  • 2012-10-08. CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2017-09-29. Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2017-12-21. Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats in BMC CANCER
  • 2013-05-10. Antioxidant activity and components of a traditional chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2011-11-29. Role of VHL gene mutation in human renal cell carcinoma in TUMOR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12894-018-0421-9

    DOI

    http://dx.doi.org/10.1186/s12894-018-0421-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110098343

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30463555


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cisplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidative Stress", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Random Allocation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Sprague-Dawley", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rutin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sperm Motility", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spermatozoa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Testis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jahan", 
            "givenName": "Sarwat", 
            "id": "sg:person.01145161315.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Munawar", 
            "givenName": "Asma", 
            "id": "sg:person.0763217475.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763217475.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Razak", 
            "givenName": "Suhail", 
            "id": "sg:person.01357705511.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anam", 
            "givenName": "Sara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ain", 
            "givenName": "Qurat Ul", 
            "id": "sg:person.012117363073.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012117363073.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/grid.412621.2", 
              "name": [
                "Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ullah", 
            "givenName": "Hizb", 
            "id": "sg:person.0721665472.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665472.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, Faculty of Biological SciencesQuaid-i-Azam University, Islamabad, Pakistan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Biochemistry, Faculty of Biological SciencesQuaid-i-Azam University, Islamabad, Pakistan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Afsar", 
            "givenName": "Tayyaba", 
            "id": "sg:person.01243457111.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Abulmeaty", 
            "givenName": "Mahmoud", 
            "id": "sg:person.011622251375.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622251375.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
              "id": "http://www.grid.ac/institutes/grid.56302.32", 
              "name": [
                "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Almajwal", 
            "givenName": "Ali", 
            "id": "sg:person.0760740725.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1472-6882-13-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019015113", 
              "https://doi.org/10.1186/1472-6882-13-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-12-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009347052", 
              "https://doi.org/10.1186/1472-6882-12-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40659-015-0022-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039008890", 
              "https://doi.org/10.1186/s40659-015-0022-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-011-0257-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011683016", 
              "https://doi.org/10.1007/s13277-011-0257-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2008-2231-22-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034769988", 
              "https://doi.org/10.1186/2008-2231-22-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-12-178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050541789", 
              "https://doi.org/10.1186/1472-6882-12-178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-13-99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046419455", 
              "https://doi.org/10.1186/1472-6882-13-99"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-017-3898-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099911590", 
              "https://doi.org/10.1186/s12885-017-3898-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12906-017-1976-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091997252", 
              "https://doi.org/10.1186/s12906-017-1976-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-011-1692-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001939173", 
              "https://doi.org/10.1007/s00280-011-1692-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-153x-6-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044053463", 
              "https://doi.org/10.1186/1752-153x-6-12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1590/s0102-695x2013000500009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011484134", 
              "https://doi.org/10.1590/s0102-695x2013000500009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-153x-6-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049859845", 
              "https://doi.org/10.1186/1752-153x-6-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-11-21", 
        "datePublishedReg": "2018-11-21", 
        "description": "BackgroundCisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats.Methods28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7\u00a0mg/kg) on day first and received saline for next 13\u00a0days. Third group received i.p injection of cisplatin at day one and treated with rutin (75\u00a0mg/kg) orally for next 13\u00a0days. Fourth group was treated with rutin orally for 13\u00a0days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters.ResultsCisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues, and change of the intra-testicular testosterone concentrations. Rutin co-treatment resulted in reversing cisplatin effect on DNA damage, sperm count, histological and biochemical parameters.ConclusionThese results indicated that rutin co-treatment could ameliorate cisplatin-induced reproductive toxicity in male rats.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12894-018-0421-9", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024960", 
            "issn": [
              "1471-2490"
            ], 
            "name": "BMC Urology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "keywords": [
          "cisplatin-induced reproductive toxicity", 
          "thiobarbituric acid reactive substances", 
          "male rats", 
          "reproductive toxicity", 
          "intra-testicular testosterone concentration", 
          "intra-peritoneal injection", 
          "standard antineoplastic drugs", 
          "daily sperm production", 
          "number of spermatogonia", 
          "epithelial cell height", 
          "acid reactive substances", 
          "ResultsCisplatin treatment", 
          "testicular toxicity", 
          "P injection", 
          "testosterone concentrations", 
          "sperm count", 
          "solid tumors", 
          "cisplatin effect", 
          "ameliorative effect", 
          "cis-diammine dichloroplatinum", 
          "antineoplastic drugs", 
          "tubular diameter", 
          "ConclusionThese results", 
          "testicular tissue", 
          "rats", 
          "biochemical parameters", 
          "oxidative stress", 
          "day one", 
          "reactive substances", 
          "significant decrease", 
          "fourth group", 
          "sperm production", 
          "third group", 
          "second group", 
          "first group", 
          "cisplatin", 
          "saline", 
          "days", 
          "toxicity", 
          "present study", 
          "reproductive organs", 
          "DNA damage", 
          "injection", 
          "group", 
          "rutin", 
          "cell height", 
          "BackgroundCisplatin", 
          "neoplasms", 
          "tumors", 
          "drugs", 
          "dichloroplatinum", 
          "treatment", 
          "organs", 
          "effect", 
          "tissue", 
          "count", 
          "animals", 
          "spermatogonia", 
          "reduction", 
          "head", 
          "head length", 
          "spermatids", 
          "damage", 
          "spermatocytes", 
          "decrease", 
          "study", 
          "substances", 
          "changes", 
          "concentration", 
          "DNA", 
          "stress", 
          "number", 
          "CP", 
          "diameter", 
          "length", 
          "production", 
          "results", 
          "variety", 
          "parameters", 
          "height", 
          "platinum", 
          "one", 
          "shielding effect"
        ], 
        "name": "Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats", 
        "pagination": "107", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110098343"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12894-018-0421-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30463555"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12894-018-0421-9", 
          "https://app.dimensions.ai/details/publication/pub.1110098343"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_775.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12894-018-0421-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12894-018-0421-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12894-018-0421-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12894-018-0421-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12894-018-0421-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    313 TRIPLES      21 PREDICATES      135 URIs      114 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12894-018-0421-9 schema:about N1a49d631268d4757a2e2a9eedb44e8cc
    2 N29478ea284984d9dadd6917ed0e681ee
    3 N3cdc7e7feb964a0db297b39eb51c3a82
    4 N4c50485f8ec14a8f9c8776849dbdc52e
    5 N58740fe167b940c6aaefd8cd3af5763a
    6 N5cfce1c4feb841c896bdda07afa5ac26
    7 N66bb9b54746a442e861ccaa4df421f17
    8 N72034552f2564b77905a1e148f13473a
    9 Na30b199ce2e54f068d48fea8ca749ccf
    10 Nb05e423554e7420c816840147c3ce71a
    11 Nb876cd0c2abd46d2b017c1862962e216
    12 Nc70e83bf6faa41d3a88dd6cae1fc2986
    13 Nf8987781175e479d8dad0a5f740cab67
    14 Nfe7e5e699956454587dc2fe185bc2418
    15 anzsrc-for:11
    16 anzsrc-for:1114
    17 schema:author Ne4f7cb9b57c9477da1a00ff644c48620
    18 schema:citation sg:pub.10.1007/s00280-011-1692-y
    19 sg:pub.10.1007/s13277-011-0257-3
    20 sg:pub.10.1186/1472-6882-12-1
    21 sg:pub.10.1186/1472-6882-12-178
    22 sg:pub.10.1186/1472-6882-13-1
    23 sg:pub.10.1186/1472-6882-13-99
    24 sg:pub.10.1186/1752-153x-6-1
    25 sg:pub.10.1186/1752-153x-6-12
    26 sg:pub.10.1186/2008-2231-22-27
    27 sg:pub.10.1186/s12885-017-3898-9
    28 sg:pub.10.1186/s12906-017-1976-9
    29 sg:pub.10.1186/s40659-015-0022-y
    30 sg:pub.10.1590/s0102-695x2013000500009
    31 schema:datePublished 2018-11-21
    32 schema:datePublishedReg 2018-11-21
    33 schema:description BackgroundCisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which is used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects of rutin against CP induced testicular toxicity in rats.Methods28 male rats were divided into four groups. First group was given saline orally while second group received intra-peritoneal (i.p) injection of cisplatin (7 mg/kg) on day first and received saline for next 13 days. Third group received i.p injection of cisplatin at day one and treated with rutin (75 mg/kg) orally for next 13 days. Fourth group was treated with rutin orally for 13 days. Animals were sacrificed on 14th day and reproductive organs were analyzed for various parameters.ResultsCisplatin treatment resulted in a significant decrease in daily sperm production, decrease in head length and % DNA in head, reduction of epithelial cell height, tubular diameter, reduction of the number of spermatogonia, spermatocytes and spermatids, increase in the thiobarbituric acid reactive substances (TBARS) and oxidative stress in testicular tissues, and change of the intra-testicular testosterone concentrations. Rutin co-treatment resulted in reversing cisplatin effect on DNA damage, sperm count, histological and biochemical parameters.ConclusionThese results indicated that rutin co-treatment could ameliorate cisplatin-induced reproductive toxicity in male rats.
    34 schema:genre article
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N6dfe80406820484f9c55bd750508844c
    37 Nbc38ad66236a40ca97999ce6144470ed
    38 sg:journal.1024960
    39 schema:keywords BackgroundCisplatin
    40 CP
    41 ConclusionThese results
    42 DNA
    43 DNA damage
    44 P injection
    45 ResultsCisplatin treatment
    46 acid reactive substances
    47 ameliorative effect
    48 animals
    49 antineoplastic drugs
    50 biochemical parameters
    51 cell height
    52 changes
    53 cis-diammine dichloroplatinum
    54 cisplatin
    55 cisplatin effect
    56 cisplatin-induced reproductive toxicity
    57 concentration
    58 count
    59 daily sperm production
    60 damage
    61 day one
    62 days
    63 decrease
    64 diameter
    65 dichloroplatinum
    66 drugs
    67 effect
    68 epithelial cell height
    69 first group
    70 fourth group
    71 group
    72 head
    73 head length
    74 height
    75 injection
    76 intra-peritoneal injection
    77 intra-testicular testosterone concentration
    78 length
    79 male rats
    80 neoplasms
    81 number
    82 number of spermatogonia
    83 one
    84 organs
    85 oxidative stress
    86 parameters
    87 platinum
    88 present study
    89 production
    90 rats
    91 reactive substances
    92 reduction
    93 reproductive organs
    94 reproductive toxicity
    95 results
    96 rutin
    97 saline
    98 second group
    99 shielding effect
    100 significant decrease
    101 solid tumors
    102 sperm count
    103 sperm production
    104 spermatids
    105 spermatocytes
    106 spermatogonia
    107 standard antineoplastic drugs
    108 stress
    109 study
    110 substances
    111 testicular tissue
    112 testicular toxicity
    113 testosterone concentrations
    114 thiobarbituric acid reactive substances
    115 third group
    116 tissue
    117 toxicity
    118 treatment
    119 tubular diameter
    120 tumors
    121 variety
    122 schema:name Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats
    123 schema:pagination 107
    124 schema:productId N3207ae9cfa73470e8d8d550778a63cbc
    125 Nd03c915dba374f98abfefc7707c7c516
    126 Nea8db38c60014b879ee7fa0a21b4ea98
    127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110098343
    128 https://doi.org/10.1186/s12894-018-0421-9
    129 schema:sdDatePublished 2022-12-01T06:37
    130 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    131 schema:sdPublisher N42a7f3b0b55843b29c1d7e7ca53bd964
    132 schema:url https://doi.org/10.1186/s12894-018-0421-9
    133 sgo:license sg:explorer/license/
    134 sgo:sdDataset articles
    135 rdf:type schema:ScholarlyArticle
    136 N0d5c514c6f6a497abd78e1c25a861bbb rdf:first sg:person.012117363073.13
    137 rdf:rest Nab99ef156c4442b8b3605ae1221b5b14
    138 N1a49d631268d4757a2e2a9eedb44e8cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Sperm Motility
    140 rdf:type schema:DefinedTerm
    141 N1d27631072ac48a4ac9418d1ff9e659e rdf:first sg:person.01357705511.88
    142 rdf:rest Nacde0ee23ae044029f665cce046cf264
    143 N26fa28474f9b4275bd1ecc93aadb0866 rdf:first sg:person.011622251375.76
    144 rdf:rest N6990e2d625bf4738b09a4361ce27b1bd
    145 N29478ea284984d9dadd6917ed0e681ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Random Allocation
    147 rdf:type schema:DefinedTerm
    148 N3207ae9cfa73470e8d8d550778a63cbc schema:name doi
    149 schema:value 10.1186/s12894-018-0421-9
    150 rdf:type schema:PropertyValue
    151 N3cdc7e7feb964a0db297b39eb51c3a82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Testis
    153 rdf:type schema:DefinedTerm
    154 N42a7f3b0b55843b29c1d7e7ca53bd964 schema:name Springer Nature - SN SciGraph project
    155 rdf:type schema:Organization
    156 N4c50485f8ec14a8f9c8776849dbdc52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Rats
    158 rdf:type schema:DefinedTerm
    159 N521711fb949148d4819dea6e185077b9 schema:affiliation grid-institutes:grid.412621.2
    160 schema:familyName Anam
    161 schema:givenName Sara
    162 rdf:type schema:Person
    163 N58740fe167b940c6aaefd8cd3af5763a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name DNA Damage
    165 rdf:type schema:DefinedTerm
    166 N5cfce1c4feb841c896bdda07afa5ac26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Male
    168 rdf:type schema:DefinedTerm
    169 N5ec6b0b3be05488b9a4255b3e4c2fa02 rdf:first sg:person.01243457111.54
    170 rdf:rest N26fa28474f9b4275bd1ecc93aadb0866
    171 N66bb9b54746a442e861ccaa4df421f17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Reproduction
    173 rdf:type schema:DefinedTerm
    174 N6990e2d625bf4738b09a4361ce27b1bd rdf:first sg:person.0760740725.04
    175 rdf:rest rdf:nil
    176 N6dfe80406820484f9c55bd750508844c schema:issueNumber 1
    177 rdf:type schema:PublicationIssue
    178 N72034552f2564b77905a1e148f13473a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Antineoplastic Agents
    180 rdf:type schema:DefinedTerm
    181 Na30b199ce2e54f068d48fea8ca749ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Animals
    183 rdf:type schema:DefinedTerm
    184 Nab99ef156c4442b8b3605ae1221b5b14 rdf:first sg:person.0721665472.94
    185 rdf:rest N5ec6b0b3be05488b9a4255b3e4c2fa02
    186 Nacde0ee23ae044029f665cce046cf264 rdf:first N521711fb949148d4819dea6e185077b9
    187 rdf:rest N0d5c514c6f6a497abd78e1c25a861bbb
    188 Nb05e423554e7420c816840147c3ce71a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Rats, Sprague-Dawley
    190 rdf:type schema:DefinedTerm
    191 Nb876cd0c2abd46d2b017c1862962e216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Spermatozoa
    193 rdf:type schema:DefinedTerm
    194 Nbc38ad66236a40ca97999ce6144470ed schema:volumeNumber 18
    195 rdf:type schema:PublicationVolume
    196 Nc70e83bf6faa41d3a88dd6cae1fc2986 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cisplatin
    198 rdf:type schema:DefinedTerm
    199 Nd03c915dba374f98abfefc7707c7c516 schema:name dimensions_id
    200 schema:value pub.1110098343
    201 rdf:type schema:PropertyValue
    202 Ne4f7cb9b57c9477da1a00ff644c48620 rdf:first sg:person.01145161315.83
    203 rdf:rest Neca49077c5364d8f85f436a97023f1a1
    204 Nea8db38c60014b879ee7fa0a21b4ea98 schema:name pubmed_id
    205 schema:value 30463555
    206 rdf:type schema:PropertyValue
    207 Neca49077c5364d8f85f436a97023f1a1 rdf:first sg:person.0763217475.36
    208 rdf:rest N1d27631072ac48a4ac9418d1ff9e659e
    209 Nf8987781175e479d8dad0a5f740cab67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Oxidative Stress
    211 rdf:type schema:DefinedTerm
    212 Nfe7e5e699956454587dc2fe185bc2418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Rutin
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Medical and Health Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Paediatrics and Reproductive Medicine
    220 rdf:type schema:DefinedTerm
    221 sg:journal.1024960 schema:issn 1471-2490
    222 schema:name BMC Urology
    223 schema:publisher Springer Nature
    224 rdf:type schema:Periodical
    225 sg:person.01145161315.83 schema:affiliation grid-institutes:grid.412621.2
    226 schema:familyName Jahan
    227 schema:givenName Sarwat
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83
    229 rdf:type schema:Person
    230 sg:person.011622251375.76 schema:affiliation grid-institutes:grid.56302.32
    231 schema:familyName Abulmeaty
    232 schema:givenName Mahmoud
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622251375.76
    234 rdf:type schema:Person
    235 sg:person.012117363073.13 schema:affiliation grid-institutes:grid.412621.2
    236 schema:familyName Ain
    237 schema:givenName Qurat Ul
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012117363073.13
    239 rdf:type schema:Person
    240 sg:person.01243457111.54 schema:affiliation grid-institutes:None
    241 schema:familyName Afsar
    242 schema:givenName Tayyaba
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54
    244 rdf:type schema:Person
    245 sg:person.01357705511.88 schema:affiliation grid-institutes:grid.56302.32
    246 schema:familyName Razak
    247 schema:givenName Suhail
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88
    249 rdf:type schema:Person
    250 sg:person.0721665472.94 schema:affiliation grid-institutes:grid.412621.2
    251 schema:familyName Ullah
    252 schema:givenName Hizb
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665472.94
    254 rdf:type schema:Person
    255 sg:person.0760740725.04 schema:affiliation grid-institutes:grid.56302.32
    256 schema:familyName Almajwal
    257 schema:givenName Ali
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04
    259 rdf:type schema:Person
    260 sg:person.0763217475.36 schema:affiliation grid-institutes:grid.412621.2
    261 schema:familyName Munawar
    262 schema:givenName Asma
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763217475.36
    264 rdf:type schema:Person
    265 sg:pub.10.1007/s00280-011-1692-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001939173
    266 https://doi.org/10.1007/s00280-011-1692-y
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/s13277-011-0257-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011683016
    269 https://doi.org/10.1007/s13277-011-0257-3
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/1472-6882-12-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009347052
    272 https://doi.org/10.1186/1472-6882-12-1
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1186/1472-6882-12-178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050541789
    275 https://doi.org/10.1186/1472-6882-12-178
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1186/1472-6882-13-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019015113
    278 https://doi.org/10.1186/1472-6882-13-1
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1186/1472-6882-13-99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046419455
    281 https://doi.org/10.1186/1472-6882-13-99
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1186/1752-153x-6-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049859845
    284 https://doi.org/10.1186/1752-153x-6-1
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/1752-153x-6-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044053463
    287 https://doi.org/10.1186/1752-153x-6-12
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/2008-2231-22-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034769988
    290 https://doi.org/10.1186/2008-2231-22-27
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/s12885-017-3898-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099911590
    293 https://doi.org/10.1186/s12885-017-3898-9
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1186/s12906-017-1976-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091997252
    296 https://doi.org/10.1186/s12906-017-1976-9
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1186/s40659-015-0022-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039008890
    299 https://doi.org/10.1186/s40659-015-0022-y
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1590/s0102-695x2013000500009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011484134
    302 https://doi.org/10.1590/s0102-695x2013000500009
    303 rdf:type schema:CreativeWork
    304 grid-institutes:None schema:alternateName Department of Biochemistry, Faculty of Biological SciencesQuaid-i-Azam University, Islamabad, Pakistan
    305 schema:name Department of Biochemistry, Faculty of Biological SciencesQuaid-i-Azam University, Islamabad, Pakistan
    306 rdf:type schema:Organization
    307 grid-institutes:grid.412621.2 schema:alternateName Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
    308 schema:name Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
    309 rdf:type schema:Organization
    310 grid-institutes:grid.56302.32 schema:alternateName Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
    311 schema:name Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
    312 Reproductive physiology laboratory, Department of animal sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan
    313 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...