PD-L1 expression in papillary renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-13

AUTHORS

Takanobu Motoshima, Yoshihiro Komohara, Chaoya Ma, Arni Kusuma Dewi, Hirotsugu Noguchi, Sohsuke Yamada, Toshiyuki Nakayama, Shohei Kitada, Yoshiaki Kawano, Wataru Takahashi, Masaaki Sugimoto, Motohiro Takeya, Naohiro Fujimoto, Yoshinao Oda, Masatoshi Eto

ABSTRACT

BackgroundThe immune escape or tolerance of cancer cells is considered to be closely involved in cancer progression. Programmed death-1 (PD-1) is an inhibitory receptor expressed on activating T cells, and several types of cancer cells were found to express PD-1 ligand 1 (PD-L1) and ligand 2 (PD-L2).MethodsIn the present study, we investigated PD-L1/2 expression in papillary renal cell carcinoma (pRCC).ResultWe found PD-L1 expression in 29 of 102 cases, but no PD-L2 expression was seen. PD-L1 expression was not significantly correlated with any clinicopathological factor, including progression-free survival and overall survival. The frequency of PD-L1-positive cases was higher in type 2 (36%) than in type 1 (22%) pRCC; however, there was no significant difference in the percentages of score 0 cases (p value = 0.084 in Chi-square test). The frequency of high PD-L1 expression cases was higher in type 2 (23%) than in type 1 (11%), and the frequency of high PD-L1 expression cases was higher in grade 3/4 (21%) than in grade 1/2 (13%). However, no significant association was found between PD-L1 expression and all clinicopathological factors in pRCC.ConclusionHigh expression of PD-L1 in cancer cells was potentially associated to highly histological grade of malignancy in pRCC. The evaluation of the PD-L1 protein might still be useful for predicting the efficacy of anti-cancer immunotherapy using immuno-checkpoint inhibitors, however, not be useful for predicting the clinical prognosis. More... »

PAGES

8

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URI

http://scigraph.springernature.com/pub.10.1186/s12894-016-0195-x

DOI

http://dx.doi.org/10.1186/s12894-016-0195-x

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https://app.dimensions.ai/details/publication/pub.1031875313

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28086852


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26 schema:keywords ConclusionHigh expression
27 Immuno-checkpoint inhibitors
28 MethodsIn
29 PD-1 ligand 1
30 PD-L1 expression
31 PD-L1 protein
32 PD-L1/2 expression
33 PD-L2 expression
34 ResultWe
35 T cells
36 anti-cancer immunotherapy
37 association
38 cancer cells
39 cancer progression
40 carcinoma
41 cases
42 cell carcinoma
43 cells
44 clinical prognosis
45 clinicopathological factors
46 death-1
47 differences
48 efficacy
49 escape
50 evaluation
51 expression
52 expression cases
53 factors
54 frequency
55 grade
56 grade 1/2
57 grade 3/4
58 histological grade
59 immune escape
60 immunotherapy
61 inhibitors
62 inhibitory receptors
63 ligand 1
64 malignancy
65 overall survival
66 papillary renal cell carcinoma
67 percentage
68 positive cases
69 present study
70 prognosis
71 progression
72 progression-free survival
73 protein
74 receptors
75 renal cell carcinoma
76 significant association
77 significant differences
78 study
79 survival
80 tolerance
81 type 1
82 type 2
83 types
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