Significance of postoperative adjuvant chemotherapy with an oxaliplatin-based regimen after simultaneous curative resection for colorectal cancer and synchronous colorectal liver ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-09

AUTHORS

Kiichi Sugimoto, Kazuhiro Sakamoto, Yuki Ii, Kota Amemiya, Hiroyuki Sugo, Tomoaki Ito, Shinya Munakata, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Koichi Sato, Akio Saiura, Seiji Kawasaki

ABSTRACT

BackgroundExpansion of the indication for liver resection and new regimens for systemic chemotherapy have improved postoperative outcomes for synchronous colorectal liver metastases (CRLM). However, such cases can still have a high recurrence rate, even after curative resection. Therefore, there is a need for postoperative adjuvant chemotherapy (POAC) after liver resection in patients with CRLM. There are few studies of the efficacy of POAC with an oxaliplatin-based regimen after simultaneous resection for colorectal cancer and CRLM with curative intent. The goal of the study was to compare POAC with oxaliplatin-based and fluoropyrimidine regimens using propensity score (PS) matching analysis.MethodsThe subjects were 94 patients who received POAC after simultaneous resection for colorectal cancer and synchronous CRLM, and were enrolled retrospectively. The patients were placed in a L-OHP (+) group (POAC with an oxaliplatin-based regimen, n = 47) and a L-OHP (−) group (POAC with a fluoropyrimidine regimen, n = 47). Recurrence-free (RFS), cancer-specific (CSS), unresectable recurrence-free (URRFS), remnant liver recurrence-free (RLRFS), and extrahepatic recurrence-free (EHRFS) survival were analyzed.ResultsBefore PS matching, the L-OHP (+) and (−) groups had no significant differences in RFS, CSS, URRFS, RLRFS, and EHRFS. Univariate analysis indicated significant differences in age, preoperative serum CEA (≤ 30.0 ng/mL/ > 30.0 ng/mL), differentiation of primary tumor (differentiated/undifferentiated), T classification (T1–3/T4), number of hepatic lesions and maximum diameter of the hepatic lesion between the L-OHP (+) and (−) groups. After PS matching using these confounders, RFS was significantly better among patients in the L-OHP (+) group compared with the L-OHP (−) group (HR 0.40, 95% CI 0.17–0.96, p = 0.04). In addition, there was a trend towards better RLRFS among patients in the L-OHP (+) group compared with the L-OHP (−) group (HR 0.42, 95% CI 0.17–1.02, p = 0.055). However, there were no significant differences in CSS, URRFS and EHRFS between the L-OHP (+) and (−) groups.ConclusionsPS matching analysis demonstrated the efficacy of POAC with an oxaliplatin-based regimen in RFS and RLRFS. More... »

PAGES

188

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12893-021-01193-4

DOI

http://dx.doi.org/10.1186/s12893-021-01193-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137041153

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33836701


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxaliplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propensity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugimoto", 
        "givenName": "Kiichi", 
        "id": "sg:person.013777134017.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013777134017.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01343042240.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343042240.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.482668.6", 
          "name": [
            "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ii", 
        "givenName": "Yuki", 
        "id": "sg:person.010651416477.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010651416477.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.482668.6", 
          "name": [
            "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amemiya", 
        "givenName": "Kota", 
        "id": "sg:person.010046427403.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010046427403.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.482668.6", 
          "name": [
            "Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugo", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.01156724143.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156724143.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.482667.9", 
          "name": [
            "Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Tomoaki", 
        "id": "sg:person.01321031202.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321031202.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munakata", 
        "givenName": "Shinya", 
        "id": "sg:person.0730023440.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730023440.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Makoto", 
        "id": "sg:person.01356376603.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356376603.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kojima", 
        "givenName": "Yutaka", 
        "id": "sg:person.01160500440.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160500440.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomiki", 
        "givenName": "Yuichi", 
        "id": "sg:person.016266353622.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016266353622.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.482667.9", 
          "name": [
            "Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Koichi", 
        "id": "sg:person.01372350065.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372350065.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saiura", 
        "givenName": "Akio", 
        "id": "sg:person.0612301703.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawasaki", 
        "givenName": "Seiji", 
        "id": "sg:person.0745271456.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745271456.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00268-015-3034-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009633901", 
          "https://doi.org/10.1007/s00268-015-3034-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-019-01485-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1117184829", 
          "https://doi.org/10.1007/s10147-019-01485-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-3504-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020566781", 
          "https://doi.org/10.1245/s10434-014-3504-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-015-9719-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033034985", 
          "https://doi.org/10.1007/s10585-015-9719-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-04-09", 
    "datePublishedReg": "2021-04-09", 
    "description": "BackgroundExpansion of the indication for liver resection and new regimens for systemic chemotherapy have improved postoperative outcomes for synchronous colorectal liver metastases (CRLM). However, such cases can still have a high recurrence rate, even after curative resection. Therefore, there is a need for postoperative adjuvant chemotherapy (POAC) after liver resection in patients with CRLM. There are few studies of the efficacy of POAC with an oxaliplatin-based regimen after simultaneous resection for colorectal cancer and CRLM with curative intent. The goal of the study was to compare POAC with oxaliplatin-based and fluoropyrimidine regimens using propensity score (PS) matching analysis.MethodsThe subjects were 94 patients who received POAC after simultaneous resection for colorectal cancer and synchronous CRLM, and were enrolled retrospectively. The patients were placed in a L-OHP (+) group (POAC with an oxaliplatin-based regimen, n\u2009=\u200947) and a L-OHP (\u2212) group (POAC with a fluoropyrimidine regimen, n\u2009=\u200947). Recurrence-free (RFS), cancer-specific (CSS), unresectable recurrence-free (URRFS), remnant liver recurrence-free (RLRFS), and extrahepatic recurrence-free (EHRFS) survival were analyzed.ResultsBefore PS matching, the L-OHP (+) and (\u2212) groups had no significant differences in RFS, CSS, URRFS, RLRFS, and EHRFS. Univariate analysis indicated significant differences in age, preoperative serum CEA (\u2264\u200930.0\u00a0ng/mL/\u2009>\u200930.0\u00a0ng/mL), differentiation of primary tumor (differentiated/undifferentiated), T classification (T1\u20133/T4), number of hepatic lesions and maximum diameter of the hepatic lesion between the L-OHP (+) and (\u2212) groups. After PS matching using these confounders, RFS was significantly better among patients in the L-OHP (+) group compared with the L-OHP (\u2212) group (HR 0.40, 95% CI 0.17\u20130.96, p\u2009=\u20090.04). In addition, there was a trend towards better RLRFS among patients in the L-OHP (+) group compared with the L-OHP (\u2212) group (HR 0.42, 95% CI 0.17\u20131.02, p\u2009=\u20090.055). However, there were no significant differences in CSS, URRFS and EHRFS between the L-OHP (+) and (\u2212) groups.ConclusionsPS matching analysis demonstrated the efficacy of POAC with an oxaliplatin-based regimen in RFS and RLRFS.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12893-021-01193-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024958", 
        "issn": [
          "1471-2482"
        ], 
        "name": "BMC Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "synchronous colorectal liver metastases", 
      "postoperative adjuvant chemotherapy", 
      "L-OHP group", 
      "colorectal liver metastases", 
      "oxaliplatin-based regimen", 
      "colorectal cancer", 
      "L-OHP", 
      "curative resection", 
      "adjuvant chemotherapy", 
      "simultaneous resection", 
      "liver resection", 
      "liver metastases", 
      "PS matching", 
      "hepatic lesions", 
      "extrahepatic recurrence-free survival", 
      "significant differences", 
      "Propensity Score Matching Analysis", 
      "simultaneous curative resection", 
      "recurrence-free survival", 
      "preoperative serum CEA", 
      "high recurrence rate", 
      "fluoropyrimidine regimens", 
      "systemic chemotherapy", 
      "curative intent", 
      "postoperative outcomes", 
      "new regimens", 
      "MethodsThe subjects", 
      "serum CEA", 
      "recurrence rate", 
      "T classification", 
      "remnant liver", 
      "primary tumor", 
      "resection", 
      "patients", 
      "regimen", 
      "propensity score", 
      "chemotherapy", 
      "RFS", 
      "cancer", 
      "regimens", 
      "maximum diameter", 
      "metastasis", 
      "Matching Analysis", 
      "lesions", 
      "efficacy", 
      "group", 
      "such cases", 
      "confounders", 
      "tumors", 
      "differences", 
      "liver", 
      "CEA", 
      "survival", 
      "outcomes", 
      "age", 
      "scores", 
      "study", 
      "indications", 
      "subjects", 
      "CSS", 
      "differentiation", 
      "analysis", 
      "cases", 
      "significance", 
      "rate", 
      "intent", 
      "need", 
      "addition", 
      "classification", 
      "number", 
      "diameter", 
      "trends", 
      "goal", 
      "matching"
    ], 
    "name": "Significance of postoperative adjuvant chemotherapy with an oxaliplatin-based regimen after simultaneous curative resection for colorectal cancer and synchronous colorectal liver metastasis: a propensity score matching analysis", 
    "pagination": "188", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1137041153"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12893-021-01193-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33836701"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12893-021-01193-4", 
      "https://app.dimensions.ai/details/publication/pub.1137041153"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_881.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12893-021-01193-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12893-021-01193-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12893-021-01193-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12893-021-01193-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12893-021-01193-4'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      113 URIs      101 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12893-021-01193-4 schema:about N170f022b5c234f8997e52b5cf37c5275
2 N1ccfc377bcb448ea8d43d162351f61ce
3 N3ee42f806feb46e6b3b84392652bc8b2
4 N5e348e3e204140a2a08b99c67758dead
5 N8a9708c7382e475486361a438b59510d
6 Na0c99ffac97040e1b6a48986f0c3d6b7
7 Nb5a84562ab4641f1a78f92e714598151
8 Nbb042b32964a475ea356d5597db17740
9 Nbfc52e2dacb94c13a8775086c8d030aa
10 Nfce92448fb724e59a8cc57087ee94b6c
11 anzsrc-for:11
12 anzsrc-for:1112
13 schema:author N3ad28165eba94fd3a28a143014ff47e8
14 schema:citation sg:pub.10.1007/s00268-015-3034-4
15 sg:pub.10.1007/s10147-019-01485-z
16 sg:pub.10.1007/s10585-015-9719-0
17 sg:pub.10.1245/s10434-014-3504-1
18 schema:datePublished 2021-04-09
19 schema:datePublishedReg 2021-04-09
20 schema:description BackgroundExpansion of the indication for liver resection and new regimens for systemic chemotherapy have improved postoperative outcomes for synchronous colorectal liver metastases (CRLM). However, such cases can still have a high recurrence rate, even after curative resection. Therefore, there is a need for postoperative adjuvant chemotherapy (POAC) after liver resection in patients with CRLM. There are few studies of the efficacy of POAC with an oxaliplatin-based regimen after simultaneous resection for colorectal cancer and CRLM with curative intent. The goal of the study was to compare POAC with oxaliplatin-based and fluoropyrimidine regimens using propensity score (PS) matching analysis.MethodsThe subjects were 94 patients who received POAC after simultaneous resection for colorectal cancer and synchronous CRLM, and were enrolled retrospectively. The patients were placed in a L-OHP (+) group (POAC with an oxaliplatin-based regimen, n = 47) and a L-OHP (−) group (POAC with a fluoropyrimidine regimen, n = 47). Recurrence-free (RFS), cancer-specific (CSS), unresectable recurrence-free (URRFS), remnant liver recurrence-free (RLRFS), and extrahepatic recurrence-free (EHRFS) survival were analyzed.ResultsBefore PS matching, the L-OHP (+) and (−) groups had no significant differences in RFS, CSS, URRFS, RLRFS, and EHRFS. Univariate analysis indicated significant differences in age, preoperative serum CEA (≤ 30.0 ng/mL/ > 30.0 ng/mL), differentiation of primary tumor (differentiated/undifferentiated), T classification (T1–3/T4), number of hepatic lesions and maximum diameter of the hepatic lesion between the L-OHP (+) and (−) groups. After PS matching using these confounders, RFS was significantly better among patients in the L-OHP (+) group compared with the L-OHP (−) group (HR 0.40, 95% CI 0.17–0.96, p = 0.04). In addition, there was a trend towards better RLRFS among patients in the L-OHP (+) group compared with the L-OHP (−) group (HR 0.42, 95% CI 0.17–1.02, p = 0.055). However, there were no significant differences in CSS, URRFS and EHRFS between the L-OHP (+) and (−) groups.ConclusionsPS matching analysis demonstrated the efficacy of POAC with an oxaliplatin-based regimen in RFS and RLRFS.
21 schema:genre article
22 schema:isAccessibleForFree true
23 schema:isPartOf Nc48f8688aee44459b5581cfd50658fd5
24 Ne66b8883976c406b8a535e3c595dae93
25 sg:journal.1024958
26 schema:keywords CEA
27 CSS
28 L-OHP
29 L-OHP group
30 Matching Analysis
31 MethodsThe subjects
32 PS matching
33 Propensity Score Matching Analysis
34 RFS
35 T classification
36 addition
37 adjuvant chemotherapy
38 age
39 analysis
40 cancer
41 cases
42 chemotherapy
43 classification
44 colorectal cancer
45 colorectal liver metastases
46 confounders
47 curative intent
48 curative resection
49 diameter
50 differences
51 differentiation
52 efficacy
53 extrahepatic recurrence-free survival
54 fluoropyrimidine regimens
55 goal
56 group
57 hepatic lesions
58 high recurrence rate
59 indications
60 intent
61 lesions
62 liver
63 liver metastases
64 liver resection
65 matching
66 maximum diameter
67 metastasis
68 need
69 new regimens
70 number
71 outcomes
72 oxaliplatin-based regimen
73 patients
74 postoperative adjuvant chemotherapy
75 postoperative outcomes
76 preoperative serum CEA
77 primary tumor
78 propensity score
79 rate
80 recurrence rate
81 recurrence-free survival
82 regimen
83 regimens
84 remnant liver
85 resection
86 scores
87 serum CEA
88 significance
89 significant differences
90 simultaneous curative resection
91 simultaneous resection
92 study
93 subjects
94 such cases
95 survival
96 synchronous colorectal liver metastases
97 systemic chemotherapy
98 trends
99 tumors
100 schema:name Significance of postoperative adjuvant chemotherapy with an oxaliplatin-based regimen after simultaneous curative resection for colorectal cancer and synchronous colorectal liver metastasis: a propensity score matching analysis
101 schema:pagination 188
102 schema:productId N4b88f0da358c44ffb9981276d87ebac1
103 N9cb347e02b414edc8aa77b4b26d2b078
104 Nebedeede41cb4ca5bfebefc1efad2da8
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137041153
106 https://doi.org/10.1186/s12893-021-01193-4
107 schema:sdDatePublished 2022-09-02T16:05
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N8dc19348bb034f68afd7c4030896b2e5
110 schema:url https://doi.org/10.1186/s12893-021-01193-4
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N0175591061be4258b293d9572ceebe90 rdf:first sg:person.01343042240.52
115 rdf:rest Naf6334145c3c4a4bb9475462dadca856
116 N044cf7a9dd034f539b94823c65610fd7 rdf:first sg:person.010046427403.76
117 rdf:rest N893caaf9198c4cdc8b5a7277a70aad55
118 N170f022b5c234f8997e52b5cf37c5275 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Chemotherapy, Adjuvant
120 rdf:type schema:DefinedTerm
121 N1ccfc377bcb448ea8d43d162351f61ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Colorectal Neoplasms
123 rdf:type schema:DefinedTerm
124 N219c0f4fbf3a4a71b84751954a040497 rdf:first sg:person.0730023440.22
125 rdf:rest Ndaadd51c8f3046ff8bbb7690b51deff7
126 N3ad28165eba94fd3a28a143014ff47e8 rdf:first sg:person.013777134017.58
127 rdf:rest N0175591061be4258b293d9572ceebe90
128 N3ee42f806feb46e6b3b84392652bc8b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Retrospective Studies
130 rdf:type schema:DefinedTerm
131 N4b88f0da358c44ffb9981276d87ebac1 schema:name doi
132 schema:value 10.1186/s12893-021-01193-4
133 rdf:type schema:PropertyValue
134 N5e348e3e204140a2a08b99c67758dead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Treatment Outcome
136 rdf:type schema:DefinedTerm
137 N6199dff925d24cb3b3c0de4e33c7ef06 rdf:first sg:person.0612301703.87
138 rdf:rest N7e56c9318feb46e4a1f1ac0422e7b7c9
139 N78b36748e5ff4ab086c1a60b6726b495 rdf:first sg:person.01372350065.75
140 rdf:rest N6199dff925d24cb3b3c0de4e33c7ef06
141 N7e56c9318feb46e4a1f1ac0422e7b7c9 rdf:first sg:person.0745271456.06
142 rdf:rest rdf:nil
143 N893caaf9198c4cdc8b5a7277a70aad55 rdf:first sg:person.01156724143.99
144 rdf:rest N93bba3d70f4f4109bdb59602a84c4287
145 N8a9708c7382e475486361a438b59510d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Postoperative Care
147 rdf:type schema:DefinedTerm
148 N8dc19348bb034f68afd7c4030896b2e5 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N93bba3d70f4f4109bdb59602a84c4287 rdf:first sg:person.01321031202.81
151 rdf:rest N219c0f4fbf3a4a71b84751954a040497
152 N9a7e59852dfa4b96b9a88530b16081f1 rdf:first sg:person.01160500440.85
153 rdf:rest Ne1fa4940005c4a6482dbd74f765b2703
154 N9cb347e02b414edc8aa77b4b26d2b078 schema:name pubmed_id
155 schema:value 33836701
156 rdf:type schema:PropertyValue
157 Na0c99ffac97040e1b6a48986f0c3d6b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Naf6334145c3c4a4bb9475462dadca856 rdf:first sg:person.010651416477.11
161 rdf:rest N044cf7a9dd034f539b94823c65610fd7
162 Nb5a84562ab4641f1a78f92e714598151 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Oxaliplatin
164 rdf:type schema:DefinedTerm
165 Nbb042b32964a475ea356d5597db17740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Liver Neoplasms
167 rdf:type schema:DefinedTerm
168 Nbfc52e2dacb94c13a8775086c8d030aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hepatectomy
170 rdf:type schema:DefinedTerm
171 Nc48f8688aee44459b5581cfd50658fd5 schema:volumeNumber 21
172 rdf:type schema:PublicationVolume
173 Ndaadd51c8f3046ff8bbb7690b51deff7 rdf:first sg:person.01356376603.82
174 rdf:rest N9a7e59852dfa4b96b9a88530b16081f1
175 Ne1fa4940005c4a6482dbd74f765b2703 rdf:first sg:person.016266353622.12
176 rdf:rest N78b36748e5ff4ab086c1a60b6726b495
177 Ne66b8883976c406b8a535e3c595dae93 schema:issueNumber 1
178 rdf:type schema:PublicationIssue
179 Nebedeede41cb4ca5bfebefc1efad2da8 schema:name dimensions_id
180 schema:value pub.1137041153
181 rdf:type schema:PropertyValue
182 Nfce92448fb724e59a8cc57087ee94b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Propensity Score
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
189 schema:name Oncology and Carcinogenesis
190 rdf:type schema:DefinedTerm
191 sg:journal.1024958 schema:issn 1471-2482
192 schema:name BMC Surgery
193 schema:publisher Springer Nature
194 rdf:type schema:Periodical
195 sg:person.010046427403.76 schema:affiliation grid-institutes:grid.482668.6
196 schema:familyName Amemiya
197 schema:givenName Kota
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010046427403.76
199 rdf:type schema:Person
200 sg:person.010651416477.11 schema:affiliation grid-institutes:grid.482668.6
201 schema:familyName Ii
202 schema:givenName Yuki
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010651416477.11
204 rdf:type schema:Person
205 sg:person.01156724143.99 schema:affiliation grid-institutes:grid.482668.6
206 schema:familyName Sugo
207 schema:givenName Hiroyuki
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156724143.99
209 rdf:type schema:Person
210 sg:person.01160500440.85 schema:affiliation grid-institutes:grid.258269.2
211 schema:familyName Kojima
212 schema:givenName Yutaka
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160500440.85
214 rdf:type schema:Person
215 sg:person.01321031202.81 schema:affiliation grid-institutes:grid.482667.9
216 schema:familyName Ito
217 schema:givenName Tomoaki
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321031202.81
219 rdf:type schema:Person
220 sg:person.01343042240.52 schema:affiliation grid-institutes:grid.258269.2
221 schema:familyName Sakamoto
222 schema:givenName Kazuhiro
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343042240.52
224 rdf:type schema:Person
225 sg:person.01356376603.82 schema:affiliation grid-institutes:grid.258269.2
226 schema:familyName Takahashi
227 schema:givenName Makoto
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356376603.82
229 rdf:type schema:Person
230 sg:person.01372350065.75 schema:affiliation grid-institutes:grid.482667.9
231 schema:familyName Sato
232 schema:givenName Koichi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372350065.75
234 rdf:type schema:Person
235 sg:person.013777134017.58 schema:affiliation grid-institutes:grid.258269.2
236 schema:familyName Sugimoto
237 schema:givenName Kiichi
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013777134017.58
239 rdf:type schema:Person
240 sg:person.016266353622.12 schema:affiliation grid-institutes:grid.258269.2
241 schema:familyName Tomiki
242 schema:givenName Yuichi
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016266353622.12
244 rdf:type schema:Person
245 sg:person.0612301703.87 schema:affiliation grid-institutes:grid.258269.2
246 schema:familyName Saiura
247 schema:givenName Akio
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87
249 rdf:type schema:Person
250 sg:person.0730023440.22 schema:affiliation grid-institutes:grid.258269.2
251 schema:familyName Munakata
252 schema:givenName Shinya
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730023440.22
254 rdf:type schema:Person
255 sg:person.0745271456.06 schema:affiliation grid-institutes:grid.258269.2
256 schema:familyName Kawasaki
257 schema:givenName Seiji
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745271456.06
259 rdf:type schema:Person
260 sg:pub.10.1007/s00268-015-3034-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009633901
261 https://doi.org/10.1007/s00268-015-3034-4
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s10147-019-01485-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1117184829
264 https://doi.org/10.1007/s10147-019-01485-z
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s10585-015-9719-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033034985
267 https://doi.org/10.1007/s10585-015-9719-0
268 rdf:type schema:CreativeWork
269 sg:pub.10.1245/s10434-014-3504-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020566781
270 https://doi.org/10.1245/s10434-014-3504-1
271 rdf:type schema:CreativeWork
272 grid-institutes:grid.258269.2 schema:alternateName Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
273 Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan
274 schema:name Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
275 Department of Hepatobiliary-Pancreatic Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan
276 rdf:type schema:Organization
277 grid-institutes:grid.482667.9 schema:alternateName Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan
278 schema:name Department of Surgery, Juntendo University Shizuoka Hospital, Shizuoka, Japan
279 rdf:type schema:Organization
280 grid-institutes:grid.482668.6 schema:alternateName Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan
281 schema:name Department of General Surgery, Juntendo University Nerima Hospital, Tokyo, Japan
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...