A case report of triple neural tube defect: revisiting the multisite closure theory View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-06

AUTHORS

Jayant Kumar Yadav, Ahtesham Khizar, Pradhumna Kumar Yadav, Ghulam Mustafa, Sajid Nazir Bhatti

ABSTRACT

BackgroundTriple neural tube defects are rare. To the author’s knowledge, there are only four reported cases available in the literature up to date. Controversies exist with regards to the development of neural tube defects. We revisit the multisite closure theory and try to explain the mechanism of neural tube defects in our case.Case presentationWe report a case of one-month-old baby boy who presented to us with three distinct neural tube defects. He had occipital and cervical encephaloceles along with thoracolumbar myelomeningocele accompanied by syrinx and mild hydrocephalus. All the three defects were surgically corrected with good neurological outcome.ConclusionIn the multisite model of human neural tube closure, there are only two fusion sites and two neuropores unlike in mouse. This can explain the origin of open neural tube defects including anencephaly and myelomeningocele (as in our case) but cannot account for the development of encephalocele, which appears to be a post neurulation defect. More... »

PAGES

164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12893-019-0633-2

DOI

http://dx.doi.org/10.1186/s12893-019-0633-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122359525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31694612


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